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Laboratory of Cardiovascular Science
1997 - 1998 Publications

  1. Anderson, D.E., Dhokalia, A., Parsons, D., and Bagrov, A.Y.: Sodium sensitivity in young adults with high resting end-tidal CO2. J Hypertens 16: 1015-22, 1998. [Abs]

  2. Anderson, D.E.: Cardiorenal effects of behavioral inhibition of breathing. Biol Psychol 49: 151-63, 1998. [Abs]

  3. Bagrov, A.Y., Fedorova, O.V., Dmitrieva, R.I., Howald, W.N., Hunter, A.P., Kuznetsova, E.A., and Shpen, V.M.: Characterization of a urinary bufodienolide Na+,K+-ATPase inhibitor in patients after acute myocardial infarction. Hypertension 31: 1097-103, 1998. [Abs]

  4. Bogdanov, K.Y., Spurgeon, H.A., Vinogradova, T.M., and Lakatta, E.G.: Modulation of the transient outward current in adult rat ventricular myocytes by polyunsaturated fatty acids. Am J Physiol 274: H571-9, 1998. [Abs]

  5. Chen, C.H., Ting, C.T., Lin, S.J., Hsu, T.L., Ho, S.J., Chou, P., Chang, M.S., O'Connor, F., Spurgeon, H., Lakatta, E., and Yin, F.C.: Which arterial and cardiac parameters best predict left ventricular mass?. Circulation 98: 422-8, 1998. [Abs]

  6. Cheng, L., Mantile, G., Pauly, R., Nater, C., Felici, A., Monticone, R., Bilato, C., Gluzband, Y.A., Crow, M.T., Stetler-Stevenson, W., and Capogrossi, M.C.: Adenovirus-mediated gene transfer of the human tissue inhibitor of metalloproteinase-2 blocks vascular smooth muscle cell invasiveness In vitro and modulates neointimal development In vivo. Circulation 98: 2195-201, 1998. [Abs]

  7. Crow, M.T., Long, S., Guglielmi, M.B., Asai, T., and Lakatta, E.G.: The role of the tumor suppressor gene p53 in cardiomyocyte apoptosis. Heart Failure and Reviews 3: 45-61, 1998.

  8. Dhokalia, A., Parsons, D.J., and Anderson, D.E.: Resting end-tidal CO2 association with age, gender, and personality. Psychosom Med 60: 33-7, 1998. [Abs]

  9. Doris, P.A. and Bagrov, A.Y.: Endogenous sodium pump inhibitors and blood pressure regulations: An update on recent progress. Proceedings of Society Experimental Biology and Medicine 218: 156-167, 1998.

  10. Fedorova, O.V., Anderson, D.E., and Bagrov, A.Y.: Plasma marinobufagenin-like and ouabain-like immunoreactivity in adrenocorticotropin-treated rats. Am J Hypertens 11: 796-802, 1998. [Abs]

  11. Fedorova, O.V., Doris, P.A., and Bagrov, A.Y.: Endogenous marinobufagenin-like factor in acute plasma volume expansion. Clin Exp Hypertens 20: 581-91, 1998. [Abs]

  12. Fleg, J. L., Kitzman, D. W., Aronow, W. S., Rich, M. W., Gardin, J. M., and Slone, S. A.: Physician management of patients with heart failure and normal versus decreased left ventricular systolic function. Council on Geriatric Cardiology. Am J Cardiol 81: 506-9, 1998. [Abs]

  13. Gambassi, G., Spurgeon, H.A., Ziman, B.D., Lakatta, E.G., and Capogrossi, M.C.: Opposing effects of alpha 1-adrenergic receptor subtypes on Ca2+ and pH homeostasis in rat cardiac myocytes. Am J Physiol 274: H1152-62, 1998. [Abs]

  14. Gonick, H.C., Ding, Y., Vaziri, N.D., Bagrov, A.Y., and Fedorova, O.V.: Simultaneous measurement of marinobufagenin, ouabain, and hypertension- associated protein in various disease states. Clin Exp Hypertens 20: 617-27, 1998. [Abs]

  15. Griffiths, E.J., Ocampo, C.J., Savage, J.S., Rutter, G.A., Hansford, R.G., Stern, M.D., and Silverman, H.S.: Mitochondrial calcium transporting pathways during hypoxia and reoxygenation in single rat cardiomyocytes. Cardiovasc Res 39: 423-33, 1998. [Abs]

  16. Hagberg, J M., Goldberg, A.P., Lakatta, L., O'Connor, F.C., Becker, L.C., Lakatta, E.G., and Fleg, J.L.: Expanded blood volumes contribute to the increased cardiovascular performance of endurance-trained older men. J Appl Physiol 85: 484-9, 1998. [Abs]

  17. Hu, Q., Corda, S., Zweier, J.L., Capogrossi, M.C., and Ziegelstein, R.C.: Hydrogen peroxide induces intracellular calcium oscillations in human aortic endothelial cells. Circulation 97: 268-75, 1998. [Abs]

  18. Jenkins, G.M., Crow, M.T., Bilato, C., Gluzband, Y., Ryu, W.S., Li, Z., Stetler-Stevenson, W., Nater, C., Froehlich, J.P., Lakatta, E.G., and Cheng, L.: Increased expression of membrane-type matrix metalloproteinase and preferential localization of matrix metalloproteinase-2 to the neointima of balloon-injured rat carotid arteries. Circulation 97: 82-90, 1998. [Abs]

  19. Katzel, L.I., Fleg, J.L., Busby-Whitehead, M.J., Sorkin, J.D., Becker, L.C., Lakatta, E.G., and Goldberg, A.P.: Exercise-induced silent myocardial ischemia in master athletes. Am J Cardiol 81: 261-5, 1998. [Abs]

  20. Koban, M.U., Moorman, A.F., Holtz, J., Yacoub, M.H., and Boheler, K.R.: Expressional analysis of the cardiac Na-Ca exchanger in rat development and senescence. Cardiovasc Res 37: 405-23, 1998. [Abs]

  21. Lakatta, E. G.: Aging and cardiovascular structure and function in healthy sedentary humans. Aging (Milano) 10: 162-4, 1998. [Abs]

  22. Long, X., Crow, M.T., Sollott, S.J., O'Neill, L., Menees, D.S., de Lourdes Hipolito, M., Boluyt, M.O., Asai, T., and Lakatta, E.G.: Enhanced expression of p53 and apoptosis induced by blockade of the vacuolar proton ATPase in cardiomyocytes. J Clin Invest 101: 1453-61, 1998. [Abs]

  23. Nagai, Y., Metter, E. J., Earley, C. J., Kemper, M. K., Becker, L. C., Lakatta, E. G., and Fleg, J. L.: Increased carotid artery intimal-medial thickness in asymptomatic older subjects with exercise-induced myocardial ischemia. Circulation 98: 1504-9, 1998. [Abs]

  24. Philbin, E.F., Garg, R., Danisa, K., Denny, M., Gosselin, G., Hassapoyannes, C., Horney, A., Johnstone, D.E., Lang, R.M., Ramanathan, K., Safford, R.E., Sarma, R.J., Weiss, R., Williford, W.O., and Fleg, J.L.: The relationship between cardiothoracic ratio and left ventricular ejection fraction in congestive heart failure. Digitalis Investigation Group. Arch Intern Med 158: 501-6, 1998. [Abs]

  25. Riccioni, T., Cirielli, C., Wang, X., Passaniti, A., and Capogrossi, M.C.: Adenovirus-mediated wild-type p53 overexpression inhibits endothelial cell differentiation in vitro and angiogenesis in vivo. Gene Ther 5: 747-54, 1998. [Abs]

  26. Rywik, T.M., Zink, R.C., Gittings, N.S., Khan, A.A., Wright, J.G., O'Connor, F. C., and Fleg, J.L.: Independent prognostic significance of ischemic ST-segment response limited to recovery from treadmill exercise in asymptomatic subjects. Circulation 97: 2117-22, 1998. [Abs]

  27. Senzaki, H., Gluzband, Y.A., Pak, P.H., Crow, M.T., Janicki, J.S., and Kass, D.A.: Synergistic exacerbation of diastolic stiffness from short-term tachycardia-induced cardiodepression and angiotensin II. Circ Res 82: 503-12, 1998. [Abs]

  28. Shah, A.M., Sollott, S.J., and Lakatta, E.G.: Physio-pharmacological evaluation of myocardial performance: an integrative approach. Cardiovasc Res 39: 148-54, 1998. [Abs]

  29. Sham, J.S.K., Song, L.S., Chen, Y., Deng, L.H., Stern, M.D., Lakatta, E.G., and Cheng, H.: Termination of Ca2+ release by a local inactivation of ryanodine receptors in cardiac myocytes. Proc Natl Acad Sci U S A 95: 15096-15101, 1998.

  30. Shefer, V.I. and Talan, M.I.: The effect of exercise training in cold on shivering and nonshivering thermogenesis in adult and aged C57BL/6J mice. Exp Gerontol 33: 467-76, 1998. [Abs]

  31. Smith, G.D., Keizer, J.E., Stern, M.D., Lederer, W.J., and Cheng, H.: A simple numerical model of calcium spark formation and detection in cardiac myocytes. Biophys J 75: 15-32, 1998. [Abs]

  32. Song, L.S., Sham, J.S., Stern, M.D., Lakatta, E.G., and Cheng, H.: Direct measurement of SR release flux by tracking 'Ca2+ spikes' in rat cardiac myocytes. J Physiol (Lond) 512: 677-91, 1998. [Abs]

  33. Stern, M.D.: Exploring local calcium feedback: trying to fool mother nature. J Gen Physiol 112: 259-62, 1998. [Abs]

  34. Wong, K., Boheler, K.R., Bishop, J., Petrou, M., and Yacoub, M.H.: Clenbuterol induces cardiac hypertrophy with normal functional, morphological and molecular features. Cardiovasc Res 37: 115-22, 1998. [Abs]

  35. Xiao, R.P., Tomhave, E.D., Wang, D.J., Ji, X., Boluyt, M.O., Cheng, H., Lakatta, E.G., and Koch, W.J.: Age-associated reductions in cardiac beta1- and beta2-adrenergic responses without changes in inhibitory G proteins or receptor kinases. J Clin Invest 101: 1273-82, 1998. [Abs]

  36. Zheng, J.S., O'Neill, L., Long, X., Webb, T.E., Barnard, E.A., Lakatta, E.G., and Boluyt, M.O.: Stimulation of P2Y receptors activates c-fos gene expression and inhibits DNA synthesis in cultured cardiac fibroblasts. Cardiovasc Res 37: 718-28, 1998. [Abs]

  37. Zhou, Y.Y., Lakatta, E.G., and Xiao, R.P.: Age-associated alterations in calcium current and its modulation in cardiac myocytes. Drugs Aging 13: 159-71, 1998. [Abs]

  38. Ziegelstein, R.C., Blank, P.S., Cheng, L., and Capogrossi, M.C.: Cytosolic alkalinization of vascular endothelial cells produced by an abrupt reduction in fluid shear stress. Circ Res 82: 803-9, 1998. [Abs]

  39. Bilato, C., Curto, K.A., Monticone, R.E., Pauly, R.R., White, A.J., and Crow, M.T.: The inhibition of vascular smooth muscle cell migration by peptide and antibody antagonists of the alphavbeta3 integrin complex is reversed by activated calcium/calmodulin- dependent protein kinaseII. J Clin Invest 100: 693-704, 1997. [Abs]

  40. Boateng, S., Seymour, A.M., Dunn, M., Yacoub, M., and Boheler, K.: Inhibition of endogenous cardiac phosphatase activity and measurement of sarcoplasmic reticulum calcium uptake: a possible role of phospholamban phosphorylation in the hypertrophied myocardium. Biochem Biophys Res Commun 239: 701-5, 1997. [Abs]

  41. Boluyt, M.O., Zheng, J.S., Younes, A., Long, X., O'Neill, L., Silverman, H., Lakatta, E.G., and Crow, M.T.: Rapamycin inhibits alpha 1-adrenergic receptor-stimulated cardiac myocyte hypertrophy but not activation of hypertrophy-associated genes. Evidence for involvement of p70 S6 kinase. Circ Res 81: 176-86, 1997. [Abs]

  42. Brooks, W.W., Bing, O.H., Conrad, C.H., O'Neill, L., Crow, M.T., Lakatta, E.G., Dostal, D.E., Baker, K.M., and Boluyt, M.O.: Captopril modifies gene expression in hypertrophied and failing hearts of aged spontaneously hypertensive rats. Hypertension 30: 1362-8, 1997. [Abs]

  43. Chefer, S.I., Talan, M.I., and Engel, B.T.: Central neural correlates of learned heart rate control during exercise: central command demystified. J Appl Physiol 83: 1448-53, 1997. [Abs]

  44. Cirielli, C., Capogrossi, M.C., and Passaniti, A.: Anti-tumor gene therapy. J Neurooncol 31: 217-23, 1997. [Abs]

  45. Correia, L.C., Atalar, E., Kelemen, M.D., Ocali, O., Hutchins, G.M., Fleg, J.L., Gerstenblith, G., Zerhouni, E.A., and Lima, J.A.: Intravascular magnetic resonance imaging of aortic atherosclerotic plaque composition. Arterioscler Thromb Vasc Biol 17: 3626-32, 1997. [Abs]

  46. Demas, G.E., Chefer, V., Talan, M.I., and Nelson, R.J.: Metabolic costs of mounting an antigen-stimulated immune response in adult and aged C57BL/6J mice. Am J Physiol 273: R1631-7, 1997. [Abs]

  47. Dodd-o, J.M., Zheng, G., Silverman, H.S., Lakatta, E.G., and Ziegelstein, R.C.: Endothelium-independent relaxation of aortic rings by the nitric oxide synthase inhibitor diphenyleneiodonium. Br J Pharmacol 120: 857-64, 1997. [Abs]

  48. Fedorova, O.V. and Bagrov, A.Y.: Inhibition of Na/K ATPase from rat aorta by two Na/K pump inhibitors, ouabain and marinobufagenin: evidence of interaction with different alpha-subunit isoforms. Am J Hypertens 10: 929-35, 1997. [Abs]

  49. Froehlich, J.P., Taniguchi, K., Fendler, K., Mahaney, J.E., Thomas, D.D., and Albers, R.W.: Complex kinetic behavior in the Na,K- and Ca-ATPases. Evidence for subunit-subunit interactions and energy conservation during catalysis. Ann N Y Acad Sci 834: 280-96, 1997. [Abs]

  50. Gomez, A.M., Valdivia, H.H., Cheng, H., Lederer, M.R., Santana, L.F., Cannell, M.B., McCune, S.A., Altschuld, R.A., and Lederer, W.J.: Defective excitation-contraction coupling in experimental cardiac hypertrophy and heart failure. Science 276: 800-6, 1997. [Abs]

  51. Gorospe, M., Cirielli, C., Wang, X., Seth, P., Capogrossi, M. C., and Holbrook, N.J.: p21(Waf1/Cip1) protects against p53-mediated apoptosis of human melanoma cells. Oncogene 14: 929-35, 1997. [Abs]

  52. Griffiths, E.J., Wei, S.K., Haigney, M.C., Ocampo, C.J., Stern, M.D., and Silverman, H.S.: Inhibition of mitochondrial calcium efflux by clonazepam in intact single rat cardiomyocytes and effects on NADH production. Cell Calcium 21: 321-9, 1997. [Abs]

  53. Griffiths, E.J., Stern, M.D., and Silverman, H.S.: Measurement of mitochondrial calcium in single living cardiomyocytes by selective removal of cytosolic indo 1. Am J Physiol 273: C37-44, 1997. [Abs]

  54. Hartung, K., Froehlich, J.P., and Fendler, K.: Time-resolved charge translocation by the Ca-ATPase from sarcoplasmic reticulum after an ATP concentration jump. Biophys J 72: 2503-14, 1997. [Abs]

  55. Haydar, S.R., Rywik, T., and Fleg, J.L.: Isolated systolic hypertension in the nursing home. Nursing Home Medicine 5: 41-49, 1997.

  56. Irani, K., Xia, Y., Zweier, J.L., Sollott, S.J., Der, C.J., Fearon, E.R., Sundaresan, M., Finkel, T., and Goldschmidt-Clermont, P.J.: Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts. Science 275: 1649-52, 1997. [Abs]

  57. Kane, D. J., Fendler, K., Grell, E., Bamberg, E., Taniguchi, K., Froehlich, J. P., and Clarke, R. J.: Stopped-flow kinetic investigations of conformational changes of pig kidney Na+,K+-ATPase. Biochemistry 36: 13406-20, 1997. [Abs]

  58. Katzel, L.I., Busby-Whitehead, M.J., Hagberg, J.M., and Fleg, J.L.: Abnormal exercise electrocardiograms in master athletes after three months of deconditioning. J Am Geriatr Soc 45: 744-6, 1997. [Abs]

  59. Kaya, S., Yokoyama, A., Imagawa, T., Taniguchi, K., Froehlich, J.P., and Albers, R.W.: Cloning of the eel electroplax Na+,K(+)-ATPase alpha subunit. Ann N Y Acad Sci 834: 129-31, 1997. [Abs]

  60. Korzick, D.H., Xiao, R.P., Ziman, B.D., Koch, W.J., Lefkowitz, R.J., and Lakatta, E.G.: Transgenic manipulation of beta-adrenergic receptor kinase modifies cardiac myocyte contraction to norepinephrine. Am J Physiol 272: H590-6, 1997. [Abs]

  61. Li, Z., Cheng, H., Lederer, W.J., Froehlich, J., and Lakatta, E.G.: Enhanced proliferation and migration and altered cytoskeletal proteins in early passage smooth muscle cells from young and old rat aortic explants. Exp Mol Pathol 64: 1-11, 1997. [Abs]

  62. Li, Z., Bing, O.H., Long, X., Robinson, K.G., and Lakatta, E.G.: Increased cardiomyocyte apoptosis during the transition to heart failure in the spontaneously hypertensive rat. Am J Physiol 272: H2313-9, 1997. [Abs]

  63. Lindle, R.S., Metter, E.J., Lynch, N.A., Fleg, J.L., Fozard, J.L., Tobin, J., Roy, T.A., and Hurley, B.F.: Age and gender comparisons of muscle strength in 654 women and men aged 20-93 yr. J Appl Physiol 83: 1581-7, 1997. [Abs]

  64. Long, X., Boluyt, M.O., Hipolito, M.L., Lundberg, M.S., Zheng, J.S., O'Neill, L., Cirielli, C., Lakatta, E.G., and Crow, M.T.: p53 and the hypoxia-induced apoptosis of cultured neonatal rat cardiac myocytes. J Clin Invest 99: 2635-43, 1997. [Abs]

  65. Melillo, G., Scoccianti, M., Kovesdi, I., Safi, J., Jr., Riccioni, T., and Capogrossi, M.C.: Gene therapy for collateral vessel development. Cardiovasc Res 35: 480-9, 1997. [Abs]

  66. Miyashita, Y., Sollott, S.J., Cheng, L., Kinsella, J.L., Koh, E., Lakatta, E.G., and Froehlich, J.P.: Redistribution of intracellular Ca2+ stores after beta-adrenergic stimulation of rat tail artery SMC. Am J Physiol 272: H244-55, 1997. [Abs]

  67. O'Connor, F.C., Mayuga, R., Arrington, C.T., and Fleg, J.L.: Do echocardiographic changes explain the age-associated increase in exercise-induced supraventricular arrhythmias?. Aging (Milano) 9: 120-6, 1997. [Abs]

  68. Pauly, R.R., Bilato, C., Cheng, L., Monticone, R., and Crow, M.T.: Vascular smooth muscle cell cultures. Methods Cell Biol 52: 133-54, 1997. [Abs]

  69. Pearson, J.D., Morrell, C.H., Brant, L.J., Landis, P.K., and Fleg, J.L.: Age-associated changes in blood pressure in a longitudinal study of healthy men and women. J Gerontol A Biol Sci Med Sci 52: M177-83, 1997. [Abs]

  70. Pepe, S., Xiao, R.P., Hohl, C., Altschuld, R., and Lakatta, E.G.: 'Cross talk' between opioid peptide and adrenergic receptor signaling in isolated rat heart. Circulation 95: 2122-9, 1997. [Abs]

  71. Pierzchalski, P., Reiss, K., Cheng, W., Cirielli, C., Kajstura, J., Nitahara, J. A., Rizk, M., Capogrossi, M.C., and Anversa, P.: p53 Induces myocyte apoptosis via the activation of the renin- angiotensin system. Exp Cell Res 234: 57-65, 1997. [Abs]

  72. Pili, R., Chang, J., Muhlhauser, J., Crystal, R.G., Capogrossi, M.C., and Passaniti, A.: Adenovirus-mediated gene transfer of fibroblast growth factor-1: angiogenesis and tumorigenicity in nude mice. Int J Cancer 73: 258-63, 1997. [Abs]

  73. Ribadeau Dumas, A., Wisnewsky, C., Boheler, K.R., Ter Keurs, H., Fiszman, M.Y., and Schwartz, K.: The sarco(endo)plasmic reticulum Ca(2+)-ATPase gene is regulated at the transcriptional level during compensated left ventricular hypertrophy in the rat. C R Acad Sci III 320: 963-9, 1997. [Abs]

  74. Rios, E. and Stern, M.D.: Calcium in close quarters: microdomain feedback in excitation- contraction coupling and other cell biological phenomena. Annu Rev Biophys Biomol Struct 26: 47-82, 1997. [Abs]

  75. Safi, J., Jr., Gloe, T.R., Riccioni, T., Kovesdi, I., and Capogrossi, M.C.: Gene therapy with angiogenic factors: a new potential approach to the treatment of ischemic diseases. J Mol Cell Cardiol 29: 2311-25, 1997. [Abs]

  76. Shah, A.M., Mebazaa, A., Yang, Z.K., Cuda, G., Lankford, E.B., Pepper, C.B., Sollott, S.J., Sellers, J.R., Robotham, J.L., and Lakatta, E.G.: Inhibition of myocardial crossbridge cycling by hypoxic endothelial cells: a potential mechanism for matching oxygen supply and demand? Circ Res 80: 688-98, 1997. [Abs]

  77. Shefer, V.I. and Talan, M.I.: The effect of exercise training in a cold environment on thermoregulation in adult and aged C57BL/6J mice. Exp Gerontol 32: 695-705, 1997. [Abs]

  78. Shefer, V.I. and Talan, M.I.: Change in heat loss as a part of adaptation to repeated cold exposures in adult and aged male C57BL/6J mice. Exp Gerontol 32: 325-32, 1997. [Abs]

  79. Silverman, H.S., Wei, S., Haigney, M.C., Ocampo, C.J., and Stern, M.D.: Myocyte adaptation to chronic hypoxia and development of tolerance to subsequent acute severe hypoxia. Circ Res 80: 699-707, 1997. [Abs]

  80. Song, L.S., Stern, M.D., Lakatta, E.G., and Cheng, H.: Partial depletion of sarcoplasmic reticulum calcium does not prevent calcium sparks in rat ventricular myocytes. J Physiol (Lond) 505: 665-75, 1997. [Abs]

  81. Stern, M.D., Pizarro, G., and Rios, E.: Local control model of excitation-contraction coupling in skeletal muscle. J Gen Physiol 110: 415-40, 1997. [Abs]

  82. Talan, M.: Age-related changes in thermoregulation of mice. Ann N Y Acad Sci 813: 95-100, 1997. [Abs]

  83. Wheeler, D.M., Rice, R.T., duBell, W.H., and Spurgeon, H.A.: Initial contractile response of isolated rat heart cells to halothane, enflurane, and isoflurane. Anesthesiology 86: 137-46, 1997. [Abs]

  84. Wong, K., Boheler, K.R., Petrou, M., and Yacoub, M.H.: Pharmacological modulation of pressure-overload cardiac hypertrophy: changes in ventricular function, extracellular matrix, and gene expression. Circulation 96: 2239-46, 1997. [Abs]

  85. Xiao, R.P., Valdivia, H.H., Bogdanov, K., Valdivia, C., Lakatta, E.G., and Cheng, H.: The immunophilin FK506-binding protein modulates Ca2+ release channel closure in rat heart. J Physiol (Lond) 500: 343-54, 1997. [Abs]

  86. Xiao, R.P., Pepe, S., Spurgeon, H.A., Capogrossi, M.C., and Lakatta, E.G.: Opioid peptide receptor stimulation reverses beta-adrenergic effects in rat heart cells. Am J Physiol 272: H797-805, 1997. [Abs]

  87. Zhou, Y.Y., Cheng, H., Bogdanov, K.Y., Hohl, C., Altschuld, R., Lakatta, E.G., and Xiao, R.P.: Localized cAMP-dependent signaling mediates beta 2-adrenergic modulation of cardiac excitation-contraction coupling. Am J Physiol 273: H1611-8, 1997. [Abs]

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