Muurahainen N, Santos G, Kleintop M, Pettit R, Balser J, Falutz J, Glesby M, Kotler D; Conference on Retroviruses and Opportunistic Infections.

7th Conf Retrovir Oppor Infect Jan 30 Feb 2 2000 Conf Retrovir Oppor Infect 7th 2000 San Franc Calif. 2000 Jan 30-Feb 2; 7: 80 (abstract no. 26).

Serono Labs Inc., Norwell, MA.

Objective: To compare manifestations of HARS or lipodystrophy syndrome' in a database of male (M) & female (F) HIV patient (pt) case reports. Methods: The survey included 395 pts from 49 centers accruing cases with body shape abnormalities diagnosed by MD physical exam and patient self-assessment. Cases were classified as having any fat accumulation (FA), any fat depletion (FD) or both. SALSA(TM) (self-ascertained lipodystrophy syndrome assessment) questionnaires asked in detail about morphology. Chart review established histories (hx) of hypertriglyceridemia (HTG), hypercholesterolemia (HC), and hyperglycemia (HGL). Gender differences were ascertained by Fisher's exact test. Results: The 324 M and 71 F cases were aged 25 to 71 (mean = 43) years, with mean (+/- SD) CD4 counts 404 (+/- 607cells/mm3), mean BMI 26 (+/- 11) kg/m2 , and 62% with plasma HIV-1-RNA below 500 copies/ml (VL<500). There were no significant gender differences in percentages (%) with VL<500, and % receiving antiretrovirals (97%M, 94%F), but 19%M and 37%F had not received protease inhibitors (p<.0014). Fat accumulation (FA, in the breast area, abdomen, neck, and/or as a hump) occurred in 84%M and 97%F (p <.0019). Fat depletion (FD, in the face, limbs, and/or buttocks) occurred in 77%M and 61%F (p<.0069). A mix (FA+FD) was reported in 65% M and 58%F (NS). Hx of HTG, HC, & HGL was noted in 68%, 54%, and 11% of male cases, and 32%, 32%, and 7% of female cases, respectively (p < .001, .001, NS). Conclusion: When surveyed using the same methodology, M & F with HARS present with different patterns of morphologic and metabolic abnormalities. Additional investigation is needed to delineate the extent to which these gender differences may be attributable to drug, immunologic, hormonal, or other parameters.

Publication Types:

• Meeting Abstracts

Keywords:

• AIDS Vaccines
• Acquired Immunodeficiency Syndrome
• Adipose Tissue
• Body Constitution
• Female
• HIV Infections
• HIV Seropositivity
• HIV-Associated Lipodystrophy Syndrome
• Humans
• Male
• Protease Inhibitors
• Sex Characteristics
• Syndrome

Other ID:

• GWAIDS0005408

UI: 102242905

From Meeting Abstracts