Bibliographic Citation
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Title | Antigenic mosaic of Methanogenium spp. : analysis with poly- and monoclonal antibody probes |
Creator/Author | Macario, A.J.L. ; Dugan, C.B. ; de Macario, E.C. |
Publication Date | 1987 Feb 01 |
OSTI Identifier | OSTI ID: 6351969 |
DOE Contract Number | FG02-84ER13197 |
Other Number(s) | Journal ID: CODEN: JOBAA |
Resource Type | Journal Article |
Resource Relation | Journal: J. Bacteriol.; (United States); Journal Volume: 169:2 |
Research Org | New York State Dept. of Health, Albany |
Subject | 59 BASIC BIOLOGICAL SCIENCES; METHANOGENIC BACTERIA; IMMUNOASSAY; ANTIGENS; BIOLOGICAL VARIABILITY; ECOLOGY; IMMUNOLOGY; MONOCLONAL ANTIBODIES; ANTIBODIES; BACTERIA; MICROORGANISMS |
Description/Abstract | Eight well-characterized Methanogenium strains, including the six described type strains, were analyzed with poly- and monoclonal antibody probes to examine the antigenic mosaic of the genus. The pattern of cross-reactions showed that the mosaic is complex and varies with the strains; thus, these organisms have developed a considerable antigenic diversity, which is expressed in their envelopes. Every strain shared at least one determinant with at least one other strain, demonstrating the antigenic cohesiveness of the group. This finding, together with the fact that most strains displayed a distinctive antigenic fingerprint (notwithstanding the limited number of probes available), emphasizes the potential of antibodies for rapid identification of new isolates and for direct elucidation of Methanogenium strains in microbial mixtures. |
Country of Publication | United States |
Language | English |
Format | Size: Pages: 666-669 |
System Entry Date | 2007 Feb 06 |
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