National Toxicology Program

CASRN: 12035-72-2

Related: NICKEL SULFATE HEXAHYDRATE (10101-97-0)

Formula: NI3-S2

Synonyms/Common Names:

• NICKEL SULFIDE

Known Uses:

MAJOR COMPONENT IN NICKEL REFINERY FLUE DUST. NOT USED COMMERCIALLY IN U.S. (TDB)

Short-Term Toxicity

• 2-WEEK (Inhalation)  (C61654) Completed 
  •   (Peer Review 11/29/1994) Citation: Benson JM, Barr EB, Bechtold WE, Cheng YS. Fate of Inhaled Nickel Oxide and Nickel Subsulfide in F344/N Rats. Inhalation Toxicology, 6:167-183, 1994.
  • NTIS No. PB97-116784  (Peer Review 11/29/1994)
    Citation: Toxicology and Carcinogenesis Studies of Nickel Subsulfide (CAS No. 12035-72-2) in F344 Rats and B6C3F1 Mice (Inhalation Studies)
  •   (Peer Review 11/29/1994) Citation: Benson JM, Barr EB, Bechtold WE, Cheng YS. Fate of Inhaled Nickel Oxide and Nickel Subsulfide in F344/N Rats. Inhalation Toxicology, 6:167-183, 1994.
  • NTIS No. PB97-116784  (Peer Review 11/29/1994)
    Citation: Toxicology and Carcinogenesis Studies of Nickel Subsulfide (CAS No. 12035-72-2) in F344 Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, 0.6, 1.2, 2.5, 5, OR 10 MG/MG; 5/GROUP
• 13-WEEK (Inhalation)  (C61654) Completed 
  •   (Peer Review 11/29/1994) Citation: Benson JM, Barr EB, Bechtold WE, Cheng YS. Fate of Inhaled Nickel Oxide and Nickel Subsulfide in F344/N Rats. Inhalation Toxicology, 6:167-183, 1994.
  • NTIS No. PB97-116784  (Peer Review 11/29/1994)
    Citation: Toxicology and Carcinogenesis Studies of Nickel Subsulfide (CAS No. 12035-72-2) in F344 Rats and B6C3F1 Mice (Inhalation Studies)
  •   (Peer Review 11/29/1994) Citation: Benson JM, Barr EB, Bechtold WE, Cheng YS. Fate of Inhaled Nickel Oxide and Nickel Subsulfide in F344/N Rats. Inhalation Toxicology, 6:167-183, 1994.
  • NTIS No. PB97-116784  (Peer Review 11/29/1994)
    Citation: Toxicology and Carcinogenesis Studies of Nickel Subsulfide (CAS No. 12035-72-2) in F344 Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, .15, OR 2.5 MG/M3; 10/GROUP

Long-Term Carcinogenicity

• 2-YEAR (Inhalation)  (C61654) Report Complete 
  •   (Peer Review 11/29/1994) Citation: Benson JM, Barr EB, Bechtold WE, Cheng YS. Fate of Inhaled Nickel Oxide and Nickel Subsulfide in F344/N Rats. Inhalation Toxicology, 6:167-183, 1994.
  • TR-453 (NTIS No. PB97-116784)  (Peer Review 11/29/1994)
    Toxicology and Carcinogenesis Studies of Nickel Subsulfide (CAS No. 12035-72-2) in F344 Rats and B6C3F1 Mice (Inhalation Studies)
  •   (Peer Review 11/29/1994) Citation: Benson JM, Barr EB, Bechtold WE, Cheng YS. Fate of Inhaled Nickel Oxide and Nickel Subsulfide in F344/N Rats. Inhalation Toxicology, 6:167-183, 1994.
  • TR-453 (NTIS No. PB97-116784)  (Peer Review 11/29/1994)
    Toxicology and Carcinogenesis Studies of Nickel Subsulfide (CAS No. 12035-72-2) in F344 Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Clear Evidence 
  • Female Rats Clear Evidence 
  • Male Mice No Evidence 
  • Female Mice No Evidence 
  • Dose: R: 0, 0.075, OR 0.15 M: 0, 0.6, OR 1.2 MG/M3; 50/GROUP

Genetic Toxicology

• Micronucleus  (A50848) Completed 
  • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
  • Mice: B6C3F1
  • Male Negative 
  • Female Negative 
• Salmonella  (498230) Completed 
  •  Inconclusive