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Partial table of contents: Overview of Mutagenesis Techniques (T. Fong). The Substituted-Cysteine Accessibility Method (J. Javitch). Metal-Ions as Atomic Scale Probes of G Protein-Coupled Receptor Structure (J. Schetz & D. Sibley). Genetic Approaches for Studying the Structure and Function of G Protein-Coupled Receptors in Yeast (C. Sommers & M. Dumont). Electron-Crystallographic Analysis of Two-Dimensional Rhodopsin Crystals (G. Schertler). Site-Directed Spin-Labeling (SDSL) Studies of the G Protein-Coupled Receptor Rhodopsin (D. Farrens). Lead Discovery and Development for G Protein-Coupled Receptors (D. Underwood & M. Cascieri). Index.