Home
Search
Study Topics
Glossary
|
|
|
|
|
|
Sponsored by: |
University Hospital, Bordeaux |
---|---|
Information provided by: | University Hospital, Bordeaux |
ClinicalTrials.gov Identifier: | NCT00221819 |
To humidify gases during non invasive ventilation, both to heated humidifier (HH) and heat and moisture exchanger (HME) are routinely used. Patients receiving non invasive ventilation for acute respiratory failure were randomized to HME or HH. The purpose of this study was to evaluate respiratory parameters and arterial blood gases (ABG) of patients during NIV with small dead space HME compared to HH.
Condition | Intervention |
---|---|
Acute Lung Injury Pneumonia Chronic Obstructive Pulmonary Disease Acute Heart Failure |
Device: heated humidifier (device) Device: Heat and moisture exchanger (device) |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Open Label, Active Control, Crossover Assignment, Pharmacodynamics Study |
Official Title: | Prospective Study of the Influence of the Humidification Mode on Ventilation Parameters and Arterial Blood Gases in Non Invasive Ventilation |
Study Start Date: | June 2004 |
Estimated Study Completion Date: | June 2005 |
Objective: Few data are reported in the field of noninvasive ventilation (NIV) regarding humidification devices. It was previously suggested that standard heat and moisture exchangers (HME) had adverse gasometrical and clinical outcomes in acute respiratory failure (ARF) of chronic respiratory failure patients (CRF). This study was performed to evaluate respiratory parameters and arterial blood gases (ABG) of patients during NIV with small dead space HME compared to heated humidifier (HH).
Design: Prospective randomized cross-over study. Setting: A 16-bed medical intensive care unit (ICU) and a 14-bed medico surgical ICU.
Patients: Patients receiving NIV for ARF in the context of CRF or hypoxic ARF and patients with persistent weaning failure receiving NIV just after extubation.
Measurements: HME and HH were randomly compared during 2 NIV periods of 30 minutes separated by a 20 to 30 minutes period of spontaneous breathing with oxygen. ABG were collected at baseline and at the end of each period. As well as respiratory parameters including volumes, pressures, P0.1, a comfort score, capnometry and oxygen saturation. Two sets of patients were successively studied whether they have a flex tube added to the ventilatory circuit or not.
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
-
France | |
Département de Réanimation Médicale, Hôpital Pellegrin-Tripode, Place A. Raba Léon, | |
Bordeaux, France, 33076 |
Principal Investigator: | alexandre Boyer, Dr | University Hospital, Bordeaux |
Study ID Numbers: | 9300-02 |
Study First Received: | September 20, 2005 |
Last Updated: | September 20, 2005 |
ClinicalTrials.gov Identifier: | NCT00221819 |
Health Authority: | France: Afssaps - French Health Products Safety Agency |
Humidification Heat and moisture exchanger Heated humidifier, non invasive ventilation |
Heart Failure Lung Diseases, Obstructive Heart Diseases Respiratory Tract Infections Respiratory Tract Diseases Lung Diseases |
Respiration Disorders Respiratory Distress Syndrome, Adult Acute respiratory distress syndrome Pneumonia Pulmonary Disease, Chronic Obstructive |
Cardiovascular Diseases |