US 7,425,341 B1 | ||
Rapidly disintegrable tablets | ||
Michael N. Grimshaw, St. Louis, Mo. (US); Donald J. Barbieri, Fenton, Mo. (US); Louise M. Vizzini, St. John, Mo. (US); and Steve F. Marsh, St. Charles, Mo. (US) | ||
Assigned to K.V. Pharmaceutical Company, St. Louis, Mo. (US) | ||
Filed on Sep. 11, 2007, as Appl. No. 11/853,355. | ||
Application 11/853355 is a division of application No. 10/929856, filed on Aug. 30, 2004, granted, now 7,282,217. | ||
Claims priority of provisional application 60/498948, filed on Aug. 29, 2003. | ||
Int. Cl. A61K 9/36 (2006.01); A61K 47/00 (2006.01); A66K 9/26 (2006.01) |
U.S. Cl. 424—479 [424/470; 424/439] | 28 Claims |
1. A process for producing a rapidly disintegrating tablet, wherein the process comprises:
(i) wet-granulating a mixture comprising a directly compressible, water soluble carbohydrate; a directly compressible, water
insoluble filler; a beneficial ingredient; and a solvent, to form a wet granulate;
(ii) drying the wet granulate, to produce a directly compressible dry granulate;
(iii) adding one or more ingredients selected from the group consisting of disintegrants, lubricants, water soluble fillers,
and water insoluble fillers;
(iv) optionally adding one or more ingredients selected from the group consisting of surface active agents, flavorants, sweeteners,
and colorants; and,
(v) compressing, to form the tablet, wherein, when contacted with an aqueous fluid, the tablet disintegrates rapidly to form
a suspension, slurry or dispersion.
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