NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:40:52 FINAL#1/MICE Facility: Southern Research Institute Chemical CAS #: 7775-09-9 Lock Date: 10/16/01 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:40:52 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 50 50 50 50 Early Deaths Natural Death 10 10 12 7 Moribund Sacrifice 3 5 6 8 Accidently Killed 1 Survivors Terminal Sacrifice 36 34 31 35 Moribund Sacrifice 1 Other 1 Animals Examined Microscopically 50 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Esophagus (49) (50) (50) (50) Gallbladder (40) (44) (44) (48) Intestine Large, Cecum (44) (47) (47) (47) Hemangioma 1 (2%) Intestine Small, Duodenum (46) (47) (47) (50) Adenoma 1 (2%) Polyp Adenomatous 1 (2%) Intestine Small, Jejunum (45) (47) (47) (47) Histiocytic Sarcoma 1 (2%) Intestine Small, Ileum (42) (45) (46) (47) Liver (49) (50) (49) (50) Hemangioma 2 (4%) Hemangiosarcoma 1 (2%) 2 (4%) Hemangiosarcoma, Metastatic, Spleen 1 (2%) Hepatoblastoma 1 (2%) Hepatocellular Carcinoma 2 (4%) 6 (12%) 11 (22%) 6 (12%) Hepatocellular Carcinoma, Multiple 1 (2%) 7 (14%) 4 (8%) 3 (6%) Hepatocellular Adenoma 15 (31%) 9 (18%) 14 (29%) 8 (16%) Hepatocellular Adenoma, Multiple 15 (31%) 10 (20%) 12 (24%) 15 (30%) Histiocytic Sarcoma 1 (2%) 1 (2%) Mesentery (30) (32) (27) (24) Fibrosarcoma 1 (4%) Fibrous Histiocytoma 1 (3%) Hemangiosarcoma 1 (4%) Hepatocellular Carcinoma, Metastatic, Liver 1 (4%) Histiocytic Sarcoma 1 (4%) Page 2 NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:40:52 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont Sarcoma, Metastatic, Skin 1 (4%) Schwannoma Malignant, Metastatic, Skin 1 (3%) Oral Mucosa (2) (1) Squamous Cell Carcinoma 1 (50%) Squamous Cell Papilloma 1 (100%) Pancreas (46) (47) (49) (48) Fibrosarcoma, Metastatic, Mesentery 1 (2%) Histiocytic Sarcoma 1 (2%) Sarcoma, Metastatic, Skin 1 (2%) Acinus, Sarcoma 1 (2%) Salivary Glands (48) (47) (49) (50) Hepatocellular Carcinoma, Metastatic, Liver 1 (2%) Histiocytic Sarcoma 1 (2%) Stomach, Forestomach (49) (50) (50) (49) Squamous Cell Carcinoma 1 (2%) 1 (2%) Squamous Cell Papilloma 1 (2%) 1 (2%) Squamous Cell Papilloma, Multiple 1 (2%) Stomach, Glandular (49) (48) (50) (49) Hepatocellular Carcinoma, Metastatic, Liver 1 (2%) Tongue (2) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (49) (50) (49) (50) Hemangiosarcoma, Metastatic, Spleen 1 (2%) Hepatocellular Carcinoma, Metastatic, Liver 1 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (50) (49) (49) (50) Histiocytic Sarcoma 1 (2%) Osteosarcoma, Metastatic, Bone 1 (2%) Subcapsular, Adenoma 1 (2%) Adrenal Medulla (50) (49) (49) (50) Pheochromocytoma Malignant 2 (4%) Pheochromocytoma Complex 1 (2%) Pheochromocytoma Benign 1 (2%) 1 (2%) Islets, Pancreatic (46) (47) (49) (49) Adenoma 2 (4%) 2 (4%) 3 (6%) Carcinoma 1 (2%) Pituitary Gland (46) (45) (48) (50) Page 3 NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:40:52 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont Histiocytic Sarcoma 1 (2%) Pars Distalis, Adenoma 3 (7%) 2 (4%) 4 (8%) 4 (8%) Thyroid Gland (48) (50) (49) (50) Follicular Cell, Adenoma 1 (2%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Clitoral Gland (47) (47) (47) (49) Ovary (45) (45) (47) (50) Choriocarcinoma 2 (4%) Cystadenoma 1 (2%) 4 (9%) 1 (2%) 1 (2%) Granulosa Cell Tumor Malignant 1 (2%) Granulosa Cell Tumor Benign 1 (2%) 1 (2%) 1 (2%) 5 (10%) Histiocytic Sarcoma 2 (4%) 1 (2%) Luteoma 3 (7%) 1 (2%) Yolk Sac Carcinoma 1 (2%) Uterus (50) (50) (50) (50) Hemangiosarcoma 1 (2%) Histiocytic Sarcoma 2 (4%) 1 (2%) Leiomyosarcoma 1 (2%) Polyp Stromal 1 (2%) 3 (6%) Yolk Sac Carcinoma, Metastatic, Ovary 1 (2%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (50) (50) (50) Hemangiosarcoma 1 (2%) 1 (2%) 2 (4%) Histiocytic Sarcoma 1 (2%) Lymph Node (7) (5) (11) (9) Histiocytic Sarcoma 1 (9%) Liposarcoma, Metastatic, Skin 1 (20%) Iliac, Histiocytic Sarcoma 2 (18%) Iliac, Liposarcoma, Metastatic, Skin 1 (20%) Mediastinal, Sarcoma, Metastatic, Pancreas 1 (9%) Pancreatic, Histiocytic Sarcoma 1 (9%) Renal, Histiocytic Sarcoma 1 (9%) 1 (11%) Page 4 NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:40:52 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont Lymph Node, Mandibular (46) (46) (49) (49) Histiocytic Sarcoma 2 (4%) Squamous Cell Carcinoma, Metastatic, Uncertain Primary Site 1 (2%) Lymph Node, Mesenteric (47) (49) (49) (49) Histiocytic Sarcoma 1 (2%) 2 (4%) Histiocytic Sarcoma, Metastatic, Mesentery 1 (2%) Yolk Sac Carcinoma, Metastatic, Ovary 1 (2%) Spleen (49) (48) (49) (50) Hemangiosarcoma 2 (4%) 1 (2%) 1 (2%) Histiocytic Sarcoma 2 (4%) Sarcoma, Metastatic, Skin 1 (2%) Thymus (48) (44) (48) (48) Hepatocellular Carcinoma, Metastatic, Liver 1 (2%) Histiocytic Sarcoma 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (50) (50) (50) (50) Adenoma 1 (2%) Carcinoma 1 (2%) Skin (48) (50) (50) (50) Hemangioma 1 (2%) Squamous Cell Carcinoma 1 (2%) Subcutaneous Tissue, Fibrosarcoma 1 (2%) 2 (4%) Subcutaneous Tissue, Hemangioma 1 (2%) Subcutaneous Tissue, Hemangiosarcoma 1 (2%) Subcutaneous Tissue, Liposarcoma 1 (2%) Subcutaneous Tissue, Sarcoma 1 (2%) Subcutaneous Tissue, Schwannoma Malignant 3 (6%) 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (50) (50) (50) Osteosarcoma 1 (2%) 1 (2%) 2 (4%) Sarcoma 1 (2%) Skeletal Muscle (2) (4) (6) Histiocytic Sarcoma, Metastatic, Mesentery 1 (25%) Rhabdomyosarcoma 1 (50%) 1 (25%) 2 (33%) Sarcoma, Metastatic, Pancreas 1 (25%) Sarcoma, Metastatic, Skin 1 (17%) Page 5 NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:40:52 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM - cont Yolk Sac Carcinoma, Metastatic, Ovary 1 (17%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (50) (50) (50) Osteosarcoma, Metastatic, Bone 1 (2%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (50) (50) (49) (50) Alveolar/Bronchiolar Adenoma 3 (6%) 1 (2%) 3 (6%) Alveolar/Bronchiolar Carcinoma 1 (2%) 1 (2%) 1 (2%) 1 (2%) Alveolar/Bronchiolar Carcinoma, Multiple 1 (2%) Hepatocellular Carcinoma, Metastatic, Liver 1 (2%) 3 (6%) 5 (10%) 2 (4%) Histiocytic Sarcoma 1 (2%) 1 (2%) Liposarcoma, Metastatic, Skin 1 (2%) Osteosarcoma, Metastatic, Bone 1 (2%) Sarcoma, Metastatic, Skin 1 (2%) Nose (50) (50) (50) (50) Carcinoma 1 (2%) Histiocytic Sarcoma 1 (2%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (50) (48) (50) (50) Harderian Gland (50) (50) (50) (49) Adenoma 11 (22%) 9 (18%) 5 (10%) 6 (12%) Carcinoma 1 (2%) 1 (2%) Histiocytic Sarcoma 1 (2%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (49) (49) (50) Hepatocellular Carcinoma, Metastatic, Liver 1 (2%) Histiocytic Sarcoma 1 (2%) Osteosarcoma, Metastatic, Bone 1 (2%) Urinary Bladder (49) (50) (50) (50) Page 6 NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:40:52 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(50) *(50) *(50) *(50) Histiocytic Sarcoma 1 (2%) 4 (8%) 2 (4%) Leukemia Granulocytic 1 (2%) Lymphoma Malignant 23 (46%) 19 (38%) 28 (56%) 27 (54%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 7 NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:40:52 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 47 45 46 47 Total Primary Neoplasms 99 87 108 105 Total Animals with Benign Neoplasms 38 27 33 31 Total Benign Neoplasms 58 40 44 53 Total Animals with Malignant Neoplasms 33 38 41 41 Total Malignant Neoplasms 41 47 64 52 Total Animals with Metastatic Neoplasms 2 5 10 5 Total Metastatic Neoplasm 2 8 20 11 Total Animals with Malignant Neoplasms 1 Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 8 NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:40:52 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 50 50 50 50 Early Deaths Natural Death 7 4 5 7 Moribund Sacrifice 5 5 4 10 Survivors Terminal Sacrifice 38 41 41 33 Animals Examined Microscopically 50 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Colon (48) (50) (50) (50) Histiocytic Sarcoma, Metastatic, Liver 1 (2%) Intestine Large, Cecum (47) (49) (49) (48) Carcinoma 1 (2%) Histiocytic Sarcoma 1 (2%) Histiocytic Sarcoma, Metastatic, Liver 1 (2%) Intestine Small, Duodenum (48) (50) (49) (49) Adenoma 1 (2%) Carcinoma 1 (2%) Carcinoma, Metastatic, Islets, Pancreatic 1 (2%) Polyp Adenomatous 2 (4%) Intestine Small, Jejunum (47) (49) (50) (50) Adenoma 1 (2%) 1 (2%) Carcinoma 2 (4%) 2 (4%) 2 (4%) Liver (48) (50) (50) (50) Carcinoma, Metastatic, Islets, Pancreatic 1 (2%) Cholangiocarcinoma 1 (2%) 1 (2%) Hemangioma 1 (2%) Hemangiosarcoma 1 (2%) 2 (4%) 1 (2%) 2 (4%) Hemangiosarcoma, Metastatic, Spleen 1 (2%) Hepatoblastoma 5 (10%) 3 (6%) 1 (2%) 3 (6%) Hepatoblastoma, Multiple 1 (2%) Hepatocellular Carcinoma 14 (29%) 13 (26%) 14 (28%) 12 (24%) Hepatocellular Carcinoma, Multiple 6 (13%) 1 (2%) 5 (10%) 1 (2%) Hepatocellular Adenoma 16 (33%) 15 (30%) 13 (26%) 14 (28%) Hepatocellular Adenoma, Multiple 14 (29%) 17 (34%) 23 (46%) 16 (32%) Histiocytic Sarcoma 1 (2%) 2 (4%) 2 (4%) Ito Cell Tumor Malignant 1 (2%) Leiomyosarcoma, Metastatic, Mesentery 1 (2%) Page 9 NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:40:52 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont Mesentery (9) (10) (10) (8) Cholangiocarcinoma, Metastatic, Liver 1 (11%) Hepatocellular Carcinoma, Metastatic, Liver 1 (10%) 1 (13%) Histiocytic Sarcoma 2 (25%) Histiocytic Sarcoma, Metastatic, Liver 1 (11%) Ito Cell Tumor Malignant, Metastatic, Liver 1 (10%) Leiomyosarcoma 1 (11%) Liposarcoma 1 (10%) Pancreas (48) (50) (50) (50) Cholangiocarcinoma, Metastatic, Liver 1 (2%) Hepatocellular Carcinoma, Metastatic, Liver 1 (2%) 1 (2%) Histiocytic Sarcoma, Metastatic, Liver 1 (2%) Salivary Glands (50) (50) (50) (50) Histiocytic Sarcoma 1 (2%) Stomach, Forestomach (49) (50) (50) (50) Leiomyosarcoma, Metastatic, Mesentery 1 (2%) Squamous Cell Papilloma 2 (4%) 2 (4%) Stomach, Glandular (48) (50) (50) (50) Adenoma 2 (4%) Histiocytic Sarcoma, Metastatic, Liver 1 (2%) Leiomyosarcoma, Metastatic, Mesentery 1 (2%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (50) (50) (50) (50) Cholangiocarcinoma, Metastatic, Liver 1 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (50) (50) (50) (50) Adenoma 1 (2%) 1 (2%) 1 (2%) 1 (2%) Hepatocellular Carcinoma, Metastatic, Liver 1 (2%) Bilateral, Subcapsular, Adenoma 1 (2%) Subcapsular, Adenoma 1 (2%) 3 (6%) 4 (8%) 2 (4%) Islets, Pancreatic (48) (50) (50) (50) Adenoma 1 (2%) 1 (2%) Carcinoma 1 (2%) Pituitary Gland (47) (47) (45) (49) Pars Distalis, Adenoma 1 (2%) ____________________________________________________________________________________________________________________________________ Page 10 NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:40:52 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (50) (50) (50) (50) Cholangiocarcinoma, Metastatic, Liver 1 (2%) Histiocytic Sarcoma, Metastatic, Liver 1 (2%) Prostate (50) (50) (50) (50) Seminal Vesicle (50) (50) (50) (50) Histiocytic Sarcoma, Metastatic, Liver 1 (2%) Testes (50) (50) (50) (50) Interstitial Cell, Adenoma 2 (4%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (49) (50) (50) (50) Hemangiosarcoma, Metastatic, Spleen 1 (2%) Histiocytic Sarcoma 1 (2%) Lymph Node (3) (1) (3) Mediastinal, Carcinoma, Metastatic, Harderian Gland 1 (33%) Mediastinal, Hepatocellular Carcinoma, Metastatic, Liver 1 (100%) 1 (33%) Mediastinal, Histiocytic Sarcoma, Metastatic, Liver 1 (33%) Mediastinal, Leiomyosarcoma, Metastatic, Mesentery 1 (33%) Pancreatic, Hepatocellular Carcinoma, Metastatic, Liver 1 (100%) Pancreatic, Histiocytic Sarcoma, Metastatic, Liver 1 (33%) Renal, Hepatocellular Carcinoma, Metastatic, Liver 1 (100%) Renal, Histiocytic Sarcoma, Metastatic, Liver 1 (33%) Renal, Leiomyosarcoma, Metastatic, Mesentery 1 (33%) Lymph Node, Mandibular (49) (48) (45) (49) Histiocytic Sarcoma 1 (2%) Lymph Node, Mesenteric (47) (50) (50) (50) Hepatocellular Carcinoma, Metastatic, Liver 1 (2%) Page 11 NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:40:52 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont Histiocytic Sarcoma 1 (2%) Leiomyosarcoma, Metastatic, Mesentery 1 (2%) Spleen (48) (50) (50) (50) Hemangiosarcoma 1 (2%) Histiocytic Sarcoma 1 (2%) 1 (2%) Histiocytic Sarcoma, Metastatic, Liver 1 (2%) Leiomyosarcoma, Metastatic, Mesentery 1 (2%) Thymus (43) (43) (40) (44) Alveolar/Bronchiolar Carcinoma, Metastatic, Lung 1 (3%) Hepatocellular Carcinoma, Metastatic, Liver 1 (3%) Leiomyosarcoma, Metastatic, Mesentery 1 (2%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (50) (50) (50) (50) Subcutaneous Tissue, Fibrous Histiocytoma 1 (2%) Subcutaneous Tissue, Lipoma 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (50) (50) (50) Carcinoma, Metastatic, Harderian Gland 1 (2%) Skeletal Muscle (3) (1) (3) (2) Alveolar/Bronchiolar Carcinoma, Metastatic, Lung 2 (67%) Hepatocellular Carcinoma, Metastatic, Liver 1 (50%) Histiocytic Sarcoma, Metastatic, Liver 1 (33%) Leiomyosarcoma, Metastatic, Mesentery 1 (33%) Rhabdomyosarcoma 1 (50%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ Page 12 NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:40:52 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (50) (50) (50) (50) Alveolar/Bronchiolar Adenoma 6 (12%) 4 (8%) 7 (14%) 6 (12%) Alveolar/Bronchiolar Carcinoma 4 (8%) 5 (10%) 6 (12%) 4 (8%) Alveolar/Bronchiolar Carcinoma, Multiple 1 (2%) Carcinoma, Metastatic, Harderian Gland 1 (2%) Carcinoma, Metastatic, Kidney 1 (2%) Hemangiosarcoma 1 (2%) Hepatoblastoma, Metastatic, Liver 1 (2%) 2 (4%) Hepatocellular Carcinoma, Metastatic, Liver 9 (18%) 2 (4%) 4 (8%) 6 (12%) Histiocytic Sarcoma 1 (2%) 1 (2%) Histiocytic Sarcoma, Metastatic, Liver 1 (2%) Leiomyosarcoma, Metastatic, Mesentery 1 (2%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Harderian Gland (50) (50) (50) (49) Adenoma 6 (12%) 4 (8%) 4 (8%) 6 (12%) Carcinoma 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (49) (50) (50) (50) Alveolar/Bronchiolar Carcinoma, Metastatic, Lung 1 (2%) Hepatocellular Carcinoma, Metastatic, Liver 1 (2%) Renal Tubule, Adenoma 1 (2%) Renal Tubule, Carcinoma 1 (2%) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(50) *(50) *(50) *(50) Histiocytic Sarcoma 1 (2%) 2 (4%) 3 (6%) Lymphoma Malignant 3 (6%) 1 (2%) 3 (6%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 13 NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:40:52 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 45 45 47 45 Total Primary Neoplasms 86 76 95 87 Total Animals with Benign Neoplasms 34 38 37 34 Total Benign Neoplasms 47 48 59 51 Total Animals with Malignant Neoplasms 29 22 30 27 Total Malignant Neoplasms 39 28 36 36 Total Animals with Metastatic Neoplasms 12 5 9 8 Total Metastatic Neoplasm 38 5 20 14 Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 14 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------