| US 7,377,277 B2 | ||
| Blister packages with frames and associated methods of fabricating dry powder drug containment systems | ||
| Anthony James Hickey, Chapel Hill, N.C. (US); Timothy Crowder, Durham, N.C. (US); Jeffrey Alan Warden, Raleigh, N.C. (US); Keith Arthur Johnson, Durham, N.C. (US); Mark Ennis Ketner, Apex, N.C. (US); Jay Kinsley Fording, Matthews, N.C. (US); Michael Duane Garten, Charlotte, N.C. (US); William Myles Riley, Richmond, Va. (US); Sean Derek Anderson, Richmond, Va. (US); Bruce Seymour Ferris, Richmond, Va. (US); and Paul Gilbert Rockwell, Chesterfield, Va. (US) | ||
| Assigned to Oriel Therapeutics, Inc., Durham, N.C. (US) | ||
| Filed on Oct. 21, 2004, as Appl. No. 10/970,549. | ||
| Claims priority of provisional application 60/514727, filed on Oct. 27, 2003. | ||
| Prior Publication US 2005/0109659 A1, May 26, 2005 | ||
| Int. Cl. A61M 15/00 (2006.01); A61M 16/00 (2006.01); B05D 7/14 (2006.01); B65D 83/06 (2006.01) | ||
| U.S. Cl. 128—203.21 [128/203.15; 128/203.19] | 55 Claims |
| 1. A multi-dose blister package adapted for use in an inhaler, comprising:
a substantially rigid frame member configured to resist flexure having a plurality of spaced apart apertures;
a ceiling having a corresponding plurality of spaced apart projections, the ceiling disposed under the frame member and oriented
relative to the frame member so that a respective ceiling projection extends through and rises above a respective frame aperture;
a flexible floor underlying and attached to the ceiling, wherein the ceiling and floor are configured to define a plurality
of spaced apart scaled blisters therebetween, wherein the floor comprises a flexible piezoelectric material; and
a quantity of dry powder held in each sealed blister;
wherein the frame member has a thickness that is at least five times greater than that of the ceiling and floor, and wherein,
the blister package is configured so that the blister is opened from the ceiling while the floor remains intact.
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