NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 FINAL#1/MICE Facility: Southern Research Institute Chemical CAS #: 7775-09-9 Lock Date: 10/16/01 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Note: Animals arranged according to days on test Page 1 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 _____________________________________________________________________________________________________________________ | 2| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 7| 4| 2| 7| 8| 9| 9| 9| 0| 3| 3| 6| 7| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 1| 0| 4| 6| 8| 1| 1| 7| 6| 0| 9| 0| 4| 0| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 MG/L | 1| 1| 2| 2| 0| 0| 4| 0| 2| 3| 4| 3| 2| 4| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| | 3| 7| 8| 7| 4| 5| 6| 6| 5| 3| 2| 0| 2| 5| 1| 2| 3| 1| 2| 4| 5| 6| 8| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Gallbladder | A A + + A + + A + A A A A A + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | A + + + + + + + + A + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + A + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + A + + A + + + A A A A + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | A + + + + + + A + A + A + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | A A + + + + + + I A A + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | A M + + A + + A M A A + + + + + + + + + + + + M +| |__________________________________________________________________________| Liver | A + + + + + + + + + + + + + + + + + + + + + + + +| Hemangioma | X | Hemangiosarcoma | | Hepatoblastoma | | Hepatocellular Carcinoma | X | Hepatocellular Carcinoma, Multiple | | Hepatocellular Adenoma | X X X X| Hepatocellular Adenoma, Multiple | X X X X X X | |__________________________________________________________________________| Mesentery | A + + + + + + + + + + + + + + + + + + | Fibrous Histiocytoma | | Schwannoma Malignant, Metastatic, | | Skin | X | |__________________________________________________________________________| Oral Mucosa | + +| Squamous Cell Carcinoma | X| |__________________________________________________________________________| Pancreas | A A + + A + + M + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Salivary Glands | + + + + M + + + M + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 2 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 _____________________________________________________________________________________________________________________ | 2| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 7| 4| 2| 7| 8| 9| 9| 9| 0| 3| 3| 6| 7| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 1| 0| 4| 6| 8| 1| 1| 7| 6| 0| 9| 0| 4| 0| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 MG/L | 1| 1| 2| 2| 0| 0| 4| 0| 2| 3| 4| 3| 2| 4| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| | 3| 7| 8| 7| 4| 5| 6| 6| 5| 3| 2| 0| 2| 5| 1| 2| 3| 1| 2| 4| 5| 6| 8| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | |__________________________________________________________________________| Stomach, Forestomach | A + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | A + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | | |__________________________________________________________________________| Heart | + + + + + + + + M + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcapsular, Adenoma | | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Malignant | X | Pheochromocytoma Benign | X | |__________________________________________________________________________| Islets, Pancreatic | A A + + A + + M + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | M M + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | M + + + I M + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | | |__________________________________________________________________________| Thyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | I + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 3 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 _____________________________________________________________________________________________________________________ | 2| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 7| 4| 2| 7| 8| 9| 9| 9| 0| 3| 3| 6| 7| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 1| 0| 4| 6| 8| 1| 1| 7| 6| 0| 9| 0| 4| 0| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 MG/L | 1| 1| 2| 2| 0| 0| 4| 0| 2| 3| 4| 3| 2| 4| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| | 3| 7| 8| 7| 4| 5| 6| 6| 5| 3| 2| 0| 2| 5| 1| 2| 3| 1| 2| 4| 5| 6| 8| 9| 0| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | |__________________________________________________________________________| Ovary | A + + + + + + + + + + + + + + + M I M + + + + + +| Cystadenoma | | Granulosa Cell Tumor Benign | | Luteoma | X X | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Polyp Stromal | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | |__________________________________________________________________________| Lymph Node | + + + +| |__________________________________________________________________________| Lymph Node, Mandibular | + + + + M + + + M + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node, Mesenteric | A + + + + + + + + + + + + + + + + + M + + + M + +| |__________________________________________________________________________| Spleen | A + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | |__________________________________________________________________________| Thymus | + + + + + + + + M + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skin | + + + + + + I + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Schwannoma | | Malignant | X X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 4 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 _____________________________________________________________________________________________________________________ | 2| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 7| 4| 2| 7| 8| 9| 9| 9| 0| 3| 3| 6| 7| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 1| 0| 4| 6| 8| 1| 1| 7| 6| 0| 9| 0| 4| 0| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 MG/L | 1| 1| 2| 2| 0| 0| 4| 0| 2| 3| 4| 3| 2| 4| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| | 3| 7| 8| 7| 4| 5| 6| 6| 5| 3| 2| 0| 2| 5| 1| 2| 3| 1| 2| 4| 5| 6| 8| 9| 0| __________________________________________|__________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X| Alveolar/Bronchiolar Carcinoma | | Hepatocellular Carcinoma, Metastatic,| | Liver | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | |__________________________________________________________________________| Trachea | I + + + M + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X X | Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Urinary Bladder | A + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X X X X X X X X X X X| __________________________________________|__________________________________________________________________________| Page 5 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0 MG/L | 2| 2| 4| 4| 4| 5| 0| 0| 0| 1| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 3| 3| 3| 3| L | | 6| 9| 7| 8| 9| 0| 7| 8| 9| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| 1| 2| 4| 5| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + M + + + + + + + + + +| 40 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + I + + + + + +| 48 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 44 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 45 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 42 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hemangioma | X | 2 | Hemangiosarcoma | X | 1 | Hepatoblastoma | X | 1 | Hepatocellular Carcinoma | X | 2 | Hepatocellular Carcinoma, Multiple | X | 1 | Hepatocellular Adenoma | X X X X X X X X X X X| 15 | Hepatocellular Adenoma, Multiple | X X X X X X X X X | 15 | |__________________________________________________________________________|____________| Mesentery | + + + + + + + + + + + + | 30 | Fibrous Histiocytoma | X | 1 | Schwannoma Malignant, Metastatic, | | | Skin | | 1 | |__________________________________________________________________________|____________| Oral Mucosa | | 2 | Squamous Cell Carcinoma | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 6 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0 MG/L | 2| 2| 4| 4| 4| 5| 0| 0| 0| 1| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 3| 3| 3| 3| L | | 6| 9| 7| 8| 9| 0| 7| 8| 9| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| 1| 2| 4| 5| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + | 1 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcapsular, Adenoma | X | 1 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pheochromocytoma Malignant | X | 2 | Pheochromocytoma Benign | | 1 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 | |__________________________________________________________________________|____________| Parathyroid Gland | M M + + + + + + + + + + + + + + + + M + + + + + +| 45 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| 46 | Pars Distalis, Adenoma | X X X | 3 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| 48 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 7 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0 MG/L | 2| 2| 4| 4| 4| 5| 0| 0| 0| 1| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 3| 3| 3| 3| L | | 6| 9| 7| 8| 9| 0| 7| 8| 9| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| 1| 2| 4| 5| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Follicular Cell, Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + M + I + + + + + + + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + I +| 45 | Cystadenoma | X | 1 | Granulosa Cell Tumor Benign | X | 1 | Luteoma | X | 3 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Polyp Stromal | X | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | | 1 | |__________________________________________________________________________|____________| Lymph Node | + + + | 7 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + I + + + + + + + + I + + + + + + +| 46 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hemangiosarcoma | X | 2 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + I + + + + + + + +| 48 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 8 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0 MG/L | 2| 2| 4| 4| 4| 5| 0| 0| 0| 1| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 3| 3| 3| 3| L | | 6| 9| 7| 8| 9| 0| 7| 8| 9| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| 1| 2| 4| 5| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + I + + + + + + + +| 48 | Subcutaneous Tissue, Schwannoma | | | Malignant | X | 3 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X | 3 | Alveolar/Bronchiolar Carcinoma | X | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X | 1 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma | | 1 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 9 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0 MG/L | 2| 2| 4| 4| 4| 5| 0| 0| 0| 1| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 3| 3| 3| 3| L | | 6| 9| 7| 8| 9| 0| 7| 8| 9| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| 1| 2| 4| 5| | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM - cont | | | | | | Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X X X X X X X | 11 | Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X X X X X X X X X X X X| 23 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 10 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 _____________________________________________________________________________________________________________________ | 4| 4| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 6| 9| 1| 5| 6| 6| 7| 7| 8| 0| 1| 1| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 1| 2| 3| 2| 1| 8| 3| 4| 2| 6| 3| 4| 7| 9| 7| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 500 MG/L | 9| 6| 9| 8| 9| 6| 0| 7| 8| 8| 9| 5| 8| 9| 9| 5| 5| 5| 6| 6| 6| 6| 7| 9| 5| | 3| 8| 6| 8| 9| 3| 0| 7| 6| 5| 2| 8| 4| 7| 0| 7| 6| 9| 0| 6| 7| 9| 0| 8| 1| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Gallbladder | + M A A + + + + + + + + M A A + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + A + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + A + A + + + + + + + + + + A + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + A + A + + + + + + + + + + A + + + + + + + + + +| Adenoma | X | |__________________________________________________________________________| Intestine Small, Jejunum | + + + A + + + + + + + + A + A + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + A A A + + + + + + + A + + A + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Hemangiosarcoma, Metastatic, Spleen | X | Hepatocellular Carcinoma | X X X | Hepatocellular Carcinoma, Multiple | X X X | Hepatocellular Adenoma | X X X X | Hepatocellular Adenoma, Multiple | X X | |__________________________________________________________________________| Mesentery | + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Pancreas | + A A A + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Salivary Glands | + M M + + + + + + + + + + M + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma | | |__________________________________________________________________________| Stomach, Glandular | + A + A + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 11 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 _____________________________________________________________________________________________________________________ | 4| 4| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 6| 9| 1| 5| 6| 6| 7| 7| 8| 0| 1| 1| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 1| 2| 3| 2| 1| 8| 3| 4| 2| 6| 3| 4| 7| 9| 7| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 500 MG/L | 9| 6| 9| 8| 9| 6| 0| 7| 8| 8| 9| 5| 8| 9| 9| 5| 5| 5| 6| 6| 6| 6| 7| 9| 5| | 3| 8| 6| 8| 9| 3| 0| 7| 6| 5| 2| 8| 4| 7| 0| 7| 6| 9| 0| 6| 7| 9| 0| 8| 1| __________________________________________|__________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma, Metastatic, Spleen | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + M +| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + M +| |__________________________________________________________________________| Islets, Pancreatic | + A A A + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | |__________________________________________________________________________| Parathyroid Gland | + + + + + + M + + + + + M + + + + + + + + + M + +| |__________________________________________________________________________| Pituitary Gland | + M + + + + + M + + + + + + + + + + M + + + + + +| Pars Distalis, Adenoma | X X | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + M + + + + + + + + + + + + + + + I + + + + + +| |__________________________________________________________________________| Ovary | + M + I + + + + + + M + + M + + + + + + + + + + +| Cystadenoma | X | Granulosa Cell Tumor Benign | | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | __________________________________________|__________________________________________________________________________| Page 12 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 _____________________________________________________________________________________________________________________ | 4| 4| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 6| 9| 1| 5| 6| 6| 7| 7| 8| 0| 1| 1| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 1| 2| 3| 2| 1| 8| 3| 4| 2| 6| 3| 4| 7| 9| 7| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 500 MG/L | 9| 6| 9| 8| 9| 6| 0| 7| 8| 8| 9| 5| 8| 9| 9| 5| 5| 5| 6| 6| 6| 6| 7| 9| 5| | 3| 8| 6| 8| 9| 3| 0| 7| 6| 5| 2| 8| 4| 7| 0| 7| 6| 9| 0| 6| 7| 9| 0| 8| 1| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X| |__________________________________________________________________________| Lymph Node | + + + + | Liposarcoma, Metastatic, Skin | X | Iliac, Liposarcoma, Metastatic, Skin | X | |__________________________________________________________________________| Lymph Node, Mandibular | + M M + + + + + + + + + + M + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | |__________________________________________________________________________| Spleen | + A + A + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | |__________________________________________________________________________| Thymus | + + M + M + + + + + I + + M M + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangioma | | Subcutaneous Tissue, Fibrosarcoma | X | Subcutaneous Tissue, Liposarcoma | X | Subcutaneous Tissue, Schwannoma | | Malignant | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma | X | |__________________________________________________________________________| Skeletal Muscle | + + | __________________________________________|__________________________________________________________________________| Page 13 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 _____________________________________________________________________________________________________________________ | 4| 4| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 6| 9| 1| 5| 6| 6| 7| 7| 8| 0| 1| 1| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 1| 2| 3| 2| 1| 8| 3| 4| 2| 6| 3| 4| 7| 9| 7| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 500 MG/L | 9| 6| 9| 8| 9| 6| 0| 7| 8| 8| 9| 5| 8| 9| 9| 5| 5| 5| 6| 6| 6| 6| 7| 9| 5| | 3| 8| 6| 8| 9| 3| 0| 7| 6| 5| 2| 8| 4| 7| 0| 7| 6| 9| 0| 6| 7| 9| 0| 8| 1| __________________________________________|__________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | Rhabdomyosarcoma | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Alveolar/Bronchiolar Carcinoma | | Hepatocellular Carcinoma, Metastatic,| | Liver | X X | Liposarcoma, Metastatic, Skin | X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + A + A + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X | Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + A + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant | X X X X X X X X X | __________________________________________|__________________________________________________________________________| Page 14 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 500 MG/L | 5| 5| 5| 5| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 7| 7| 7| 7| 7| 8| 8| 6| 6| 6| 6| L | | 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 1| 4| 5| 1| 2| 3| 4| 5| 7| 9| 1| 2| 4| 5| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 44 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Adenoma | | 1 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 45 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | X | 2 | Hemangiosarcoma, Metastatic, Spleen | | 1 | Hepatocellular Carcinoma | X X X | 6 | Hepatocellular Carcinoma, Multiple | X X X X| 7 | Hepatocellular Adenoma | X X X X X | 9 | Hepatocellular Adenoma, Multiple | X X X X X X X X | 10 | |__________________________________________________________________________|____________| Mesentery | + + + + + + + + + + + + + + + +| 32 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 15 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 500 MG/L | 5| 5| 5| 5| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 7| 7| 7| 7| 7| 8| 8| 6| 6| 6| 6| L | | 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 1| 4| 5| 1| 2| 3| 4| 5| 7| 9| 1| 2| 4| 5| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Squamous Cell Carcinoma | X | 1 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | | 3 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma, Metastatic, Spleen | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Adenoma | X | 2 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Pituitary Gland | + + M + + + + + + + + + + + M + + + + + + + + + +| 45 | Pars Distalis, Adenoma | | 2 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 16 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 500 MG/L | 5| 5| 5| 5| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 7| 7| 7| 7| 7| 8| 8| 6| 6| 6| 6| L | | 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 1| 4| 5| 1| 2| 3| 4| 5| 7| 9| 1| 2| 4| 5| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | | | | Clitoral Gland | + + + + + + + + + + + + + M + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + I + + + + + + + + + + + + + + +| 45 | Cystadenoma | X X X | 4 | Granulosa Cell Tumor Benign | X | 1 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | | 1 | |__________________________________________________________________________|____________| Lymph Node | + | 5 | Liposarcoma, Metastatic, Skin | | 1 | Iliac, Liposarcoma, Metastatic, Skin | | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + M + + + +| 46 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Histiocytic Sarcoma | X | 1 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Hemangiosarcoma | | 1 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + I + + + + + + +| 44 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 17 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 500 MG/L | 5| 5| 5| 5| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 7| 7| 7| 7| 7| 8| 8| 6| 6| 6| 6| L | | 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 1| 4| 5| 1| 2| 3| 4| 5| 7| 9| 1| 2| 4| 5| | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangioma | X | 1 | Subcutaneous Tissue, Fibrosarcoma | | 1 | Subcutaneous Tissue, Liposarcoma | | 1 | Subcutaneous Tissue, Schwannoma | | | Malignant | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Osteosarcoma | | 1 | |__________________________________________________________________________|____________| Skeletal Muscle | | 2 | Rhabdomyosarcoma | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X | 1 | Alveolar/Bronchiolar Carcinoma | X| 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X | 3 | Liposarcoma, Metastatic, Skin | | 1 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 18 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 500 MG/L | 5| 5| 5| 5| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 7| 7| 7| 7| 7| 8| 8| 6| 6| 6| 6| L | | 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 1| 4| 5| 1| 2| 3| 4| 5| 7| 9| 1| 2| 4| 5| | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X X X X X X | 9 | Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant | X X X X X X X X X X| 19 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 19 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 _____________________________________________________________________________________________________________________ | 0| 0| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 2| 3| 8| 0| 0| 4| 7| 0| 1| 1| 2| 6| 6| 8| 1| 1| 1| 2| 2| 3| 3| 3| 3| 3| 3| | 7| 4| 6| 3| 3| 2| 4| 2| 8| 8| 2| 1| 2| 3| 1| 2| 9| 0| 3| 4| 4| 4| 4| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1000MG/L | 3| 0| 2| 1| 2| 3| 0| 0| 4| 4| 1| 0| 2| 2| 1| 3| 2| 3| 4| 2| 2| 3| 4| 4| 4| | 9| 3| 4| 3| 6| 5| 1| 7| 3| 9| 6| 2| 5| 2| 4| 4| 9| 3| 0| 7| 8| 0| 6| 7| 8| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Gallbladder | + + + A + + + + + + M + + A A A + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + A + + + A + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + A + + + + + + A + + + A + + + + + + + + + +| Hemangioma | | |__________________________________________________________________________| Intestine Small, Duodenum | + + + A + + + + + + M + + A + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + A + + + + + + + + + + + A A + + + + + + + + + +| Histiocytic Sarcoma | | |__________________________________________________________________________| Intestine Small, Ileum | + + + A + + + + + + A + + A A + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + A + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X X X X X| Hepatocellular Carcinoma, Multiple | X | Hepatocellular Adenoma | X X X X X X X | Hepatocellular Adenoma, Multiple | X X X| Histiocytic Sarcoma | X | |__________________________________________________________________________| Mesentery | + + + + + + + + + + + + + + + + +| Fibrosarcoma | X | Hepatocellular Carcinoma, Metastatic,| | Liver | X | Histiocytic Sarcoma | X | |__________________________________________________________________________| Pancreas | + + + A + + + + + + + + + + + + + + + + + + + + +| Fibrosarcoma, Metastatic, Mesentery | X | Histiocytic Sarcoma | | Acinus, Sarcoma | X | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 20 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 _____________________________________________________________________________________________________________________ | 0| 0| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 2| 3| 8| 0| 0| 4| 7| 0| 1| 1| 2| 6| 6| 8| 1| 1| 1| 2| 2| 3| 3| 3| 3| 3| 3| | 7| 4| 6| 3| 3| 2| 4| 2| 8| 8| 2| 1| 2| 3| 1| 2| 9| 0| 3| 4| 4| 4| 4| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1000MG/L | 3| 0| 2| 1| 2| 3| 0| 0| 4| 4| 1| 0| 2| 2| 1| 3| 2| 3| 4| 2| 2| 3| 4| 4| 4| | 9| 3| 4| 3| 6| 5| 1| 7| 3| 9| 6| 2| 5| 2| 4| 4| 9| 3| 0| 7| 8| 0| 6| 7| 8| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Salivary Glands | + + + + + + + + + + + + + + + + + I + + + + + + +| Hepatocellular Carcinoma, Metastatic,| | Liver | X | Histiocytic Sarcoma | | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma | | Squamous Cell Papilloma | | Squamous Cell Papilloma, Multiple | X | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma, Metastatic,| | Liver | X | |__________________________________________________________________________| Tongue | + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + M + + + + + + + + + + + + + +| Hepatocellular Carcinoma, Metastatic,| | Liver | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + A + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Osteosarcoma, Metastatic, Bone | X | |__________________________________________________________________________| Adrenal Medulla | + + + A + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Islets, Pancreatic | + + + A + + + + + + + + + + + + + + + + + + + + +| Adenoma | | |__________________________________________________________________________| Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + M| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 21 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 _____________________________________________________________________________________________________________________ | 0| 0| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 2| 3| 8| 0| 0| 4| 7| 0| 1| 1| 2| 6| 6| 8| 1| 1| 1| 2| 2| 3| 3| 3| 3| 3| 3| | 7| 4| 6| 3| 3| 2| 4| 2| 8| 8| 2| 1| 2| 3| 1| 2| 9| 0| 3| 4| 4| 4| 4| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1000MG/L | 3| 0| 2| 1| 2| 3| 0| 0| 4| 4| 1| 0| 2| 2| 1| 3| 2| 3| 4| 2| 2| 3| 4| 4| 4| | 9| 3| 4| 3| 6| 5| 1| 7| 3| 9| 6| 2| 5| 2| 4| 4| 9| 3| 0| 7| 8| 0| 6| 7| 8| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Histiocytic Sarcoma | | Pars Distalis, Adenoma | | |__________________________________________________________________________| Thyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| |__________________________________________________________________________| Ovary | + + + M + + + + + + + + M + + + + + + + + + + + +| Choriocarcinoma | X | Cystadenoma | X | Granulosa Cell Tumor Benign | | Histiocytic Sarcoma | X | Luteoma | | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Leiomyosarcoma | | |__________________________________________________________________________| Vagina | + | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X X | |__________________________________________________________________________| Lymph Node | + + + + + + | Histiocytic Sarcoma | | Iliac, Histiocytic Sarcoma | X | Mediastinal, Sarcoma, Metastatic, | | Pancreas | X | Pancreatic, Histiocytic Sarcoma | | __________________________________________|__________________________________________________________________________| Page 22 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 _____________________________________________________________________________________________________________________ | 0| 0| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 2| 3| 8| 0| 0| 4| 7| 0| 1| 1| 2| 6| 6| 8| 1| 1| 1| 2| 2| 3| 3| 3| 3| 3| 3| | 7| 4| 6| 3| 3| 2| 4| 2| 8| 8| 2| 1| 2| 3| 1| 2| 9| 0| 3| 4| 4| 4| 4| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1000MG/L | 3| 0| 2| 1| 2| 3| 0| 0| 4| 4| 1| 0| 2| 2| 1| 3| 2| 3| 4| 2| 2| 3| 4| 4| 4| | 9| 3| 4| 3| 6| 5| 1| 7| 3| 9| 6| 2| 5| 2| 4| 4| 9| 3| 0| 7| 8| 0| 6| 7| 8| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Renal, Histiocytic Sarcoma | | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + M + + + + + + +| Histiocytic Sarcoma | X | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Histiocytic Sarcoma, Metastatic, | | Mesentery | X | |__________________________________________________________________________| Spleen | + + + A + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Histiocytic Sarcoma | X | |__________________________________________________________________________| Thymus | + + + + + + + + + + M + + + + + + + + + + + + + +| Hepatocellular Carcinoma, Metastatic,| | Liver | X | Histiocytic Sarcoma | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma | | Subcutaneous Tissue, Hemangiosarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma | X | Sarcoma | X | |__________________________________________________________________________| Skeletal Muscle | + + + | Histiocytic Sarcoma, Metastatic, | | __________________________________________|__________________________________________________________________________| Page 23 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 _____________________________________________________________________________________________________________________ | 0| 0| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 2| 3| 8| 0| 0| 4| 7| 0| 1| 1| 2| 6| 6| 8| 1| 1| 1| 2| 2| 3| 3| 3| 3| 3| 3| | 7| 4| 6| 3| 3| 2| 4| 2| 8| 8| 2| 1| 2| 3| 1| 2| 9| 0| 3| 4| 4| 4| 4| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1000MG/L | 3| 0| 2| 1| 2| 3| 0| 0| 4| 4| 1| 0| 2| 2| 1| 3| 2| 3| 4| 2| 2| 3| 4| 4| 4| | 9| 3| 4| 3| 6| 5| 1| 7| 3| 9| 6| 2| 5| 2| 4| 4| 9| 3| 0| 7| 8| 0| 6| 7| 8| __________________________________________|__________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | Mesentery | X | Rhabdomyosarcoma | | Sarcoma, Metastatic, Pancreas | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma, Metastatic, Bone | X | |__________________________________________________________________________| Peripheral Nerve | + + | |__________________________________________________________________________| Spinal Cord | + + + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Carcinoma | X | Alveolar/Bronchiolar Carcinoma, | | Multiple | | Hepatocellular Carcinoma, Metastatic,| | Liver | X X | Histiocytic Sarcoma | X | Osteosarcoma, Metastatic, Bone | X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X| Histiocytic Sarcoma | | __________________________________________|__________________________________________________________________________| Page 24 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 _____________________________________________________________________________________________________________________ | 0| 0| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 2| 3| 8| 0| 0| 4| 7| 0| 1| 1| 2| 6| 6| 8| 1| 1| 1| 2| 2| 3| 3| 3| 3| 3| 3| | 7| 4| 6| 3| 3| 2| 4| 2| 8| 8| 2| 1| 2| 3| 1| 2| 9| 0| 3| 4| 4| 4| 4| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1000MG/L | 3| 0| 2| 1| 2| 3| 0| 0| 4| 4| 1| 0| 2| 2| 1| 3| 2| 3| 4| 2| 2| 3| 4| 4| 4| | 9| 3| 4| 3| 6| 5| 1| 7| 3| 9| 6| 2| 5| 2| 4| 4| 9| 3| 0| 7| 8| 0| 6| 7| 8| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + A + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma, Metastatic,| | Liver | X | Histiocytic Sarcoma | | Osteosarcoma, Metastatic, Bone | X | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X X X | Leukemia Granulocytic | X | Lymphoma Malignant | X X X X X X X X X X X| __________________________________________|__________________________________________________________________________| Page 25 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 1000MG/L | 5| 1| 1| 1| 2| 2| 0| 0| 0| 0| 0| 1| 3| 3| 3| 3| 3| 1| 1| 1| 2| 4| 4| 4| 4| L | | 0| 1| 2| 5| 1| 3| 4| 5| 6| 8| 9| 0| 1| 2| 6| 7| 8| 7| 8| 9| 0| 1| 2| 4| 5| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + + I + + + + + + + + +| 44 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Hemangioma | X | 1 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Histiocytic Sarcoma | X | 1 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hepatocellular Carcinoma | X X X X X X| 11 | Hepatocellular Carcinoma, Multiple | X X X | 4 | Hepatocellular Adenoma | X X X X X X X | 14 | Hepatocellular Adenoma, Multiple | X X X X X X X X X | 12 | Histiocytic Sarcoma | | 1 | |__________________________________________________________________________|____________| Mesentery | + + + + + + + + + + | 27 | Fibrosarcoma | | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 1 | Histiocytic Sarcoma | | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 26 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 1000MG/L | 5| 1| 1| 1| 2| 2| 0| 0| 0| 0| 0| 1| 3| 3| 3| 3| 3| 1| 1| 1| 2| 4| 4| 4| 4| L | | 0| 1| 2| 5| 1| 3| 4| 5| 6| 8| 9| 0| 1| 2| 6| 7| 8| 7| 8| 9| 0| 1| 2| 4| 5| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Fibrosarcoma, Metastatic, Mesentery | | 1 | Histiocytic Sarcoma | X | 1 | Acinus, Sarcoma | | 1 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 1 | Histiocytic Sarcoma | X | 1 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Squamous Cell Carcinoma | X | 1 | Squamous Cell Papilloma | X | 1 | Squamous Cell Papilloma, Multiple | | 1 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 1 | |__________________________________________________________________________|____________| Tongue | | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Histiocytic Sarcoma | X | 1 | Osteosarcoma, Metastatic, Bone | | 1 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 27 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 1000MG/L | 5| 1| 1| 1| 2| 2| 0| 0| 0| 0| 0| 1| 3| 3| 3| 3| 3| 1| 1| 1| 2| 4| 4| 4| 4| L | | 0| 1| 2| 5| 1| 3| 4| 5| 6| 8| 9| 0| 1| 2| 6| 7| 8| 7| 8| 9| 0| 1| 2| 4| 5| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Adenoma | X X | 2 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + I + + + + + + + + +| 48 | Histiocytic Sarcoma | X | 1 | Pars Distalis, Adenoma | X X X X | 4 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + I + + + + + + I + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + I + + + +| 47 | Choriocarcinoma | X | 2 | Cystadenoma | | 1 | Granulosa Cell Tumor Benign | X | 1 | Histiocytic Sarcoma | X | 2 | Luteoma | X | 1 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X | 2 | Leiomyosarcoma | X | 1 | |__________________________________________________________________________|____________| Vagina | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 28 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 1000MG/L | 5| 1| 1| 1| 2| 2| 0| 0| 0| 0| 0| 1| 3| 3| 3| 3| 3| 1| 1| 1| 2| 4| 4| 4| 4| L | | 0| 1| 2| 5| 1| 3| 4| 5| 6| 8| 9| 0| 1| 2| 6| 7| 8| 7| 8| 9| 0| 1| 2| 4| 5| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | | 2 | |__________________________________________________________________________|____________| Lymph Node | + + + + + | 11 | Histiocytic Sarcoma | X | 1 | Iliac, Histiocytic Sarcoma | X | 2 | Mediastinal, Sarcoma, Metastatic, | | | Pancreas | | 1 | Pancreatic, Histiocytic Sarcoma | X | 1 | Renal, Histiocytic Sarcoma | X | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Histiocytic Sarcoma | X | 2 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + I| 49 | Histiocytic Sarcoma | X | 2 | Histiocytic Sarcoma, Metastatic, | | | Mesentery | | 1 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hemangiosarcoma | | 1 | Histiocytic Sarcoma | X | 2 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + M + + + + + + + + + + + +| 48 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 1 | Histiocytic Sarcoma | X | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 29 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 1000MG/L | 5| 1| 1| 1| 2| 2| 0| 0| 0| 0| 0| 1| 3| 3| 3| 3| 3| 1| 1| 1| 2| 4| 4| 4| 4| L | | 0| 1| 2| 5| 1| 3| 4| 5| 6| 8| 9| 0| 1| 2| 6| 7| 8| 7| 8| 9| 0| 1| 2| 4| 5| | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Squamous Cell Carcinoma | X | 1 | Subcutaneous Tissue, Hemangiosarcoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Osteosarcoma | | 1 | Sarcoma | | 1 | |__________________________________________________________________________|____________| Skeletal Muscle | + | 4 | Histiocytic Sarcoma, Metastatic, | | | Mesentery | | 1 | Rhabdomyosarcoma | X | 1 | Sarcoma, Metastatic, Pancreas | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Osteosarcoma, Metastatic, Bone | | 1 | |__________________________________________________________________________|____________| Peripheral Nerve | | 2 | |__________________________________________________________________________|____________| Spinal Cord | | 3 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Alveolar/Bronchiolar Carcinoma | | 1 | Alveolar/Bronchiolar Carcinoma, | | | Multiple | X | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 30 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 1000MG/L | 5| 1| 1| 1| 2| 2| 0| 0| 0| 0| 0| 1| 3| 3| 3| 3| 3| 1| 1| 1| 2| 4| 4| 4| 4| L | | 0| 1| 2| 5| 1| 3| 4| 5| 6| 8| 9| 0| 1| 2| 6| 7| 8| 7| 8| 9| 0| 1| 2| 4| 5| | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | | | | Hepatocellular Carcinoma, Metastatic,| | | Liver | X X X| 5 | Histiocytic Sarcoma | | 1 | Osteosarcoma, Metastatic, Bone | | 1 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X | 1 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X X | 5 | Histiocytic Sarcoma | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 1 | Histiocytic Sarcoma | X | 1 | Osteosarcoma, Metastatic, Bone | | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X | 4 | Leukemia Granulocytic | | 1 | Lymphoma Malignant | X X X X X X X X X X X X X X X X X| 28 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 31 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 _____________________________________________________________________________________________________________________ | 1| 4| 4| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 4| 5| 7| 3| 4| 9| 1| 4| 6| 8| 8| 8| 8| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | 2| 7| 5| 5| 5| 0| 7| 8| 6| 7| 1| 5| 5| 8| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2000MG/L | 5| 5| 9| 9| 9| 8| 7| 6| 9| 6| 8| 7| 8| 6| 8| 5| 5| 5| 5| 6| 6| 6| 6| 7| 8| | 2| 9| 2| 9| 7| 9| 6| 0| 5| 3| 8| 9| 0| 1| 7| 1| 3| 4| 5| 6| 7| 8| 9| 0| 6| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + A + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + M + A + + + A + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Polyp Adenomatous | X | |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + A + + + + A + + + A + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + + + + M + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X X | Hepatocellular Carcinoma, Multiple | X X | Hepatocellular Adenoma | X X X X | Hepatocellular Adenoma, Multiple | X X X X X | Histiocytic Sarcoma | X | |__________________________________________________________________________| Mesentery | + + + + + + + + + + + + | Hemangiosarcoma | | Sarcoma, Metastatic, Skin | | |__________________________________________________________________________| Oral Mucosa | + | Squamous Cell Papilloma | X | |__________________________________________________________________________| Pancreas | + + + + + M A + + + + + + + + + + + + + + + + + +| Sarcoma, Metastatic, Skin | | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 32 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 _____________________________________________________________________________________________________________________ | 1| 4| 4| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 4| 5| 7| 3| 4| 9| 1| 4| 6| 8| 8| 8| 8| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | 2| 7| 5| 5| 5| 0| 7| 8| 6| 7| 1| 5| 5| 8| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2000MG/L | 5| 5| 9| 9| 9| 8| 7| 6| 9| 6| 8| 7| 8| 6| 8| 5| 5| 5| 5| 6| 6| 6| 6| 7| 8| | 2| 9| 2| 9| 7| 9| 6| 0| 5| 3| 8| 9| 0| 1| 7| 1| 3| 4| 5| 6| 7| 8| 9| 0| 6| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Stomach, Forestomach | + + + M + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | X | |__________________________________________________________________________| Stomach, Glandular | + + + M + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Complex | X | Pheochromocytoma Benign | X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + A + + + + + + + + + + + + + + + + + +| Adenoma | X X | Carcinoma | | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + M M| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 33 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 _____________________________________________________________________________________________________________________ | 1| 4| 4| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 4| 5| 7| 3| 4| 9| 1| 4| 6| 8| 8| 8| 8| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | 2| 7| 5| 5| 5| 0| 7| 8| 6| 7| 1| 5| 5| 8| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2000MG/L | 5| 5| 9| 9| 9| 8| 7| 6| 9| 6| 8| 7| 8| 6| 8| 5| 5| 5| 5| 6| 6| 6| 6| 7| 8| | 2| 9| 2| 9| 7| 9| 6| 0| 5| 3| 8| 9| 0| 1| 7| 1| 3| 4| 5| 6| 7| 8| 9| 0| 6| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cystadenoma | X| Granulosa Cell Tumor Malignant | X | Granulosa Cell Tumor Benign | | Histiocytic Sarcoma | X | Yolk Sac Carcinoma | X | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Polyp Stromal | | Yolk Sac Carcinoma, Metastatic, Ovary| X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | |__________________________________________________________________________| Lymph Node | + + + + + | Renal, Histiocytic Sarcoma | X | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma, Metastatic, | | Uncertain Primary Site | | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Yolk Sac Carcinoma, Metastatic, Ovary| X | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Sarcoma, Metastatic, Skin | | |__________________________________________________________________________| Thymus | + + + + M + + + + + + + + + M + + + + + + + + + +| Histiocytic Sarcoma | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 34 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 _____________________________________________________________________________________________________________________ | 1| 4| 4| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 4| 5| 7| 3| 4| 9| 1| 4| 6| 8| 8| 8| 8| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | 2| 7| 5| 5| 5| 0| 7| 8| 6| 7| 1| 5| 5| 8| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2000MG/L | 5| 5| 9| 9| 9| 8| 7| 6| 9| 6| 8| 7| 8| 6| 8| 5| 5| 5| 5| 6| 6| 6| 6| 7| 8| | 2| 9| 2| 9| 7| 9| 6| 0| 5| 3| 8| 9| 0| 1| 7| 1| 3| 4| 5| 6| 7| 8| 9| 0| 6| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Fibrosarcoma | X X | Subcutaneous Tissue, Hemangioma | X | Subcutaneous Tissue, Sarcoma | | Subcutaneous Tissue, Schwannoma | | Malignant | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma | X X | |__________________________________________________________________________| Skeletal Muscle | + + + + + | Rhabdomyosarcoma | X X | Sarcoma, Metastatic, Skin | | Yolk Sac Carcinoma, Metastatic, Ovary| X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Peripheral Nerve | + + | |__________________________________________________________________________| Spinal Cord | + + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Alveolar/Bronchiolar Carcinoma | | Hepatocellular Carcinoma, Metastatic,| | Liver | X | Histiocytic Sarcoma | X | Sarcoma, Metastatic, Skin | | __________________________________________|__________________________________________________________________________| Page 35 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 _____________________________________________________________________________________________________________________ | 1| 4| 4| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 4| 5| 7| 3| 4| 9| 1| 4| 6| 8| 8| 8| 8| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | 2| 7| 5| 5| 5| 0| 7| 8| 6| 7| 1| 5| 5| 8| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2000MG/L | 5| 5| 9| 9| 9| 8| 7| 6| 9| 6| 8| 7| 8| 6| 8| 5| 5| 5| 5| 6| 6| 6| 6| 7| 8| | 2| 9| 2| 9| 7| 9| 6| 0| 5| 3| 8| 9| 0| 1| 7| 1| 3| 4| 5| 6| 7| 8| 9| 0| 6| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X X| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X X | Lymphoma Malignant | X X X X X X X X X X X | __________________________________________|__________________________________________________________________________| Page 36 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A | 2000MG/L | 9| 6| 6| 6| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 5| 5| 5| 7| 7| 7| 7| 7| 9| 9| 0| L | | 0| 2| 4| 5| 7| 8| 1| 2| 3| 4| 5| 1| 3| 4| 6| 7| 8| 1| 2| 3| 4| 5| 6| 8| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + I + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Intestine Large, Colon | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Polyp Adenomatous | | 1 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + M + + + + + +| 47 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatocellular Carcinoma | X X X X | 6 | Hepatocellular Carcinoma, Multiple | X | 3 | Hepatocellular Adenoma | X X X X | 8 | Hepatocellular Adenoma, Multiple | X X X X X X X X X X | 15 | Histiocytic Sarcoma | | 1 | |__________________________________________________________________________|____________| Mesentery | + + + + + + + + + + + + | 24 | Hemangiosarcoma | X | 1 | Sarcoma, Metastatic, Skin | X | 1 | |__________________________________________________________________________|____________| Oral Mucosa | | 1 | Squamous Cell Papilloma | | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 37 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A | 2000MG/L | 9| 6| 6| 6| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 5| 5| 5| 7| 7| 7| 7| 7| 9| 9| 0| L | | 0| 2| 4| 5| 7| 8| 1| 2| 3| 4| 5| 1| 3| 4| 6| 7| 8| 1| 2| 3| 4| 5| 6| 8| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Sarcoma, Metastatic, Skin | X | 1 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Squamous Cell Papilloma | | 1 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + | 1 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pheochromocytoma Complex | | 1 | Pheochromocytoma Benign | | 1 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Adenoma | X | 3 | Carcinoma | X | 1 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| 47 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Adenoma | X X | 4 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 38 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A | 2000MG/L | 9| 6| 6| 6| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 5| 5| 5| 7| 7| 7| 7| 7| 9| 9| 0| L | | 0| 2| 4| 5| 7| 8| 1| 2| 3| 4| 5| 1| 3| 4| 6| 7| 8| 1| 2| 3| 4| 5| 6| 8| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + I| 49 | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cystadenoma | | 1 | Granulosa Cell Tumor Malignant | | 1 | Granulosa Cell Tumor Benign | X X X X X | 5 | Histiocytic Sarcoma | | 1 | Yolk Sac Carcinoma | | 1 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | Polyp Stromal | X X X | 3 | Yolk Sac Carcinoma, Metastatic, Ovary| | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | |__________________________________________________________________________|____________| Lymph Node | + + + + | 9 | Renal, Histiocytic Sarcoma | | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 | Squamous Cell Carcinoma, Metastatic, | | | Uncertain Primary Site | X | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 39 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A | 2000MG/L | 9| 6| 6| 6| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 5| 5| 5| 7| 7| 7| 7| 7| 9| 9| 0| L | | 0| 2| 4| 5| 7| 8| 1| 2| 3| 4| 5| 1| 3| 4| 6| 7| 8| 1| 2| 3| 4| 5| 6| 8| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 | Yolk Sac Carcinoma, Metastatic, Ovary| | 1 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Sarcoma, Metastatic, Skin | X | 1 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Histiocytic Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcutaneous Tissue, Fibrosarcoma | | 2 | Subcutaneous Tissue, Hemangioma | | 1 | Subcutaneous Tissue, Sarcoma | X | 1 | Subcutaneous Tissue, Schwannoma | | | Malignant | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Osteosarcoma | | 2 | |__________________________________________________________________________|____________| Skeletal Muscle | + | 6 | Rhabdomyosarcoma | | 2 | Sarcoma, Metastatic, Skin | X | 1 | Yolk Sac Carcinoma, Metastatic, Ovary| | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 40 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A | 2000MG/L | 9| 6| 6| 6| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 5| 5| 5| 7| 7| 7| 7| 7| 9| 9| 0| L | | 0| 2| 4| 5| 7| 8| 1| 2| 3| 4| 5| 1| 3| 4| 6| 7| 8| 1| 2| 3| 4| 5| 6| 8| 0| | _____________________________________________________________________________________________________________________|____________| NERVOUS SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Peripheral Nerve | | 2 | |__________________________________________________________________________|____________| Spinal Cord | | 2 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X X | 3 | Alveolar/Bronchiolar Carcinoma | X | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X | 2 | Histiocytic Sarcoma | | 1 | Sarcoma, Metastatic, Skin | X | 1 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Adenoma | X X | 6 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 41 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A | 2000MG/L | 9| 6| 6| 6| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 5| 5| 5| 7| 7| 7| 7| 7| 9| 9| 0| L | | 0| 2| 4| 5| 7| 8| 1| 2| 3| 4| 5| 1| 3| 4| 6| 7| 8| 1| 2| 3| 4| 5| 6| 8| 0| | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM - cont | | | | | | Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 2 | Lymphoma Malignant | X X X X X X X X X X X X X X X X | 27 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 42 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 _____________________________________________________________________________________________________________________ | 3| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 0| 8| 6| 6| 6| 0| 2| 2| 3| 6| 6| 9| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | 1| 4| 1| 1| 2| 3| 3| 5| 8| 1| 3| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/L | 0| 5| 1| 3| 1| 2| 2| 3| 0| 3| 1| 1| 0| 2| 3| 3| 4| 4| 4| 4| 0| 2| 2| 2| 3| | 7| 0| 4| 8| 5| 8| 5| 9| 9| 1| 0| 8| 8| 6| 5| 6| 2| 5| 8| 9| 2| 2| 3| 7| 2| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Gallbladder | A + + + A + A M + + M M + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | A + + + + + A + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma, Metastatic, | | Liver | X | |__________________________________________________________________________| Intestine Large, Rectum | A + + + + + + + + + + + + + I + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | A + + + + + A + + + A + + + + + + + + + + + + + +| Histiocytic Sarcoma, Metastatic, | | Liver | X | |__________________________________________________________________________| Intestine Small, Duodenum | A + + + + + A + + + + + + + + + + + + + + + + + +| Adenoma | | |__________________________________________________________________________| Intestine Small, Jejunum | A + + + + A + + + + + A + + + + + + + + + + + + +| Carcinoma | | |__________________________________________________________________________| Intestine Small, Ileum | A + + + + + A + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | A + + + + + A + + + + + + + + + + + + + + + + + +| Cholangiocarcinoma | X | Hemangiosarcoma | | Hepatoblastoma | X X X | Hepatoblastoma, Multiple | | Hepatocellular Carcinoma | X X X X X X X | Hepatocellular Carcinoma, Multiple | X X | Hepatocellular Adenoma | X X X X X X X X X| Hepatocellular Adenoma, Multiple | X X X X X | Histiocytic Sarcoma | X | Leiomyosarcoma, Metastatic, Mesentery| X | |__________________________________________________________________________| Mesentery | + + + + + + | Cholangiocarcinoma, Metastatic, Liver| X | __________________________________________|__________________________________________________________________________| Page 43 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 _____________________________________________________________________________________________________________________ | 3| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 0| 8| 6| 6| 6| 0| 2| 2| 3| 6| 6| 9| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | 1| 4| 1| 1| 2| 3| 3| 5| 8| 1| 3| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/L | 0| 5| 1| 3| 1| 2| 2| 3| 0| 3| 1| 1| 0| 2| 3| 3| 4| 4| 4| 4| 0| 2| 2| 2| 3| | 7| 0| 4| 8| 5| 8| 5| 9| 9| 1| 0| 8| 8| 6| 5| 6| 2| 5| 8| 9| 2| 2| 3| 7| 2| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Histiocytic Sarcoma, Metastatic, | | Liver | X | Leiomyosarcoma | X | |__________________________________________________________________________| Pancreas | A + + + + + A + + + + + + + + + + + + + + + + + +| Cholangiocarcinoma, Metastatic, Liver| X | Hepatocellular Carcinoma, Metastatic,| | Liver | X | Histiocytic Sarcoma, Metastatic, | | Liver | X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | A + + + + + + + + + + + + + + + + + + + + + + + +| Leiomyosarcoma, Metastatic, Mesentery| X | |__________________________________________________________________________| Stomach, Glandular | A + + + + + A + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma, Metastatic, | | Liver | X | Leiomyosarcoma, Metastatic, Mesentery| X | |__________________________________________________________________________| Tooth | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cholangiocarcinoma, Metastatic, Liver| X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Bilateral, Subcapsular, Adenoma | X | Subcapsular, Adenoma | | |__________________________________________________________________________| Adrenal Medulla | + + + + + + A + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 44 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 _____________________________________________________________________________________________________________________ | 3| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 0| 8| 6| 6| 6| 0| 2| 2| 3| 6| 6| 9| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | 1| 4| 1| 1| 2| 3| 3| 5| 8| 1| 3| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/L | 0| 5| 1| 3| 1| 2| 2| 3| 0| 3| 1| 1| 0| 2| 3| 3| 4| 4| 4| 4| 0| 2| 2| 2| 3| | 7| 0| 4| 8| 5| 8| 5| 9| 9| 1| 0| 8| 8| 6| 5| 6| 2| 5| 8| 9| 2| 2| 3| 7| 2| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | |__________________________________________________________________________| Islets, Pancreatic | A + + + + + A + + + + + + + + + + + + + + + + + +| Adenoma | | |__________________________________________________________________________| Parathyroid Gland | M + + + + M M + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + M + + + + M + + + + + + + + + M + + +| |__________________________________________________________________________| Thyroid Gland | I + + + + + M + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma, Metastatic, | | Liver | X | |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma, Metastatic, | | Liver | X | |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | A + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + + + | Mediastinal, Histiocytic Sarcoma, | | Metastatic, Liver | X | __________________________________________|__________________________________________________________________________| Page 45 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 _____________________________________________________________________________________________________________________ | 3| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 0| 8| 6| 6| 6| 0| 2| 2| 3| 6| 6| 9| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | 1| 4| 1| 1| 2| 3| 3| 5| 8| 1| 3| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/L | 0| 5| 1| 3| 1| 2| 2| 3| 0| 3| 1| 1| 0| 2| 3| 3| 4| 4| 4| 4| 0| 2| 2| 2| 3| | 7| 0| 4| 8| 5| 8| 5| 9| 9| 1| 0| 8| 8| 6| 5| 6| 2| 5| 8| 9| 2| 2| 3| 7| 2| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Mediastinal, Leiomyosarcoma, | | Metastatic, Mesentery | X | Pancreatic, Histiocytic Sarcoma, | | Metastatic, Liver | X | Renal, Histiocytic Sarcoma, | | Metastatic, Liver | X | Renal, Leiomyosarcoma, Metastatic, | | Mesentery | X | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node, Mesenteric | A + + I + + A + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma, Metastatic,| | Liver | X | Leiomyosarcoma, Metastatic, Mesentery| X | |__________________________________________________________________________| Spleen | A + + + + + A + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma, Metastatic, | | Liver | X | Leiomyosarcoma, Metastatic, Mesentery| X | |__________________________________________________________________________| Thymus | M + + + + + + + + M M + + + + + + + + + M + + + +| Leiomyosarcoma, Metastatic, Mesentery| X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + + | Histiocytic Sarcoma, Metastatic, | | __________________________________________|__________________________________________________________________________| Page 46 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 _____________________________________________________________________________________________________________________ | 3| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 0| 8| 6| 6| 6| 0| 2| 2| 3| 6| 6| 9| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | 1| 4| 1| 1| 2| 3| 3| 5| 8| 1| 3| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/L | 0| 5| 1| 3| 1| 2| 2| 3| 0| 3| 1| 1| 0| 2| 3| 3| 4| 4| 4| 4| 0| 2| 2| 2| 3| | 7| 0| 4| 8| 5| 8| 5| 9| 9| 1| 0| 8| 8| 6| 5| 6| 2| 5| 8| 9| 2| 2| 3| 7| 2| __________________________________________|__________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | Liver | X | Leiomyosarcoma, Metastatic, Mesentery| X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X | Alveolar/Bronchiolar Carcinoma | X X X X | Hepatoblastoma, Metastatic, Liver | | Hepatocellular Carcinoma, Metastatic,| | Liver | X X X X X X X | Histiocytic Sarcoma, Metastatic, | | Liver | X | Leiomyosarcoma, Metastatic, Mesentery| X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + M + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | A + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Urinary Bladder | + + + + + + A + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 47 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 __________________________________________|__________________________________________________________________________ | 3| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 0| 8| 6| 6| 6| 0| 2| 2| 3| 6| 6| 9| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | 1| 4| 1| 1| 2| 3| 3| 5| 8| 1| 3| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| _____________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/L | 0| 5| 1| 3| 1| 2| 2| 3| 0| 3| 1| 1| 0| 2| 3| 3| 4| 4| 4| 4| 0| 2| 2| 2| 3| | 7| 0| 4| 8| 5| 8| 5| 9| 9| 1| 0| 8| 8| 6| 5| 6| 2| 5| 8| 9| 2| 2| 3| 7| 2| _____________________________________________________________________________________________________________________ SYSTEMIC LESIONS - cont | | | | Histiocytic Sarcoma | X | Lymphoma Malignant | X | __________________________________________|__________________________________________________________________________| Page 48 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 MG/L | 4| 4| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 4| 4| 1| 2| 3| 3| 4| 4| L | | 4| 7| 1| 3| 4| 5| 6| 2| 3| 6| 7| 9| 0| 1| 9| 4| 7| 0| 6| 1| 4| 0| 3| 1| 3| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 44 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Histiocytic Sarcoma, Metastatic, | | | Liver | | 1 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Histiocytic Sarcoma, Metastatic, | | | Liver | | 1 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Adenoma | X | 1 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Carcinoma | X X | 2 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + M + + + + + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Cholangiocarcinoma | | 1 | Hemangiosarcoma | X| 1 | Hepatoblastoma | X X | 5 | Hepatoblastoma, Multiple | X | 1 | Hepatocellular Carcinoma | X X X X X X X | 14 | Hepatocellular Carcinoma, Multiple | X X X X | 6 | Hepatocellular Adenoma | X X X X X X X | 16 | Hepatocellular Adenoma, Multiple | X X X X X X X X X| 14 | Histiocytic Sarcoma | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 49 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 MG/L | 4| 4| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 4| 4| 1| 2| 3| 3| 4| 4| L | | 4| 7| 1| 3| 4| 5| 6| 2| 3| 6| 7| 9| 0| 1| 9| 4| 7| 0| 6| 1| 4| 0| 3| 1| 3| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Leiomyosarcoma, Metastatic, Mesentery| | 1 | |__________________________________________________________________________|____________| Mesentery | + + + | 9 | Cholangiocarcinoma, Metastatic, Liver| | 1 | Histiocytic Sarcoma, Metastatic, | | | Liver | | 1 | Leiomyosarcoma | | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Cholangiocarcinoma, Metastatic, Liver| | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 1 | Histiocytic Sarcoma, Metastatic, | | | Liver | | 1 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leiomyosarcoma, Metastatic, Mesentery| | 1 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Histiocytic Sarcoma, Metastatic, | | | Liver | | 1 | Leiomyosarcoma, Metastatic, Mesentery| | 1 | |__________________________________________________________________________|____________| Tooth | + | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cholangiocarcinoma, Metastatic, Liver| | 1 | _____________________________________________________________________________________________________________________| | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 50 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 MG/L | 4| 4| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 4| 4| 1| 2| 3| 3| 4| 4| L | | 4| 7| 1| 3| 4| 5| 6| 2| 3| 6| 7| 9| 0| 1| 9| 4| 7| 0| 6| 1| 4| 0| 3| 1| 3| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 1 | Bilateral, Subcapsular, Adenoma | | 1 | Subcapsular, Adenoma | X | 1 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Adenoma | X | 1 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| 46 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma, Metastatic, | | | Liver | | 1 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma, Metastatic, | | | Liver | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 51 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 MG/L | 4| 4| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 4| 4| 1| 2| 3| 3| 4| 4| L | | 4| 7| 1| 3| 4| 5| 6| 2| 3| 6| 7| 9| 0| 1| 9| 4| 7| 0| 6| 1| 4| 0| 3| 1| 3| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Lymph Node | | 3 | Mediastinal, Histiocytic Sarcoma, | | | Metastatic, Liver | | 1 | Mediastinal, Leiomyosarcoma, | | | Metastatic, Mesentery | | 1 | Pancreatic, Histiocytic Sarcoma, | | | Metastatic, Liver | | 1 | Renal, Histiocytic Sarcoma, | | | Metastatic, Liver | | 1 | Renal, Leiomyosarcoma, Metastatic, | | | Mesentery | | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 1 | Leiomyosarcoma, Metastatic, Mesentery| | 1 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Histiocytic Sarcoma, Metastatic, | | | Liver | | 1 | Leiomyosarcoma, Metastatic, Mesentery| | 1 | |__________________________________________________________________________|____________| Thymus | M + + + + + + + M + + + + + + + + + + + + M + + +| 43 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 52 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 MG/L | 4| 4| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 4| 4| 1| 2| 3| 3| 4| 4| L | | 4| 7| 1| 3| 4| 5| 6| 2| 3| 6| 7| 9| 0| 1| 9| 4| 7| 0| 6| 1| 4| 0| 3| 1| 3| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | Leiomyosarcoma, Metastatic, Mesentery| | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Skeletal Muscle | + | 3 | Histiocytic Sarcoma, Metastatic, | | | Liver | | 1 | Leiomyosarcoma, Metastatic, Mesentery| | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X X X X| 6 | Alveolar/Bronchiolar Carcinoma | | 4 | Hepatoblastoma, Metastatic, Liver | X | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X X | 9 | Histiocytic Sarcoma, Metastatic, | | | Liver | | 1 | Leiomyosarcoma, Metastatic, Mesentery| | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 53 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 MG/L | 4| 4| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 4| 4| 1| 2| 3| 3| 4| 4| L | | 4| 7| 1| 3| 4| 5| 6| 2| 3| 6| 7| 9| 0| 1| 9| 4| 7| 0| 6| 1| 4| 0| 3| 1| 3| | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X X X| 6 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X X| 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 54 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 _____________________________________________________________________________________________________________________ | 4| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 7| 7| 0| 6| 9| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 1| 4| 7| 4| 8| 8| 3| 1| 2| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 500 MG/L | 6| 8| 9| 9| 6| 5| 8| 5| 8| 7| 7| 8| 8| 9| 9| 5| 5| 5| 5| 6| 7| 7| 7| 7| 9| | 1| 5| 2| 9| 5| 1| 3| 9| 2| 3| 4| 7| 8| 6| 8| 3| 4| 7| 8| 4| 5| 6| 7| 9| 1| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Gallbladder | + M M + M A + + + + + + + + + + + + + + + M + I +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | M + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + M| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X X | Hepatoblastoma | X X | Hepatocellular Carcinoma | X X X X X| Hepatocellular Carcinoma, Multiple | | Hepatocellular Adenoma | X X X X | Hepatocellular Adenoma, Multiple | X X X X X X X X X X | Ito Cell Tumor Malignant | X | |__________________________________________________________________________| Mesentery | + + + +| Ito Cell Tumor Malignant, Metastatic,| | Liver | X | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 55 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 _____________________________________________________________________________________________________________________ | 4| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 7| 7| 0| 6| 9| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 1| 4| 7| 4| 8| 8| 3| 1| 2| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 500 MG/L | 6| 8| 9| 9| 6| 5| 8| 5| 8| 7| 7| 8| 8| 9| 9| 5| 5| 5| 5| 6| 7| 7| 7| 7| 9| | 1| 5| 2| 9| 5| 1| 3| 9| 2| 3| 4| 7| 8| 6| 8| 3| 4| 7| 8| 4| 5| 6| 7| 9| 1| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | |__________________________________________________________________________| Tooth | + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Subcapsular, Adenoma | X X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + M + + + + M + + + + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 56 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 _____________________________________________________________________________________________________________________ | 4| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 7| 7| 0| 6| 9| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 1| 4| 7| 4| 8| 8| 3| 1| 2| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 500 MG/L | 6| 8| 9| 9| 6| 5| 8| 5| 8| 7| 7| 8| 8| 9| 9| 5| 5| 5| 5| 6| 7| 7| 7| 7| 9| | 1| 5| 2| 9| 5| 1| 3| 9| 2| 3| 4| 7| 8| 6| 8| 3| 4| 7| 8| 4| 5| 6| 7| 9| 1| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node, Mandibular | M + I + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Thymus | M + + + I + + + + + M + + + + + + + + + + + M + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Peripheral Nerve | + | |__________________________________________________________________________| Spinal Cord | + | __________________________________________|__________________________________________________________________________| Page 57 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 _____________________________________________________________________________________________________________________ | 4| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 7| 7| 0| 6| 9| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 1| 4| 7| 4| 8| 8| 3| 1| 2| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 500 MG/L | 6| 8| 9| 9| 6| 5| 8| 5| 8| 7| 7| 8| 8| 9| 9| 5| 5| 5| 5| 6| 7| 7| 7| 7| 9| | 1| 5| 2| 9| 5| 1| 3| 9| 2| 3| 4| 7| 8| 6| 8| 3| 4| 7| 8| 4| 5| 6| 7| 9| 1| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Alveolar/Bronchiolar Carcinoma | X X | Hepatoblastoma, Metastatic, Liver | X | Hepatocellular Carcinoma, Metastatic,| | Liver | X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Renal Tubule, Adenoma | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | __________________________________________|__________________________________________________________________________| Page 58 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 500 MG/L | 0| 5| 5| 5| 6| 6| 6| 6| 7| 7| 8| 8| 8| 8| 9| 6| 6| 6| 7| 7| 8| 9| 9| 9| 9| L | | 0| 2| 5| 6| 0| 2| 6| 9| 0| 1| 0| 4| 6| 9| 4| 3| 7| 8| 2| 8| 1| 0| 3| 5| 7| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Gallbladder | + + + + + + + + + M + + + + + + + + + + M + I + +| 41 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Carcinoma | X X | 2 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | | 2 | Hepatoblastoma | X | 3 | Hepatocellular Carcinoma | X X X X X X X X | 13 | Hepatocellular Carcinoma, Multiple | X | 1 | Hepatocellular Adenoma | X X X X X X X X X X X| 15 | Hepatocellular Adenoma, Multiple | X X X X X X X | 17 | Ito Cell Tumor Malignant | | 1 | |__________________________________________________________________________|____________| Mesentery | + + + + + + | 10 | Ito Cell Tumor Malignant, Metastatic,| | | Liver | | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 59 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 500 MG/L | 0| 5| 5| 5| 6| 6| 6| 6| 7| 7| 8| 8| 8| 8| 9| 6| 6| 6| 7| 7| 8| 9| 9| 9| 9| L | | 0| 2| 5| 6| 0| 2| 6| 9| 0| 1| 0| 4| 6| 9| 4| 3| 7| 8| 2| 8| 1| 0| 3| 5| 7| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 2 | |__________________________________________________________________________|____________| Tooth | + + | 4 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 1 | Subcapsular, Adenoma | X | 3 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + M + + + + M| 48 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Pituitary Gland | + M + + + + + + M + + + + + I + + + + + + + + + +| 47 | Pars Distalis, Adenoma | X | 1 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 60 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 500 MG/L | 0| 5| 5| 5| 6| 6| 6| 6| 7| 7| 8| 8| 8| 8| 9| 6| 6| 6| 7| 7| 8| 9| 9| 9| 9| L | | 0| 2| 5| 6| 0| 2| 6| 9| 0| 1| 0| 4| 6| 9| 4| 3| 7| 8| 2| 8| 1| 0| 3| 5| 7| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + M + + I + + M + + + + + + + + + +| 43 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 61 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 500 MG/L | 0| 5| 5| 5| 6| 6| 6| 6| 7| 7| 8| 8| 8| 8| 9| 6| 6| 6| 7| 7| 8| 9| 9| 9| 9| L | | 0| 2| 5| 6| 0| 2| 6| 9| 0| 1| 0| 4| 6| 9| 4| 3| 7| 8| 2| 8| 1| 0| 3| 5| 7| | _____________________________________________________________________________________________________________________|____________| MUSCULOSKELETAL SYSTEM - cont | | | | | | Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Peripheral Nerve | | 1 | |__________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X X X | 4 | Alveolar/Bronchiolar Carcinoma | X X X | 5 | Hepatoblastoma, Metastatic, Liver | X | 2 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X | 2 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X X | 4 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 62 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 500 MG/L | 0| 5| 5| 5| 6| 6| 6| 6| 7| 7| 8| 8| 8| 8| 9| 6| 6| 6| 7| 7| 8| 9| 9| 9| 9| L | | 0| 2| 5| 6| 0| 2| 6| 9| 0| 1| 0| 4| 6| 9| 4| 3| 7| 8| 2| 8| 1| 0| 3| 5| 7| | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM - cont | | | | | | Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Renal Tubule, Adenoma | X | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 63 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 _____________________________________________________________________________________________________________________ | 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 5| 6| 7| 0| 6| 6| 7| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| | 3| 8| 2| 0| 7| 7| 8| 2| 3| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1000MG/L | 0| 2| 2| 4| 1| 3| 2| 0| 0| 0| 1| 1| 2| 2| 3| 3| 3| 4| 4| 4| 4| 0| 0| 1| 1| | 9| 4| 8| 0| 7| 0| 7| 4| 3| 8| 2| 6| 6| 9| 1| 4| 9| 1| 2| 4| 8| 2| 5| 0| 3| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Gallbladder | + + I + + + + + M + + + + + M + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + + + + + +| Polyp Adenomatous | | |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Cholangiocarcinoma | X | Hemangioma | X | Hemangiosarcoma | X | Hemangiosarcoma, Metastatic, Spleen | X | Hepatoblastoma | X | Hepatocellular Carcinoma | X X X X X X X X X| Hepatocellular Carcinoma, Multiple | X X X | Hepatocellular Adenoma | X X X X X X X | Hepatocellular Adenoma, Multiple | X X X X X X X X X X | Histiocytic Sarcoma | X| |__________________________________________________________________________| Mesentery | + + + + + + | Hepatocellular Carcinoma, Metastatic,| | Liver | X | Liposarcoma | X | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 64 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 _____________________________________________________________________________________________________________________ | 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 5| 6| 7| 0| 6| 6| 7| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| | 3| 8| 2| 0| 7| 7| 8| 2| 3| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1000MG/L | 0| 2| 2| 4| 1| 3| 2| 0| 0| 0| 1| 1| 2| 2| 3| 3| 3| 4| 4| 4| 4| 0| 0| 1| 1| | 9| 4| 8| 0| 7| 0| 7| 4| 3| 8| 2| 6| 6| 9| 1| 4| 9| 1| 2| 4| 8| 2| 5| 0| 3| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Hepatocellular Carcinoma, Metastatic,| | Liver | X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | X | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tooth | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Subcapsular, Adenoma | X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| |__________________________________________________________________________| Pituitary Gland | + + M M + + + + + + + + M + + + + + + + + + + + +| |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | __________________________________________|__________________________________________________________________________| Page 65 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 _____________________________________________________________________________________________________________________ | 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 5| 6| 7| 0| 6| 6| 7| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| | 3| 8| 2| 0| 7| 7| 8| 2| 3| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1000MG/L | 0| 2| 2| 4| 1| 3| 2| 0| 0| 0| 1| 1| 2| 2| 3| 3| 3| 4| 4| 4| 4| 0| 0| 1| 1| | 9| 4| 8| 0| 7| 0| 7| 4| 3| 8| 2| 6| 6| 9| 1| 4| 9| 1| 2| 4| 8| 2| 5| 0| 3| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Cholangiocarcinoma, Metastatic, Liver| X | |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma, Metastatic, Spleen | X | |__________________________________________________________________________| Lymph Node | + | Mediastinal, Hepatocellular | | Carcinoma, Metastatic, Liver | X | Pancreatic, Hepatocellular Carcinoma,| | Metastatic, Liver | X | Renal, Hepatocellular Carcinoma, | | Metastatic, Liver | X | |__________________________________________________________________________| Lymph Node, Mandibular | + + + M + + + + + + + + + + + + M M M M + + + + +| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Histiocytic Sarcoma | X| |__________________________________________________________________________| Thymus | + + M + + + M + + + M + + + + M + + + M + + + + M| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | X | __________________________________________|__________________________________________________________________________| Page 66 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 _____________________________________________________________________________________________________________________ | 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 5| 6| 7| 0| 6| 6| 7| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| | 3| 8| 2| 0| 7| 7| 8| 2| 3| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1000MG/L | 0| 2| 2| 4| 1| 3| 2| 0| 0| 0| 1| 1| 2| 2| 3| 3| 3| 4| 4| 4| 4| 0| 0| 1| 1| | 9| 4| 8| 0| 7| 0| 7| 4| 3| 8| 2| 6| 6| 9| 1| 4| 9| 1| 2| 4| 8| 2| 5| 0| 3| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Hepatocellular Carcinoma, Metastatic,| | Liver | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Fibrous | | Histiocytoma | | Subcutaneous Tissue, Lipoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Harderian | | Gland | | |__________________________________________________________________________| Skeletal Muscle | + + + | Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | X X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Peripheral Nerve | + + | |__________________________________________________________________________| Spinal Cord | + + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X | Alveolar/Bronchiolar Carcinoma | X X X X X X | Alveolar/Bronchiolar Carcinoma, | | __________________________________________|__________________________________________________________________________| Page 67 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 _____________________________________________________________________________________________________________________ | 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 5| 6| 7| 0| 6| 6| 7| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| | 3| 8| 2| 0| 7| 7| 8| 2| 3| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1000MG/L | 0| 2| 2| 4| 1| 3| 2| 0| 0| 0| 1| 1| 2| 2| 3| 3| 3| 4| 4| 4| 4| 0| 0| 1| 1| | 9| 4| 8| 0| 7| 0| 7| 4| 3| 8| 2| 6| 6| 9| 1| 4| 9| 1| 2| 4| 8| 2| 5| 0| 3| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Multiple | | Carcinoma, Metastatic, Kidney | | Hepatocellular Carcinoma, Metastatic,| | Liver | X X X | Histiocytic Sarcoma | X| |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | X | Hepatocellular Carcinoma, Metastatic,| | Liver | X | Renal Tubule, Carcinoma | | |__________________________________________________________________________| Urethra | + | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X| __________________________________________|__________________________________________________________________________| Page 68 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 1000MG/L | 1| 2| 2| 3| 3| 4| 4| 4| 0| 0| 1| 1| 2| 3| 3| 4| 5| 0| 1| 1| 2| 2| 3| 3| 4| L | | 5| 0| 3| 2| 6| 5| 6| 7| 1| 7| 1| 9| 2| 5| 7| 9| 0| 6| 4| 8| 1| 5| 3| 8| 3| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + I + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Polyp Adenomatous | X X | 2 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 1 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cholangiocarcinoma | | 1 | Hemangioma | | 1 | Hemangiosarcoma | | 1 | Hemangiosarcoma, Metastatic, Spleen | | 1 | Hepatoblastoma | | 1 | Hepatocellular Carcinoma | X X X X X | 14 | Hepatocellular Carcinoma, Multiple | X X | 5 | Hepatocellular Adenoma | X X X X X X | 13 | Hepatocellular Adenoma, Multiple | X X X X X X X X X X X X X | 23 | Histiocytic Sarcoma | X | 2 | |__________________________________________________________________________|____________| Mesentery | + + + + | 10 | Hepatocellular Carcinoma, Metastatic,| | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 69 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 1000MG/L | 1| 2| 2| 3| 3| 4| 4| 4| 0| 0| 1| 1| 2| 3| 3| 4| 5| 0| 1| 1| 2| 2| 3| 3| 4| L | | 5| 0| 3| 2| 6| 5| 6| 7| 1| 7| 1| 9| 2| 5| 7| 9| 0| 6| 4| 8| 1| 5| 3| 8| 3| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Liver | | 1 | Liposarcoma | | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 1 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Squamous Cell Papilloma | X | 2 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Tooth | + | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 1 | Subcapsular, Adenoma | X X X | 4 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + M + + + + + + + + + + + + M + + + + +| 47 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 70 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 1000MG/L | 1| 2| 2| 3| 3| 4| 4| 4| 0| 0| 1| 1| 2| 3| 3| 4| 5| 0| 1| 1| 2| 2| 3| 3| 4| L | | 5| 0| 3| 2| 6| 5| 6| 7| 1| 7| 1| 9| 2| 5| 7| 9| 0| 6| 4| 8| 1| 5| 3| 8| 3| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Pituitary Gland | + + + + + + + + + + + + + + + + + + M + M + + + +| 45 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| 48 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cholangiocarcinoma, Metastatic, Liver| | 1 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma, Metastatic, Spleen | | 1 | |__________________________________________________________________________|____________| Lymph Node | | 1 | Mediastinal, Hepatocellular | | | Carcinoma, Metastatic, Liver | | 1 | Pancreatic, Hepatocellular Carcinoma,| | | Metastatic, Liver | | 1 | Renal, Hepatocellular Carcinoma, | | | Metastatic, Liver | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 71 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 1000MG/L | 1| 2| 2| 3| 3| 4| 4| 4| 0| 0| 1| 1| 2| 3| 3| 4| 5| 0| 1| 1| 2| 2| 3| 3| 4| L | | 5| 0| 3| 2| 6| 5| 6| 7| 1| 7| 1| 9| 2| 5| 7| 9| 0| 6| 4| 8| 1| 5| 3| 8| 3| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 45 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | | 1 | Histiocytic Sarcoma | | 1 | |__________________________________________________________________________|____________| Thymus | + + M + + + + + + + + + + + + M + + M + M + + + +| 40 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcutaneous Tissue, Fibrous | | | Histiocytoma | X | 1 | Subcutaneous Tissue, Lipoma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Harderian | | | Gland | X | 1 | |__________________________________________________________________________|____________| Skeletal Muscle | | 3 | Alveolar/Bronchiolar Carcinoma, | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 72 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 1000MG/L | 1| 2| 2| 3| 3| 4| 4| 4| 0| 0| 1| 1| 2| 3| 3| 4| 5| 0| 1| 1| 2| 2| 3| 3| 4| L | | 5| 0| 3| 2| 6| 5| 6| 7| 1| 7| 1| 9| 2| 5| 7| 9| 0| 6| 4| 8| 1| 5| 3| 8| 3| | _____________________________________________________________________________________________________________________|____________| MUSCULOSKELETAL SYSTEM - cont | | | | | | Metastatic, Lung | | 2 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Peripheral Nerve | | 2 | |__________________________________________________________________________|____________| Spinal Cord | | 2 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X X X X | 7 | Alveolar/Bronchiolar Carcinoma | | 6 | Alveolar/Bronchiolar Carcinoma, | | | Multiple | X | 1 | Carcinoma, Metastatic, Kidney | X | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X | 4 | Histiocytic Sarcoma | | 1 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X X | 4 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 73 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 1000MG/L | 1| 2| 2| 3| 3| 4| 4| 4| 0| 0| 1| 1| 2| 3| 3| 4| 5| 0| 1| 1| 2| 2| 3| 3| 4| L | | 5| 0| 3| 2| 6| 5| 6| 7| 1| 7| 1| 9| 2| 5| 7| 9| 0| 6| 4| 8| 1| 5| 3| 8| 3| | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM - cont | | | | | | Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 1 | Renal Tubule, Carcinoma | X | 1 | |__________________________________________________________________________|____________| Urethra | | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 74 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 _____________________________________________________________________________________________________________________ | 2| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 8| 6| 3| 7| 9| 0| 1| 1| 4| 4| 5| 5| 6| 9| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| | 8| 5| 5| 0| 5| 5| 6| 8| 0| 0| 2| 7| 4| 4| 1| 9| 1| 9| 9| 9| 9| 9| 9| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2000MG/L | 5| 7| 9| 9| 0| 6| 6| 7| 6| 9| 8| 5| 8| 7| 7| 8| 5| 5| 6| 7| 7| 8| 8| 8| 9| | 6| 7| 1| 9| 0| 7| 0| 1| 3| 8| 2| 4| 4| 5| 6| 9| 8| 1| 9| 2| 4| 3| 5| 7| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Gallbladder | + + + + I + + I M + + + A + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + A + + + + + + A + + + + + + + + + + + +| Carcinoma | | Histiocytic Sarcoma | X | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + I + + + + + + + + + + + + + + + + + + +| Carcinoma | | Carcinoma, Metastatic, Islets, | | Pancreatic | | |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | X X | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Islets, | | Pancreatic | | Hemangiosarcoma | | Hepatoblastoma | X | Hepatocellular Carcinoma | X X X X X X X X X| Hepatocellular Carcinoma, Multiple | X | Hepatocellular Adenoma | X X X X X X X X X| Hepatocellular Adenoma, Multiple | X X X X X | Histiocytic Sarcoma | X X | |__________________________________________________________________________| Mesentery | + + + + + + | Hepatocellular Carcinoma, Metastatic,| | __________________________________________|__________________________________________________________________________| Page 75 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 _____________________________________________________________________________________________________________________ | 2| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 8| 6| 3| 7| 9| 0| 1| 1| 4| 4| 5| 5| 6| 9| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| | 8| 5| 5| 0| 5| 5| 6| 8| 0| 0| 2| 7| 4| 4| 1| 9| 1| 9| 9| 9| 9| 9| 9| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2000MG/L | 5| 7| 9| 9| 0| 6| 6| 7| 6| 9| 8| 5| 8| 7| 7| 8| 5| 5| 6| 7| 7| 8| 8| 8| 9| | 6| 7| 1| 9| 0| 7| 0| 1| 3| 8| 2| 4| 4| 5| 6| 9| 8| 1| 9| 2| 4| 3| 5| 7| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Liver | X | Histiocytic Sarcoma | X | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | X X | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tooth | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Hepatocellular Carcinoma, Metastatic,| | Liver | X | Subcapsular, Adenoma | X| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + M + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 76 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 _____________________________________________________________________________________________________________________ | 2| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 8| 6| 3| 7| 9| 0| 1| 1| 4| 4| 5| 5| 6| 9| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| | 8| 5| 5| 0| 5| 5| 6| 8| 0| 0| 2| 7| 4| 4| 1| 9| 1| 9| 9| 9| 9| 9| 9| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2000MG/L | 5| 7| 9| 9| 0| 6| 6| 7| 6| 9| 8| 5| 8| 7| 7| 8| 5| 5| 6| 7| 7| 8| 8| 8| 9| | 6| 7| 1| 9| 0| 7| 0| 1| 3| 8| 2| 4| 4| 5| 6| 9| 8| 1| 9| 2| 4| 3| 5| 7| 0| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Interstitial Cell, Adenoma | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | |__________________________________________________________________________| Lymph Node | + + + | Mediastinal, Carcinoma, Metastatic, | | Harderian Gland | X | Mediastinal, Hepatocellular | | Carcinoma, Metastatic, Liver | X | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + + + + + + + + +| Histiocytic Sarcoma | X | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 77 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 _____________________________________________________________________________________________________________________ | 2| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 8| 6| 3| 7| 9| 0| 1| 1| 4| 4| 5| 5| 6| 9| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| | 8| 5| 5| 0| 5| 5| 6| 8| 0| 0| 2| 7| 4| 4| 1| 9| 1| 9| 9| 9| 9| 9| 9| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2000MG/L | 5| 7| 9| 9| 0| 6| 6| 7| 6| 9| 8| 5| 8| 7| 7| 8| 5| 5| 6| 7| 7| 8| 8| 8| 9| | 6| 7| 1| 9| 0| 7| 0| 1| 3| 8| 2| 4| 4| 5| 6| 9| 8| 1| 9| 2| 4| 3| 5| 7| 0| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Histiocytic Sarcoma | X | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | |__________________________________________________________________________| Thymus | + + + + + M + + + I + + + + M + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + + | Hepatocellular Carcinoma, Metastatic,| | Liver | X | Rhabdomyosarcoma | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Peripheral Nerve | + | |__________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X X | Alveolar/Bronchiolar Carcinoma | X X | Carcinoma, Metastatic, Harderian | | __________________________________________|__________________________________________________________________________| Page 78 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 _____________________________________________________________________________________________________________________ | 2| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 8| 6| 3| 7| 9| 0| 1| 1| 4| 4| 5| 5| 6| 9| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| | 8| 5| 5| 0| 5| 5| 6| 8| 0| 0| 2| 7| 4| 4| 1| 9| 1| 9| 9| 9| 9| 9| 9| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2000MG/L | 5| 7| 9| 9| 0| 6| 6| 7| 6| 9| 8| 5| 8| 7| 7| 8| 5| 5| 6| 7| 7| 8| 8| 8| 9| | 6| 7| 1| 9| 0| 7| 0| 1| 3| 8| 2| 4| 4| 5| 6| 9| 8| 1| 9| 2| 4| 3| 5| 7| 0| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Gland | X | Hemangiosarcoma | | Hepatocellular Carcinoma, Metastatic,| | Liver | X X X X X X | Histiocytic Sarcoma | X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + I + + + + + + + + + + + + + + + +| Adenoma | X X X | Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X X | Lymphoma Malignant | X | __________________________________________|__________________________________________________________________________| Page 79 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 2000MG/L | 9| 9| 5| 6| 7| 8| 8| 9| 9| 5| 6| 6| 6| 7| 7| 7| 8| 9| 5| 5| 5| 6| 6| 8| 9| L | | 2| 6| 7| 1| 0| 0| 1| 3| 5| 2| 2| 4| 6| 3| 8| 9| 8| 7| 3| 5| 9| 5| 8| 6| 4| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + I + + +| 45 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Carcinoma | X | 1 | Histiocytic Sarcoma | | 1 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Carcinoma | X | 1 | Carcinoma, Metastatic, Islets, | | | Pancreatic | X | 1 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 1 | Carcinoma | | 2 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Islets, | | | Pancreatic | X | 1 | Hemangiosarcoma | X X | 2 | Hepatoblastoma | X X | 3 | Hepatocellular Carcinoma | X X X | 12 | Hepatocellular Carcinoma, Multiple | | 1 | Hepatocellular Adenoma | X X X X X | 14 | Hepatocellular Adenoma, Multiple | X X X X X X X X X X X| 16 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 80 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 2000MG/L | 9| 9| 5| 6| 7| 8| 8| 9| 9| 5| 6| 6| 6| 7| 7| 7| 8| 9| 5| 5| 5| 6| 6| 8| 9| L | | 2| 6| 7| 1| 0| 0| 1| 3| 5| 2| 2| 4| 6| 3| 8| 9| 8| 7| 3| 5| 9| 5| 8| 6| 4| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Histiocytic Sarcoma | | 2 | |__________________________________________________________________________|____________| Mesentery | + + | 8 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 1 | Histiocytic Sarcoma | X | 2 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Squamous Cell Papilloma | | 2 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Tooth | + + | 3 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + | 1 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 1 | Subcapsular, Adenoma | X | 2 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 81 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 2000MG/L | 9| 9| 5| 6| 7| 8| 8| 9| 9| 5| 6| 6| 6| 7| 7| 7| 8| 9| 5| 5| 5| 6| 6| 8| 9| L | | 2| 6| 7| 1| 0| 0| 1| 3| 5| 2| 2| 4| 6| 3| 8| 9| 8| 7| 3| 5| 9| 5| 8| 6| 4| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + I + + + + + + +| 49 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 1 | Carcinoma | X | 1 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Interstitial Cell, Adenoma | X | 2 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 82 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 2000MG/L | 9| 9| 5| 6| 7| 8| 8| 9| 9| 5| 6| 6| 6| 7| 7| 7| 8| 9| 5| 5| 5| 6| 6| 8| 9| L | | 2| 6| 7| 1| 0| 0| 1| 3| 5| 2| 2| 4| 6| 3| 8| 9| 8| 7| 3| 5| 9| 5| 8| 6| 4| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | Histiocytic Sarcoma | | 1 | |__________________________________________________________________________|____________| Lymph Node | | 3 | Mediastinal, Carcinoma, Metastatic, | | | Harderian Gland | | 1 | Mediastinal, Hepatocellular | | | Carcinoma, Metastatic, Liver | | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Histiocytic Sarcoma | | 1 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | |__________________________________________________________________________|____________| Thymus | + + + M + M + + + + + + + + + + + + + + + + M + +| 44 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Skeletal Muscle | | 2 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 83 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 2000MG/L | 9| 9| 5| 6| 7| 8| 8| 9| 9| 5| 6| 6| 6| 7| 7| 7| 8| 9| 5| 5| 5| 6| 6| 8| 9| L | | 2| 6| 7| 1| 0| 0| 1| 3| 5| 2| 2| 4| 6| 3| 8| 9| 8| 7| 3| 5| 9| 5| 8| 6| 4| | _____________________________________________________________________________________________________________________|____________| MUSCULOSKELETAL SYSTEM - cont | | | | | | Rhabdomyosarcoma | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Peripheral Nerve | | 1 | |__________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X X | 6 | Alveolar/Bronchiolar Carcinoma | X X | 4 | Carcinoma, Metastatic, Harderian | | | Gland | | 1 | Hemangiosarcoma | X | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 6 | Histiocytic Sarcoma | | 1 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Adenoma | X X X | 6 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 84 NTP Experiment-Test: 96010-04 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03 Route: DOSED WATER Time: 10:48:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 2000MG/L | 9| 9| 5| 6| 7| 8| 8| 9| 9| 5| 6| 6| 6| 7| 7| 7| 8| 9| 5| 5| 5| 6| 6| 8| 9| L | | 2| 6| 7| 1| 0| 0| 1| 3| 5| 2| 2| 4| 6| 3| 8| 9| 8| 7| 3| 5| 9| 5| 8| 6| 4| | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM - cont | | | | | | Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X | 3 | Lymphoma Malignant | X X | 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 85 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------