Q is thienyl optionally substituted with 1-2 independent R³ substituents;

Y is aryl which is optionally substituted with 1-4 independent R³¹ substituents;

J is —NR¹R², —OR¹, or —SR¹;

A is quinolinyl which is optionally substituted by 1-5 independent R⁴ substituents;

R¹ and R²are C_0-6alkyl, aryl, cycloC_3-10alkyl, cycloC_3-10alkenyl, C_2-6alkenyl, C_2-6alkynyl, each of which is optionally substituted by 1-5 independent R⁴¹ substituents;

R³ and R³¹ each independently is C_0-6alkyl, cycloC_3-10alkyl, haloalkyl, halogen, cyanoC_0-6alkyl, nitroC_0-6alkyl, hydroxyC_0-6alkyl, C_0-6alkylaminoC_0-6alkyl, acylC_0-6alkyl, substituted acyl, acylaminoC_0-6alkyl, substituted acylamino, acyloxyC_0-6alkyl, substituted acyloxy, arC_0-6alkyl, heteroarylC_0-6alkyl, arylhydrazino, alkylsulfonamidoC_0-6alkyl, arylsulfonamidoC_0-6alkyl, alkylsulfonylC_0-6alkyl, arylsulfonylC_0-6alkyl, alkylsulfinylC_0-6alkyl, heterocyclylsulfonylC_0-6alkyl, silyl, siloxyC_0-6alkyl, alkenoxyC_0-6alkyl, alkynoxyC_0-6alkyl, C_0-6alkoxyC_0-6alkyl, C_1-6alkylthioC_0-6alkyl, C_2-6alkenyl, acylC_2-6alkenyl, C_2-6alkynyl, acylC_2-6alkynyl, arC_0-6alkylaminoC_0-6alkyl, arC_0-6alkylthioC_0-6alkyl, arC_0-6alkoxyC_0-6alkyl, substituted arC_0-6alkoxy, substituted arC_0-6alkylthio, or substituted arC_0-6alkoxy;

R⁴ and R⁴¹ each independently is C_0-6alkyl, cycloC_3-10alkyl, oxo, halogen, haloalkyl, cyanoC_0-6alkyl, nitroC_0-6alkyl, hydroxyC_0-6alkyl, (C_0-6alkyl)(C_0-6alkyl)aminoC_0-6alkyl, (C_0-6alkyl)(C_0-6alkyl)amino(C_1-6alkyl)aminoC_0-6alkyl, acylaminoC_0-6alkylamino, acylC_0-6alkyl, (C_0-6alkyl)(C_0-6alkyl)aminoacyl, substituted acyl, guanidinoC_0-6alkyl, hydroxyiminoC_0-6alkyl, acylaminoC_0-6alkyl, optionally substituted acylamino, optionally substituted acyloxyC_0-6alkyl, optionally substituted arC_0-6alkyl, optionally substituted heteroarylC_0-6alkyl, optionally substituted heterocyclylC_0-6alkyl, cyanoaminoC_0-6alkyl, C_0-6alkylhydrazino, heterocyclylamino, arC_0-6alkylhydrazino, alkylsulfonylC_0-6alkyl, arC_0-6alkylsulfonylC_0-6alkyl, alkylsulfinylC_0-6alkyl, alkylsulfonamidoC_0-6alkyl, arC_0-6alkylsulfonamidoC_0-6alkyl, aminoC_0-6alkylsulfonyl, C_0-6alkylaminosulfonyl, acylC_1-6alkylsulfonyl, heterocyclylsulfonyl, aminoC_0-6alkylsulfinyl, acylC_1-6alkylsulfinyl, silyl, siloxy, alkenoxy, alkynoxy, C_2-6alkenyl, acylC_2-6alkenyl, C_2-6alkynyl, acylC_2-6alkynyl, hydroxyC_2-6alkynyl, aminoC_2-6alkynyl, C_1-6alkoxyC_0-6alkyl, C_1-6alkylthioC_0-6alkyl, hydroxyC_1-6alkoxyC_0-6alkyl, hydroxyC_1-6alkylthioC_0-6alkyl, acylC_1-6alkoxyC_0-6alkyl, acylC_1-6alkylthioC_0-6alkyl, C_0-6alkylaminoC_1-6alkoxyC_0-6alkyl, C_0-6alkylaminoC_1-6alkylthioC_0-6alkyl, acylaminoC_1-6alkoxyC_0-6alkyl, acylaminoC_1-6alkylthioC_0-6alkyl, arC_0-6alkylaminoC_0-6alkyl, arC_0-6alkylthioC_0-6alkyl, arC_0-6alkoxyC_0-6alkyl, arC_0-6alkylamino, arC_0-6alkylaminoC_0-6alkyl, arC_0-6alkylthio, optionally substituted arC_0-6alkoxy, optionally substituted arC_0-6alkylthio, or optionally substituted arC_0-6alkoxy; and

R⁵ is C_0-6alkyl, C_1-6alkoxyC_1-6alkyl, C_1-6alkylthioC_1-6alkyl, C_0-6alkylaminoC_1-6alkyl, arC_0-6alkyl;

provided that the compound is not

2,2,2-trifluoroethyl N′-cyano-N-{4-[({3-[(quinolin-4-ylmethyl)amino]thien-2-yl}carbonyl)amino]phenyl}-imidocarbamate;

2,2,2-trifluoroethyl N-{2-chloro-5-[({3-[(quinolin-4-ylmethyl)amino]thien-2-yl}carbonyl)amino]phenyl}-N′-cyanoimidocarbamate; or

N-{1-[(cyanoimino)(dimethylamino)methyl]-2,3-dihydro-1H-indol-6-yl}-3-((quinolin-4-ylmethyl)amino)thiophene-2-carboxamide;

or a pharmaceutically acceptable salt thereof.