NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 FINAL#1, CORE STUDY MICE Facility: Battelle Columbus Laboratory Chemical CAS #: 126-98-7 Lock Date: 06/26/98 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Page 1 NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 _____________________________________________________________________________________________________________________ | 5| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| DAY ON TEST | 9| 3| 4| 3| 3| 3| 0| 0| 2| 0| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| | 3| 1| 5| 1| 2| 2| 7| 9| 3| 4| 2| 3| 2| 1| 1| 2| 2| 2| 1| 1| 2| 1| 1| 5| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Periesophageal Tissue, Inflammation, | | Chronic Active | 2 | __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Epithelium, Ulcer | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | | Clear Cell Focus | X X | Eosinophilic Focus | X X | Hematopoietic Cell Proliferation | 1 | Infiltration Cellular, Mononuclear | | Cell | 1 2 1 1 2 2 1 1 1 1 1 1 1 1 1| Inflammation, Chronic Active | 1 1 1 1 2 2 1 2 1 1 1 1 1 1 1 1| Mixed Cell Focus | | Necrosis | 2 4 | Pigmentation | 1 1 1 1 1 1 1| Tension Lipidosis | | Hepatocyte, Vacuolization Cytoplasmic| 1 2 2 | __________________________________________________________________________| Mesentery | + + + + + + + + | Fibrosis | 4 2 2 2 | Inflammation, Chronic Active | 2 3 1 | Mineralization | 1 2 | Fat, Necrosis | 4 4 4 4 | __________________________________________________________________________| Oral Mucosa | + +| Gingival, Foreign Body | X X| Gingival, Inflammation, Chronic | | Active | 2 2| Pharyngeal, Foreign Body | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | | __________________________________________________________________________| Salivary Glands | + + M + + + M + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Diverticulum | | Epithelium, Hyperplasia | 1 3 3 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 _____________________________________________________________________________________________________________________ | 5| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| DAY ON TEST | 9| 3| 4| 3| 3| 3| 0| 0| 2| 0| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| | 3| 1| 5| 1| 2| 2| 7| 9| 3| 4| 2| 3| 2| 1| 1| 2| 2| 2| 1| 1| 2| 1| 1| 5| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Epithelium, Inflammation, Chronic | | Active | 1 | Epithelium, Ulcer | 2 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 1| Epithelium, Erosion | | Glands, Ectasia | 1 1 1 2 1 1 1 1 1| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + M + + + + + + + + + + + + + + + + + +| Aorta, Mineralization | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 1 | Artery, Mineralization | | Valve, Inflammation, Suppurative | 4 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hypertrophy | 2 | Capsule, Hyperplasia | 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2| __________________________________________________________________________| Parathyroid Gland | + + M + + + + M + + + M + + M + + + + + M + + + M| __________________________________________________________________________| Pituitary Gland | + + + + + + I + + + + + + + + + + + + + + + + + +| Pars Distalis, Angiectasis | 1 | Pars Distalis, Cyst | | Pars Distalis, Hyperplasia | 2 2 2 1 | __________________________________________________________________________| Thyroid Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | | Inflammation, Chronic Active | | Follicle, Cyst | 2 2 2 | Follicular Cell, Hyperplasia | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 1 1 | Inflammation, Chronic Active | 2 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 _____________________________________________________________________________________________________________________ | 5| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| DAY ON TEST | 9| 3| 4| 3| 3| 3| 0| 0| 2| 0| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| | 3| 1| 5| 1| 2| 2| 7| 9| 3| 4| 2| 3| 2| 1| 1| 2| 2| 2| 1| 1| 2| 1| 1| 5| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 2 2 2 2 2 4 2 | Mineralization | | Pigmentation | 1 1 1 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydrometra | 4 2 2 4 2 4 4 4 4 4 4 | Inflammation, Chronic Active | 3 | Thrombosis | 4 | Endometrium, Hyperplasia, Cystic | 3 2 2 1 2 1 2 2 1 2 1| Endometrium, Hyperplasia | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 3 | Myelofibrosis | | __________________________________________________________________________| Lymph Node | + + + | Mediastinal, Hyperplasia, Lymphoid | | Mediastinal, Infiltration Cellular, | | Histiocyte | | Pancreatic, Fibrosis | 2 | Pancreatic, Hyperplasia, Lymphoid | 3 | Pancreatic, Pigmentation | 2 | __________________________________________________________________________| Lymph Node, Mandibular | + + M + + + M + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | 4 3 3 4| Infiltration Cellular, Plasma Cell | | Pigmentation | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 4 4 | Hemorrhage | 2 2 | Hyperplasia, Lymphoid | 3 4| Pigmentation | 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 3 2 3 2 2 2 3 2 3| Hyperplasia, Lymphoid | 2 | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 1 2 2 2 2 2 1 1 1 | Ectopic Parathyroid Gland | 2 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Cystic | 3 2 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 4 | Epidermis, Ulcer | 4 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 _____________________________________________________________________________________________________________________ | 5| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| DAY ON TEST | 9| 3| 4| 3| 3| 3| 0| 0| 2| 0| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| | 3| 1| 5| 1| 2| 2| 7| 9| 3| 4| 2| 3| 2| 1| 1| 2| 2| 2| 1| 1| 2| 1| 1| 5| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosclerosis | 4| __________________________________________________________________________| Skeletal Muscle | + + | Infiltration Cellular, Mononuclear | | Cell | 2 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 | __________________________________________________________________________| Peripheral Nerve | + | Sciatic, Axon, Degeneration | 2 | __________________________________________________________________________| Spinal Cord | + | Demyelination | 2 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 | Mineralization | 1 1 | Pigmentation | 1 | Alveolar Epithelium, Hyperplasia | | Alveolus, Infiltration Cellular, | | Histiocyte | 3 | Artery, Mediastinum, Mineralization | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + | Atrophy | 4 | __________________________________________________________________________| Harderian Gland | + + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Accumulation, Hyaline Droplet | 3 3 | Infarct, Multiple | 2 | Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 2 1 1 1 2 1 1 1 1 1 2| Inflammation, Chronic Active | | Mineralization | 1 | Nephropathy | 1 2 1 2 2 1 1 1| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 _____________________________________________________________________________________________________________________ | 5| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| DAY ON TEST | 9| 3| 4| 3| 3| 3| 0| 0| 2| 0| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| | 3| 1| 5| 1| 2| 2| 7| 9| 3| 4| 2| 3| 2| 1| 1| 2| 2| 2| 1| 1| 2| 1| 1| 5| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | Capsule, Mineralization | | Cortex, Cyst | | Papilla, Inflammation, Acute | 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 2 1 1 1 1 1 1 1 4 1 1 1 1| Inflammation, Chronic Active | | Pigmentation | 2 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 6| 7| 4| 7| 7| | DAY ON TEST | 6| 3| 3| 8| 3| 3| 7| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 6| 6| 3| 9| 3| 3| | | 2| 2| 1| 7| 2| 1| 1| 2| 2| 1| 7| 2| 1| 1| 2| 2| 2| 2| 2| 2| 8| 2| 2| 1| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Periesophageal Tissue, Inflammation, | | | Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 1 2.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 | Inflammation, Chronic Active | 4| 1 4.0| Epithelium, Ulcer | 4| 1 4.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X | 1 | Clear Cell Focus | X | 3 | Eosinophilic Focus | X X X X X X X | 9 | Hematopoietic Cell Proliferation | 2 | 2 1.5| Infiltration Cellular, Mononuclear | | | Cell | 2 1 1 1 1 1 1 1 1 2 1 2 2 1 1| 30 1.2| Inflammation, Chronic Active | 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1| 32 1.1| Mixed Cell Focus | X X X | 3 | Necrosis | 1 | 3 2.3| Pigmentation | 1 1 1 1 1 1 1 1 1 1 1| 18 1.0| Tension Lipidosis | X X | 2 | Hepatocyte, Vacuolization Cytoplasmic| 2 1 2 2 | 7 1.7| __________________________________________________________________________|____________| Mesentery | + + + + + + + + | 16 | Fibrosis | 2 3 3 2 | 8 2.5| Inflammation, Chronic Active | 2 2 | 5 2.0| Mineralization | 2 1 2 | 5 1.6| Fat, Necrosis | 4 4 4 4 | 8 4.0| __________________________________________________________________________|____________| Oral Mucosa | + | 3 | Gingival, Foreign Body | | 2 | Gingival, Inflammation, Chronic | | | Active | | 2 2.0| Pharyngeal, Foreign Body | X | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acinus, Atrophy | 4 | 1 4.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 6| 7| 4| 7| 7| | DAY ON TEST | 6| 3| 3| 8| 3| 3| 7| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 6| 6| 3| 9| 3| 3| | | 2| 2| 1| 7| 2| 1| 1| 2| 2| 1| 7| 2| 1| 1| 2| 2| 2| 2| 2| 2| 8| 2| 2| 1| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Infiltration Cellular, Mononuclear | | | Cell | 1 2 1 1 1 1 1 1 1 1 1 1 1| 27 1.1| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Diverticulum | X | 1 | Epithelium, Hyperplasia | | 3 2.3| Epithelium, Inflammation, Chronic | | | Active | | 1 1.0| Epithelium, Ulcer | | 1 2.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | | 1 1.0| Epithelium, Erosion | 2 | 1 2.0| Glands, Ectasia | 1 1 1 1 1 1 1 | 16 1.1| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Aorta, Mineralization | 2 | 1 2.0| __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | | 1 1.0| Artery, Mineralization | 2 | 1 2.0| Valve, Inflammation, Suppurative | | 1 4.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 | Hypertrophy | | 1 2.0| Capsule, Hyperplasia | 2 2 2 1 2 2 1 2 2 2 2 2 2 2 3 2 2 1 2 3 2 2 2| 48 2.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 | Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 41 2.0| __________________________________________________________________________|____________| Parathyroid Gland | M + + + + + M + + + + M + M + + + + + + + + + M +| 39 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Pars Distalis, Angiectasis | 1 | 2 1.0| Pars Distalis, Cyst | 1 | 1 1.0| Pars Distalis, Hyperplasia | 1 1 1 2 2 | 9 1.6| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Infiltration Cellular, Mononuclear | | | Cell | 1 | 1 1.0| Inflammation, Chronic Active | 2 | 1 2.0| Follicle, Cyst | 2 2 | 5 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 6| 7| 4| 7| 7| | DAY ON TEST | 6| 3| 3| 8| 3| 3| 7| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 6| 6| 3| 9| 3| 3| | | 2| 2| 1| 7| 2| 1| 1| 2| 2| 1| 7| 2| 1| 1| 2| 2| 2| 2| 2| 2| 8| 2| 2| 1| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Follicular Cell, Hyperplasia | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | 1 | 4 1.0| Inflammation, Chronic Active | 1 | 2 1.5| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 3 4 2 2 3 4 3 4 2| 17 2.6| Mineralization | 2 2 | 2 2.0| Pigmentation | 2 2 2 2 | 7 1.6| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hydrometra | 2 4 4 4 2 4 3 2 1 4 3 3| 23 3.2| Inflammation, Chronic Active | | 1 3.0| Thrombosis | | 1 4.0| Endometrium, Hyperplasia, Cystic | 2 1 2 2 2 2 2 2 1 2 2 2 1 2 3 2| 27 1.8| Endometrium, Hyperplasia | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 2 3.0| Myelofibrosis | 2 3 | 2 2.5| __________________________________________________________________________|____________| Lymph Node | + + + + + + | 9 | Mediastinal, Hyperplasia, Lymphoid | 4 | 1 4.0| Mediastinal, Infiltration Cellular, | | | Histiocyte | 4 | 1 4.0| Pancreatic, Fibrosis | | 1 2.0| Pancreatic, Hyperplasia, Lymphoid | | 1 3.0| Pancreatic, Pigmentation | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Hyperplasia, Lymphoid | 2 | 5 3.2| Infiltration Cellular, Plasma Cell | 3 | 1 3.0| Pigmentation | 2 2 2 | 3 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + M + + + + + + + + + + M + + + + M + +| 47 | Ectasia | | 2 4.0| Hemorrhage | | 2 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 6| 7| 4| 7| 7| | DAY ON TEST | 6| 3| 3| 8| 3| 3| 7| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 6| 6| 3| 9| 3| 3| | | 2| 2| 1| 7| 2| 1| 1| 2| 2| 1| 7| 2| 1| 1| 2| 2| 2| 2| 2| 2| 8| 2| 2| 1| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Hyperplasia, Lymphoid | | 2 3.5| Pigmentation | | 1 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | 2 2 3 3 3 3 2 3| 18 2.5| Hyperplasia, Lymphoid | | 1 2.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + M + + + M + M + +| 47 | Cyst | 2 2 2 1 2 1 2 2 2 2| 20 1.7| Ectopic Parathyroid Gland | | 1 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 | Hyperplasia, Cystic | 4 | 3 3.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 1 4.0| Epidermis, Ulcer | | 1 4.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Osteosclerosis | | 1 4.0| __________________________________________________________________________|____________| Skeletal Muscle | + + | 4 | Infiltration Cellular, Mononuclear | | | Cell | | 1 2.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | 1 | 2 1.0| __________________________________________________________________________|____________| Peripheral Nerve | | 1 | Sciatic, Axon, Degeneration | | 1 2.0| __________________________________________________________________________|____________| Spinal Cord | | 1 | Demyelination | | 1 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 1 | 2 1.5| Mineralization | 1 1 1 | 5 1.0| Pigmentation | | 1 1.0| Alveolar Epithelium, Hyperplasia | 1 | 1 1.0| Alveolus, Infiltration Cellular, | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 6| 7| 4| 7| 7| | DAY ON TEST | 6| 3| 3| 8| 3| 3| 7| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 6| 6| 3| 9| 3| 3| | | 2| 2| 1| 7| 2| 1| 1| 2| 2| 1| 7| 2| 1| 1| 2| 2| 2| 2| 2| 2| 8| 2| 2| 1| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Histiocyte | | 1 3.0| Artery, Mediastinum, Mineralization | 2 | 1 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 2 | 1 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 2 | Atrophy | | 1 4.0| __________________________________________________________________________|____________| Harderian Gland | + + | 4 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accumulation, Hyaline Droplet | | 2 3.0| Infarct, Multiple | | 1 2.0| Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 2 1 1 1 1 1 1 2 2 2 1 1 1 2 1 1| 35 1.2| Inflammation, Chronic Active | 1 | 1 1.0| Mineralization | 1 1 1 1 | 5 1.0| Nephropathy | 2 1 1 1 1 2 1| 15 1.3| Capsule, Mineralization | 2 | 1 2.0| Cortex, Cyst | 2 2 | 2 2.0| Papilla, Inflammation, Acute | | 1 2.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 | 28 1.2| Inflammation, Chronic Active | 4 | 1 4.0| Pigmentation | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 6| 4| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 6| 7| 3| 2| 3| 3| 3| 0| 3| 4| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| | 0| 1| 2| 0| 8| 7| 6| 1| 1| 1| 2| 2| 9| 1| 4| 2| 2| 1| 2| 2| 0| 1| 1| 1| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1.5 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | 4 | Epithelium, Inflammation, Suppurative| 4 | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Basophilic Focus | X X X X X X | Clear Cell Focus | X X X X X | Eosinophilic Focus | X X | Hematopoietic Cell Proliferation | 2 1 | Hepatodiaphragmatic Nodule | X | Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Inflammation, Chronic Active | 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | Mixed Cell Focus | | Necrosis | 2 | Pigmentation | 1 1 1 1 1 1 1 1 1 | Tension Lipidosis | X | Hepatocyte, Vacuolization Cytoplasmic| 2 1 1 2 | __________________________________________________________________________| Mesentery | + + + + + | Fibrosis | 2 2 2 2 | Hemorrhage | 4 | Inflammation, Chronic Active | 2 2 3 | Mineralization | 2 2 2 3 | Fat, Necrosis | 4 4 4 4 | __________________________________________________________________________| Oral Mucosa | + + | Gingival, Foreign Body | X X | Gingival, Inflammation, Chronic | | Active | 1 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 1 1 1 2 1 2 1 1 1 1 1 1| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperkeratosis | 4 | Epithelium, Hyperplasia | 2 2 | Epithelium, Inflammation, Chronic | | Active | 1 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 6| 4| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 6| 7| 3| 2| 3| 3| 3| 0| 3| 4| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| | 0| 1| 2| 0| 8| 7| 6| 1| 1| 1| 2| 2| 9| 1| 4| 2| 2| 1| 2| 2| 0| 1| 1| 1| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1.5 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Epithelium, Ulcer | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectopic Tissue | | Mineralization | | Epithelium, Dysplasia | | Glands, Ectasia | 1 2 1 1 1 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Valve, Inflammation, Chronic Active | 4 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 1 | Infiltration Cellular, Mononuclear | | Cell | | Capsule, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + M +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + I + + + + + + + + + + + + + + + +| Pars Distalis, Angiectasis | 3 | Pars Distalis, Hemorrhage | | Pars Distalis, Hyperplasia | 2 2 3 2 1| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | | Follicle, Cyst | 2 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 | Inflammation, Chronic Active | | Pigmentation | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 3 | Cyst | 4 2 2 3 2 3 4 | Hemorrhage | | Mineralization | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 6| 4| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 6| 7| 3| 2| 3| 3| 3| 0| 3| 4| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| | 0| 1| 2| 0| 8| 7| 6| 1| 1| 1| 2| 2| 9| 1| 4| 2| 2| 1| 2| 2| 0| 1| 1| 1| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1.5 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Pigmentation | 2 2 2 2 2 1 2 2 2| Thrombosis | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydrometra | 4 3 3 2 2 2 4 4 4 3 2 2 3 2 3 3| Inflammation, Suppurative | | Pigmentation | 2 | Endometrium, Hyperplasia, Cystic | 2 3 2 3 2 2 2 2 2 3 1 2 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 4 | Myelofibrosis | 2 | __________________________________________________________________________| Lymph Node | + + + | Lumbar, Ectasia | 3 | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | 3 4 | Pigmentation | 1 1 1 2 2 1 1 1 2 2 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + I + + + + + + + M + + + + + + + + + + + +| Hemorrhage | 2 | Inflammation, Chronic Active | 4 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 3 2 4 4 2 2 2 3 2 2 2 3 | Hyperplasia, Lymphoid | | Necrosis | 2 | __________________________________________________________________________| Thymus | + + + + M + + + + + + + + + + + + + + + + M + M +| Cyst | 2 3 2 2 2 2 2 2| Ectopic Parathyroid Gland | 2 | Thymocyte, Necrosis | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Cystic | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Inflammation, Chronic Active | 1 | Meninges, Hemorrhage | 3 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 6| 4| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 6| 7| 3| 2| 3| 3| 3| 0| 3| 4| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| | 0| 1| 2| 0| 8| 7| 6| 1| 1| 1| 2| 2| 9| 1| 4| 2| 2| 1| 2| 2| 0| 1| 1| 1| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1.5 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 3 | Inflammation, Chronic Active | | Mineralization | 1 | Thrombosis | | Alveolar Epithelium, Hyperplasia | 2 | Mediastinum, Mineralization | 3 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Atrophy | 4 | __________________________________________________________________________| Harderian Gland | + + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Accumulation, Hyaline Droplet | | Infiltration Cellular, Mononuclear | | Cell | 1 1 2 1 2 1 1 1 1 1 3 1 1 2 2 1 1 1 1 1 1 1| Inflammation, Chronic Active | 2 | Mineralization | 1 1 | Nephropathy | 2 2 3 2 1 1 1 1 1 1 1| Cortex, Cyst | 3 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 2 2 1 1 1 1 1| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 3| 5| 7| 7| 7| 7| 7| 7| 4| 2| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 5| 3| 3| 7| 6| 3| 3| 3| 1| 2| 3| 0| 8| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| | | 1| 6| 2| 2| 4| 8| 1| 2| 1| 1| 2| 1| 5| 9| 1| 1| 2| 2| 1| 2| 1| 0| 1| 0| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 1.5 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ulcer | | 1 4.0| Epithelium, Inflammation, Suppurative| | 1 4.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 3 | 1 3.0| Basophilic Focus | X | 7 | Clear Cell Focus | X | 6 | Eosinophilic Focus | X | 3 | Hematopoietic Cell Proliferation | | 2 1.5| Hepatodiaphragmatic Nodule | | 1 | Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1| 36 1.0| Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 36 1.0| Mixed Cell Focus | X | 1 | Necrosis | 2 | 2 2.0| Pigmentation | 1 1 1| 12 1.0| Tension Lipidosis | X X| 3 | Hepatocyte, Vacuolization Cytoplasmic| 2 1 1 4 2 | 9 1.8| __________________________________________________________________________|____________| Mesentery | + + + + + + | 11 | Fibrosis | 2 2 3 | 7 2.1| Hemorrhage | | 1 4.0| Inflammation, Chronic Active | 3 2 3 | 6 2.5| Mineralization | 2 2 2 | 7 2.1| Fat, Necrosis | 4 4 4 | 7 4.0| __________________________________________________________________________|____________| Oral Mucosa | + + + | 5 | Gingival, Foreign Body | X X X | 5 | Gingival, Inflammation, Chronic | | | Active | 2 2 2 | 5 1.8| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | 2 2 1 1 1 2 1 2 1 1 1 1| 29 1.2| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 3| 5| 7| 7| 7| 7| 7| 7| 4| 2| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 5| 3| 3| 7| 6| 3| 3| 3| 1| 2| 3| 0| 8| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| | | 1| 6| 2| 2| 4| 8| 1| 2| 1| 1| 2| 1| 5| 9| 1| 1| 2| 2| 1| 2| 1| 0| 1| 0| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 1.5 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperkeratosis | | 1 4.0| Epithelium, Hyperplasia | | 2 2.0| Epithelium, Inflammation, Chronic | | | Active | 2 | 2 1.5| Epithelium, Ulcer | 4 | 1 4.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectopic Tissue | 2 | 1 2.0| Mineralization | 1 | 1 1.0| Epithelium, Dysplasia | 3 | 1 3.0| Glands, Ectasia | 1 1 1 1 | 9 1.1| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Valve, Inflammation, Chronic Active | | 1 4.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | | 1 1.0| Infiltration Cellular, Mononuclear | | | Cell | 1 | 1 1.0| Capsule, Hyperplasia | 2 2 2 2 1 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 48 1.9| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 37 2.0| __________________________________________________________________________|____________| Parathyroid Gland | M + M + + + M + + + + + M M + + + M + M + + M M +| 39 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Pars Distalis, Angiectasis | 1 1 | 3 1.7| Pars Distalis, Hemorrhage | 4 | 1 4.0| Pars Distalis, Hyperplasia | 1 2 2 1 1 2 2| 12 1.8| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Hyperplasia | 3 | 1 3.0| Follicle, Cyst | 2 | 3 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 3| 5| 7| 7| 7| 7| 7| 7| 4| 2| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 5| 3| 3| 7| 6| 3| 3| 3| 1| 2| 3| 0| 8| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| | | 1| 6| 2| 2| 4| 8| 1| 2| 1| 1| 2| 1| 5| 9| 1| 1| 2| 2| 1| 2| 1| 0| 1| 0| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 1.5 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | 1 | 2 1.0| Inflammation, Chronic Active | 2 | 1 2.0| Pigmentation | 2 | 1 2.0| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | | 1 3.0| Cyst | 2 2 2 4 2 2 2 | 14 2.6| Hemorrhage | 4 | 1 4.0| Mineralization | 2 2 2 | 3 2.0| Pigmentation | 2 2 1 1 2 2 1 | 16 1.8| Thrombosis | 3 | 1 3.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hydrometra | 3 4 4 3 4 3 4 3 4 4 4 3 | 28 3.2| Inflammation, Suppurative | 3 | 1 3.0| Pigmentation | | 1 2.0| Endometrium, Hyperplasia, Cystic | 2 2 2 1 2 1 2 2 1 1 2 | 24 1.9| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 4 | 2 4.0| Myelofibrosis | 2 3 | 3 2.3| __________________________________________________________________________|____________| Lymph Node | + + + | 6 | Lumbar, Ectasia | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + M + + + + + + +| 49 | Hyperplasia, Lymphoid | 4 4 | 4 3.8| Pigmentation | 1 2 2 2 2 2 | 16 1.6| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Hemorrhage | | 1 2.0| Inflammation, Chronic Active | | 1 4.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | 2 3 2 3 2 2 2 3 2| 22 2.5| Hyperplasia, Lymphoid | 2 2 2 | 3 2.0| Necrosis | | 1 2.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + M + + + + M + + M + + + M| 43 | Cyst | 2 2 2 1 1 2 2 1 2 | 17 1.9| Ectopic Parathyroid Gland | | 1 2.0| Thymocyte, Necrosis | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 3| 5| 7| 7| 7| 7| 7| 7| 4| 2| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 5| 3| 3| 7| 6| 3| 3| 3| 1| 2| 3| 0| 8| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| | | 1| 6| 2| 2| 4| 8| 1| 2| 1| 1| 2| 1| 5| 9| 1| 1| 2| 2| 1| 2| 1| 0| 1| 0| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 1.5 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Cystic | 3 | 1 3.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skeletal Muscle | + | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 2 | 1 2.0| Inflammation, Chronic Active | | 1 1.0| Meninges, Hemorrhage | | 1 3.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | | 1 3.0| Inflammation, Chronic Active | 1 | 1 1.0| Mineralization | | 1 1.0| Thrombosis | 2 | 1 2.0| Alveolar Epithelium, Hyperplasia | | 1 2.0| Mediastinum, Mineralization | | 1 3.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | Atrophy | | 1 4.0| __________________________________________________________________________|____________| Harderian Gland | | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accumulation, Hyaline Droplet | 3 | 1 3.0| Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 2 1 1 1 1 2 1 1 1 2 1 1 1 1 1 1 1| 42 1.2| Inflammation, Chronic Active | | 1 2.0| Mineralization | 1 1 1| 5 1.0| Nephropathy | 2 1 1 1 1 1 2 1| 19 1.4| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 3| 5| 7| 7| 7| 7| 7| 7| 4| 2| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 5| 3| 3| 7| 6| 3| 3| 3| 1| 2| 3| 0| 8| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| | | 1| 6| 2| 2| 4| 8| 1| 2| 1| 1| 2| 1| 5| 9| 1| 1| 2| 2| 1| 2| 1| 0| 1| 0| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 1.5 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Cortex, Cyst | 3 | 3 2.3| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | 1 1 2 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1| 31 1.1| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 8| 3| 3| 3| 3| 0| 3| 3| 3| 3| 1| 3| 3| 3| | 1| 0| 2| 2| 1| 2| 2| 2| 1| 1| 3| 9| 3| 2| 1| 2| 2| 0| 2| 1| 1| 6| 2| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Metaplasia, Squamous | 3 | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + A + + + + + + + +| Angiectasis | | Basophilic Focus | X | Clear Cell Focus | X X X | Eosinophilic Focus | X X X X X | Hematopoietic Cell Proliferation | 1 1 1 1 2 | Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1| Inflammation, Chronic Active | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 | Mineralization | 4 | Mixed Cell Focus | X| Necrosis | | Pigmentation | 1 1 1 1 2 | Hepatocyte, Vacuolization Cytoplasmic| 2 | __________________________________________________________________________| Mesentery | + + + + + + + + | Fibrosis | 3 2 2 2 | Inflammation, Chronic Active | 1 2 2 1 | Mineralization | 1 1 2 2 2 1 1 | Pigmentation | 2 | Thrombosis | 4 | Fat, Necrosis | 4 4 4 4 4 | __________________________________________________________________________| Oral Mucosa | + | Gingival, Foreign Body | | Gingival, Inflammation, Chronic | | Active | 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 2 2 1 1 1 2 1 1 1 1 2 1 2 1 1 1 2| Inflammation, Chronic Active | | Mineralization | 1 | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 8| 3| 3| 3| 3| 0| 3| 3| 3| 3| 1| 3| 3| 3| | 1| 0| 2| 2| 1| 2| 2| 2| 1| 1| 3| 9| 3| 2| 1| 2| 2| 0| 2| 1| 1| 6| 2| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Epithelium, Hyperplasia | | Epithelium, Inflammation, Chronic | | Active | | Epithelium, Ulcer | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Glands, Ectasia | 1 1 1 1 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hypertrophy | | Capsule, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 3 2 2 2 1 2 2 2| Zona Reticularis, Hyperplasia | 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| __________________________________________________________________________| Parathyroid Gland | M + M M + M + + M + M M + M M M + + + + + + M M +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| Pars Distalis, Angiectasis | 2 | Pars Distalis, Cyst | 2 | Pars Distalis, Hyperplasia | 2 2 2 | Pars Distalis, Pigmentation | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectopic Thymus | | Follicle, Cyst | 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 | Duct, Cyst | 3 2 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 2 2 2 4 2 2 4 4 2| Hemorrhage | 4 3 4 | Mineralization | 1 1 | Pigmentation | 2 1 2 2 2 2 1| Thrombosis | 4 3 4 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 8| 3| 3| 3| 3| 0| 3| 3| 3| 3| 1| 3| 3| 3| | 1| 0| 2| 2| 1| 2| 2| 2| 1| 1| 3| 9| 3| 2| 1| 2| 2| 0| 2| 1| 1| 6| 2| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Hydrometra | 3 2 4 3 2 2 4 3 2 2 2 2| Endometrium, Hyperplasia, Cystic | 3 2 1 2 2 2 1 2 3 2 1 1 2 1 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 4 4 | __________________________________________________________________________| Lymph Node | + + + + | Lumbar, Hyperplasia, Lymphoid | | Mediastinal, Hyperplasia, Lymphoid | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + M M + + M + + + + + + +| Hyperplasia, Lymphoid | 2 4 4 | Pigmentation | 2 2 2 2 2 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + M + +| Hyperplasia, Lymphoid | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + A + + + + + + + +| Hematopoietic Cell Proliferation | 2 2 2 2 4 3 3 2 2 | Hyperplasia, Lymphoid | | Mineralization | 4 | Pigmentation | 2 | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + M M + +| Cyst | 2 2 2 2 1 2 2 2 2 2| Ectopic Parathyroid Gland | | Hyperplasia, Lymphoid | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Peripheral Nerve | | __________________________________________________________________________| Spinal Cord | | Demyelination | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Mineralization | | Thrombosis | 2 | Alveolar Epithelium, Hyperplasia | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 8| 3| 3| 3| 3| 0| 3| 3| 3| 3| 1| 3| 3| 3| | 1| 0| 2| 2| 1| 2| 2| 2| 1| 1| 3| 9| 3| 2| 1| 2| 2| 0| 2| 1| 1| 6| 2| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + A + + + + + + + +| Hydronephrosis | 3 | Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 1 2 1 1 1 1 1 1 2 1 1 1 1 1| Mineralization | 1 1 | Nephropathy | 1 1 1 1 1 1 1| Pigmentation | 2 | Cortex, Cyst | | Renal Tubule, Casts Protein | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 1 1 1 2 1 1| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| | | 9| 1| 0| 2| 1| 2| 2| 1| 2| 1| 1| 1| 0| 0| 2| 1| 0| 2| 1| 0| 0| 1| 2| 2| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 3 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | | 1 1.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Metaplasia, Squamous | | 1 3.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Angiectasis | 2 | 1 2.0| Basophilic Focus | X | 2 | Clear Cell Focus | X X X | 6 | Eosinophilic Focus | X X X X X X | 11 | Hematopoietic Cell Proliferation | 1 | 6 1.2| Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 2 1 1 2 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1| 40 1.1| Inflammation, Chronic Active | 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1| 41 1.1| Mineralization | | 1 4.0| Mixed Cell Focus | X X | 3 | Necrosis | 2 2 | 2 2.0| Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 | 17 1.1| Hepatocyte, Vacuolization Cytoplasmic| 2 2 | 3 2.0| __________________________________________________________________________|____________| Mesentery | + + + + + + + | 15 | Fibrosis | 3 2 2 3 3 3 | 10 2.5| Inflammation, Chronic Active | 3 3 2 2 | 8 2.0| Mineralization | 2 3 1 2 3 | 12 1.8| Pigmentation | | 1 2.0| Thrombosis | | 1 4.0| Fat, Necrosis | 4 4 4 4 4 4 | 11 4.0| __________________________________________________________________________|____________| Oral Mucosa | + | 2 | Gingival, Foreign Body | X | 1 | Gingival, Inflammation, Chronic | | | Active | 2 | 2 2.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 3| 1 3.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| | | 9| 1| 0| 2| 1| 2| 2| 1| 2| 1| 1| 1| 0| 0| 2| 1| 0| 2| 1| 0| 0| 1| 2| 2| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 3 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 2 1 1 1 1 1 1 1 1 2 1 | 32 1.3| Inflammation, Chronic Active | 1 1 | 2 1.0| Mineralization | | 1 1.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Epithelium, Hyperplasia | 2 | 1 2.0| Epithelium, Inflammation, Chronic | | | Active | 2 1 | 2 1.5| Epithelium, Ulcer | 4 | 1 4.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Glands, Ectasia | 1 1 1 1 1 2 | 10 1.1| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hypertrophy | 2 | 1 2.0| Capsule, Hyperplasia | 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 50 2.0| Zona Reticularis, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 40 2.0| __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + M M + + M| 34 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Pars Distalis, Angiectasis | 2 2 2 1 1| 6 1.7| Pars Distalis, Cyst | 1 | 2 1.5| Pars Distalis, Hyperplasia | 2 2 2 2 1 2 2| 10 1.9| Pars Distalis, Pigmentation | 2 | 1 2.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectopic Thymus | 2 | 1 2.0| Follicle, Cyst | 2 3 | 3 2.3| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| | | 9| 1| 0| 2| 1| 2| 2| 1| 2| 1| 1| 1| 0| 0| 2| 1| 0| 2| 1| 0| 0| 1| 2| 2| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 3 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Infiltration Cellular, Mononuclear | | | Cell | 1 1 | 3 1.0| Duct, Cyst | | 2 2.5| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 4 2 2 2 2 2 2 2 | 18 2.4| Hemorrhage | 4 | 4 3.8| Mineralization | | 2 1.0| Pigmentation | 2 1 2 2 | 11 1.7| Thrombosis | | 3 3.7| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hydrometra | 2 4 2 4 3 4 4 3 4 2 2 2 4 4 3 2 4 3 3 | 31 2.9| Endometrium, Hyperplasia, Cystic | 2 2 2 2 2 2 1 2 2 2 | 24 1.8| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 4 4 | 4 4.0| __________________________________________________________________________|____________| Lymph Node | + + + + | 8 | Lumbar, Hyperplasia, Lymphoid | 4 | 1 4.0| Mediastinal, Hyperplasia, Lymphoid | 2 3 | 2 2.5| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + + + + + + + + +| 46 | Hyperplasia, Lymphoid | | 3 3.3| Pigmentation | 1 2 2 2| 9 1.9| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + M M + + +| 47 | Hyperplasia, Lymphoid | 4 | 1 4.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hematopoietic Cell Proliferation | 3 2 3 3 2 3 | 15 2.5| Hyperplasia, Lymphoid | 3 | 1 3.0| Mineralization | | 1 4.0| Pigmentation | | 1 2.0| __________________________________________________________________________|____________| Thymus | M + + + + + + + + + + + + + + + + + + M + + + + +| 46 | Cyst | 2 3 1 2 2 2 2 2 2 2 2 2 2| 23 2.0| Ectopic Parathyroid Gland | 1 | 1 1.0| Hyperplasia, Lymphoid | 4 4 | 2 4.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| | | 9| 1| 0| 2| 1| 2| 2| 1| 2| 1| 1| 1| 0| 0| 2| 1| 0| 2| 1| 0| 0| 1| 2| 2| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 3 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skeletal Muscle | + + | 2 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Peripheral Nerve | + | 1 | __________________________________________________________________________|____________| Spinal Cord | + + | 2 | Demyelination | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 1 1 2 | 3 1.3| Mineralization | 1 1 | 2 1.0| Thrombosis | | 1 2.0| Alveolar Epithelium, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | + + | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hydronephrosis | | 1 3.0| Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 3 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 44 1.1| Mineralization | 1 1 1| 5 1.0| Nephropathy | 2 1 3 1 1 1 1 1 1 1 1 1 1 2 1 | 22 1.2| Pigmentation | | 1 2.0| Cortex, Cyst | 2 | 1 2.0| Renal Tubule, Casts Protein | 3 | 1 3.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 1 1 2 1 2 1 1 1 1 1 1 1 2 1| 29 1.1| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 _____________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 7| 6| 7| 7| 7| 7| 6| 5| 7| 4| 4| 4| 4| 4| DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 0| 3| 4| 3| 3| 3| 3| 4| 8| 3| 8| 8| 8| 8| 8| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 1| 1| 1| 2| 2| 2| 1| 1| 1| 0| 0| 0| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + M + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Peyer's Patch, Hyperplasia, Lymphoid | 3 | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | | Clear Cell Focus | X | Eosinophilic Focus | X | Hematopoietic Cell Proliferation | 1 | Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Mineralization | | Necrosis | | Pigmentation | 1 1 | Hepatocyte, Vacuolization Cytoplasmic| 1 1 1 1 2 1 1 1 1| __________________________________________________________________________| Mesentery | + | Fibrosis | 2 | Mineralization | | Fat, Necrosis | 4 | __________________________________________________________________________| Oral Mucosa | | __________________________________________________________________________| Pancreas | + + + + + + + + + + M + + + + + + + A + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 2 | Acinus, Hyperplasia | 2 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 2 1 1 1 1 1 1 1 | Inflammation, Chronic Active | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Epithelium, Hyperplasia | | Epithelium, Inflammation, Chronic | | Active | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | | Glands, Ectasia | 1 1 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 _____________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 7| 6| 7| 7| 7| 7| 6| 5| 7| 4| 4| 4| 4| 4| DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 0| 3| 4| 3| 3| 3| 3| 4| 8| 3| 8| 8| 8| 8| 8| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 1| 1| 1| 2| 2| 2| 1| 1| 1| 0| 0| 0| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | | Hematopoietic Cell Proliferation | | Capsule, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 1 2 2 2 2 2 2 2 2 2| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + A + + + + + +| Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + M + + + M + + M + + M + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + I + + + + + +| Pars Distalis, Angiectasis | 2 2 | Pars Distalis, Cyst | 2 1 | Pars Distalis, Hyperplasia | 2 2 1 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 | Follicle, Cyst | 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 | Inflammation, Chronic Active | | Duct, Cyst | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + I + + + + + + + + + + + +| Cyst | 2 3 2 | Hemorrhage | | Inflammation, Suppurative | | Mineralization | 2 | Pigmentation | 1 1 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 4 | Hemorrhage | | Hydrometra | 2 2 2 2 2 2 4 3 3 4 2 | Endometrium, Hyperplasia, Cystic | 2 2 2 2 3 2 2 2 2 2 2 1 1 1| __________________________________________________________________________| Vagina | + | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 _____________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 7| 6| 7| 7| 7| 7| 6| 5| 7| 4| 4| 4| 4| 4| DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 0| 3| 4| 3| 3| 3| 3| 4| 8| 3| 8| 8| 8| 8| 8| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 1| 1| 1| 2| 2| 2| 1| 1| 1| 0| 0| 0| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Lymph Node | | Lumbar, Ectasia | | Mediastinal, Inflammation | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + M + +| Hyperplasia, Lymphoid | | Pigmentation | 2 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + + + A + + + + + +| Hyperplasia, Lymphoid | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + A + + + + + +| Hematopoietic Cell Proliferation | 3 | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 2 1 2 2 2 2 2| Thymocyte, Necrosis | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Mineralization | 1 | Necrosis | | Alveolus, Infiltration Cellular, | | Histiocyte | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + | Atrophy | | Anterior Chamber, Infiltration | | Cellular, Polymorphonuclear | 3 | Cornea, Inflammation, Chronic Active | 2 | __________________________________________________________________________| Harderian Gland | + | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 _____________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 7| 6| 7| 7| 7| 7| 6| 5| 7| 4| 4| 4| 4| 4| DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 0| 3| 4| 3| 3| 3| 3| 4| 8| 3| 8| 8| 8| 8| 8| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 1| 1| 1| 2| 2| 2| 1| 1| 1| 0| 0| 0| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Mineralization | 1 1 | Nephropathy | 1 1 1 1 | Cortex, Cyst | 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 1 1 1 1 1 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 2| 7| 3| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 1| 3| 3| 0| 3| 3| 3| 9| 1| 3| 4| | | 2| 2| 1| 0| 2| 1| 2| 1| 1| 0| 2| 1| 3| 2| 4| 0| 1| 3| 1| 2| 1| 4| 2| 1| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A | 6 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + M + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Peyer's Patch, Hyperplasia, Lymphoid | 3 | 2 3.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X | 2 | Clear Cell Focus | | 1 | Eosinophilic Focus | X X | 3 | Hematopoietic Cell Proliferation | 1 | 2 1.0| Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 1 2 1 1 1 2 1 1 1 1 1 | 30 1.1| Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 2 1 1 1 1 2 1 2 1 1 1 1 | 38 1.1| Mineralization | 1| 1 1.0| Necrosis | 3| 1 3.0| Pigmentation | 1 1 1 1 1 | 7 1.0| Hepatocyte, Vacuolization Cytoplasmic| 2 2 2 2 1 2 1 2 1 | 18 1.4| __________________________________________________________________________|____________| Mesentery | + + + | 4 | Fibrosis | 2 | 2 2.0| Mineralization | 2 | 1 2.0| Fat, Necrosis | 4 4 | 3 4.0| __________________________________________________________________________|____________| Oral Mucosa | + | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Infiltration Cellular, Mononuclear | | | Cell | | 2 1.5| Acinus, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 | Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 27 1.0| Inflammation, Chronic Active | 4 | 1 4.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Epithelium, Hyperplasia | 3 | 1 3.0| Epithelium, Inflammation, Chronic | | | Active | 2 | 1 2.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 2| 7| 3| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 1| 3| 3| 0| 3| 3| 3| 9| 1| 3| 4| | | 2| 2| 1| 0| 2| 1| 2| 1| 1| 0| 2| 1| 3| 2| 4| 0| 1| 3| 1| 2| 1| 4| 2| 1| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A | 6 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Mineralization | 1| 1 1.0| Glands, Ectasia | 1 | 3 1.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 2| 1 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Adrenal Cortical Nodule | 2 1 | 2 1.5| Hematopoietic Cell Proliferation | 1 | 1 1.0| Capsule, Hyperplasia | 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 1| 50 1.9| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 3 | 1 3.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 | 33 2.0| __________________________________________________________________________|____________| Parathyroid Gland | + M M + + + + M + M + + + + + + M + + + + + + + M| 40 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Pars Distalis, Angiectasis | | 2 2.0| Pars Distalis, Cyst | | 2 1.5| Pars Distalis, Hyperplasia | 3 2 2 3 2 2 2 2 | 11 2.1| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | | 1 1.0| Follicle, Cyst | 2 2 2 | 4 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Peritoneum | + | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| 49 | Infiltration Cellular, Mononuclear | | | Cell | | 1 1.0| Inflammation, Chronic Active | 2 | 1 2.0| Duct, Cyst | 2 3 | 2 2.5| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Cyst | 3 2 2 2 3 3 4| 10 2.6| Hemorrhage | 2| 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 2| 7| 3| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 1| 3| 3| 0| 3| 3| 3| 9| 1| 3| 4| | | 2| 2| 1| 0| 2| 1| 2| 1| 1| 0| 2| 1| 3| 2| 4| 0| 1| 3| 1| 2| 1| 4| 2| 1| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A | 6 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Inflammation, Suppurative | 2| 1 2.0| Mineralization | | 1 2.0| Pigmentation | 1 2 2 2 | 6 1.5| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | | 1 4.0| Hemorrhage | 2 | 1 2.0| Hydrometra | 3 3 4 2 4 2 4 4 4 | 20 2.9| Endometrium, Hyperplasia, Cystic | 1 2 2 1 2 1 2 2 3 3 2 2 2 1 2 1 1 1| 32 1.8| __________________________________________________________________________|____________| Vagina | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Lymph Node | + + + + + | 5 | Lumbar, Ectasia | 4 | 1 4.0| Mediastinal, Inflammation | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + M + + + + + + + + + M + + +| 47 | Hyperplasia, Lymphoid | 2 | 1 2.0| Pigmentation | 2 2 2 | 4 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + M + + + + + M + + + + + +| 46 | Hyperplasia, Lymphoid | 3 | 1 3.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hematopoietic Cell Proliferation | 2 2 2 3 2 3 3 2 4| 10 2.6| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + M + + + + + + M| 48 | Cyst | 2 2 2 2 2 2 2 2 2 2 1 | 19 1.9| Thymocyte, Necrosis | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 2| 7| 3| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 1| 3| 3| 0| 3| 3| 3| 9| 1| 3| 4| | | 2| 2| 1| 0| 2| 1| 2| 1| 1| 0| 2| 1| 3| 2| 4| 0| 1| 3| 1| 2| 1| 4| 2| 1| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A | 6 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Inflammation, Chronic Active | 2 | 1 2.0| Mineralization | 1 | 2 1.0| Necrosis | 3 | 1 3.0| Alveolus, Infiltration Cellular, | | | Histiocyte | 1 3 | 2 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + | 4 | Atrophy | 4 | 1 4.0| Anterior Chamber, Infiltration | | | Cellular, Polymorphonuclear | | 1 3.0| Cornea, Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Harderian Gland | + | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 35 1.0| Mineralization | 1 1 1 2| 6 1.2| Nephropathy | 1 1 1 1 1 | 9 1.0| Cortex, Cyst | | 1 2.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 1 1 1 2 1 1 1 1 | 22 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 6| 7| 0| 7| 7| DAY ON TEST | 3| 3| 2| 7| 9| 3| 0| 0| 2| 3| 2| 3| 3| 3| 3| 0| 7| 2| 3| 3| 5| 1| 7| 2| 3| | 0| 1| 9| 0| 4| 1| 9| 0| 9| 0| 9| 0| 1| 0| 0| 1| 7| 9| 8| 0| 0| 2| 3| 9| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + M + + + + + + + + + + + + + + + + M + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Clear Cell Focus | X X X X| Eosinophilic Focus | X X X X X X X X X | Hepatodiaphragmatic Nodule | X | Infiltration Cellular, Mast Cell | | Infiltration Cellular, Mononuclear | | Cell | 3 1 1 1 1 | Inflammation, Chronic Active | 1 1 1 1 3 2 1 2 1 | Malformation | | Necrosis | 2 3 3 | Pigmentation | 2 1 | Tension Lipidosis | | Hepatocyte, Vacuolization Cytoplasmic| 2 1 1 2| __________________________________________________________________________| Mesentery | + | Fibrosis | | Inflammation, Chronic Active | | Thrombosis | 4 | Fat, Necrosis | | __________________________________________________________________________| Oral Mucosa | + + + + + + + + + + + + + + | Gingival, Foreign Body | X X X X X X X X X X X X X | Gingival, Inflammation, Acute | 1 1 1 1 | Gingival, Inflammation, Chronic | | Active | 1 2 1 2 2 2 2 1 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +| Granuloma | 2 | Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 | Inflammation, Chronic | 1 | Mineralization | 1 | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| Epithelium, Hyperplasia | 2 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 6| 7| 0| 7| 7| DAY ON TEST | 3| 3| 2| 7| 9| 3| 0| 0| 2| 3| 2| 3| 3| 3| 3| 0| 7| 2| 3| 3| 5| 1| 7| 2| 3| | 0| 1| 9| 0| 4| 1| 9| 0| 9| 0| 9| 0| 1| 0| 0| 1| 7| 9| 8| 0| 0| 2| 3| 9| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Epithelium, Inflammation, Chronic | | Active | 2 | Epithelium, Ulcer | 4 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | | Epithelium, Erosion | 2 | Epithelium, Inflammation, Chronic | | Active | | Glands, Ectasia | 1 1 1 1 1 1| __________________________________________________________________________| Tooth | + | Malformation | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + I + +| Inflammation, Chronic Active | 3 | Mineralization | 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Fatty | 1 | Hyperplasia | 3 1 1 2 3 3 2| Hypertrophy | 3 3 2 1 1 3 1 2 1 2 1 1 2| Metaplasia, Osseous | 3 | Capsule, Hyperplasia | 2 2 1 1 1 1 1 2 2 2 2 1 1 1 1 1 1 1| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 1 3 2 2 2 2 2 2 3 3 2 2 3 3 2 2 2 2 2 2 3| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + M + M + M + + + + M + + +| Cyst | 2 | __________________________________________________________________________| Pituitary Gland | + + + I + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Cyst | | Pars Distalis, Hyperplasia | 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Follicle, Cyst | 3 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 | Granuloma Sperm | 3 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 6| 7| 0| 7| 7| DAY ON TEST | 3| 3| 2| 7| 9| 3| 0| 0| 2| 3| 2| 3| 3| 3| 3| 0| 7| 2| 3| 3| 5| 1| 7| 2| 3| | 0| 1| 9| 0| 4| 1| 9| 0| 9| 0| 9| 0| 1| 0| 0| 1| 7| 9| 8| 0| 0| 2| 3| 9| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Infiltration Cellular, Mononuclear | | Cell | 1 1 1 2 1 1 1 1 1 1 | Inflammation, Chronic Active | | Mineralization | 1 | __________________________________________________________________________| Penis | + | Hemorrhage | 3 | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 | Infiltration Cellular, Mononuclear | | Cell | 1 1 2 2 1 2 2 1| Inflammation, Chronic Active | 2 4 1 4 | Duct, Cyst | 2 2 3 3 3 2 3 2| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 | Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 1 1 1 2 1 1 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 2 | Germinal Epithelium, Atrophy | 4 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + | __________________________________________________________________________| Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | 2 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 | Hemorrhage | 3 | Hyperplasia, Lymphoid | 3 | Hyperplasia, Plasma Cell | | Inflammation, Granulomatous | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 3 3 2 4 2| Hyperplasia, Lymphoid | 2 | __________________________________________________________________________| Thymus | M + + M + + + + + + + + + M + + M + M + + + + +| Cyst | 2 2 2 2 1 | Ectopic Parathyroid Gland | 1 | Ectopic Thyroid | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 6| 7| 0| 7| 7| DAY ON TEST | 3| 3| 2| 7| 9| 3| 0| 0| 2| 3| 2| 3| 3| 3| 3| 0| 7| 2| 3| 3| 5| 1| 7| 2| 3| | 0| 1| 9| 0| 4| 1| 9| 0| 9| 0| 9| 0| 1| 0| 0| 1| 7| 9| 8| 0| 0| 2| 3| 9| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 2 | Inflammation, Chronic Active | 2 | Mineralization | 1 1| Thrombosis | 2 4 | Alveolar Epithelium, Hyperplasia | 2 4 | Alveolus, Infiltration Cellular, | | Histiocyte | | Bronchiole, Foreign Body | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | X | Inflammation, Chronic Active | 2 | Nasolacrimal Duct, Inflammation, | | Suppurative | 2 1 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Cornea, Inflammation, Suppurative | 2 | __________________________________________________________________________| Harderian Gland | + + | Infiltration Cellular, Mononuclear | | Cell | 1 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + +| Infarct | 3 2 | Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 1 1 1 1 | Inflammation, Chronic Active | | Metaplasia, Osseous | 3 | Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Nephropathy | 1 1 2 1 1 2 1 1 2 2 2 2 1 3 1 2 1 1| Cortex, Cyst | 2 2 2 2 2 1| Renal Tubule, Hyperplasia | 2 2 2 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 6| 7| 0| 7| 7| DAY ON TEST | 3| 3| 2| 7| 9| 3| 0| 0| 2| 3| 2| 3| 3| 3| 3| 0| 7| 2| 3| 3| 5| 1| 7| 2| 3| | 0| 1| 9| 0| 4| 1| 9| 0| 9| 0| 9| 0| 1| 0| 0| 1| 7| 9| 8| 0| 0| 2| 3| 9| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | Renal Tubule, Necrosis | 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 1 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 __________________________________________________________________________________________________________________________________ | 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| | DAY ON TEST | 3| 8| 6| 9| 3| 2| 3| 3| 3| 2| 9| 3| 3| 3| 3| 3| 2| 2| 3| 2| 1| 3| 3| 3| 2| | | 1| 3| 3| 4| 1| 9| 0| 0| 1| 9| 4| 0| 1| 1| 0| 1| 9| 9| 0| 9| 3| 1| 0| 1| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + M + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Angiectasis | | 1 2.0| Clear Cell Focus | X X X | 7 | Eosinophilic Focus | X X X X X X X | 16 | Hepatodiaphragmatic Nodule | | 1 | Infiltration Cellular, Mast Cell | 2 | 1 2.0| Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 | 9 1.2| Inflammation, Chronic Active | 1 2 1 1 2 1 1 1 1 1 1 1 1 | 22 1.3| Malformation | 2 | 1 2.0| Necrosis | 2 2 2 | 6 2.3| Pigmentation | 2 | 3 1.7| Tension Lipidosis | X | 1 | Hepatocyte, Vacuolization Cytoplasmic| 1 1 | 6 1.3| __________________________________________________________________________|____________| Mesentery | + + | 3 | Fibrosis | 2 | 1 2.0| Inflammation, Chronic Active | 2 | 1 2.0| Thrombosis | | 1 4.0| Fat, Necrosis | 4 | 1 4.0| __________________________________________________________________________|____________| Oral Mucosa | + + + + + + + + + + + + + + + + + | 31 | Gingival, Foreign Body | X X X X X X X X X X X X X X | 27 | Gingival, Inflammation, Acute | 1 1 1 1 1 | 9 1.0| Gingival, Inflammation, Chronic | | | Active | 2 1 2 1 2 2 1 2 2 2 | 19 1.7| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Infiltration Cellular, Mononuclear | | | Cell | 1 | 1 1.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Granuloma | | 1 2.0| Infiltration Cellular, Mononuclear | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 __________________________________________________________________________________________________________________________________ | 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| | DAY ON TEST | 3| 8| 6| 9| 3| 2| 3| 3| 3| 2| 9| 3| 3| 3| 3| 3| 2| 2| 3| 2| 1| 3| 3| 3| 2| | | 1| 3| 3| 4| 1| 9| 0| 0| 1| 9| 4| 0| 1| 1| 0| 1| 9| 9| 0| 9| 3| 1| 0| 1| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Cell | 1 2 1 1 1 1 1 1 1 | 22 1.0| Inflammation, Chronic | | 1 1.0| Mineralization | | 1 1.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Epithelium, Hyperplasia | 3 | 2 2.5| Epithelium, Inflammation, Chronic | | | Active | 3 | 2 2.5| Epithelium, Ulcer | | 1 4.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Ulcer | 4 | 1 4.0| Epithelium, Erosion | | 1 2.0| Epithelium, Inflammation, Chronic | | | Active | 4 | 1 4.0| Glands, Ectasia | 1 1 2 1 2 1 1 1 1 1 1 | 17 1.1| __________________________________________________________________________|____________| Tooth | + + + + + | 6 | Malformation | X X X X X | 6 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Inflammation, Chronic Active | 1 | 2 2.0| Mineralization | 1 | 2 1.5| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Degeneration, Fatty | | 1 1.0| Hyperplasia | 1 3 3 2 2 2 1 | 14 2.1| Hypertrophy | 3 1 2 1 3 2 2 1 1 1 1 2 2| 26 1.7| Metaplasia, Osseous | | 1 3.0| Capsule, Hyperplasia | 1 1 1 2 1 2 2 1 2 1 2 1 1 2 2 1 2 3 2 1 1 3 1| 41 1.5| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 2 2 2 2 2 2 2 2 2 3 2 3 3 2 2 2 2 2 2 2 3 2 2 2 3| 47 2.2| __________________________________________________________________________|____________| Parathyroid Gland | + + + M + + + + + + M + + + + + + + + + M + + + +| 42 | Cyst | | 1 2.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Pars Distalis, Cyst | 2 | 1 2.0| Pars Distalis, Hyperplasia | 2 | 2 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 __________________________________________________________________________________________________________________________________ | 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| | DAY ON TEST | 3| 8| 6| 9| 3| 2| 3| 3| 3| 2| 9| 3| 3| 3| 3| 3| 2| 2| 3| 2| 1| 3| 3| 3| 2| | | 1| 3| 3| 4| 1| 9| 0| 0| 1| 9| 4| 0| 1| 1| 0| 1| 9| 9| 0| 9| 3| 1| 0| 1| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Follicle, Cyst | | 2 2.5| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Atrophy | | 1 3.0| Granuloma Sperm | 3 | 2 3.0| Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 2 1 1 1 | 17 1.1| Inflammation, Chronic Active | 3 | 1 3.0| Mineralization | 1 | 2 1.0| __________________________________________________________________________|____________| Penis | | 1 | Hemorrhage | | 1 3.0| __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Atrophy | | 1 3.0| Infiltration Cellular, Mononuclear | | | Cell | 1 1 2 1 2 2 2 1 2 1 1 2 1 | 21 1.5| Inflammation, Chronic Active | 2 1 1 3 2 2 4 2 3 | 13 2.4| Duct, Cyst | 3 2 2 2 2 2 2 2 3 3 | 18 2.4| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Atrophy | | 1 3.0| Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 25 1.0| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Atrophy | | 1 3.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Mineralization | 1 | 2 1.5| Germinal Epithelium, Atrophy | | 1 4.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Lymph Node | + +| 3 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + M + + + + + + I + + + + + +| 46 | Hyperplasia, Lymphoid | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + M M + + + + + + + + + + + + + + + + + + + + +| 46 | Hematopoietic Cell Proliferation | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 __________________________________________________________________________________________________________________________________ | 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| | DAY ON TEST | 3| 8| 6| 9| 3| 2| 3| 3| 3| 2| 9| 3| 3| 3| 3| 3| 2| 2| 3| 2| 1| 3| 3| 3| 2| | | 1| 3| 3| 4| 1| 9| 0| 0| 1| 9| 4| 0| 1| 1| 0| 1| 9| 9| 0| 9| 3| 1| 0| 1| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Hemorrhage | | 1 3.0| Hyperplasia, Lymphoid | | 1 3.0| Hyperplasia, Plasma Cell | 3 | 1 3.0| Inflammation, Granulomatous | 4 | 1 4.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hematopoietic Cell Proliferation | 2 4 3 3 3 2 2| 12 2.8| Hyperplasia, Lymphoid | | 1 2.0| __________________________________________________________________________|____________| Thymus | + + M M + + + + + + + + + + M M + + + + + + + + +| 40 | Cyst | 1 1 2 2 1 1 2 1 2 2 2 | 16 1.6| Ectopic Parathyroid Gland | 2 1 | 3 1.3| Ectopic Thyroid | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Skeletal Muscle | + | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Infiltration Cellular, Mononuclear | | | Cell | | 1 2.0| Inflammation, Chronic Active | 2 | 2 2.0| Mineralization | 1 | 3 1.0| Thrombosis | 1 | 3 2.3| Alveolar Epithelium, Hyperplasia | 1 | 3 2.3| Alveolus, Infiltration Cellular, | | | Histiocyte | 1 3 3 2 | 4 2.3| Bronchiole, Foreign Body | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Foreign Body | X X | 3 | Inflammation, Chronic Active | 4 | 2 3.0| Nasolacrimal Duct, Inflammation, | | | Suppurative | 2 | 4 1.5| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 __________________________________________________________________________________________________________________________________ | 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| | DAY ON TEST | 3| 8| 6| 9| 3| 2| 3| 3| 3| 2| 9| 3| 3| 3| 3| 3| 2| 2| 3| 2| 1| 3| 3| 3| 2| | | 1| 3| 3| 4| 1| 9| 0| 0| 1| 9| 4| 0| 1| 1| 0| 1| 9| 9| 0| 9| 3| 1| 0| 1| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | Cornea, Inflammation, Suppurative | | 1 2.0| __________________________________________________________________________|____________| Harderian Gland | + | 3 | Infiltration Cellular, Mononuclear | | | Cell | | 1 1.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Infarct | | 2 2.5| Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 1 2 1 1 1 1 2 1 1 1 1 1 1 1 | 27 1.1| Inflammation, Chronic Active | 1 | 1 1.0| Metaplasia, Osseous | 2 | 2 2.5| Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 43 1.0| Nephropathy | 2 2 1 1 2 2 1 2 2 1 1 1 2 2 1 1 2 2 2 2 1 1 1 2 1| 43 1.5| Cortex, Cyst | 2 2 2 1 3| 11 1.9| Renal Tubule, Hyperplasia | 2 2 2 2 2 2 | 9 2.0| Renal Tubule, Necrosis | | 1 2.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 1 1 | 12 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 2| 2| 2| 3| 3| 3| 3| 3| 3| 2| 2| 2| 6| 2| 3| 2| 2| 2| 3| 3| 1| 3| 3| | 1| 1| 9| 9| 9| 1| 0| 1| 1| 1| 1| 5| 9| 9| 3| 9| 0| 9| 9| 9| 1| 0| 4| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1.5 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Periesophageal Tissue, Inflammation, | | Chronic Active | | __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + M + + + + + + + + + + + +| Hyperplasia | 3 3 | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X | Clear Cell Focus | X X X X X X | Eosinophilic Focus | X X X X | Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 1 | Inflammation, Chronic Active | 1 1 1 1 1 1| Mixed Cell Focus | X X X X| Necrosis | 2 3 2 2 | Hepatocyte, Vacuolization Cytoplasmic| 2 1 1 2 1| __________________________________________________________________________| Mesentery | + + | Fibrosis | 2 | Inflammation, Chronic Active | | Mineralization | | Fat, Necrosis | 4 | __________________________________________________________________________| Oral Mucosa | + + + + + + + + + + + + + + +| Gingival, Foreign Body | X X X X X X X X X X X X X X X| Gingival, Inflammation, Acute | 1 2 1| Gingival, Inflammation, Chronic | 1 | Gingival, Inflammation, Chronic | | Active | 1 1 1 1 2 2 1 2 2 1 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Mineralization | 1 | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Epithelium, Hyperplasia | 2 2 | Epithelium, Inflammation, Chronic | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 2| 2| 2| 3| 3| 3| 3| 3| 3| 2| 2| 2| 6| 2| 3| 2| 2| 2| 3| 3| 1| 3| 3| | 1| 1| 9| 9| 9| 1| 0| 1| 1| 1| 1| 5| 9| 9| 3| 9| 0| 9| 9| 9| 1| 0| 4| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1.5 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Active | | Epithelium, Ulcer | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | Mineralization | | Epithelium, Hyperplasia | 2 | Epithelium, Inflammation, Chronic | | Active | | Glands, Ectasia | 1 1 2 1 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 | Artery, Inflammation, Chronic Active | 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 1 1 2 2 2| Hypertrophy | 1 2 2 2 2 2 3 1 3 2 1 3 2 1 2 2| Inflammation, Suppurative | | Capsule, Hyperplasia | 2 2 2 2 2 1 1 2 1 1 1 2 1 2 2 1 1 2 2 1 2| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 3 3 2 2 2 3| __________________________________________________________________________| Parathyroid Gland | M M + + + + + + + + M + + + + + M + M + + + M + M| Cyst | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Cyst | | Pars Distalis, Hyperplasia | 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicle, Cyst | 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1| Inflammation, Chronic Active | 2 | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 2 2 2 1 2 1 2 1 2 1 2 1 1 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 2| 2| 2| 3| 3| 3| 3| 3| 3| 2| 2| 2| 6| 2| 3| 2| 2| 2| 3| 3| 1| 3| 3| | 1| 1| 9| 9| 9| 1| 0| 1| 1| 1| 1| 5| 9| 9| 3| 9| 0| 9| 9| 9| 1| 0| 4| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1.5 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Inflammation, Chronic Active | 3 2 2 2 | Duct, Cyst | 2 2 2 3 2 2 2 2 2 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 1 1 1 1 1 2 1 1 1| Artery, Inflammation, Chronic Active | 2 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | | Infiltration Cellular, Mononuclear | | Cell | 1 | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 | Mineralization | | Germinal Epithelium, Atrophy | 2 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + | Inguinal, Hyperplasia, Plasma Cell | | Lumbar, Hyperplasia, Plasma Cell | | Mediastinal, Hyperplasia, Plasma Cell| | Pancreatic, Hyperplasia, Lymphoid | | Renal, Hyperplasia, Plasma Cell | | Renal, Inflammation, Suppurative | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + + + M + + + + +| Hyperplasia, Lymphoid | | Hyperplasia, Plasma Cell | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + M + M + M + + M + + + M + + + + + + + + +| Hyperplasia, Lymphoid | | Hyperplasia, Plasma Cell | | Inflammation, Suppurative | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 3 2 3 4 2 2 2 | Hyperplasia, Lymphoid | 3 | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + M + + + + + + M + +| Cyst | 2 2 2 2 1 2 2 | Ectopic Parathyroid Gland | 2 | Mineralization | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Epidermis, Hyperplasia | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 2| 2| 2| 3| 3| 3| 3| 3| 3| 2| 2| 2| 6| 2| 3| 2| 2| 2| 3| 3| 1| 3| 3| | 1| 1| 9| 9| 9| 1| 0| 1| 1| 1| 1| 5| 9| 9| 3| 9| 0| 9| 9| 9| 1| 0| 4| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1.5 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Epidermis, Ulcer | | Subcutaneous Tissue, Fibrosis | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 | Infiltration Cellular, Mononuclear | | Cell | | Inflammation, Chronic | 1 | Inflammation, Chronic Active | 2 | Mineralization | 1 | Thrombosis | 2 | Alveolar Epithelium, Hyperplasia | 2 2 2 | Alveolus, Infiltration Cellular, | | Histiocyte | 3 2 2 3| Mediastinum, Inflammation, | | Suppurative | 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | X X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Cornea, Inflammation, Chronic Active | 2 | Cornea, Metaplasia, Squamous | 4 | __________________________________________________________________________| Harderian Gland | + + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Infarct | | Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 2 1 1 1 3 1 1 1 1 1 1 1 1 | Metaplasia, Osseous | | Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Nephropathy | 2 1 1 1 2 2 2 2 1 2 2 2 1 2 1 2 2 2 2 1 1 2 2 2| Artery, Inflammation, Chronic Active | 3 | Cortex, Cyst | 2 3 2 2 | Renal Tubule, Hyperplasia | 2 2 2 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 2| 2| 2| 3| 3| 3| 3| 3| 3| 2| 2| 2| 6| 2| 3| 2| 2| 2| 3| 3| 1| 3| 3| | 1| 1| 9| 9| 9| 1| 0| 1| 1| 1| 1| 5| 9| 9| 3| 9| 0| 9| 9| 9| 1| 0| 4| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1.5 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 2| 3| 2| 3| 3| 2| 2| 2| 2| 3| 2| 0| 2| 3| 3| | | 0| 0| 0| 0| 0| 4| 1| 1| 0| 0| 9| 0| 9| 1| 0| 9| 9| 9| 5| 0| 9| 5| 9| 0| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 1.5 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Periesophageal Tissue, Inflammation, | | | Chronic Active | 2 | 1 2.0| __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 3 | 3 3.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X | 4 | Clear Cell Focus | X X X X | 10 | Eosinophilic Focus | X X X X X X | 10 | Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 1 | 11 1.0| Inflammation, Chronic Active | 1 2 1 1 1 1 1 2 1 1 1 1 1 1 1| 21 1.1| Mixed Cell Focus | X X X X X X X | 11 | Necrosis | 2 | 5 2.2| Hepatocyte, Vacuolization Cytoplasmic| 2 2 2 2 1 | 10 1.6| __________________________________________________________________________|____________| Mesentery | + + + + | 6 | Fibrosis | | 1 2.0| Inflammation, Chronic Active | 2 | 1 2.0| Mineralization | 2 | 1 2.0| Fat, Necrosis | 3 | 2 3.5| __________________________________________________________________________|____________| Oral Mucosa | + + + + + + + + + + + + + + +| 30 | Gingival, Foreign Body | X X X X X X X X X X X X X X| 29 | Gingival, Inflammation, Acute | | 3 1.3| Gingival, Inflammation, Chronic | | 1 1.0| Gingival, Inflammation, Chronic | | | Active | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3| 26 1.8| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | 2 | 1 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 2| 3| 2| 3| 3| 2| 2| 2| 2| 3| 2| 0| 2| 3| 3| | | 0| 0| 0| 0| 0| 4| 1| 1| 0| 0| 9| 0| 9| 1| 0| 9| 9| 9| 5| 0| 9| 5| 9| 0| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 1.5 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 35 1.0| Mineralization | | 1 1.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Epithelium, Hyperplasia | 2 | 3 2.0| Epithelium, Inflammation, Chronic | | | Active | 2 | 1 2.0| Epithelium, Ulcer | 4 | 1 4.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 1 2.0| Mineralization | 1 | 1 1.0| Epithelium, Hyperplasia | | 1 2.0| Epithelium, Inflammation, Chronic | | | Active | 2 | 1 2.0| Glands, Ectasia | 1 1 1 1 1 1 | 10 1.1| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 1 1.0| Artery, Inflammation, Chronic Active | | 1 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 1 1 2 1| 12 1.6| Hypertrophy | 2 2 1 2 3 1 2 3 2 2 3 2 2 1 2 1 1 1| 34 1.9| Inflammation, Suppurative | 1 | 1 1.0| Capsule, Hyperplasia | 2 1 1 2 1 1 1 2 1 1 2 1 2 2 1 1 1 1 2 2 | 41 1.5| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 3 2 2| 43 2.1| __________________________________________________________________________|____________| Parathyroid Gland | + + M + + M + M M + + M + + M + + + + M + + M + +| 35 | Cyst | 2 2 | 2 2.0| __________________________________________________________________________|____________| Pituitary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 | Pars Distalis, Cyst | 2 2 | 2 2.0| Pars Distalis, Hyperplasia | 2 | 2 2.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Follicle, Cyst | 2 | 2 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 53 NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 2| 3| 2| 3| 3| 2| 2| 2| 2| 3| 2| 0| 2| 3| 3| | | 0| 0| 0| 0| 0| 4| 1| 1| 0| 0| 9| 0| 9| 1| 0| 9| 9| 9| 5| 0| 9| 5| 9| 0| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 1.5 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | 1 1 2 1 1 1 1 1 1 2 1 | 26 1.1| Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | 2 1 2 1 1 3 1 1 1 1 1| 25 1.4| Inflammation, Chronic Active | 3 2 | 6 2.3| Duct, Cyst | 2 2 2 3 2 3 2 3 2 2 3 | 20 2.3| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1| 31 1.1| Artery, Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Dilatation | 4 | 1 4.0| Infiltration Cellular, Mononuclear | | | Cell | 1 | 2 1.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 1 2.0| Mineralization | 1 1 | 2 1.0| Germinal Epithelium, Atrophy | | 2 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node | + + + + | 5 | Inguinal, Hyperplasia, Plasma Cell | 2 | 1 2.0| Lumbar, Hyperplasia, Plasma Cell | 3 | 1 3.0| Mediastinal, Hyperplasia, Plasma Cell| 2 | 1 2.0| Pancreatic, Hyperplasia, Lymphoid | 4 | 1 4.0| Renal, Hyperplasia, Plasma Cell | 4 | 1 4.0| Renal, Inflammation, Suppurative | 1 | 1 1.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Hyperplasia, Lymphoid | 4 | 1 4.0| Hyperplasia, Plasma Cell | 4 | 1 4.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + + + + + + M + + +| 43 | Hyperplasia, Lymphoid | 4 | 1 4.0| Hyperplasia, Plasma Cell | 4 | 1 4.0| Inflammation, Suppurative | 2 | 1 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 2| 3| 2| 3| 3| 2| 2| 2| 2| 3| 2| 0| 2| 3| 3| | | 0| 0| 0| 0| 0| 4| 1| 1| 0| 0| 9| 0| 9| 1| 0| 9| 9| 9| 5| 0| 9| 5| 9| 0| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 1.5 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Hematopoietic Cell Proliferation | 2 2 3 3 2 3 | 13 2.5| Hyperplasia, Lymphoid | 3 4 3 | 4 3.3| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Cyst | 2 2 2 1 2 2 2 2 1 1 2 2| 19 1.8| Ectopic Parathyroid Gland | | 1 2.0| Mineralization | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 1 4 | 2 2.5| Epidermis, Hyperplasia | 3 4 | 2 3.5| Epidermis, Ulcer | 1 4 | 2 2.5| Subcutaneous Tissue, Fibrosis | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | | 1 2.0| Infiltration Cellular, Mononuclear | | | Cell | 2 | 1 2.0| Inflammation, Chronic | | 1 1.0| Inflammation, Chronic Active | 3 | 2 2.5| Mineralization | | 1 1.0| Thrombosis | 1 | 2 1.5| Alveolar Epithelium, Hyperplasia | 2 2 2 | 6 2.0| Alveolus, Infiltration Cellular, | | | Histiocyte | 2 2 3 2| 8 2.4| Mediastinum, Inflammation, | | | Suppurative | | 1 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Foreign Body | X | 3 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 2| 3| 2| 3| 3| 2| 2| 2| 2| 3| 2| 0| 2| 3| 3| | | 0| 0| 0| 0| 0| 4| 1| 1| 0| 0| 9| 0| 9| 1| 0| 9| 9| 9| 5| 0| 9| 5| 9| 0| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 1.5 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Eye | | 1 | Cornea, Inflammation, Chronic Active | | 1 2.0| Cornea, Metaplasia, Squamous | | 1 4.0| __________________________________________________________________________|____________| Harderian Gland | | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infarct | 4 3| 2 3.5| Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 2 1 1| 37 1.1| Metaplasia, Osseous | 2 | 1 2.0| Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 49 1.0| Nephropathy | 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 1 1 2 2 1 2 2| 48 1.8| Artery, Inflammation, Chronic Active | | 1 3.0| Cortex, Cyst | 2 2 2 2 2 2 2 1 | 12 2.0| Renal Tubule, Hyperplasia | 2 2 2 2 2 | 8 2.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1| 17 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 2| 3| 3| 3| 2| 2| 5| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 2| | 0| 1| 9| 1| 1| 0| 9| 9| 5| 9| 0| 9| 9| 1| 0| 1| 0| 1| 1| 9| 1| 0| 9| 1| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 3 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + M + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | | Hyperplasia | 3 | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Peyer's Patch, Hyperplasia, Lymphoid | 2 | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Basophilic Focus | X X X | Clear Cell Focus | X X X X X X | Eosinophilic Focus | X X X X X X X | Fibrosis | | Hematopoietic Cell Proliferation | 2 1 | Infiltration Cellular, Mononuclear | | Cell | 1 1 1 | Inflammation, Chronic Active | 1 3 1 1 2 1 1 1 1 1 1| Inflammation, Granulomatous | 3 | Mineralization | | Mixed Cell Focus | X X X X X | Necrosis | 2 | Pigmentation | | Tension Lipidosis | X | Bile Duct, Cyst | 3 | Hepatocyte, Vacuolization Cytoplasmic| 1 1 1 2 | Hepatocyte, Portal, Hypertrophy | | Hepatocyte, Centrilobular, | | Degeneration | | __________________________________________________________________________| Mesentery | + + + + + | Inflammation, Chronic Active | 3 | Inflammation, Granulomatous | 3 3 | Mineralization | 1 | Fat, Necrosis | 4 | __________________________________________________________________________| Oral Mucosa | + + + + + + + + + +| Gingival, Foreign Body | X X X X X X X X X| Gingival, Inflammation, Acute | 1 1 1 2 1| Gingival, Inflammation, Chronic | | Active | 1 2 1 2 1 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 2| 3| 3| 3| 2| 2| 5| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 2| | 0| 1| 9| 1| 1| 0| 9| 9| 5| 9| 0| 9| 9| 1| 0| 1| 0| 1| 1| 9| 1| 0| 9| 1| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 3 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 | Inflammation, Chronic Active | 4 | Mineralization | 1 | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst, Squamous | | Epithelium, Hyperplasia | 3 | Epithelium, Inflammation, Chronic | | Active | 2 2 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Epithelium, Hyperplasia | 2 | Epithelium, Inflammation, Chronic | | Active | 2 | Glands, Ectasia | 1 1 1 1 1 1 1 1 1 1 | Serosa, Inflammation, Granulomatous | 3 | __________________________________________________________________________| Tooth | | Malformation | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 1 | Hyperplasia | 1 2 2 1 2 2 2 2 2 | Hypertrophy | 1 2 1 2 2 1 2 2 1 2 2 1 2 | Capsule, Hyperplasia | 1 2 1 1 2 2 2 1 1 1 1 1 2 2 1 1 2 1 1 1 2 1 1| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 1 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 | __________________________________________________________________________| Parathyroid Gland | M + + + + + + + + + + + + M + + + + + + + + + + +| Cyst | 2 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Cyst | 1 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicle, Cyst | 3 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 2| 3| 3| 3| 2| 2| 5| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 2| | 0| 1| 9| 1| 1| 0| 9| 9| 5| 9| 0| 9| 9| 1| 0| 1| 0| 1| 1| 9| 1| 0| 9| 1| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 3 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Coagulating Gland | | Inflammation, Suppurative | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Granuloma Sperm | 2 | Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | Mineralization | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 1 1 2 1 2 1 1 2 2 1 2 1 2 1 | Inflammation, Chronic Active | 3 3 2 2 2| Duct, Cyst | 2 2 2 3 3 2 2 2 2| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Inflammation, Suppurative | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Mineralization | | Germinal Epithelium, Atrophy | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 4 | __________________________________________________________________________| Lymph Node | + + | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Plasma Cell | | Infiltration Cellular, | | Polymorphonuclear | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | 3 | Inflammation, Chronic Active | 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 2 2 2 3 4 2 | Hyperplasia, Lymphoid | | __________________________________________________________________________| Thymus | + + + M + + + + + + + + + + + + + + + + + + + + +| Atypia Cellular | | Cyst | 2 2 2 2 2 | Ectopic Parathyroid Gland | | Thymocyte, Necrosis | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 2| 3| 3| 3| 2| 2| 5| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 2| | 0| 1| 9| 1| 1| 0| 9| 9| 5| 9| 0| 9| 9| 1| 0| 1| 0| 1| 1| 9| 1| 0| 9| 1| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 3 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 | Inflammation, Chronic Active | 4 4 1 | Epidermis, Hyperkeratosis | 2 | Epidermis, Hyperplasia | 3 3 | Epidermis, Ulcer | 4 4 | Epidermis, Pinna, Hyperplasia | 3 | Epidermis, Pinna, Ulcer | 4 | Pinna, Inflammation, Chronic Active | 2 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 | Thrombosis | 2 | Alveolar Epithelium, Hyperplasia | 2 | Alveolus, Infiltration Cellular, | | Histiocyte | 2 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | X X | Inflammation, Chronic Active | 1 | Nasolacrimal Duct, Inflammation, | | Suppurative | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + + + + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Infarct | | Infiltration Cellular, Mononuclear | | Cell | 1 1 1 3 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Inflammation, Chronic Active | 2 | Inflammation, Suppurative | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 2| 3| 3| 3| 2| 2| 5| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 2| | 0| 1| 9| 1| 1| 0| 9| 9| 5| 9| 0| 9| 9| 1| 0| 1| 0| 1| 1| 9| 1| 0| 9| 1| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 3 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Nephropathy | 1 2 2 1 3 1 2 1 2 1 1 2 1 1 1 2 2 1 1 2 1 1 1 1| Cortex, Cyst | | Renal Tubule, Hyperplasia | 2 2 2 2 2 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Infiltration Cellular, Mononuclear | | Cell | 1 1 1 | Inflammation, Suppurative | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 2| 2| 3| 2| 2| 3| 3| 2| 3| 2| 1| 3| 3| 9| 2| 3| 2| 3| 0| 2| 2| 3| 3| 0| | | 9| 9| 9| 1| 9| 9| 0| 1| 9| 0| 9| 2| 0| 0| 4| 9| 1| 9| 1| 2| 9| 9| 1| 1| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 3 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | 2 | 1 2.0| Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Peyer's Patch, Hyperplasia, Lymphoid | | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | | 1 2.0| Basophilic Focus | X X X | 6 | Clear Cell Focus | X X X X | 10 | Eosinophilic Focus | X X X X X | 12 | Fibrosis | 2 | 1 2.0| Hematopoietic Cell Proliferation | 1 | 3 1.3| Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 | 7 1.0| Inflammation, Chronic Active | 1 1 1 1 1 1 2 1 | 19 1.2| Inflammation, Granulomatous | | 1 3.0| Mineralization | 2 | 1 2.0| Mixed Cell Focus | X X X X X X | 11 | Necrosis | | 1 2.0| Pigmentation | 2 1 | 2 1.5| Tension Lipidosis | | 1 | Bile Duct, Cyst | | 1 3.0| Hepatocyte, Vacuolization Cytoplasmic| 2 1 2 2 2 | 9 1.6| Hepatocyte, Portal, Hypertrophy | 3 | 1 3.0| Hepatocyte, Centrilobular, | | | Degeneration | 3 | 1 3.0| __________________________________________________________________________|____________| Mesentery | + | 6 | Inflammation, Chronic Active | | 1 3.0| Inflammation, Granulomatous | | 2 3.0| Mineralization | | 1 1.0| Fat, Necrosis | | 1 4.0| __________________________________________________________________________|____________| Oral Mucosa | + + + + + + + + + + + + + + + + +| 27 | Gingival, Foreign Body | X X X X X X X X X X X X X X X X X| 26 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 2| 2| 3| 2| 2| 3| 3| 2| 3| 2| 1| 3| 3| 9| 2| 3| 2| 3| 0| 2| 2| 3| 3| 0| | | 9| 9| 9| 1| 9| 9| 0| 1| 9| 0| 9| 2| 0| 0| 4| 9| 1| 9| 1| 2| 9| 9| 1| 1| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 3 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Gingival, Inflammation, Acute | 1 1 1 1 2 | 10 1.2| Gingival, Inflammation, Chronic | | | Active | 2 2 1 2 2 2 1 1 2 2 2| 16 1.6| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 36 1.0| Inflammation, Chronic Active | | 1 4.0| Mineralization | | 1 1.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst, Squamous | 3 | 1 3.0| Epithelium, Hyperplasia | | 1 3.0| Epithelium, Inflammation, Chronic | | | Active | | 2 2.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Epithelium, Hyperplasia | | 1 2.0| Epithelium, Inflammation, Chronic | | | Active | | 1 2.0| Glands, Ectasia | 1 1 2 1 1 1 1 1 1 1 | 20 1.1| Serosa, Inflammation, Granulomatous | | 1 3.0| __________________________________________________________________________|____________| Tooth | + | 1 | Malformation | X | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | | 1 1.0| Hyperplasia | 1 2 1 2 2 2 2 | 16 1.8| Hypertrophy | 1 2 2 2 1 1 2 2 2 1 2 1 2 2 1| 28 1.6| Capsule, Hyperplasia | 2 1 2 2 1 2 2 1 1 1 1 2 1 3 2 2 1| 40 1.5| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | | 1 1.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 48 2.1| __________________________________________________________________________|____________| Parathyroid Gland | + M M M + M + + + M M + + + + + M + M + + + + M +| 39 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 2| 2| 3| 2| 2| 3| 3| 2| 3| 2| 1| 3| 3| 9| 2| 3| 2| 3| 0| 2| 2| 3| 3| 0| | | 9| 9| 9| 1| 9| 9| 0| 1| 9| 0| 9| 2| 0| 0| 4| 9| 1| 9| 1| 2| 9| 9| 1| 1| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 3 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Cyst | | 1 2.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + I + + + + + + + +| 49 | Pars Distalis, Cyst | 2 2 1 | 5 1.6| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Follicle, Cyst | | 2 2.5| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Coagulating Gland | +| 1 | Inflammation, Suppurative | 3| 1 3.0| __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Granuloma Sperm | | 1 2.0| Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 30 1.0| Mineralization | 1 | 1 1.0| __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | 1 1 2 1 1 1 1 2 1 2 2 2| 27 1.4| Inflammation, Chronic Active | 4 1 | 7 2.4| Duct, Cyst | 3 2 2 2 2 2 2 3 2 | 18 2.2| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 34 1.0| Inflammation, Suppurative | 3| 1 3.0| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | 1 1 | 2 1.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 4 | 1 4.0| Mineralization | 1 | 1 1.0| Germinal Epithelium, Atrophy | 3 2 | 2 2.5| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 4 4 | 4 3.8| __________________________________________________________________________|____________| Lymph Node | + | 3 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 2| 2| 3| 2| 2| 3| 3| 2| 3| 2| 1| 3| 3| 9| 2| 3| 2| 3| 0| 2| 2| 3| 3| 0| | | 9| 9| 9| 1| 9| 9| 0| 1| 9| 0| 9| 2| 0| 0| 4| 9| 1| 9| 1| 2| 9| 9| 1| 1| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 3 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Hyperplasia, Plasma Cell | 3 | 1 3.0| Infiltration Cellular, | | | Polymorphonuclear | 3 | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 | Hyperplasia, Lymphoid | | 1 3.0| Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | 2 2 3 3 2 2 3 | 14 2.4| Hyperplasia, Lymphoid | 3 | 1 3.0| __________________________________________________________________________|____________| Thymus | + + + + + + M + + + + + + + + + M + + + + M + + +| 46 | Atypia Cellular | 1 | 1 1.0| Cyst | 1 1 2 2 2 1 1 2 2 1 2 2 2| 18 1.7| Ectopic Parathyroid Gland | 2 2 1 | 3 1.7| Thymocyte, Necrosis | 2| 1 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | | 1 1.0| Inflammation, Chronic Active | | 3 3.0| Epidermis, Hyperkeratosis | | 1 2.0| Epidermis, Hyperplasia | | 2 3.0| Epidermis, Ulcer | | 2 4.0| Epidermis, Pinna, Hyperplasia | | 1 3.0| Epidermis, Pinna, Ulcer | | 1 4.0| Pinna, Inflammation, Chronic Active | | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skeletal Muscle | + + | 2 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | | 1 2.0| Thrombosis | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 2| 2| 3| 2| 2| 3| 3| 2| 3| 2| 1| 3| 3| 9| 2| 3| 2| 3| 0| 2| 2| 3| 3| 0| | | 9| 9| 9| 1| 9| 9| 0| 1| 9| 0| 9| 2| 0| 0| 4| 9| 1| 9| 1| 2| 9| 9| 1| 1| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 3 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Alveolar Epithelium, Hyperplasia | 3 2 2 2 | 5 2.2| Alveolus, Infiltration Cellular, | | | Histiocyte | 2 | 3 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Foreign Body | X X | 4 | Inflammation, Chronic Active | 4 2 | 3 2.3| Nasolacrimal Duct, Inflammation, | | | Suppurative | 4 | 1 4.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | + + + | 7 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infarct | 2 | 1 2.0| Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 39 1.1| Inflammation, Chronic Active | | 1 2.0| Inflammation, Suppurative | 1| 1 1.0| Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 47 1.0| Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 2 1 1 2 1 1 2 2 1| 47 1.3| Cortex, Cyst | 3 2 1 2 1 2 2 2 | 8 1.9| Renal Tubule, Hyperplasia | 2 2 2 | 9 2.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 3| 1 3.0| Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 1 1 | 9 1.0| Inflammation, Suppurative | 2| 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 6| 7| 7| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| DAY ON TEST | 3| 2| 3| 3| 3| 3| 3| 2| 3| 3| 0| 2| 3| 3| 8| 8| 8| 8| 8| 8| 8| 3| 3| 2| 3| | 0| 9| 0| 0| 0| 0| 0| 9| 1| 0| 3| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 0| 9| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 6 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 4 | __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + M + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Peyer's Patch, Hyperplasia, Lymphoid | 2 | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X | Clear Cell Focus | X X X | Eosinophilic Focus | X| Hematopoietic Cell Proliferation | 1 | Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 | Inflammation, Chronic Active | 1 1 1 1 1 2 1 1 1 1 1 1 | Mixed Cell Focus | X | Pigmentation | 1 1 | Bile Duct, Cyst | 3 | Bile Duct, Hyperplasia | 3 | Hepatocyte, Vacuolization Cytoplasmic| 2 1 1 1 2 2 2 1| __________________________________________________________________________| Mesentery | + | Inflammation, Chronic Active | 2 | __________________________________________________________________________| Oral Mucosa | + + + + | Gingival, Foreign Body | X X X X | Gingival, Inflammation, Acute | 1 2 | Gingival, Inflammation, Chronic | | Active | 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 2 | Artery, Mineralization | 2 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Epithelium, Hyperplasia | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | | Glands, Ectasia | 1 1 1 2 | __________________________________________________________________________| Tooth | + + | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 6| 7| 7| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| DAY ON TEST | 3| 2| 3| 3| 3| 3| 3| 2| 3| 3| 0| 2| 3| 3| 8| 8| 8| 8| 8| 8| 8| 3| 3| 2| 3| | 0| 9| 0| 0| 0| 0| 0| 9| 1| 0| 3| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 0| 9| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 6 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Malformation | X X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 | Mineralization | 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 2 3 1 1 1| Hypertrophy | 1 1 2 2 2 2 2 1 2 1| Capsule, Hyperplasia | 2 2 1 2 2 1 1 1 1 1 1 2 3 1 1 1 1 1 1 1 2 2 1 2| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2 2 2 3 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + M + + + M M M M + + + + + + +| Cyst | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Atypia Cellular | 2 | Pars Distalis, Cyst | 1 2 1 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Coagulating Gland | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1| Inflammation, Chronic Active | 2 | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 1 1 2 1 1 2 2 1 1 1 2 1 1| Inflammation, Chronic Active | 2 | Duct, Cyst | 2 2 2 3 3 3 2 2 2 2| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 6| 7| 7| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| DAY ON TEST | 3| 2| 3| 3| 3| 3| 3| 2| 3| 3| 0| 2| 3| 3| 8| 8| 8| 8| 8| 8| 8| 3| 3| 2| 3| | 0| 9| 0| 0| 0| 0| 0| 9| 1| 0| 3| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 0| 9| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 6 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | | __________________________________________________________________________| Thymus | + + + + + + + + + + + M + + + + + + + + + + + + +| Cyst | 1 2 2 1 2 1 2 | Ectopic Parathyroid Gland | 1 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 | Mineralization | | Thrombosis | | Alveolar Epithelium, Hyperplasia | 2 2 2| Alveolus, Infiltration Cellular, | | Histiocyte | 3 3 | Mediastinum, Inflammation, Chronic | | Active | 2 | Pleura, Inflammation, Chronic Active | 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | __________________________________________________________________________| Harderian Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 6| 7| 7| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| DAY ON TEST | 3| 2| 3| 3| 3| 3| 3| 2| 3| 3| 0| 2| 3| 3| 8| 8| 8| 8| 8| 8| 8| 3| 3| 2| 3| | 0| 9| 0| 0| 0| 0| 0| 9| 1| 0| 3| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 0| 9| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 6 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1| Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Nephropathy | 1 2 2 1 2 2 1 2 2 1 1 1 1 1 1 1 1 1 2 2 1 2| Cortex, Cyst | 2 2 2 2| Renal Tubule, Hyperplasia | 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 2| 2| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 3| 2| 2| 1| 2| | | 1| 3| 9| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 9| 9| 0| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 6 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 1 4.0| __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Peyer's Patch, Hyperplasia, Lymphoid | | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X | 2 | Clear Cell Focus | X | 4 | Eosinophilic Focus | X X | 3 | Hematopoietic Cell Proliferation | | 1 1.0| Infiltration Cellular, Mononuclear | | | Cell | 1 | 6 1.0| Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 2 | 21 1.1| Mixed Cell Focus | X | 2 | Pigmentation | 2 | 3 1.3| Bile Duct, Cyst | | 1 3.0| Bile Duct, Hyperplasia | | 1 3.0| Hepatocyte, Vacuolization Cytoplasmic| 1 2 2 2 1 2 1 2 | 16 1.6| __________________________________________________________________________|____________| Mesentery | | 1 | Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Oral Mucosa | + + + + + +| 10 | Gingival, Foreign Body | X X X X X X| 10 | Gingival, Inflammation, Acute | 1 1 1 1| 6 1.2| Gingival, Inflammation, Chronic | | | Active | 2 | 2 2.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | | 1 2.0| Artery, Mineralization | | 1 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 | 29 1.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 2| 2| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 3| 2| 2| 1| 2| | | 1| 3| 9| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 9| 9| 0| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 6 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Epithelium, Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | 1 1 | 2 1.0| Glands, Ectasia | 1 | 5 1.2| __________________________________________________________________________|____________| Tooth | | 2 | Malformation | | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 1 2.0| Mineralization | | 1 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 | 7 1.4| Hypertrophy | 2 1 2 1 2| 15 1.6| Capsule, Hyperplasia | 2 2 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1| 45 1.3| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 46 2.1| __________________________________________________________________________|____________| Parathyroid Gland | M + + + + + + + M + M M M M + + + M + + + + + + +| 38 | Cyst | 2 | 1 2.0| __________________________________________________________________________|____________| Pituitary Gland | + I + + + + I + + + + + + I + + + + I + + + + + +| 46 | Atypia Cellular | | 1 2.0| Pars Distalis, Cyst | | 3 1.3| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Coagulating Gland | + + | 2 | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 1 1 1 1| 21 1.0| Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Infiltration Cellular, Mononuclear | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 2| 2| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 3| 2| 2| 1| 2| | | 1| 3| 9| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 9| 9| 0| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 6 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Cell | 1 1 2 1 1 1 1 1 1 1 2 2 | 26 1.3| Inflammation, Chronic Active | 2 4 | 3 2.7| Duct, Cyst | 2 3 2 2 3 3 | 16 2.4| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 32 1.0| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node | + | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + M + + M + + + + + + + + + I +| 47 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + M + + + + + M + + + M + + + + + + + + + + + + +| 47 | Inflammation, Chronic Active | | 1 3.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | 2 2 3 3 | 4 2.5| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Cyst | 1 1 1 2 2 1 2 2 2 1| 17 1.5| Ectopic Parathyroid Gland | | 1 1.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M + M M M M + M M M M M M M M M M| 2 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skeletal Muscle | + | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 3 1 1 | 4 1.8| Mineralization | 1 1| 2 1.0| Thrombosis | 3 | 1 3.0| Alveolar Epithelium, Hyperplasia | 1 | 4 1.8| Alveolus, Infiltration Cellular, | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88050-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:33:12 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 2| 2| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 3| 2| 2| 1| 2| | | 1| 3| 9| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 9| 9| 0| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 6 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Histiocyte | 2 | 3 2.7| Mediastinum, Inflammation, Chronic | | | Active | | 1 2.0| Pleura, Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Foreign Body | X | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | __________________________________________________________________________|____________| Harderian Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 1 1 1 1 1| 22 1.0| Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2| 36 1.0| Nephropathy | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 2| 39 1.3| Cortex, Cyst | 2 2 2 2 2 | 9 2.0| Renal Tubule, Hyperplasia | 2 | 2 2.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 1 1 | 10 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked ------------------------------------------------------------ ---------- END OF REPORT ---------- 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