1.0 Submitter/Company Information
Submitting Company: UNION CARBIDE CORP

Submitter Comments


2.0 Submission Information

EPA Receipt Date: 06/15/92

8(e)/FYI ID Number: 8EHQ-0692-04888 A

Submission Stage: INI

Document Control Number: 88920003534

Microfiche Number: OTS0537490

3.0 Chemical Information
CAS Number: 122185-09-5

TSCA Chemical Inventory Name: 2,15-Dioxa-3,14-disilahexadecane, 3,3,14,14-tetramethoxy-

Synonyms: 1,10-BIS-TRIMETHOXYSILYLDECANE

Other Chemicals in Submission:

4.0 Study Information
Study Title:
INITIAL SUBMISSION: FOUR WEEK AEROSOL INHALATION STUDY OF 1,10-BIS(TRIMETHOXYSILYL)DECANE IN RATS: ASSESSMENT OF THE POTENTIAL TO PRODUCE LARYNGEAL GRANULOMAS WITH COVER LETTER DAT

Study Information:
Other Health Effects
Unknown Environmental Effects

Summary/Abstract:
MALE RATS WERE EXPOSED FOR 6 HOURS/DAY FOR 18 DAYS TO A GRAVIMETRIC
CONCENTRATION OF 155 MG/M3. 7/15 ANIMALS DIED OR WERE SACRIFICED MORIBUND.
CLINICAL SIGNS INCLUDED PERIOCULAR AND PERINASAL ENCRUSTATION, PERIOCULAR
SWELLING, EMACIATION, DEHYDRATION, UNKEMPT FUR, URINE STAINS, HINDLEG PARESIS
AND RAPID RESPIRATION. MICROSCOPIC ABNORMALITIES WERE NOTED IN THE PERIPHERAL
NERVES, KIDNEYS AND TESTES.