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Title Occult thyrotoxicosis: a correctable cause of idiopathic atrial fibrillation
Creator/Author Forfar, J.C. ; Miller, H.C. ; Toft, A.D.
Publication Date1979 Jul 01
OSTI IdentifierOSTI ID: 6113575
Other Number(s)CODEN: AJCDA
Resource TypeJournal Article
Resource RelationAm. J. Cardiol. ; Vol/Issue: 44:1
Research OrgRoyal Infirmary, Edinburgh, Scotland
Subject560161 -- Radionuclide Effects, Kinetics, & Toxicology-- Man; ;IODINE 131-- PHARMACOLOGY;THYROID-- DYNAMIC FUNCTION STUDIES; BLOOD;CEREBRUM;DIAGNOSIS;MYOCARDIAL INFARCTION;PATHOLOGICAL CHANGES;THERAPY;THYROXINE
Related SubjectAMINO ACIDS;BETA DECAY RADIOISOTOPES;BETA-MINUS DECAY RADIOISOTOPES;BIOLOGICAL MATERIALS;BODY;BODY FLUIDS;BRAIN;CARBOXYLIC ACIDS;CARDIOVASCULAR DISEASES;CENTRAL NERVOUS SYSTEM;DAYS LIVING RADIOISOTOPES;DISEASES;ENDOCRINE GLANDS;GLANDS;HORMONES;INTERMEDIATE MASS NUCLEI;IODINE ISOTOPES;ISOTOPES;MATERIALS;NERVOUS SYSTEM;NUCLEI;ODD-EVEN NUCLEI;ORGANIC ACIDS;ORGANIC COMPOUNDS;ORGANIC HALOGEN COMPOUNDS;ORGANIC IODINE COMPOUNDS;ORGANS;PEPTIDE HORMONES;RADIOISOTOPES;THYROID HORMONES
Description/Abstract Serum total thyroxine, triiodothyronine and thyrotropin response to thyrotropin-releasing hormone were measured in 75 consecutive patients presenting to a cardiology clinic with atrial fibrillation with no obvious cardiovascular cause.^A lack of response of serum thyrotropin to thyrotropin-releasing hormone, indicative of thyrotoxicosis, was found in 10 patients (13%), not all whom had raised serum thyroid hormone levels.^These 10 patients were predominantly male, had no clinical signs of thyrotoxicosis and a relative excess of nonpalpable autonomous thyroid nodules demonstrated with scintigraphy.^Eight of the 10 patients had reversion to stable sinus rhythm after treatment with iodine-131 or carbimazole, either spontaneously or after direct current cardioversion.^It would appear that clinically occult thyrotoxicosis can be identified consistently only with the thyrotropin-releasing hormone test and is the cause of idiopathic atrial fibrillation in a significant proportion of patients.
Country of PublicationUnited States
LanguageEnglish
FormatPages: 9-12
System Entry Date2001 May 13

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