Saito M, Siobara S, Asakura H, Matsuda T; International Conference on AIDS.
Int Conf AIDS. 1994 Aug 7-12; 10: 221 (abstract no. PB0897).
Third Department of Internal Medicine, Kanazawa University School of Medicine, Japan.
OBJECTIVE: Thrombosis is one of the complications in patients with HIV infection. The purpose of this study is to determine the status of natural coagulation inhibitors and to examine whether thrombotic tendency is exists or not in HIV-infected patients. METHODS: Eight HIV-infected men with hemophilia A or hemophilia B and age-matched 10 healthy male controls were studied. Plasma concentrations of anti-thrombin III (AT III) activity, heparin cofactor II (HC II) activity, Protein C (PC) activity, total and free protein S (PS) antigen, and C4b-binding protein were determined in patients and controls. Serum albumin level and CD4+ lymphocyte count were also measured as routine laboratory tests. RESULTS: The mean value of serum albumin was 43 g/l and the mean CD4+ lymphocyte level was 234/microliters in HIV-infected patients. The mean values of ATIII, HC II, PC, total PS and free PS were significantly lower in HIV infected patients than in controls. The mean level of C4b-binding protein in patients was normal. The concentration of AT III was only significantly correlated with CD4+ lymphocyte. No correlations were seen between the concentrations of other coagulation inhibitors and CD4+ lymphocyte counts and CDC classification. DISCUSSION AND CONCLUSION: The concentrations of coagulation inhibitors in hemophiliacs with HIV infection were significantly lower than in controls. These suggest that HIV-infected patients may be expected to be increased risk of thrombotic tendency and the concentration of ATIII was only significantly correlated with degree of immunodeficiency of all coagulation inhibitors.
Publication Types:
Keywords:
- AIDS Vaccines
- Acquired Immunodeficiency Syndrome
- Antithrombin III
- Blood Coagulation Tests
- CD4 Lymphocyte Count
- CD4-Positive T-Lymphocytes
- Case-Control Studies
- HIV
- HIV Infections
- HIV Seropositivity
- Hemophilia A
- Heparin Cofactor II
- Humans
- Male
- Protein C
- Protein S
- Protein S Deficiency
- Thrombosis
Other ID:
UI: 102210364
From Meeting Abstracts