Neuronal pathways involved in abdominal surgery-induced gastric ileus in rats.

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Title:	Neuronal pathways involved in abdominal surgery-induced gastric ileus in rats.
Author:	Barquist, E : Bonaz, B : Martinez, V : Rivier, J : Zinner, M J : Tache, Y
Citation:	Am-J-Physiol. 1996 Apr; 270(4 Pt 2): R888-94
Abstract:	The 20-min rate of gastric emptying of a noncaloric solution and c-fos expression detected by immunohistochemistry in the brain were monitored 3 h after abdominal surgery performed under 10-min enflurane anesthesia in rats. Abdominal surgery (laparotomy and 1-min manipulation of the cecum) decreased gastric emptying from 60.8 +/- 3.4 to 25.9 +/- 3.4%. Capsaicin applied to the celiac/superior mesenteric ganglia 2 wk before the experiment reduced the delay in gastric emptying induced by abdominal surgery (46.3 +/- 3.4%), whereas perivagal capsaicin application had no effect (23.6 +/- 7.9%). The corticotropin-releasing factor (CRF) antagonist [D-Phe12, Nle21,38,C alpha MeLeu37]CRF-(12--41) injected intracisternally (10-20 micrograms) prevented postoperative gastroparesis induced by surgery, while having no effect on basal gastric emptying. Abdominal surgery increased the number of Fos-positive cells in brain nuclei regulating autonomic outflow: the nucleus of the solitary tract, locus ceruleus, paraventricular nucleus, and supraoptic nucleus of the hypothalamus. These data indicate that capsaicin-sensitive splanchnic afferent fibers and activation of CRF receptors in the brain are part of the neuronal circuitry mediating gastric stasis 3 h after abdominal surgery.
Review References:	None
Notes:	Copyright American Physiological Society. Abstracts are reprinted by the permission of the publisher of the journal for volume, pages, and dates cited. Hypertext links to electronic journal sites, if available, can be found in the the Peer Reviewed Journal List on the IBIDS home page.
Language:	English
Publication Type:	Journal-Article
Keywords:	Abdomen surgery : Gastric Emptying drug effects : Postoperative Complications
URL:	http://ajpcon.physiology.org/