Colombero D, Agostini M, Lupo S; International Conference on AIDS (15th : 2004 : Bangkok, Thailand).
Int Conf AIDS. 2004 Jul 11-16; 15: abstract no. WePeB5919.
Hospital Provincial del Centenario, Rosario, Argentina
Background: Immune recovery uveitis (IRU) is an inflammatory syndrome causing visual disturbance in patients with AIDS and CMV retinitis following highly active antiretroviral therapy (HAART). The purpose of this study is to determine the characteristics and long term complications of IRU in AIDS patients with inactive cytomegalovirus (CMV) retinitis who responded to HAART. Methods: We examined 30 patients with AIDS (HAART responders) and healed CMV retinitis. In all cases initial treatment of CMV retinitis was with intravenous ganciclovir or foscarnet, and maintenance treatment with oral ganciclovir. MedianCD4 count was 32 cells/mm3 and viral load was more than 105log. Patients were observed for at least 12 months following an increase in the CD4 cell count. Results: We found 9 patients (30%) with IRU (15 eyes). The clinical findings included anterior uveitis (n=9), vitritis (n=9), macular edema (n=5), optic disc neovascularization (n=3), epiretinal membranes (n=2), papillitis (n=2), retinal detachment (n=2), cataract (n=2), and vitreous hemorrhage (n=1), Periocular and oral treatment with steroids was indicated in 6 cases with reduced visual acuity. Conclusions: IRU is a frequent manifestation in patients with CMV retinitis following HAART. Long-term follow-up in this series of patients leads to the conclusion that IRU tends to persist and produce secondary complications that could have substantial visual morbidity.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Antiretroviral Therapy, Highly Active
- CD4 Lymphocyte Count
- Cytomegalovirus Retinitis
- Epiretinal Membrane
- Foscarnet
- Ganciclovir
- Humans
- Retinal Detachment
- Retinitis
- Vision Disorders
Other ID:
UI: 102283846
From Meeting Abstracts