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Sponsored by: |
Azienda Ospedaliero-Universitaria di Parma |
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Information provided by: | Azienda Ospedaliero-Universitaria di Parma |
ClinicalTrials.gov Identifier: | NCT00816842 |
Citrulline is an amino acid produced in the intestine and in the liver, but the liver does not contribute significantly to circulating citrulline concentrations. The intestine is thus the only organ that normally releases significant amounts of citrulline into the blood stream. The investigators have designed a study looking at the value of measuring plasma citrulline concentration in patients with tropical enteropathy of mixed HIV status. The focus will be on the ability of the intestine to sustain the individual concerned from a nutritional standpoint. The investigators hypothesise that plasma citrulline concentration is a marker of small bowel absorptive integrity and an appropriate surrogate for HIV related enteropathy.
Condition |
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Malabsorption Syndromes Granulomatous Enteritis Enteritis HIV Enteropathy Ileal Diseases |
Study Type: | Observational |
Official Title: | Plasma Citrulline as Quantitative Biomarker of HIV Associate Villous Atrophy in a Tropical Enteropathy Population |
Study Start Date: | October 1998 |
Study Completion Date: | September 2008 |
Primary Completion Date: | May 2008 (Final data collection date for primary outcome measure) |
Preliminary studies reported that plasma citrulline concentrations may be a reliable biochemical marker for intestinal dysfunction and absorptive enterocyte mass. The relationship between citrulline concentration and intestinal function has been supported in other studies including those examining rejection in small bowel allografts. Concentrations of citrulline are dramatically reduced in cases of mucosal damage (e.g. moderate graft rejection or viral enteritis)and strongly correlate (inversely) with severity on biopsy. Plasma citrulline concentration is lower also in patients with villous atrophy (24±13µmol/L)than in healthy subjects (40±10µmol/L)and patients with anorexia nervosa (39±9µmol/L).Experimental studies have been carried out also in assessing the value of citrulline as a marker for severity of small bowel epithelial damage from radiation and viral infections. The plasma citrulline was shown to be a simple, non invasive and sensitive essay to monitor and quantify radiation and/or chemotherapy induced small bowel damage in mice and humans. Otherwise, the literature on citrulline as a potential marker of intestinal and nutritional integrity is young and consistent data for specific conditions as for HIV enteropathy are missing.We hypothesise that plasma citrulline concentration is a marker of small bowel absorptive integrity and an appropriate surrogate for HIV related enteropathy.
Ages Eligible for Study: | 18 Years to 80 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Tropical enteropathy with mixed HIV status
Inclusion Criteria:
Exclusion Criteria:
Zambia, Lusaka province | |
Department of Medicine, University of Zambia School of Medicine, University Teaching Hospital | |
Lusaka, Lusaka province, Zambia, P/B RW1X |
Principal Investigator: | Cinzia Papadia, MD | Azienda Ospedaliero-Universitaria di Parma |
Study Chair: | Alastair Forbes, BSc MD FRCP ILTM | University College London Hospitals |
Study Director: | Antonio Di Sabatino, MD | University of Pavia |
Responsible Party: | Azienda Ospedaliera Universitaria di Parma ( Cinzia Papadia ) |
Study ID Numbers: | EC3184, Prot 84 24/01/06 |
Study First Received: | January 2, 2009 |
Last Updated: | January 2, 2009 |
ClinicalTrials.gov Identifier: | NCT00816842 |
Health Authority: | United Kingdom: Research Ethics Committee |
citrulline malabsorption Villous atrophy enteropathy |
Crohn's disease Sexually Transmitted Diseases, Viral Metabolic Diseases Ileitis Gastrointestinal Diseases HIV Enteropathy Enteritis Acquired Immunodeficiency Syndrome Sprue, Tropical Inflammatory Bowel Diseases Intestinal Diseases Ileal Diseases |
Immunologic Deficiency Syndromes Virus Diseases Tropical sprue Digestive System Diseases HIV Infections Sexually Transmitted Diseases Crohn Disease Malabsorption Syndromes Atrophy Metabolic disorder Gastroenteritis Retroviridae Infections |
RNA Virus Infections Pathologic Processes Disease |
Immune System Diseases Syndrome Lentivirus Infections |