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 EC-number:  3.4.21.6 ----- coagulation factor Xa
EC-NUMBER 3.4.21.6
ENZYME-NAME coagulation factor Xa
ENZYME-SYSNAME Formed from the proenzyme factor X by limited proteolysis. In peptidase family S1 (trypsin family). Scutelarin (EC 3.4.21.60) has similar specificity
ENZYME-CLASS Hydrolases Acting on peptide bonds (peptidases) Serine endopeptidases
SYNONYMS activated Stuart-Prower factor;; activated blood-coagulation factor X;; activated factor X; autoprothrombin C;;   >>more synonyms
REACTION Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin
PATHWAY EMP-PATHWAYS: NO EMP PATHWAY FOUND
KEGG-PATHWAYS: Complement and coagulation cascades;   >>more KEGG pathways
GO_TERM GO:0003804:coagulation factor Xa activity
ENZYME-COMMENT NULL
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ExternalDB ----- DBLINKS
Diseases
Structure
Gene
Motif
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Other
InterPro Domains found in sequences annotated as EC 3.4.21.6
   IPR000152 Aspartic acid and asparagine hydroxylation site
   IPR000294 Vitamin K-dependent carboxylation/gamma-carboxyglutamic region
   IPR000742 EGF-like, type 3
   IPR001254 Peptidase S1 and S6, chymotrypsin/Hap
   IPR001314 Peptidase S1A, chymotrypsin
   IPR001438 EGF-like, type 2
   IPR001881 EGF-like calcium-binding
   IPR002383 Coagulation factor, Gla region
   IPR006209 EGF-like
   IPR006210 EGF
   IPR009003 Peptidase, trypsin-like serine and cysteine
   IPR012224 Peptidase S1A, coagulation factor VII/IX/X/C/Z
   IPR013032 EGF-like region
       
PIR SuperFamilies containing EC 3.4.21.6
SF001143 coagulation factor X
Taxonomic breakdown of EC 3.4.21.6 sequences
To perform phylogenetic analysis, first select some protein ids by clicking on their checkboxes, then click on one of the buttons below.
  Additional gi numbers:   
Eukaryota
Chordata
Tropidechis carinatus
54402099
IPR000152 Aspartic acid and asparagine hydroxylation site
IPR000294 Vitamin K-dependent carboxylation/gamma-carboxyglutamic region
IPR000742 EGF-like, type 3
IPR001254 Peptidase S1 and S6, chymotrypsin/Hap
IPR001314 Peptidase S1A, chymotrypsin
IPR001438 EGF-like, type 2
IPR001881 EGF-like calcium-binding
IPR002383 Coagulation factor, Gla region
IPR006209 EGF-like
IPR006210 EGF
IPR009003 Peptidase, trypsin-like serine and cysteine
IPR012224 Peptidase S1A, coagulation factor VII/IX/X/C/Z
IPR013032 EGF-like region
55794133
IPR000152 Aspartic acid and asparagine hydroxylation site
IPR000294 Vitamin K-dependent carboxylation/gamma-carboxyglutamic region
IPR000742 EGF-like, type 3
IPR001254 Peptidase S1 and S6, chymotrypsin/Hap
IPR001314 Peptidase S1A, chymotrypsin
IPR001438 EGF-like, type 2
IPR001881 EGF-like calcium-binding
IPR002383 Coagulation factor, Gla region
IPR006209 EGF-like
IPR006210 EGF
IPR009003 Peptidase, trypsin-like serine and cysteine
IPR012224 Peptidase S1A, coagulation factor VII/IX/X/C/Z
IPR013032 EGF-like region
Actinopterygii
Takifugu rubripes
74095913
IPR000152 Aspartic acid and asparagine hydroxylation site
IPR000294 Vitamin K-dependent carboxylation/gamma-carboxyglutamic region
IPR000742 EGF-like, type 3
IPR001254 Peptidase S1 and S6, chymotrypsin/Hap
IPR001314 Peptidase S1A, chymotrypsin
IPR001438 EGF-like, type 2
IPR001881 EGF-like calcium-binding
IPR002383 Coagulation factor, Gla region
IPR006209 EGF-like
IPR006210 EGF
IPR009003 Peptidase, trypsin-like serine and cysteine
IPR012224 Peptidase S1A, coagulation factor VII/IX/X/C/Z
IPR013032 EGF-like region
Aves
Gallus gallus
45384308
IPR000152 Aspartic acid and asparagine hydroxylation site
IPR000294 Vitamin K-dependent carboxylation/gamma-carboxyglutamic region
IPR000742 EGF-like, type 3
IPR001254 Peptidase S1 and S6, chymotrypsin/Hap
IPR001314 Peptidase S1A, chymotrypsin
IPR001438 EGF-like, type 2
IPR001881 EGF-like calcium-binding
IPR002383 Coagulation factor, Gla region
IPR006209 EGF-like
IPR006210 EGF
IPR009003 Peptidase, trypsin-like serine and cysteine
IPR012224 Peptidase S1A, coagulation factor VII/IX/X/C/Z
IPR013032 EGF-like region
Mammalia
Bos taurus
6064171
IPR000152 Aspartic acid and asparagine hydroxylation site
IPR000294 Vitamin K-dependent carboxylation/gamma-carboxyglutamic region
IPR000742 EGF-like, type 3
IPR001254 Peptidase S1 and S6, chymotrypsin/Hap
IPR001314 Peptidase S1A, chymotrypsin
IPR001438 EGF-like, type 2
IPR001881 EGF-like calcium-binding
IPR002383 Coagulation factor, Gla region
IPR006209 EGF-like
IPR006210 EGF
IPR009003 Peptidase, trypsin-like serine and cysteine
IPR012224 Peptidase S1A, coagulation factor VII/IX/X/C/Z
IPR013032 EGF-like region
Homo sapiens
4503625
IPR000152 Aspartic acid and asparagine hydroxylation site
IPR000294 Vitamin K-dependent carboxylation/gamma-carboxyglutamic region
IPR000742 EGF-like, type 3
IPR001254 Peptidase S1 and S6, chymotrypsin/Hap
IPR001314 Peptidase S1A, chymotrypsin
IPR001438 EGF-like, type 2
IPR001881 EGF-like calcium-binding
IPR002383 Coagulation factor, Gla region
IPR006209 EGF-like
IPR006210 EGF
IPR009003 Peptidase, trypsin-like serine and cysteine
IPR012224 Peptidase S1A, coagulation factor VII/IX/X/C/Z
IPR013032 EGF-like region
Macaca mulatta
455395
IPR001254 Peptidase S1 and S6, chymotrypsin/Hap
IPR001314 Peptidase S1A, chymotrypsin
IPR009003 Peptidase, trypsin-like serine and cysteine
Mesocricetus auratus
455393
IPR001254 Peptidase S1 and S6, chymotrypsin/Hap
IPR001314 Peptidase S1A, chymotrypsin
IPR009003 Peptidase, trypsin-like serine and cysteine
Mus musculus
74152174
IPR000152 Aspartic acid and asparagine hydroxylation site
IPR000294 Vitamin K-dependent carboxylation/gamma-carboxyglutamic region
IPR000742 EGF-like, type 3
IPR001254 Peptidase S1 and S6, chymotrypsin/Hap
IPR001314 Peptidase S1A, chymotrypsin
IPR001438 EGF-like, type 2
IPR001881 EGF-like calcium-binding
IPR002383 Coagulation factor, Gla region
IPR006209 EGF-like
IPR006210 EGF
IPR009003 Peptidase, trypsin-like serine and cysteine
IPR012224 Peptidase S1A, coagulation factor VII/IX/X/C/Z
IPR013032 EGF-like region
Oryctolagus cuniculus
3913632
IPR000152 Aspartic acid and asparagine hydroxylation site
IPR000294 Vitamin K-dependent carboxylation/gamma-carboxyglutamic region
IPR000742 EGF-like, type 3
IPR001254 Peptidase S1 and S6, chymotrypsin/Hap
IPR001314 Peptidase S1A, chymotrypsin
IPR001438 EGF-like, type 2
IPR001881 EGF-like calcium-binding
IPR002383 Coagulation factor, Gla region
IPR006209 EGF-like
IPR006210 EGF
IPR009003 Peptidase, trypsin-like serine and cysteine
IPR012224 Peptidase S1A, coagulation factor VII/IX/X/C/Z
IPR013032 EGF-like region
Rattus norvegicus
8393340
IPR000152 Aspartic acid and asparagine hydroxylation site
IPR000294 Vitamin K-dependent carboxylation/gamma-carboxyglutamic region
IPR000742 EGF-like, type 3
IPR001254 Peptidase S1 and S6, chymotrypsin/Hap
IPR001314 Peptidase S1A, chymotrypsin
IPR001438 EGF-like, type 2
IPR001881 EGF-like calcium-binding
IPR002383 Coagulation factor, Gla region
IPR006209 EGF-like
IPR006210 EGF
IPR009003 Peptidase, trypsin-like serine and cysteine
IPR012224 Peptidase S1A, coagulation factor VII/IX/X/C/Z
IPR013032 EGF-like region
  Additional gi numbers:   

To perform phylogenetic analysis:

  1. Select some ids by clicking on their checkboxes.
  2. Click on one of the buttons above.

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