National Toxicology Program

Selected information from two of the National Library of Medicine's databases: ChemIDPlus¹ and HSDB².

Names (NTP)

• Kid pest project (Methoxychlor)
• Methoxychlor
• METHOXYCHLOR (ENDOCRINE DISRUPTOR)
• METHOXYCHLOR PUBERTAL STUDY
• 1,1'-(2,2,2-TRICHLOROETHYLIDENE)BIS(4-METHOXYBENZENE) (9CI)
• Endocrine disruptor (Methoxychlor)
• Pubertal methoxychlor study

Structure

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Chemical Properties²

Property	Description
Color/Form	Colorless crystals (technical, grey powder) Dimorphic crystals CRYSTALS FROM DIL ALCOHOL White to light yellow solid A white crystalline solid Technical methoxychlor is a pale buff to gray flaky powder Colorless to light-yellow crystals.
Odor	Slight, fruity odor.
Taste	None found
Boiling Point	None found
Melting Point	87 deg C
Molecular Weight	345.65
Corrosivity	Methoxychlor will attack some forms of plastics, rubbers, and coatings. Slightly corrosive to iron and aluminum
Critical Temperature & Pressure	None found
Density/Specific Gravity	1.41 @ 25 deg C
Disassociation Constants	None found
Heat of Combustion	None found
Heat of Vaporization	None found
log P (octanol-water)	log Kow= 5.08
pH	None found
Solubilities	MODERATELY SOL IN ALCOHOL AND PETROLEUM OILS; READILY SOL IN MOST AROMATIC SOLVENTS Methylene dichloride: 60 g/100 g at 22 deg C; dichlorobenzene: 40 g/100 g at 22 deg C; cyclohexanone: 50 g/100 g at 22 deg C; methylated naphthalenes: 30 g/100 g at 22 deg C; carbon tetrachloride: 16 g/100 g at 22 deg C; odorless kerosene: 2 g/100 g at 22 deg C. /Data from table/ In g/kg at 22 deg C: chloroform 440, xylene 440, methanol 50 Readily soluble in aromatic, chlorinated, and ketonic solvents, and vegetable oils. In chloroform and xylene 440, methanol 50 (all in g/kg, 22 deg C). Very soluble in ethyl ether and benzene; soluble in ethanol Very soluble in aromatic chlorinated, or ketonic solvents. Somewhat soluble in paraffinic types. In water, 0.040 mg/l @ 24 deg C (99% purity) Soluble in alcohol. The solubilities are approximately those of DDT. In water, 0.1 mg/l @ 25 deg C
Spectral Properties	SADTLER REF NUMBER: 17345 (IR, PRISM); 5497 (UV) Intensity of mass spectral peaks: 227 M/z (100%), 228 M/z (23%), 152 M/z (10%), 138 M/z (10%) IR: 10589 (Sadtler Research Laboratories Prism Collection) MASS: 4961 (National Bureau of Standards EPA-NIH Mass Spectra Data Base, NSRDS-NBS-63) Intense mass spectral peaks: 238 m/z, 274 m/z, 308 m/z, 344 m/z
Surface Tension	None found
Vapor Density	None found
Vapor Pressure	Very low
Relative Evaporation Rate	None found
Viscosity	None found
Other Properties	GREY-FLAKY POWDER; SETTING POINT 77 DEG C; DENSITY 1.41; SOL 0.1 MG/L WATER AT 25 DEG C; 440 G/KG CHLOROFORM & XYLENE, & 50 G/KG METHANOL AT 22 DEG C /TECHNICAL GRADE/ MP: 172 deg F (77.78 deg C) MP: 89 deg C (technical, 77 deg C) Stable in oxidizing agents and to UV irradiation. Reacts with alkalis, especially in the presence of catalytically-active metals, with loss of hydrogen cloride, but more slowly than DDT. Color turns pink or tan on exposure to light. Not compatible with alkaline materials. Henry's Law constant= 2.03X10-7 atm-cu m/mol @ 25 deg C

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Uses²

• For Methoxychlor (USEPA/OPP PC Code: 034001) active products with label matches. /SRP: Registered for use in the U.S. but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./
  
• Insecticide
  
• Therap Cat (Vet): Ectoparasiticide
  
• Widely used because of long residual action against many species of insects and low toxicity to humans and warm-blooded animals. For certain insect pests on fruit and shade trees, vegetables, cattle, and around farm buildings (except poultry houses). Replacement for DDT where application may constitute a hazard to warm-blooded animals or plants. Rarely phytotoxic, and injury is usually negligible even on DDT-susceptible crops such as cucurbits.
  
• IT IS APPROVED IN US FOR USE ON 78 AGRIC CROPS (INCL SEVERAL TYPES OF SEEDS), WITH RESTRICTIONS ON USE OF TREATED SEEDS. ... FOR USE AS INSECTICIDE ON BEEF CATTLE, DAIRY CATTLE, GOATS, SHEEP, & SWINE & FOR SPRAY TREATMENT OF BARNS, GRAIN BINS, MUSHROOM HOUSES, & OTHER AGRIC PREMISES ... .
  
• Methoxychlor has been utilized extensively for the ... control of biting flies in both northern and southern regions of Canada.
  
• Insecticide effective against mosquito larvae and house-flies.
  
• Insecticide effective against mosquito larvae and house flies; recommended for use in dairy barns.
  
• Insecticide with contact and stomach action. Control of a wide range of insect pests (particularly chewing insects) in field crops, forage crops, fruit, vines, flowers, vegetables, and in forestry. Used also for control of insect pests in animal houses, dairies, and in household and industrial premises.
  
• Insecticide used to control mosquito larvae, house flies and other insect pests in field crops, fruits and vegetables; to control ecto-parasites on cattle, sheep and goats; recommended for use in dairy barns.
  
• ... Insecticide used for control of infestation affecting fruits, vegetables, forage crops, and livestock.
  

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Superlist Classes¹

• ATSDR Profile Priority List, rank : 61
  
• Overall Carcinogenic Evaluation: Group 3
  
• Reportable Quantity (RQ) = 1 lb
  
• TWA 10 mg/m3; Not classifiable as a human carcinogen
  
• TWA 15 mg/m3 total dust
  

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Notes (Sources: NTP,HSDB,RTECS,MESH)¹

• None found

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Other Registry Numbers¹

• None found

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Synonyms (Sources: NTP, HSDB,RTECS,MESH)¹

• 4-06-00-06691 (Beilstein Handbook Reference)
• 2,2-Bis(p-anisyl)-1,1,1-trichloroethane
• 1,1-Bis(p-methoxyphenyl)-2,2,2-trichloroethane
• 2,2-Bis(p-methoxyphenyl)-1,1,1-trichloroethane
• BRN 2057367
• Chemform
• Dianisyl trichloroethane
• Dianisyltrichlorethane
• 2,2-Di-p-anisyl-1,1,1-trichloroethane
• Dimethoxy-DDT
• p,p'-Dimethoxydiphenyltrichloroethane
• 2,2-Di-(p-methoxyphenyl)-1,1,1-trichloroethane
• DMDT
• ENT 1,716
• Ethane, 2,2-bis(p-anisyl)-1,1,1-trichloro-
• Ethane, 1,1,1-trichloro-2,2-bis(p-methoxyphenyl)-
• Higalmetox
• HSDB 1173
• Maralate
• Marlate
• Methoxcide
• p,p'-Methoxychlor
• Methoxychlor 2 EC
• Methoxy-DDT
• Metox
• Mezox K
• Moxie
• NCI-C00497
• OMS 466
• RCRA waste number U247
• 1,1,1-Trichloro-2,2-bis(p-anisyl)ethane
• 1,1,1-Trichloro-2,2-bis(p-methoxyphenyl)ethane
• 1,1,1-Trichloro-2,2-bis(4-methoxyphenyl)ethane
• 2,2,2-Trichloro-1,1-bis(4-methoxyphenyl)ethane
• 1,1,1-Trichloro-2,2-di(4-methoxyphenyl)ethane
• 1,1'-(2,2,2-Trichloroethylidene)bis(4-methoxybenzene)
• 4,4-(2,2,2-Trichloroethylidene)dianisole

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Links to Additional Information¹

• PubMed Cancer
• CCRIS
• DART
• EINECS
• EMIC
• GENETOX
• Haz-Map
• Household Products
• HSDB
• IRIS
• ITER
• PubMed
• MeSH Heading
• MeSH
• PubMed Toxicology
• TOXLINE
• TOXMAP
• TRI2000
• TRI2001
• TRI2002
• TRI2003
• TRI2004
• TRI95
• TRI96
• TRI97
• TRI98
• TRI99
• WebWISER
• PubChem
• TRI2005

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Footnotes

¹ Source: the National Library of Medicine's ChemIDPlus, 10/28/2007.

² Source: the National Library of Medicine's Hazardous Substance Database, 10/28/2007.