Hira S, Shroff H, Arni S; International Conference on AIDS.

Int Conf AIDS. 2000 Jul 9-14; 13: abstract no. TuOrC433.

S. Hira, Aids Research & Control Centre (Arcon), 502 Debonair Apts, Cadell Road, Mahim (W), Mumbai 400 016, India, Tel.: +91 22 444 20 28, Fax: +91 22 444 03 78, E-mail: subhash.hira@lwbbs.net

Background: To study disease progression among ARV-naive cohort of HIV-infected persons in Mumbai. Patients & Methods: Adult patients with confirmed HIV infection and presenting at Sir J. J. Hospital in Mumbai were recruited in the study. 522 patients who were followed prospectively for at least 6 months comprised of 284 - asymptomatic, 126 with ARC and 112 with AIDS. HIV-related disease progression was defined as change of clinical stage to a higher stage or death or by diagnosis of AIDS-defining opportunistic infections during the period of follow-up. Results: Among 522 persons followed for 751 person-years (p-y), male to female ratios was 4.6:1. The annual incidence of disease progression was 163/751 (21.7/100 p-y) and mortality rate was 55/751 (7.3/100 p-y). The annual incidence of active clinical tuberculosis was 52/612.5 (8.5/100 p-y). The median 50% for progression from asymptomatic to AIDS was 7.2 years. Median survival time after diagnosis of AIDS was 13.5 months. The risk of dying due to incident tuberculosis was 4.35. The important factors for progression were: unemployed males (OR 1.4; CI 0.78, 2.51), age > 35 years (OR 1.4; CI 1.29, 1.92), and incident tuberculosis (OR 22.7; CI 12.19, 42.54). No correlation was found between progression and gender. Conclusions: HIV-disease progression and death in Mumbai is twice faster than that reported for gay-men and IVDU in San Francisco. Incident tuberculosis immerged as the major cause of morbidity and mortality.

Publication Types:

• Meeting Abstracts

Keywords:

• AIDS-Related Complex
• Acquired Immunodeficiency Syndrome
• Adult
• Disease Progression
• Female
• HIV Infections
• HIV Seropositivity
• Humans
• Incidence
• India
• Male
• San Francisco
• Tuberculosis

Other ID:

• GWAIDS0001751

UI: 102239244

From Meeting Abstracts