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EC-NUMBER
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1.1.1.62
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ENZYME-NAME
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estradiol 17beta-dehydrogenase
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ENZYME-SYSNAME
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Also acts on (S)-20-hydroxypregn-4-en-3-one and related compounds, oxidizing the (S)-20-group. B-specific with respect to NAD(P)+ (cf. EC 1.1.1.149 20alpha-hydroxysteroid dehydrogenase).
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ENZYME-CLASS
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Oxidoreductases Acting on the CH-OH group of donors With NAD+ or NADP+ as acceptor
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SYNONYMS
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17beta,20alpha-hydroxysteroid dehydrogenase;;
17beta-HSD;
17beta-estradiol dehydrogenase;;
20alpha-hydroxysteroid dehydrogenase;;
>>more synonyms
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REACTION
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estradiol-17beta + NAD(P)+ = estrone + NAD(P)H + H+ [RN:R02352 R02353]
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PATHWAY
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EMP-PATHWAYS:
NO EMP PATHWAY FOUND
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KEGG-PATHWAYS:
Androgen and estrogen metabolism;
>>more KEGG pathways
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GO_TERM
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GO:0004303:estradiol 17-beta-dehydrogenase activity
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ENZYME-COMMENT
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estradiol-17beta:NAD(P)+ 17-oxidoreductase
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