1.0 Submitter/Company Information

2.0 Submission Information

Document Control Number: 86890000237

Microfiche Number: OTS0516772

3.0 Chemical Information
CAS Number: 111-76-2

TSCA Chemical Inventory Name: Ethanol, 2-butoxy-

Synonyms: ETHYLENE GLYCOL MONO-N-BUTYL ETHER

Other Chemicals in Submission:

4.0 Study Information
Study Title:
COPIES OR REFERENCES OF HEALTH AND SAFETY STUDIES ON TRIETHANOLAMINE AND GLYCOL ETHERS WITH COVER LETTER DATED 051989

Study Information:
Reproductive/Developmental Toxicity
Unknown Environmental Effects

Summary/Abstract:
[Jefferson Chem Co., Inc.; Teratologic Evaluation of Ethylene Glycol Monobutyl Ether in Fischer 344 Rats and New Zeland White Rabbits Following Inhalation Exposure, (1984), EPA Doc. No. 86-890000237, Fiche No. OTS0516772] Teratogenicity was evaluated in groups of 24 pregnant New Zeland white rabbits exposed to ethylene glycol monobutyl ether vapors at concentrations of 0, 25, 50, 100, and 200 ppm for 6 hours/day on days 6-18 of gestation. Maternal mortality was observed in 4 rabbits at 200 ppm; all surviving rabbits were sacrificed on gestation day 29 and the uteri examined. Clinical signs of maternal toxicity at 100 and 200 ppm included periocular wetness and red fluid on the trays beneath the cages. Additional clinical observations at 200 ppm included staining of the fur and perinasal wetness and discharge. There were no differences between control and treatment groups with respect to maternal body weights, hematological findings, the number of non-viable implants, preimplantation losses, percent live fetuses, sex ratios, or fetal weights. Significant (p<0.05) reductions in uterine weights and the number of total and viable implants/litter were observed at 200 ppm. The incidence of external, visceral, skeletal, and total fetal malformations at all exposure levels was not significantly different from that of the control group.