National Toxicology Program

Selected information from two of the National Library of Medicine's databases: ChemIDPlus¹ and HSDB².

Names (NTP)

• Endrin
• (1AALPHA,2BETA,2ABETA,3ALPHA,6ALPHA,6ABETA,7BETA,7AALPHA)-2,7:3,6-DIMETHANONAPHTH(2,3-B)OXIRENE, 3,4,5,6,9,9-HEXACHLORO-1-A,2,2A,3,6,6A,7,7A-OCTAHYDRO- (9CI)

Structure

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Chemical Properties²

Property	Description
Color/Form	WHITE, CRYSTALLINE SOLID Colorless to tan, crystalline solid ...
Odor	Odorless ... Mild, chemical odor.
Taste	None found
Boiling Point	None found
Melting Point	Approximately 200 deg C (rearranges above that point)
Molecular Weight	380.91
Corrosivity	Slightly corrosive to metals
Critical Temperature & Pressure	None found
Density/Specific Gravity	Specific gravity 1.7 @ 20 deg C.
Disassociation Constants	None found
Heat of Combustion	None found
Heat of Vaporization	None found
log P (octanol-water)	log Kow= 5.20
pH	None found
Solubilities	Solubility in g/100 ml solvent at 25 deg C: acetone 17, benzene 13.8, carbon tetrachloride 3.3, hexane 7.1, and xylene 18.3 In water, 0.25 mg/l @ 25 deg C Solubility of endrin in fresh water: 200 ug/l. Insol in methanol
Spectral Properties	Intense mass spectral peaks: 81 m/z (100%), 263 m/z (98%), 265 m/z (65%), 261 m/z (65%)
Surface Tension	None found
Vapor Density	None found
Vapor Pressure	3X10-6 mm Hg @ 20 deg C
Relative Evaporation Rate	None found
Viscosity	None found
Other Properties	AN ISOMER OF DIELDRIN LIGHT TAN COLOR /TECHNICAL GRADE/ MILD CHEMICAL ODOR /TECHNICAL GRADE/ Compatible with non-acidic fertilizers, herbicides, fungicides, and insecticides. Decomposes @ 245 deg C Henry's Law constant = 6.36X10-6 atm-cu m/mole @ 25 deg C

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Uses²

• For Endrin (USEPA/OPP Pesticide Code: 041601) there are 0 labels match. /SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./
  
• The active ingredient is no longer contained in any registered pesticide products ... "cancelled."
  
• IT IS A NON-SYSTEMIC & PERSISTENT INSECTICIDE USED MAINLY ON FIELD CROPS. IT IS NON-PHYTOTOXIC @ INSECTICIDAL CONCN, BUT IS SUSPECTED OF /CAUSING/ DAMAGE TO MAIZE. /SRP: FORMER USE/
  
• Insecticide used to control the army cutworm (Euxoa aoxiliaris), the pale western cutworm (Agrotis orthogonia), pine vole (Microtus pinetorium), meadow voles (Microtus species), and grasshoppers, but only when federal regulations are strictly followed. /SRP: Former use/
  
• INSECTICIDE FOR SMALL GRAINS, SUGARCANE, & APPLE ORCHARDS /SRP: FORMER USE/ **PEER REVIEWED**
  
• The only known use of endrin is as an insecticide, as an avicide, and as a rodenticide. /Former use/
  
• Endrin has been used mainly on field crops such as cotton and grains. It has also been used for grasshoppers in noncropland and to control voles and mice in orchards. /SRP: Former use/
  
• Control of a wide range of insects (particularly Lepidoptera) in cotton, maize, sugarcane, rice, cereals, ornamentals, and other crops. /SRP: Former use/
  
• Endrin was formerly used as an insecticide, rodenticide, and avicide to control cutworms, voles, grasshoppers, borers, and other pests on cotton, sugarcane, tobacco, apple orchards, and grain. Manufacture has been discontinued in the United States, and all uses of endrin in the United States have been voluntarily canceled by the manufacture, since 1986.
  

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Superlist Classes¹

• ATSDR Profile Priority List, rank : 41
  
• Overall Carcinogenic Evaluation: Group 3
  
• Reportable Quantity (RQ) = 1 lb
  
• Threshold Planning Quantity (TPQ) = 500/10000 lb
  
• TWA 0.1 mg/m3; skin; Not classifiable as a human carcinogen
  
• TWA 0.1 mg/m3; skin
  

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Notes (Sources: NTP,HSDB,RTECS,MESH)¹

• None found

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Other Registry Numbers¹

• None found

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Synonyms (Sources: NTP, HSDB,RTECS,MESH)¹

• 4-17-00-00525 (Beilstein Handbook Reference)
• BRN 0091397
• Compound 269
• EN 57
• Endrex
• Endricol
• ENT 17,251
• Experimental insecticide 269
• Hexachloroepoxyoctahydro-endo,endo-dimethanonaphthalene
• 1,2,3,4,10,10-Hexachloro-6,7-epoxy-1,4,4a,5,6,7,8,8a-octahydro-endo,endo-1,4:5,8-dimethanonaphthalene
• (1aalpha,2beta,2abeta,3alpha,6alpha,6abeta,7beta,7aalpha)-3,4,5,6,9,9-hexachloro-1a,2,2a,3,6,6a,7,7a-octahydro-2,7:3,6-dimethanonaphth(2,3-b)oxirene
• 3,4,5,6,9,9-Hexachloro-1aalpha,2beta,2abeta,3alpha,6alpha,6abeta,7beta,7aalpha-octahydro-2,7:3,6-dimethanonaphth(2,3-b)oxirene
• 3,4,5,6,9,9-Hexachloro-1a,2,2a,3,6,6a,7,7a-octahydro-2,7:3,6-dimethanonaphth(2,3-b)oxirene
• (1R,4S,4aS,5S,6S,7R,8R,8aR)-1,2,3,4,10,10-Hexachloro-1,4,4a,5,6,7,8,8a-octahydro-6,7-epoxy-1,4:5,8-dimethanonaphthalene
• 1,2,3,4,10,10-Hexachloro-1R,4S,4aS,5S,6,7R,8R,8aR-octahydro-6,7-epoxy-1,4:5,8-dimethanonaphthalene
• Hexadrin
• HSDB 198
• Mendrin
• NCI-C00157
• Nendrin
• Oktanex
• OMS 197
• RCRA waste number P051
• SD 3419
• Stardrin
• Stardrin 20

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Links to Additional Information¹

• PubMed Cancer
• CCRIS
• DART
• EINECS
• EMIC
• GENETOX
• Haz-Map
• HSDB
• IRIS
• ITER
• PubMed
• MeSH Heading
• MeSH
• PubMed Toxicology
• TOXLINE
• TOXMAP
• WebWISER
• PubChem

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Footnotes

¹ Source: the National Library of Medicine's ChemIDPlus, 10/28/2007.

² Source: the National Library of Medicine's Hazardous Substance Database, 10/28/2007.