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Title Antigenic mosaic of Methanogenium spp. : analysis with poly- and monoclonal antibody probes
Creator/Author Macario, A.J.L. ; Dugan, C.B. ; de Macario, E.C.
Publication Date1987 Feb 01
OSTI IdentifierOSTI ID: 6351969
DOE Contract NumberFG02-84ER13197
Other Number(s)Journal ID: CODEN: JOBAA
Resource TypeJournal Article
Resource RelationJournal: J. Bacteriol.; (United States); Journal Volume: 169:2
Research OrgNew York State Dept. of Health, Albany
Subject59 BASIC BIOLOGICAL SCIENCES; METHANOGENIC BACTERIA; IMMUNOASSAY; ANTIGENS; BIOLOGICAL VARIABILITY; ECOLOGY; IMMUNOLOGY; MONOCLONAL ANTIBODIES; ANTIBODIES; BACTERIA; MICROORGANISMS
Description/Abstract Eight well-characterized Methanogenium strains, including the six described type strains, were analyzed with poly- and monoclonal antibody probes to examine the antigenic mosaic of the genus. The pattern of cross-reactions showed that the mosaic is complex and varies with the strains; thus, these organisms have developed a considerable antigenic diversity, which is expressed in their envelopes. Every strain shared at least one determinant with at least one other strain, demonstrating the antigenic cohesiveness of the group. This finding, together with the fact that most strains displayed a distinctive antigenic fingerprint (notwithstanding the limited number of probes available), emphasizes the potential of antibodies for rapid identification of new isolates and for direct elucidation of Methanogenium strains in microbial mixtures.
Country of PublicationUnited States
LanguageEnglish
FormatSize: Pages: 666-669
System Entry Date2007 Feb 06

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