Bibliographic Citation
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Title | CHARACTERISTIC BONE LESIONS IN POST-IRRADIATED CARCINOMA OF THE CERVIX |
Creator/Author | Rubin, P. ; Prabhasawat, D. |
Publication Date | 1961 May 01 |
OSTI Identifier | OSTI ID: 4072295 |
Other Number(s) | CODEN: RADLA; 0033-8419 |
Resource Type | Journal Article |
Resource Relation | Radiology (U.S.); Vol: 76 |
Research Org | Univ. of Rochester, N.Y. |
Subject | BIOLOGY AND MEDICINE; BLOOD CIRCULATION; BONES; CANCER; LYMPH SYSTEM; MAN; MEDICINE; METASTASES; RADIATION INJURIES; RADIOTHERAPY; THERAPY; TISSUES |
Description/Abstract | The characteristic appearance of bone metastases and destruction in cervical carcinoma reflects its mode of spread. Three groups are recognized: direct extension, lymph-node involvement, and hematogenous metastases. The changes are mainly a result of direct invasion of bone from adjacent cancer-infiltrated tissues or lymph nodes. In direct extension, the initial changes in pelvic bones are dissolution of the cortex along the sacrosciatic notch or loss of the iliopectineal line. In lymph-node metastases, the earliest vertebral changes are a loss of body substance, rendering the articular processes on the involved side more apparent. Advanced lesions characteristically show extensive destruction of adjacent bones, joints, and intervertebral spaces, associated with a large soft-tissue mass due to aggressive local invasion and spread. Hematogenous metastases are indistingulshable from those of other neoplasms but are worthy of note because of their rarity and aggressiveness. Radionecrosis of the pelvis is readily distinguishable from metastatic involvement because of the absence of osteolysis and cortical destruction coupled with a predictable pattern of bone selerosis and fracture in femora, pubis, and ilia, depending on portal arrangements. Therapeutic measures are dependent on proper diagnosis and clinical judgment. (auth) |
Language | English |
Format | Pages: 703-17 |
System Entry Date | 2001 Jun 03 |
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