US 7,348,319 B2
Nitric oxide-releasing amidine diazeniumdiolates, compositions and uses thereof and method of making same
Joseph A Hrabie, Frederick, Md. (US); Larry K Keefer, Bethesda, Md. (US); and Ernst V Arnold, Hagerstown, Md. (US)
Assigned to United States of America as represented by the Department of Health and Human Services, Washington, D.C. (US)
Filed on Aug. 19, 2005, as Appl. No. 11/208,313.
Application 11/208313 is a division of application No. 10/198242, filed on Jul. 18, 2002, granted, now 6,949,530.
Prior Publication US 2005/0288260 A1, Dec. 29, 2005
Int. Cl. A61K 31/675 (2006.01); A61K 31/655 (2006.01)
U.S. Cl. 514—149  [514/631; 514/638; 514/773; 534/550; 534/566] 31 Claims
 
1. A compound of Formula (I):

OG Complex Work Unit Drawing
wherein R1 is an unsubstituted or substituted C1-12 straight chain alkyl, an unsubstituted or substituted C3-12 branched chain alkyl, an unsubstituted or substituted C2-12 straight chain alkenyl, an unsubstituted or substituted C3-12 branched chain alkenyl, an unsubstituted or substituted C1-12 alkoxy, halo, an unsubstituted or substituted benzyl, an unsubstituted or substituted phenyl, amino, an unsubstituted or substituted C1-12 alkylamino, an unsubstituted or substituted C6-30 arylamino, an unsubstituted or substituted C1-12 dialkylamino, an unsubstituted or substituted C6-30 diarylamino, an unsubstituted or substituted tolyl, xylyl, anisyl, mesityl, an unsubstituted or substituted C1-12 alkylthio, an unsubstituted or substituted C1-12 alkyloxy, an unsubstituted or substituted phenoxy, an unsubstituted or substituted benzyloxy, or nitro;
R2 and R3 are selected from the group consisting of hydrogen, an unsubstituted or substituted C1-12 straight chain alkyl, an unsubstituted or substituted C3-12 branched chain alkyl, an unsubstituted or substituted C2-12 straight chain alkenyl, an unsubstituted or substituted C3-12 branched chain alkenyl, an unsubstituted or substituted C3-8 cycloalkyl, benzyl or substituted benzyl, and phenyl or substituted phenyl; and R4 is polymer;
M+x is a pharmaceutically acceptable cation, x is the valence of the cation, and a and b are the smallest integers that result in a neutral compound.