LOCUS       NP_999593                509 aa            linear   MAM 24-OCT-2008
DEFINITION  cytochrome P450 17A1 [Sus scrofa].
ACCESSION   NP_999593
VERSION     NP_999593.1  GI:47523908
DBSOURCE    REFSEQ: accession NM_214428.1
KEYWORDS    .
SOURCE      Sus scrofa (pig)
  ORGANISM  Sus scrofa
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
            Sus.
REFERENCE   1  (residues 1 to 509)
  AUTHORS   Johnson,D.L., Conley,A.J. and Martin,L.L.
  TITLE     Direct electrochemistry of human, bovine and porcine cytochrome
            P450c17
  JOURNAL   J. Mol. Endocrinol. 36 (2), 349-359 (2006)
   PUBMED   16595705
  REMARK    GeneRIF: effect of substrate on the redox potential for each
            P450c17 was measured in the presence of pregnenolone, progesterone,
            17alpha-hydroxypregnenolone and 17alpha-hydroxyprogesterone
REFERENCE   2  (residues 1 to 509)
  AUTHORS   Lin,Z., Lou,Y. and Squires,E.J.
  TITLE     Identification of a single nucleotide polymorphism in porcine
            testis cytochrome P450-c17 (CYP17) and its effect on
            steroidogenesis
  JOURNAL   Biochem. Genet. 43 (9-10), 531-542 (2005)
   PUBMED   16341769
  REMARK    GeneRIF: Synthesis of androstenone in pig testis is not directly
            affected by any polymorphisms in the coding region of the porcine
            CYP17 gene.
REFERENCE   3  (residues 1 to 509)
  AUTHORS   Zhang,G. and Veldhuis,J.D.
  TITLE     Requirement for proximal putative Sp1 and AP-2 cis-deoxyribonucleic
            acid elements in mediating basal and luteinizing hormone- and
            insulin-dependent in vitro transcriptional activation of the CYP17
            gene in porcine theca cells
  JOURNAL   Endocrinology 145 (6), 2760-2766 (2004)
   PUBMED   15001547
  REMARK    GeneRIF: LH and insulin stimulate transcription of -976/+31 bp
            5'-upstream cis-acting region of porcine CYP17 gene. Maximal
            transcriptional responsiveness requires proximal Sp1 and AP-2-like
            sequences -193 to -180 bp 5' upstream of transcriptional start
            site.
REFERENCE   4  (residues 1 to 509)
  AUTHORS   Mellon,S.H., Compagnone,N.A. and Zhang,P.
  TITLE     Orphan receptors, proto-oncogenes and other nuclear factors
            regulate P450C17 gene transcription
  JOURNAL   Endocr. Res. 24 (3-4), 505-513 (1998)
   PUBMED   9888531
REFERENCE   5  (residues 1 to 509)
  AUTHORS   Zhang,P., Nason,T.F., Han,X.G. and Hall,P.F.
  TITLE     Gene for 17 alpha-hydroxylase/C (17-20) lyase P-450: complete
            nucleotide sequence of the porcine gene and 5' upstream sequence of
            the rat gene
  JOURNAL   Biochim. Biophys. Acta 1131 (3), 345-348 (1992)
   PUBMED   1627653
REFERENCE   6  (residues 1 to 509)
  AUTHORS   Conley,A.J., Graham-Lorence,S.E., Kagimoto,M., Lorence,M.C.,
            Murry,B.A., Oka,K., Sanders,D. and Mason,J.I.
  TITLE     Nucleotide sequence of a cDNA encoding porcine testis 17
            alpha-hydroxylase cytochrome P-450
  JOURNAL   Biochim. Biophys. Acta 1130 (1), 75-77 (1992)
   PUBMED   1543750
REFERENCE   7  (residues 1 to 509)
  AUTHORS   Chung,B.C., Picado-Leonard,J., Haniu,M., Bienkowski,M., Hall,P.F.,
            Shively,J.E. and Miller,W.L.
  TITLE     Cytochrome P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase):
            cloning of human adrenal and testis cDNAs indicates the same gene
            is expressed in both tissues
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 84 (2), 407-411 (1987)
   PUBMED   3025870
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M63507.1.
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Sus scrofa"
                     /db_xref="taxon:9823"
                     /chromosome="14"
     Protein         1..509
                     /product="cytochrome P450 17A1"
                     /EC_number="1.14.99.9"
                     /note="17-alpha-hydroxylase cytochrome P450; steroid
                     17-alpha-monooxygenase; cytochrome P450c17"
                     /calculated_mol_wt=57292
     Region          28..493
                     /region_name="p450"
                     /note="Cytochrome P450; cl08235"
                     /db_xref="CDD:126366"
     CDS             1..509
                     /gene="CYP17A1"
                     /gene_synonym="CYP17"
                     /gene_synonym="P450c17"
                     /coded_by="NM_214428.1:98..1627"
                     /db_xref="GeneID:403330"
ORIGIN      
        1 mwvllvffll tltylfwpkt kgsgakyprs lpvlpvvgsl pflprrghqh mnffklqdky
       61 gpifsfrlgs kttvvigdhq lakevllkkg kefsgrprvm tldilsdnqk giafadhgts
      121 wqlhrklals tfslfkggnl kleniinqei kvlcdflatr ngesidlaqp lslamtnivs
      181 ficfnfsfkk gdpalqaivn fndgildavg keilydmfpg irilpsqtle nmkqcvrmrn
      241 ellreilenr kenysrnsit nlldimiqak tnaesntggp dhnlkllsdr hmlatvadif
      301 gagvetsasv vkwivafllh ypllrkkiqd aidqnigfnr apsisdrnql vlleatirev
      361 lrfrpvsptl iphraiidss igeftidkdt dvvvnlwalh hnekewlrpd lfmperfldp
      421 tgtqlispsl sylpfgagpr scvgemlarq elflftagll qrfdlelpdd gqlpclvgnp
      481 slvlqidpfk vkikerqawk eahtegsts
//