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Title CHARACTERISTIC BONE LESIONS IN POST-IRRADIATED CARCINOMA OF THE CERVIX
Creator/Author Rubin, P. ; Prabhasawat, D.
Publication Date1961 May 01
OSTI IdentifierOSTI ID: 4072295
Other Number(s)CODEN: RADLA; 0033-8419
Resource TypeJournal Article
Resource RelationRadiology (U.S.); Vol: 76
Research OrgUniv. of Rochester, N.Y.
SubjectBIOLOGY AND MEDICINE; BLOOD CIRCULATION; BONES; CANCER; LYMPH SYSTEM; MAN; MEDICINE; METASTASES; RADIATION INJURIES; RADIOTHERAPY; THERAPY; TISSUES
Description/Abstract The characteristic appearance of bone metastases and destruction in cervical carcinoma reflects its mode of spread. Three groups are recognized: direct extension, lymph-node involvement, and hematogenous metastases. The changes are mainly a result of direct invasion of bone from adjacent cancer-infiltrated tissues or lymph nodes. In direct extension, the initial changes in pelvic bones are dissolution of the cortex along the sacrosciatic notch or loss of the iliopectineal line. In lymph-node metastases, the earliest vertebral changes are a loss of body substance, rendering the articular processes on the involved side more apparent. Advanced lesions characteristically show extensive destruction of adjacent bones, joints, and intervertebral spaces, associated with a large soft-tissue mass due to aggressive local invasion and spread. Hematogenous metastases are indistingulshable from those of other neoplasms but are worthy of note because of their rarity and aggressiveness. Radionecrosis of the pelvis is readily distinguishable from metastatic involvement because of the absence of osteolysis and cortical destruction coupled with a predictable pattern of bone selerosis and fracture in femora, pubis, and ilia, depending on portal arrangements. Therapeutic measures are dependent on proper diagnosis and clinical judgment. (auth)
LanguageEnglish
FormatPages: 703-17
System Entry Date2001 Jun 03

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