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Comprehensive alignment of G protein-coupled receptor sequences
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Human sequences are used for this alignment, unless noted.
1 50
GPCRAelegans FPGGGGGFPG GGGFPGGSNT STQPHTTSNS GGGGFPGGGG FPGGGTPFTN
GRH .......... .......... .......... .......... ..........
TRH .......... .......... .......... .......... ..........
FSHprec RQ...EVDYM TQTRGQRSSL AEDNESSYSR GF........ ..........
TSHprec MQSLRQRKSV NALNSPLHQE YEENLGDSIV GYKEKSKFQD THNNAHYYVF
LH_CGprec KQCESTVRKV SNKTLYSSML AESELSGWDY EY........ ..........
PGE_EP1 .......... .......... .......... .......... ..........
PGE_EP2 .......... .......... .......... .......... ..........
PGE_EP3 .......... .......... .......... .......... ..........
PGF .......... .......... .......... .......... ..........
PGI .......... .......... .......... .......... ..........
TXA2 .......... .......... .......... .......... ..........
PAF .......... .......... .......... .......... ..........
M2 .......... .......... .......... .......... ..........
M4 .......... .......... .......... .......... ..........
M1 .......... .......... .......... .......... ..........
M3 .......... .......... .......... .......... .MTLHNNSTT
M5 .......... .......... .......... .......... ..........
H1 .......... .......... .......... .......... ..........
H2 .......... .......... .......... .......... ..........
5HT1A .......... .......... .......... .......... ..........
5HT1B .......... .......... .......... .......... ..........
5HT1D .......... .......... .......... .......... ..........
5HT1E .......... .......... .......... .......... ..........
5HT1F .......... .......... .......... .......... ..........
5HT2A .......... .......... .........M DILCEENTSL SSTTNSLMQL
5HT2B .......... .......... .......... .......... ..........
5HT2C .......... .......... .......... ......MVNL RNAVHSFLVH
5HT5A .......... .......... .......... .......... ..........
5HT5Brat .......... .......... .......... .......... ..........
5HT6rat .......... .......... .......... .......... ..........
5HT7 .......... .......... ........MM DVNSSGRPDL YGHLRSFLLP
alpha1A .......... .......... .......... .......... ..........
alpha1B .......... .......... .......... .......... ..........
alpha1C .......... .......... .......... .......... ..........
alpha2A .......... .......... .......... .......... ..........
alpha2B .......... .......... .......... .......... ..........
alpha2C1 .......... .......... .......... .......... ..........
alpha2C2 .......... .......... .......... .......... ..........
beta1 .......... .......... .......... .......... ..........
beta2 .......... .......... .......... .......... ..........
beta3 .......... .......... .......... .......... ..........
beta4turkey .......... .......... .......... .......... ..........
D1A .......... .......... .......... .......... ..........
D2 .......... .......... .......... .......... ..........
D3 .......... .......... .......... .......... ..........
D4 .......... .......... .......... .......... ..........
D5 .......... .......... .......... .......... ..........
A1 .......... .......... .......... .......... ..........
A2a .......... .......... .......... .......... ..........
A2b .......... .......... .......... .......... ..........
A3 .......... .......... .......... .......... ..........
OCdrome PSADQILFVN VTTTVAAAAL TAAAAVSTTK SGNGNAARGY TDSDDDAGMG
ACTH .......... .......... .......... .......... ..........
MSH .......... .......... .......... .......... ..........
MC3 .......... .......MSI QKKYLEGDFV FPVSSSSFLR TLLEPQLGSA
MC4 .......... .......... .......... .......... ........MV
MC5 .......... .......... .......... .......... ..........
melatonin .......... .......... .......... .......... ..........
oxytocin .......... .......... .......... .......... ..........
conopressinLs .......... .......... .......... .........M DLELNLTNGF
V1A .......... .......... .......... .......... ..........
V1B .......... .......... .......... .......... ..........
V2 .......... .......... .......... .......... ..........
CCK_A .......... .......... .......... .......... ..........
CCK_B .......... .......... .......... .......... ..........
NPY1 .......... .......... .......... .......... ..........
NTR .......... .......... .......... .......... ......MRLN
NK1 .......... .......... .......... .......... ..........
NK2 .......... .......... .......... .......... ..........
NK3 .......... .......... ....MATLPA AETWIDGGGG VGADAVNLTA
blueops .......... .......... .......... .......... ..........
greenops .......... .......... .......... .......... ..........
redops .......... .......... .......... .......... ..........
rhodopsin .......... .......... .......... .......... ..........
violetopsGg .......... .......... .......... .......... ..........
opsin_crab .......... .......... .......... .......... ..........
ET_Aprec .......... .......... ..METLCLRA SFWLALVGCV ISDNPERYST
ET_Bprec ........MQ PPPSLCGRAL VALVLACGLS RIWGEERGFP PDRATPLLQT
ET_Cfrog .......... .......... .MATVILFVA WMACLMVGVC YQEFQTQQNF
galanin .......... .......... .......... .......... ..........
NMB .......... .......... .......... .......... ..........
GRP .......... .......... .......... .......... ..........
BRS3 .......... .......... .......... .......... ..........
deltaOP .......... .......... .......... .......... ..........
kappaOP .......... .......... .......... .......... ..........
muOP .......... .......... .......... ........MD SSAAPTNASN
OPRX .......... .......... .......... .......... ..........
CB1 LADTTFRTIT TDLLYVGSND IQYEDIKGDM ASKLGYFPQK FPLTSFRGSP
CB2 .......... .......... .......... .......... ..........
SSTR1 .......... .......... .......... .......... ..........
SSTR2 .......... .......... .......... .......... ..........
SSTR3 .......... .......... .......... .......... ..........
SSTR4 .......... .......... .......... .......... ..........
SSTR5 .......... .......... .......... .......... ..........
IL8A .......... .......... .......... .......... ..........
IL8B .......... .......... .......... .......... ..........
AT1a .......... .......... .......... .......... ..........
AT1brat .......... .......... .......... .......... ..........
AT2 .......... .......... .......... .......... ..........
BK1 .......... .......... .......... .......... ..........
BK2 .......... .......... .......... .......... ..........
P2Y7 .......... .......... .......... .......... ..........
P2Y6 .......... .......... .......... .......... ..........
P2Y5 .......... .......... .......... .......... ..........
P2Y4 .......... .......... .......... .......... ..........
P2Y3chick .......... .......... .......... .......... ..........
P2Y2 .......... .......... .......... .......... ..........
P2Y1 .......... .......... .......... .......... ..........
THRprec .......MGP RRLLLVAACF SLCGPLLSAR TRARRPESKA TNATLDPRSF
C5a .......... .......... .......... .......... ..........
GP01mouse .......... .......... .......... .......... ..........
R334rat .......... .......... .......... .......... ..........
GP21mouse .......... .......... .......... .......... ..........
GCRCmouse .......... .......... .......... ........MK VPPVLLLFLL
TXKR .......... .......... .......... .......... MASPAGNLSA
G10Drat .......... .......... .......... .......... ..........
RDC1 .......... .......... .......... .......... ..........
BLR1 .......... .......... .......... .......... ..........
CL5 .......... .......... .......... .......... ..........
LCR1 .......... .......... .......... .......... ..........
EBI1 .......... .......... .......... .......... ..........
RBS1rat .......... .......... .......... .......... ..........
EBI2 .......... .......... .......... .......... ..........
GCRTchick .......... .......... .......... .......... ..........
APJ .......... .......... .......... .......... ..........
RTArat .......... .......... .......... .......... ..........
UHRrat .......... .......... .......... .......... .........M
FMRL1 .......... .......... .......... .......... ..........
FMRL2 .......... .......... .......... .......... ..........
fMLP .......... .......... .......... .......... ..........
OLF1catfish .......... .......... .......... .......... ..........
OLF3catfish .......... .......... .......... .......... ..........
OLF8catfish .......... .......... .......... .......... ..........
OLF32Acatfish .......... .......... .......... .......... ..........
OLF32Bcatfish .......... .......... .......... .......... ..........
OLF32Ccatfish .......... .......... .......... .......... ..........
OLF32Dcatfish .......... .......... .......... .......... ..........
OLF47catfish .......... .......... .......... .......... ..........
OLF202catfish .......... .......... .......... .......... ..........
OLFCOR1chicken .......... .......... .......... .......... ..........
OLFCOR2chicken .......... .......... .......... .......... ..........
OLFCOR3chicken .......... .......... .......... .......... ..........
OLFCOR4chicken .......... .......... .......... .......... ..........
OLFCOR5chicken .......... .......... .......... .......... ..........
OLFCOR6chicken .......... .......... .......... .......... ..........
OLFdog .......... .......... .......... .......... ..........
OLF07E .......... .......... .......... .......... ..........
OLF07I .......... .......... .......... .......... ..........
OLF07J .......... .......... .......... .......... ..........
OLFOR3mouse .......... .......... .......... .......... ..........
OLFrat .......... .......... .......... .......... ..........
OLFF3rat .......... .......... .......... .......... ..........
OLFF5rat .......... .......... .......... .......... ..........
OLFF6rat .......... .......... .......... .......... ..........
OLFF12rat .......... .......... .......... .......... ..........
OLFI3rat .......... .......... .......... .......... ..........
OLFI7rat .......... .......... .......... .......... ..........
OLFI8rat .......... .......... .......... .......... ..........
OLFI9rat .......... .......... .......... .......... ..........
OLFI14rat .......... .......... .......... .......... ..........
OLFI15rat .......... .......... .......... .......... ..........
OLFOR17_40 .......... .......... .......... .......... ..........
GUST27rat .......... .......... .......... .......... ..........
RPE .......... .......... .......... .......... ..........
HHRF1 .......... .......... .......... .......... ..........
HHRF2 .......... .......... .......... .......... ..........
HHRF3 .......... .......... .......... .......... ..........
MCP-1A .......... .......... .......... .......... ..........
MCP-1B .......... .......... .......... .......... ..........
PPR1bovine .......... .......... .......... .......... ..........
51 100
GPCRAelegans QFTIPHIPNV HQSTADPPTL IPHSNHTPNG TQFHQCSKIP VQCVPKSDAF
GRH .......... ............... MANSA SPEQNQNHCS AINNSIPLMQ
TRH .......... .......... .......... ....MENETV SELNQTQLQP
FSHprec .......... .......... ...DMTYTEF DYDLCNEVVD VTCSPKPDAF
TSHprec FEEQEDEIIG FGQELKNPQE ETLQAFDSHY DYTICGDSED MVCTPKSDEF
LH_CGprec .......... .......... ...GFCLPK. .........T PRCAPEPDAF
PGE_EP1 .......MSP CGPLNLSLAG EATTCAAP.. .......... ........WV
PGE_EP2 .......... .......... ..MSTPGV.. .......... ........NS
PGE_EP3 .......... ..MGNASNDS QSEDC..E.. .......... ........TR
PGF .......... ...MSMNNSK QLVSPAAA.. .......... ........LL
PGI .......... .......... .......... .......... ......MADS
TXA2 .......... .....MWPNG SSLGPCFR.. .......... ........PT
PAF .......... .......... .......... ...M...... E.PD...HSS
M2 .......... .......... .......... ...MNNSTNS SNNSLALTSP
M4 .......... .......... .......MAN FTPVNGSSGN QSVRLVTSSS
M1 .......... .......... .......... ..MNTSAPPA VSPNITVLAP
M3 SPLFPNISSS WIHSPSDAGL PPGTVTHFGS YNVSRAAGNF SSPDGTTDDP
M5 .......... .......... .........M EGDSYHNATT VNGTPVNHQP
H1 .......... .......... .......... ..MSLPNSSC LLEDKMCEGN
H2 .......... .......... .......... .......... .MAPNGTASS
5HT1A .......... .......... ...MDVLSPG QGNNTTSPPA PFETGGNTTG
5HT1B .......... MEEPGAQCAP PPPAGSETWV PQANLSSAPS QNCSAKDYIY
5HT1D .......... ........MS PLNQSAEGLP QEA...SNRS LNATETSEAW
5HT1E .......... .......... .......... .......MNI TNCTTEASMA
5HT1F .......... .......... .......... ......MDFL NSSDQNLTSE
5HT2A NDDTRLYSND FNSGEANTSD AFNWTVDSEN RTNLSCEGCL SPSCLSLLHL
5HT2B .....MALSY RVSELQSTIP EHILQSTFVH VISSNWSGLQ TESIPEEMKQ
5HT2C LIGLLVWQCD ISVSPVAAIV TDIFNTSDGG RFKFPDGV.. ..........
5HT5A .......... .........M DLPVNLTSFS LSTPSPLETN HSLGKDDLRP
5HT5Brat .......MEV SNLSGATPGI AFPPGPESCS DSPSSGRSMG STPGGLILSG
5HT6rat .......... .......... .......... ...MVPEPGP VNSSTPAWGP
5HT7 EVGRGLPDLS PDGGADPVAG SWAPHLLSEV TASPAPTWDA PPDNASGCGE
alpha1A .....MAAAL RSVMMAGYLS EWRTPTYRST EMVQRLRMEA VQHSTSTAAV
alpha1B .......... ..MNPDLDTG HNTSAPAHWG ELKNANFTGP NQTSSNSTLP
alpha1C .......... .......... .......... ...MVFLSGN ASDSSNCTQP
alpha2A .......... .......... ...MGSLQPD AGNASWNGTE APGGGARATP
alpha2B .......... .......... .......... .......... .......MDH
alpha2C1 ........MA SPALAAALAV AAAAGPNASG AGERGSGGVA NASGASWGPP
alpha2C2 ........MA SPALAAALAV AAAAGPNASG AGERGSGGVA NASGASWGPP
beta1 MGAGVLVLGA SEPGNLSSAA PLPDGAATAA RLLVPASPPA SLLPPASESP
beta2 .......... .......... .MGQPGNGSA FLLAPNRSHA ....PDHDVT
beta3 .......... .......... ..MAPWPHEN SSLAPWPDLP TLAPNTANTS
beta4turkey .......... .......... .......... ......MTPL PAGNGSVPNC
D1A .......... .......... .......... ......MRTL NTSAMDGTGL
D2 .......... .......... .....MDPLN LSWYDDDLER QNWSRPFNGS
D3 .......... .......... .......... MASLSQLSSH LNYTCGAENS
D4 .......... .......... .....MGNRS TADADGLLAG RGPAAGASAG
D5 .......... .........M LPPGSNGTAY PGQFALYQQL AQGNAVGGSA
A1 .......... .......... .......... .......... ..........
A2a .......... .......... .......... .......... ..........
A2b .......... .......... .......... .......... ..........
A3 .......... .......... .......... .......... .......MPN
OCdrome TEAVANISGS LVEGLTTVTA ALSTAQADKD SAGECEGAVE ELHASILGLQ
ACTH .......... ........MK HIINSYEN.. .......... .....INNTA
MSH ....MAVQGS QRRLLGSLNS TPTAIPQL.. .......... .....GLAAN
MC3 LLTAMNASCC LPSVQPTLPN GSEHLQAP.. .......... .....FFSNQ
MC4 NSTHRGMHTS LHLWNRSSYR LHSNASES.. .......... .....LGKGY
MC5 ......MNSS FHLHFLDLNL NATEGNLS.. .......... .....GPNVK
melatonin .......... .......... .......... ..MQGNGSAL PNASQPVLRG
oxytocin .......... ........ME GALAANWSAE AANASAAPPG AEGNRTAGPP
conopressinLs MLMPPTKRAV IQIASNEKVG YDVSKSQPVN ATTDLNTTRM NATNSTEVSY
V1A ........MR LSAGPDAGPS GNSSPWWPLA TGAGNTSREA EALGEGNGPP
V1B .......... .......... .....MDSGP LWDANPTPRG TLSAPNATTP
V2 ........ML MASTTSAVPG HPSLPSLP.. .......... ..SNSSQERP
CCK_A .......... ........MD VVDSLLVNGS NITPPCELGL ENETLFCLDQ
CCK_B .....MELLK LNRSVQGTGP GPGASLCRPG APLLNSSSVG NLSCEPPRIR
NPY1 .......... .........M NSTLFSQVEN HSVHSNFSEK NAQLLAFEND
NTR SSAPGTPGTP AADPFQRAQA GLEEALLAPG FGNASGNASE RVLAAPSSEL
NK1 .......... .......... .......MDN VLPVDSDLSP NISTNTSEPN
NK2 .......... .......... ......MGTC DIVTEANISS GPESNTTGIT
NK3 SLAAGAATGA VETGWLQLLD QAGNLSSSPS ALGLPVASPA PSQPWANLTN
blueops .......... .......... ..MRKMSEEE FYL.FKNISS V..GPWDGPQ
greenops .....MAQQW SLQRLAGRHP QDSYEDSTQS SIFTYTNSNS T.RGPFEGPN
redops .....MAQQW SLQRLAGRHP QDSYEDSTQS SIFTYTNSNS T.RGPFEGPN
rhodopsin .......... .......... ..MNGTEGPN FYVPFSNATG VVRSPFEYPQ
violetopsGg .......... .......... ....MSSDDD FYL...FTNG SVPGPWDGPQ
opsin_crab .......... ..MANQLSYS SLGWPYQPNA SVVDTMPKEM LYMIHEHWYA
ET_Aprec NLSNHVDDFT TFRGTELSFL VTTHQPTNL. ......VLPS NGSMHNYCPQ
ET_Bprec AEIMTPPTKT LWPKGSNASL ARSLAPAEVP KGDRTAGSPP RTISPPPCQG
ET_Cfrog PDISNPSQEL NQEPAHRIVQ LDSIQNNGAL NMSTGNVLNM SPPPPSPCLS
galanin .......... .......... ......MELA VGNLSEGNAS WPEPPAPEPG
NMB .......... ......MPSK SLSNLSVTTG ANESGSVPEG WERDFLPASD
GRP .......... .........M ALNDCFLLNL EVDHFMHCNI SSHSADLPVN
BRS3 .......... ..MAQRQPHS PNQTLISITN DTESSSSVVS NDNTNKGWSG
deltaOP .........M EPAPSAGAEL Q.PPLFANAS DAYPSAFPSA GANASGPPGP
kappaOP MESPIQIFRG EPGPTCAPSA CLPPNSSAWF PGWAEPDSNG SAGSEDAQLE
muOP CTDALAYSSC SPAPSPGSWV NLSHLDGNLS DPCGPNRTNL GGRDSLCPPT
OPRX ........ME PLFPAPFWEV IYGSHLQGNL SLLSPNHSLL PPHLLLNASH
CB1 FQEKMTAGDN PQLVPADQVN ITEFYNKSLS SFKENEENIQ CGENFMDIEC
CB2 .......... .......... ......MEEC WVTEIANGSK DGLDSNPMKD
SSTR1 .MFPNGTASS PSSSPSPSPG SCGEGGGSRG PGAGAADGME EPGRNASQNG
SSTR2 .......... ......MDMA DEPLNGSHTW LSIPFDLNGS VVSTNTSNQT
SSTR3 .......... .....MDMLH PSSVSTTSEP ENASSAWPPD ATLGNVSAGP
SSTR4 .......... .MSAPSTLPP GGEEGLGTAW PSAANASSAP AEAEEAVAGP
SSTR5 .......... .....MEPLF PASTPSW... .NASSPGAAS GGGDNRTLVG
IL8A .......... ......MSNI TDPQMWDFDD LN....FTGM PPADEDYSPC
IL8B .......... ......MESD SFEDFWKGED LSNYSYSSTL PPFLLDAAPC
AT1a .......... .......... .......... .MILNSSTED GIKRIQDDCP
AT1brat .......... .......... .......... .MTLNSSTED GIKRIQDDCP
AT2 .......... ....MKGNST LATTSKNITS GLHFGLVNIS GNNESTLNCS
BK1 .......... .......... ..MASSWPPL ELQSSNQSQL FPQNATACDN
BK2 .......... .......... ........ML NVTLQGPTLN GT.FAQSKCP
P2Y7 .......... .......... .......... .......... .MNTTSSAAP
P2Y6 .......... .......... .......... ...MERDNGT IQAPGLPPTT
P2Y5 .......... .......... .......... .......... .....MVSSN
P2Y4 .......... .......... ....MASTES SLLRSLGLSP GPGSSEVELD
P2Y3chick .......... .......... .......... ........MS MANFTGGRNS
P2Y2 .......... .......... ......MAAD LGPWNDTING TWDGDELGYR
P2Y1 ........MT EVLWPAVPNG TDAAFLAGPG SSWGNSTVAS TAAVSSSFKC
THRprec LLRNPNDKYE PFWEDEEKNE SGLTEYRLVS INKSSPLQKQ LPAFISEDAS
C5a .......... .......... ..MNSFNYTT PDYGHYDDKD TLDLNTPVDK
GP01mouse .......... .....MNEDP KVNLSGLPRD CIDAGAPENI SAAVPSQGSV
R334rat .......... .....MNEDP KVNLSGLPRD CIEAGTPENI SAAVPSQGSV
GP21mouse .......... ........MM WGAGSSMAWF SAGSGSV.NV SSVDPVEEPT
GCRCmouse SSVRATEQPQ VVTEHPSMEA ALTGPNASSH FWANYTFSDW QNFVGRRRYG
TXKR WPGWGWPPPA ALRNLTSSPA PTASPSPAPS WTPSPRPGPA HPFL......
G10Drat .......... MSVIPSSRPV STLAPDNDFR EIHNWTELLH LFNQTFSDCH
RDC1 .......... .....MDLHL FDYAEPGNFS DISWPCNSSD CIVVDTVMCP
BLR1 ...MNYPLTL EMDLE..NLE DLFWELDRLD NYNDTSLVEN HLCPATEGPL
CL5 .......... .......... MEGISIYTSD NYTE.EMGSG DYDSMKEPCF
LCR1 .......... .......... MEGISIYTSD NYTE.EMGSG DYDSMKEPCF
EBI1 .MDLGKPMKS VLVVALLVIF QVCLCQDEVT DDYIGDNTTV DYTLFESLCS
RBS1rat .......... .......... .......MPT SFPELDLENF EYDDSAEACY
EBI2 .......... .......... ........MD IQMANNFTPP SATPQGNDCD
GCRTchick .......... .......... .......... .......... .....MVSSN
APJ .......... .......... .......... .MEEGGDFDN YYGADNQSEC
RTArat .......... .....MAGNC SWEAHSTNQN KMCPGMSEAL ELYSRGFLTI
UHRrat TSLPPGTTGD PDLFSGPSPA GSTPANQSAE ASESNVSATV PRAAAVTPFQ
FMRL1 .......... .......... .......... ...METNFSI PLNETEEVLP
FMRL2 .......... .......... .......... ...METNFST PLNEYEEVSY
fMLP .......... .......... .......... ...METNSSL PTNISGGTPA
OLF1catfish .......... .......... ........MT SVLNALSANA TFIRPSTFYI
OLF3catfish .......... .......... ....MADNIT SILSLTSTNA TFIRPSTFYI
OLF8catfish .......... .......... .......... ....MLAPVQ NISFTTFTLT
OLF32Acatfish .......... .......... ........MS ALNSSLLQNV SFVRPEYFFI
OLF32Bcatfish .......... .......... ........MS ALNSSLLQNV SFVRPEYFFI
OLF32Ccatfish .......... .......... ........MS ALNSSLLQNV SFVRPEYFFI
OLF32Dcatfish .......... .......... ........MN ALNSSLLQNV SFVRPEYFFI
OLF47catfish .......... .......... .......... ....MNSTNS TDSFDKGFYL
OLF202catfish .......... .......... .......... ....MPEGNI TNVKNFVILG
OLFCOR1chicken .......... .......... .......... ....MASGNC TTPTTFILSG
OLFCOR2chicken .......... .......... .......... ....MASGNC TTPTTFILSG
OLFCOR3chicken .......... .......... .......... ....MASGNC TTPTTFILSG
OLFCOR4chicken .......... .......... .......... ....MASGNC TTPTTFILSG
OLFCOR5chicken .......... .......... .......... ....MALGNC TTPTTFILSG
OLFCOR6chicken .......... .......... .......... ....MASGNC TTPTTFILSG
OLFdog .......... .......... .......... ....MTEKNQ TVVSEFVLLG
OLF07E .......... .......... .......... ....MDGGNQ SEGSEFLLLG
OLF07I .......... .......... .......... ....MMGQNQ TSISDFLLLG
OLF07J .......... .......... ...MLLCFRF GNQSMKRENF TLITDFVFQG
OLFOR3mouse .......... .......... .......... ....MEVDSN TSSGSFILMG
OLFrat .......... .......... .......... ...MMGTGNH SAVVVFVLVG
OLFF3rat .......... .......... .......... ...MDSSNRT .RVSEFLLLG
OLFF5rat .......... .......... .......... ....MSSTNQ SSVTEFLLLG
OLFF6rat .......... .......... .......... .MAWSTGQNL STPGPFILLG
OLFF12rat .......... .......... .......... ...MESGNST RRFSSFFLLG
OLFI3rat .......... .......... .......... ......MNNQ TFITQFLLLG
OLFI7rat .......... .......... .......... ...MERRNHS GRVSEFVLLG
OLFI8rat .......... .......... .......... ......MNNK TVITHFLLLG
OLFI9rat .......... .......... .......... ....MTRRNQ TAISQFFLLG
OLFI14rat .......... .......... .......... ....MTGNNQ TLILEFLLLG
OLFI15rat .......... .......... .......... ....MTEENQ TVISQFLLLF
OLFOR17_40 .......... .......... .......... .MQPESGANG TVIAEFILLG
GUST27rat .......... .......... .......... .......... ..........
RPE .......... .......... .......... .......... ...MAETSAL
HHRF1 .......... .......... ......MTPT TTTAELTTEF DYDEDATPCV
HHRF2 .......... .......... .........M TTSTNNQTLT QVSNMTNHTL
HHRF3 .......... .......... .......... .......... ..........
MCP-1A .......... .....MLSTS RSRFIRNTNE SGEEVTTFFD YDYGAPCHKF
MCP-1B .......... .....MLSTS RSRFIRNTNE SGEEVTTFFD YDYGAPCHKF
PPR1bovine .......... ......MAVE YNQSTDYYYE ENEMNDTHDY SQYEVICIKE
101 150
GPCRAelegans HPCEDIMGYV WLTVVSFMVG AVALVANLVV ALVLLTSQ.. .....RRLNV
GRH NLPTLTLSGK IRVTVTFFLF LLSATFNASF LLKLQKWTQK KEKGKKLSRM
TRH RAVVALEYQV VTILLVLIIC GLGIVGNIMV VLVVMR.... ...TKHMRTP
FSHprec NPCEDIMGYN ILRVLIWFIS ILAITGNIIV LVILTTSQYK .......LTV
TSHprec NPCEDIMGYK FLRIVVWFVS LLALLGNVFV LLILLTSHYK .......LNV
LH_CGprec NPCEDIMGYD FLRVLIWLIN ILAIMGNMTV LFVLLTSRY. ......KLTV
PGE_EP1 PNTSAVPPSG ASPALPIFSM TLGAVSNLLA LALLAQAA.G RLRRRRSATT
PGE_EP2 SASLSPDRLN SPVTIPAVMF IFGVVGNLVA IVVLCKS... ..RKEQKETT
PGE_EP3 QWLPPGE... .SPAISSVMF SAGVLGNLIA LALLARRW.R SAGRRSSLSL
PGF SNTTCQTENR LSVFFSVIFM TVGILSNSLA IAILMKAY.Q RFRQKSKA.S
PGI CRNLTYVRGS VGPATSTLMF VAGVVGNGLA LGILSARRPA RP......SA
TXA2 NITLEERRLI ASPWFAASFC VVGLASNLLA LSVLAGA... RQGGSHTRSS
PAF HMDSEFRYTL F.PIVYSIIF VLGVIANGYV LWVFARLY.P CKKFNEIK..
M2 ...YKTFEVV FIVLVAGSLS LVTIIGNILV MVSI.KVN.R HLQT.....V
M4 HNRYETVEMV FIATVTGSLS LVTVVGNILV MLSI.KVN.R QLQT.....V
M1 ..GKGPWQVA FIGITTGLLS LATVTGNLLV LISF.KVN.T ELKT.....V
M3 LGGHTVWQVV FIAFLTGILA LVTIIGNILV IVSF.KVN.K QLKT.....V
M5 LERHRLWEVI TIAAVTAVVS LITIVGNVLV MISF.KVN.S QLKT.....V
H1 KTTMASPQLM PLVVVLSTIC LVTVGLNLLV LYAVRSER.. KLHT.....V
H2 FCLDSTACKI TITVVLAVLI LITVAGNVVV CLAVGLNR.. RLRN.....L
5HT1A ISDVTVSYQV ITSLLLGTLI FCAVLGNACV VAAIALER.. SLQN.....V
5HT1B QDSISLPWKV LLVMLLALIT LATTLSNAFV IATVYRTR.. KLHT.....P
5HT1D DPRTLQALKI SLAVVLSVIT LATVLSNAFV LTTILLTR.. KLHT.....P
5HT1E IRPKTITEKM LICMTLVVIT TLTTLLNLAV IMAIGTTK.. KLHQ.....P
5HT1F ELLNRMPSKI LVSLTLSGLA LMTTTINSLV IAAIIVTR.. KLHH.....P
5HT2A QEKN...... WSALLTAVVI ILTIAGNILV IMAVSLEK.. KLQN.....A
5HT2B IVEEQGNKLH WAALLILMVI IPTIGGNTLV ILAVSLEK.. KLQY.....A
5HT2C ..QN...... WPALSIVIII IMTIGGNILV IMAVSMEK.. KLHN.....A
5HT5A SSPLLSVFGV LILTLLGFLV AATFAWNLLV LATILRVR.. TFHR.....V
5HT5Brat REPPFSAFTV LVVTLLVLLI AATFLWNLLV LVTILRVR.. AFHR.....V
5HT6rat GPPPAPGGSG WVAAALCVVI VLTAAANSLL IVLICTQP.. AVRN.....T
5HT7 QINYGRVEKV VIGSILTLIT LLTIAGNCLV VISVCFVK.. KLRQ.....P
alpha1A GGLVVSAQGV GVGVFLAAFI LMAVAGNLLV ILSVACNR.. HLQT.....V
alpha1B ..QLDITRAI SVGLVLGAFI LFAIVGNILV ILSVACNR.. HLRT.....P
alpha1C PAPVNISKAI LLGVILGGLI LFGVLCNILV ILSVACHR.. HLHS.....V
alpha2A ...YSLQVTL TLVCLAGLLM LLTVFGNVLV IIAVFTSR.. ALKA.....P
alpha2B QDPYSVQATA AIAAAITFLI LFTIFGNALV ILAVLTSR.. SLRA.....P
alpha2C1 RGQYSAGAVA GLAAVVGFLI VFTVVGNVLV VIAVLTSR.. ALRA.....P
alpha2C2 RGQYSAGAVA GLAAVVGFLI VFTVVGNVLV VIAVLTSR.. ALRA.....P
beta1 EPLSQQWTAG M.GLLMALIV LLIVAGNVLV IVAIAKTP.. RLQT.....L
beta2 QQRDEVWVVG M.GIVMSLIV LAIVFGNVLV ITAIAKFE.. RLQT.....V
beta3 GLPGVPWEAA LAGALLALAV LATVGGNLLV IVAIAWTP.. RLQT.....M
beta4turkey SWAAVLSRQW AVGAALSITI LVIVAGNLLV IVAIAKTP.. RLQT.....M
D1A VVERDFSVRI LTACFLSLLI LSTLLGNTLV CAAVIRFR.. HLRSK....V
D2 DGKADRPHYN YYATLLTLLI AVIVFGNVLV CMAVSREK.. ALQT.....T
D3 TGASQARPHA YYALSYCALI LAIVFGNGLV CMAVLKER.. ALQT.....T
D4 ASAGLAGQGA AALVGGVLLI GAVLAGNSLV CVSVATER.. ALQT.....P
D5 GAPPLGPSQV VTACLLTLLI IWTLLGNVLV CAAIVRSR.. HLRAN....M
A1 MPPSISAFQA AYIGIEVLIA LVSVPGNVLV IWAVKVNQ.. ALRD.....A
A2a ...MPIMGSS VYITVELAIA VLAILGNVLV CWAVWLNS.. NLQN.....V
A2b ..MLLETQDA LYVALELVIA ALSVAGNVLV CAAVGTAN.. TLQT.....P
A3 NSTTLSLANV TYITMEIFIG LCAIVGNVLV ICVVKLNP.. SLQT.....T
OCdrome LAVPE.WEAL LTALVLSVII VLTIIGNILV ILSVFTYK.. PLRI.....V
ACTH RNNSDCPRVV LPEEIFFTIS IVGVLENLIV LLAVFKNK.. NLQA.....P
MSH QTGARCLEVS ISDGLFLSLG LVSLVENALV VATIAKNR.. NLHS.....P
MC3 SSSAFCEQVF IKPEIFLSLG IVSLLENILV ILAVVRNG.. NLHS.....P
MC4 SDGGCYEQLF VSPEVFVTLG VISLLENILV IVAIAKNK.. NLHS.....P
MC5 NKSSPCEDMG IAVEVFLTLG VISLLENILV IGAIVKNK.. NLHS.....P
melatonin DGARPSWLAS ALACVLIFTI VVDILGNLLV ILSVYRNKKL .......RNA
oxytocin R..RNEALAR VEVAVLCLIL LLALSGNACV LLALRTTRQK .......HSR
conopressinLs FHGVDEDLLK IEIAVQATIL YMTLFGNGIV LLVLRLRRQK .......LTR
V1A RDVRNEELAK LEIAVLAVTF AVAVLGNSSV LLAL...... .HRTPRKTSR
V1B WLGRDEELAK VEIGVLATVL VLATGGNLAV LLTLGQLGRK .......RSR
V2 LDTRDPLLAR AELALLSIVF VAVALSNGLV LAALA..... RRGRRGHWAP
CCK_A PRPSKEWQPA VQILLYSLIF LLSVLGNTLV ITVLI..... RNKRM..RTV
CCK_B GAGTRELELA IRITLYAVIF LMSVGGNMLI IVVLGLS... ..RRL..RTV
NPY1 DCHLPLAMIF TLALAYGAVI ILGVSGNLAL IIIIL..... KQKEM..RNV
NTR DVNTDIYSKV LVTAVYLALF VVGTVGNTVT AFTLAR.... KKSLQSLQST
NK1 QFVQPAWQIV LWAAAYTVIV VTSVVGNVVV MWIILA.... .HKRM..RTV
NK2 AFSMPSWQLA LWAPAYLALV LVAVTGNAIV IWIILA.... .HRRM..RTV
NK3 QFVQPSWRIA LWSLAYGVVV AVAVLGNLIV IWIILA.... .HKRM..RTV
blueops YHIAPVWAFY LQAAFMGTVF LIGFPLNAMV LVATL..... RYKKL..RQP
greenops YHIAPRWVYH LTSVWMIFVV IASVFTNGLV LAATM..... KFKKL..RHP
redops YHIAPRWVYH LTSVWMIFVV TASVFTNGLV LAATM..... KFKKL..RHP
rhodopsin YYLAEPWQFS MLAAYMFLLI VLGFPINFLT LYVTVQ.... .HKKL..RTP
violetopsGg YHIAPPWAFY LQTAFMGIVF AVGTPLNAVV LWVTVRYKRL .......RQP
opsin_crab FPPMNPLWYS ILGVAMIILG IICVLGNGMV IYLMMTTKSL .......RTP
ET_Aprec QTKITSAFKY INTVISCTIF IVGMVGNATL LRIIYQ.... .NKCM..RNG
ET_Bprec PIEIKETFKY INTVVSCLVF VLGIIGNSTL LRIIYKNK.. ...CM..RNG
ET_Cfrog RAKIRHAFKY VTTILSCVIF LVGIVGNSTL LRIIYKNK.. ...CM..RNG
galanin PLFGIGVENF VTLVVFGLIF ALGVLGNSLV ITVLARSK.. ...PGKPRST
NMB GTTTELVIRC VIPSLYLLII TVGLLGNIML VKIFITNS.. ...AM..RSV
GRP DDWSHPGILY VIPAVYGVII LIGLIGNITL IKIFCTVK.. ...SM..RNV
BRS3 DNSPGIEALC AIYITYAVII SVGILGNAIL IKVFFKTK.. ...SM..QTV
deltaOP GSASSLALAI AITALYSAVC AVGLLGNVLV MFGIVRYT.. ...KM..KTA
kappaOP PAHISPAIPV IITAVYSVVF VVGLVGNSLV MFVIIRYT.. ...KM..KTA
muOP GSP.SMITAI TIMALYSIVC VVGLFGNFLV MYVIVRYT.. ...KM..KTA
OPRX GAFLPLGLKV TIVGLYLAVC VGGLLGNCLV MYVILRHT.. ...KM..KTA
CB1 FMVLNPSQQL AIAVLSLTLG TFTVLENLLV LCVILHSR.. SLRCR....P
CB2 YMILSGPQKT AVAVLCTLLG LLSALENVAV LYLILSSH.. QLRRK....P
SSTR1 TLSEGQGSAI LISFIYSVVC LVGLCGNSMV IYVILRYA.. ...KM..KTA
SSTR2 EPYYDLTSNA VLTFIYFVVC IIGLCGNTLV IYVILRYA.. ...KM..KTI
SSTR3 SPAGLAVSGV LIPLVYLVVC VVGLLGNSLV IYVVLRHT.. ...AS..PSV
SSTR4 GDARAAG.MV AIQCIYALVC LVGLVGNALV IFVILRYA.. ...KM..KTA
SSTR5 PAPSAGARAV LVPVLYLLVC AAGLGGNTLV IYVVLRFA.. ...KM..KTV
IL8A MLETETLNKY VVIIAYALVF LLSLLGNSLV MLVILYSR.. ...VG..RSV
IL8B EPESLEINKY FVVIIYALVF LLSLLGNSLV MLVILYSR.. ...VG..RSV
AT1a KAGRHNYIFV MIPTLYSIIF VVGIFGNSLV VIVIYFYM.. ...KL..KTV
AT1brat KAGRHNYIFV MIPTLYSIIF VVGIFGNSLV VIVIYFYM.. ...KL..KTV
AT2 QKPSDKH.LD AIPILYYIIF VIGFLVNIVV VTLFCCQK.. ...GP..KKV
BK1 APEAWDLLHR VLPTFIISIC FFGLLGNLFV LLVFLLPR.. .....RQLNV
BK2 QVEWLGWLNT IQPPFLWVLF VLATLENIFV LSVFCLHK.. .....SSCTV
P2Y7 PSLGVEFISL LAIILLSVAL AVGLPGNSFV VWSILKRMQ. ......KRSV
P2Y6 CVYREDFKRL LLPPVYSVVL VVGLPLNVCV IAQICASRR. ......TLTR
P2Y5 CSTEDSFKYT LYGCVFSMVF VLGLIANCVA IYIFTFTLK. ......VRNE
P2Y4 CWFDEDFKFI LLPVSYAVVF VLGLGLNAPT LWLFIFRLR. ......PWDA
P2Y3chick CTFHEEFKQV LLPLVYSVVF LLGLPLNAVV IGQIWLARK. ......ALTR
P2Y2 CRFNEDFKYV LLPVSYGVVC VLGLCLNAVG LYIFLCRLK. ......TWNA
P2Y1 ALTKTGFQFY YLPAVYILVF IIGFLGNSVA IWMFVFHMK. ......PWSG
THRprec GYLTSSWLTL FVPSVYTGVF VVSLPLNIMA IVVFILKM.. ...KV..KKP
C5a TSNTLRVPDI LALVIFAVVF LVGVLGNALV VWVTAFEA.. ...K...RTI
GP01mouse AESEPELVVN PWDIVLCSSG TLICCENAVV VLIIF.HSPS LR......AP
R334rat VESEPELVVN PWDIVLCSSG TLICCENAVV VLIIF.HSPS LR......AP
GP21mouse GPATLLPSPR AWDVVLCISG TLVSCENALV VAIIV.GTPA FR......AP
GCRCmouse AESQNPTVKA LLIVAYSFTI VFSLFGNVLV CHVIFK.NQR ......MHSA
TXKR ...QPPWAVA LWSLAYGAVV AVAVLGNLVV IWIVLA.HKR MR......TV
G10Drat MELNENTKQV VLFVFYLAIF VVGLVENVLV IC.VNCRRSG R......VGM
RDC1 NMPNKSVLLY TLSFIYIFIF VIGMIANSVV VW.VNIQAKT TGYDT.....
BLR1 ...MASFKAV FVPVAYSLIF LLGVIGNVLV LV.ILERHRQ TRSSTE....
CL5 REENANFNKI FLPTIYSIIF LTGIVGNGLV IL.VMGYQKK LRSMTDKYR.
LCR1 REENANFNKI FLPTIYSIIF LTGIVGNGLV IL.VMGYQKK LRSMTDKYR.
EBI1 KKDVRNFKAW FLPIMYSIIC FVGLLGNGLV VL.TYIYFKR LKTMTDTY..
RBS1rat LGDIVAFGTI FLSIFYSLVF TFGLVGNLLV VL.ALTNSRK SKSITDIY..
EBI2 LYAHHSTARI VMPLHYSLVF IIGLVGNLLA LV.VIVQNRK KINSTTLY..
GCRTchick CSTEDSFKYT LYGCVFSMVF VLGLIANCVA IY.IFTFTLK VRNETTTY..
APJ EYTDWKSSGA LIPAIYMLVF LLGTTGNGLV LWTVFRSSRE KRRSAD....
RTArat EQIATLPPPA VTNYIFLLLC LCGLVGNGLV LWFFGFSIK. .RT......P
UHRrat SLQLVHQLKG LIVMLYSIVV VVGLVGNCLL VLVIARVR.. .....RLHNV
FMRL1 EPAGHTVLWI FSLLVHGVTF VFGVLGNGLV IWVA.GFR.. .....MTRTV
FMRL2 ESAGYTVLRI LPLVVLGVTF VLGVLGNGLV IWVA.GFR.. .....MTRTV
fMLP VSAGYLFLDI ITYLVFAVTF VLGVLGNGLV IWVA.GFR.. .....MTHTV
OLF1catfish NGFYNIPHTK YYYAFLCIAY AVTVLGNSFI MCTIYLAR.. .....SLHTA
OLF3catfish TGLYNIPHAK YYYLFLCFVY TVTFLGNSFI MGTIYLAR.. .....SLHTA
OLF8catfish GFHDLGEWGP ILSIPYLLMF LLSSTSNLTL IYLIISQR.. .....ALHSP
OLF32Acatfish SGFSGIPFSQ YYFAFLIFIY IISLCGNSIV LFMILVDR.. .....TLHIP
OLF32Bcatfish SGFSGIPFSQ YYFVFLIFIY IISLCGNSIV LFMILVDR.. .....TLHIP
OLF32Ccatfish SGFSGIPFSQ YYFVFLIFIY IISLCGNSIV LFMILVDR.. .....TLHIP
OLF32Dcatfish SGFSGIPFSQ YYFVFLIFIY IISLCGNSIV LFMILVDR.. .....TLHIP
OLF47catfish IAYNSLGNKN YLILALGIIY LITLLCNFTL LAIILMNS.. .....SLQNP
OLF202catfish FPGLPPNYYG LVSVVMFFVY VCTLIGNCTF FTLFLREK.. .....SLQKP
OLFCOR1chicken LTD.NPGLQM PLFMVFLAIY TITLLTNLGL IALISVDL.. .....HLQTP
OLFCOR2chicken LTD.NPRLQM PLFMVFLVIY TTTLLTNLGL IALIGMDL.. .....HLQTP
OLFCOR3chicken LTD.NPGLQM PLFMVFLAIY TITLLTNLGL IRLISVDL.. .....HLQTP
OLFCOR4chicken LTD.NPGLQM PLFMVFLAIY TITLLTNLGL IRLISVDL.. .....HLQTP
OLFCOR5chicken LTD.NPRLQM PLFMVFLAIY TITLLANLGL IALISVDF.. .....HLQTP
OLFCOR6chicken LTD.NPGLQM PLFMVFLAIY TITLLTNLGL IALIRIDL.. .....QLQTP
OLFdog LPI.DPDQRD LFYALFLAMY VTTILGNLLI IVLIQLDS.. .....HLHTP
OLF07E MSE.SPEQQQ ILFWMFLSMY LVTVVGNVLI ILAISSDS.. .....RLHTP
OLF07I LPI.QPEQQN LCYALFLAMY LTTLLGNLLI IVLIRLDS.. .....HLHTP
OLF07J FSS.FHEQQI TLFGVFLALY ILTLAGNIII VTIIRIDL.. .....HLHTP
OLFOR3mouse VSD.HPHLEI IFFAVILASY LLTLVGNLTI ILLSRLDA.. .....RLHTP
OLFrat LTK.QPELLL PLFFLFLVIY VLTVVGNLGM ILLIIVSP.. .....LLHTP
OLFF3rat FVE.NKDLQP LIYGLFLSMY LVTVIGNISI IVAIISDP.. .....CLHTP
OLFF5rat LSR.QPQQQQ LLFLLFLIMY LATVLGNLLI ILAIGTDS.. .....RLHTP
OLFF6rat FPG.PRSMRI GLFLLFLVMY LLTVVGNLAI ISLVGAHR.. .....CLQTP
OLFF12rat FTE.NPQLHF LIFALFLSMY LVTVLGNLLI IMAIITQS.. .....HLHTP
OLFI3rat LPI.PEEHQH LFYALFLVMY LTTILGNLLI IVLVQLDS.. .....QLHTP
OLFI7rat FPA.PAPLRV LLFFLSLLXY VLVLTENMLI IIAIRNHP.. .....TLHKP
OLFI8rat LPI.PPEHQQ LFFALFLIMY LTTFLGNLLI VVLVQLDS.. .....HLHTP
OLFI9rat LPF.PPEYQH LFYALFLAMY LTTLLGNLII IILILLDS.. .....HLHTP
OLFI14rat LPI.PSEYHL LFYALFLAMY LTIILGNLLI IVLVRLDS.. .....HLHMP
OLFI15rat LPI.PSEHQH VFYALFLSMY LTTVLGNLII IILIHLDS.. .....HLHTP
OLFOR17_40 LLE.APGLQP VVFVLFLFAY LVTVRGNLSI LAAVLVEP.. .....KLHTP
GUST27rat ....MILNCN PFSGLFLSMY LVTVLGNLLI ILAVSSNSHL .......HNL
RPE PTGFGELEVL AVGMVLLVEA LSGLSLNTLT IFSFCKTPEL .......RTP
HHRF1 FTDVLNQSKP VTLFLYGVVF LFGSIGNFLV IFTITWRRRI .......QCS
HHRF2 NSTEIYQLFE YTRLGVWLMC IVGTFLNVLV ITTILYYRRK K......KSP
HHRF3 MTGPLFAIRT TEAVLNTFII FVGGPLNAIV LITQLLTNRV LG.....YST
MCP-1A ..DVKQIGAQ LLPPLYSLVF IFGFVGNMLV VLILINCKKL .......KCL
MCP-1B ..DVKQIGAQ LLPPLYSLVF IFGFVGNMLV VLILINCKKL .......KCL
PPR1bovine ..EVRKFAKV FLPAFFTIAF IIGLAGNSTV VAIYAYYKKR .......RTK
1111111111 1111111111 1111111111 1111111111 222
2222223333 3333334444 4444445555 5555556666 333
4567890123 4567890123 4567890123 4567890123 678
151 200
GPCRAelegans TRFLMCNLAF ADFILGLYIF ILTSVSAVTR GDYHNYVQQW QNGAGCKILG
GRH .KLLLKHLTL ANLLETLIVM PLDGMWNITV QWYA...... .GELLCKVLS
TRH TNCYLVSLAV ADLMVLVAAG LPNITDSIYG SWVYGYV... ....GCLCIT
FSHprec PRFLMCNLAF ADLCIGIYLL LIASVDIHTK SQYHNYAIDW QTGAGCDAAG
TSHprec PRFLMCNLAF ADFCMGMYLL LIASVDLYTH SEYYNHAIDW QTGPGCNTAG
LH_CGprec PRFLMCNLSF ADFCMGLYLL LIASVDSQTK GQYYNHAIDW QTGSGCSTAG
PGE_EP1 FLLFVASLLA TDLAGHVIPG ALVLRLYTA. .......GRA PAGGACHFLG
PGE_EP2 FYTLVCGLAV TDLLGTLLVS PVTIATYMKG ......QWPG GQP.LCEYST
PGE_EP3 FHVLVTELVF TDLLGTCLIS PVVLASYARN QT..LVALAP ESR.ACTYFA
PGF FLLLASGLVI TDFFGHLING AIAVFVYASD KE..WIRFDQ .SNVLCSIFG
PGI FAVLVTGLAA TDLLGTSFLS PAVFVAYARN SS..LLGLAR GGPALCDAFA
TXA2 FLTFLCGLVL TDFLGLLVTG TIVVSQHAAL FE..WHAVDP GCR.LCRFMG
PAF ..IFMVNLTM ADMLFLITLP LWIVYYQ.NQ GNWIL..... PK.FLCNVAG
M2 NNYFLFSLAC ADLIIGVFSM NLYTLYTVIG ......YWPL .GPVVCDLWL
M4 NNYFLFSLAC ADLIIGAFSM NLYTVYIIKG ......YWPL .GAVVCDLWL
M1 NNYFLLSLAC ADLIIGTFSM NLYTTYLLMG ......HWAL .GTLACDLWL
M3 NNYFLLSLAC ADLIIGVISM NLFTTYIIMN ......RWAL .GNLACDLWL
M5 NNYYLLSLAC ADLIIGIFSM NLYTTYILMG ......RWAL .GSLACDLWL
H1 GNLYIVSLSV ADLIVGAVVM PMNILYLLMS ......KWSL .GRPLCLFWL
H2 TNCFIVSLAI TDLLLGLLVL PFSAIYQLSC ......KWSF G.KVFCNIYT
5HT1A ANYLIGSLAV TDLMVSVLVL PMAALYQVLN ......KWTL .GQVTCDLFI
5HT1B ANYLIASLAV TDLLVSILVM PISTMYTVTG ......RWTL .GQVVCDFWL
5HT1D ANYLIGSLAT TDLLVSILVM PISIAYTITH ......TWNF .GQILCDIWL
5HT1E ANYLICSLAV TDLLVAVLVM PLSIIYIVMD ......RWKL .GYFLCEVWL
5HT1F ANYLICSLAV TDFLVAVLVM PFSIVYIVRE ......SWIM .GQVVCDIWL
5HT2A TNYFLMSLAI ADMLLGFLVM PVSMLTILYG .....YRWPL P.SKLCAVWI
5HT2B TNYFLMSLAV ADLLVGLFVM PIALLTIMFE .....AMWPL P.LVLCPAWL
5HT2C TNYFLMSLAI ADMLVGLLVM PLSLLAILYD .....YVWPL P.RYLCPVWI
5HT5A PHNLVASMAV SDVLVAALVM PLSLVHELS. ....GRRWQL .GRRLCQLWI
5HT5Brat PHNLVASTAV SDVLVAALVM PLSLVSELSA ....GRRWQL .GRSLCHVWI
5HT6rat SNFFLVSLFT SDLMVGLVVM PPAMLNALYG ......RWVL A.RGLCLLWT
5HT7 SNYLIVSLAL ADLSVAVAVM PFVSVTDLIG G.....KWIF .GHFFCNVFI
alpha1A TNYFIVNLAV ADLLLSATVL PFSATMEVLG ......FWAF G.RAFCDVWA
alpha1B TNYFIVNLAM ADLLLSFTVL PFSAALEVLG ......YWVL G.RIFCDIWA
alpha1C THYYIVNLAV ADLLLTSTVL PFSAIFEVLG ......YWAF G.RVFCNIWA
alpha2A QNLFLVSLAS ADILVATLVI PFSLANEVMG .Y.....WYF .GKAWCEIYL
alpha2B QNLFLVSLAA ADILVATLII PFSLANELLG .Y.....WYF R.RTWCEVYL
alpha2C1 QNLFLVSLAS ADILVATLVM PFSLANELMA .Y.....WYF .GQVWCGVYL
alpha2C2 QNLFLVSLAS ADILVATLVM PFSLANELMA .Y.....WYF .GQVWCGVYL
beta1 TNLFIMSLAS ADLVMGLLVV PFGATIVVWG ......RWEY GS.FFCELWT
beta2 TNYFITSLAC ADLVMGLAVV PFGAAHILMK ......MWTF GN.FWCEFWT
beta3 TNVFVTSLAA ADLVMGLLVV PPAATLALTG ......HWPL GA.TGCELWT
beta4turkey TNVFVTSLAC ADLVMGLLVV PPGATILLSG ......HWPY GT.VVCELWT
D1A TNFFVISLAV SDLLVAVLVM PWKAVAEIAG ......FWPF GS..FCNIWV
D2 TNYLIVSLAV ADLLVATLVM PWVVYLEVVG E......WKF S.RIHCDIFV
D3 TNYLVVSLAV ADLLVATLVM PWVVYLEVTG GV.....WNF S.RICCDVFV
D4 TNSFIVSLAA ADLLLALLVL PLFVYSEVQG GA.....WLL SPRLC.DALM
D5 TNVFIVSLAV SDLFVALLVM PWKAVAEVAG ......YWPF GA..FCDVWV
A1 TFCFIVSLAV ADVAVGALVI PLAILINIGP QTYFHTCL.. .......MVA
A2a TNYFVVSLAA ADIAVGVLAI PFAITISTGF CAACHGCL.. .......FIA
A2b TNYFLVSLAA ADVAVGLFAI PFAITISLGF CTDFYGCL.. .......FLA
A3 TFYFIVSLAL ADIAVGVLVM PLAIVVSLGI TIHFYSCL.. .......FMT
OCdrome QNFFIVSLAV ADLTVALLVL PFNVAYSILG R......WEF GI.HLCKLWL
ACTH MYFFICSLAI SDMLGSLYKI LENILIILRN MGYLKPRGSF ET.TADDIID
MSH MYCFICCLAL SDLLVSGTNV LETAVILLLE AGALVARAAV LQ.QLDNVID
MC3 MYFFLCSLAV ADMLVSVSNA LETIMIAIVH SDDYTFEDQF IQ.HMDNIFD
MC4 MYFFICSLAV ADMLVSVSNG SETIIITLLN STD.TDAQSF TV.NIDNVID
MC5 MYFFVCSLAV ADMLVSMSSA WETITIYLLN NKHLVIADAF V.RHIDNVFD
melatonin GNIFVVSLAV ADLVVAIYPY PLVLMSIFNN GWNLGYLH.. .....CQVSG
oxytocin LFFFMKHLSI ADLVVAVFQV LPQLLWDITF RFYGP..... ..DLLCRLVK
conopressinLs MQWFIAHLAF ADIFVGFFNI LPQLISDVTI VFHGDD.... ...FTCRFIK
V1A MHLFIRHLSL ADLAVAFFQV LPQMCWDITY RFRGPD.... ...WLCRVVK
V1B MHLFVLHLAL TDLAVALFQV LPQLLWDITY RFQGP..... ..DLLCRAVK
V2 IHVFIGHLCL ADLAVALFQV LPQLAWKATD RFRGPD.... ...ALCRAVK
CCK_A TNIFLLSLAV SDLMLCLFCM PFNLIPNLLK DFIFGS.... ...AVCKTTT
CCK_B TNAFLLSLAV SDLLLAVACM PFTLLPNLMG TFIFGT.... ...VICKAVS
NPY1 TNILIVNLSF SDLLVAIMCL PFTFVYTLMD HWVFGE.... ...AMCKLNP
NTR VHYHLGSLAL SDLLTLLLAM PVELYNFIWV HHPWAF.... .GDAGCRGYY
NK1 TNYFLVNLAF AEASMAAFNT VVNFTYAVHN EWYYGL.... ...FYCKFHN
NK2 TNYFIVNLAL ADLCMAAFNA AFNFVYASHN IWYFGR.... ...AFCYFQN
NK3 TNYFLVNLAF SDASMAAFNT LVNFIYALHS EWYFGA.... ...NYCRFQN
blueops LNYILVNVSF GGFLLCIFSV FPVFVASCNG YFVFGR.... ...HVCALEG
greenops LNWILVNLAV ADLAETVIAS TISVVNQVYG YFVLGH.... ...PMCVLEG
redops LNWILVNLAV ADLAETVIAS TISIVNQVSG YFVLGH.... ...PMCVLEG
rhodopsin LNYILLNLAV ADLFMVLGGF TSTLYTSLHG YFVFGP.... ...TGCNLEG
violetopsGg LNYILVNISA SGFVSCVLSV FVVFVASARG YFVFG..... ..KRVCELEA
opsin_crab TNLLVVNLAF SDFCMMAFMM PTMTSNCFAE TWILG..... ..PFMCEVYG
ET_Aprec PNALIASLAL GDLIYVVIDL PINVFKLLAG RWPFDH.NDF GV.FLCKLFP
ET_Bprec PNILIASLAL GDLLHIVIDI PINVYKLLAE DWPFGAE... ....MCKLVP
ET_Cfrog PNVLIASLAL GDLFYILIAI PIISISFWLS TGH....... ....SEYIYQ
galanin TNLFILNLSI ADLAYLLFCI PFQATVYALP TWVLGA.... ...FICKFIH
NMB PNIFISNLAA GDLLLLLTCV PVDASRYFFD EWMFGKVG.. .....CKLIP
GRP PNLFISSLAL GDLLLLITCA PVDASRYLAD RWLFGRIG.. .....CKLIP
BRS3 PNIFITSLAF GDLLLLLTCV PVDATHYLAE GWLFGRIG.. .....CKVLS
deltaOP TNIYIFNLAL ADALATSTLP FQSAKYLMET .WPFGE.... ...LLCKAVL
kappaOP TNIYIFNLAL ADALVTTTMP FQSTVYLMNS .WPFGD.... ...VLCKIVI
muOP TNIYIFNLAL ADALATSTLP FQSVNYLMGT .WPFGT.... ...ILCKIVI
OPRX TNIYIFNLAL ADTLVLLTLP FQGTDILLGF .WPFGN.... ...ALCKTVI
CB1 SYHFIGSLAV ADLLGSVIFV YSFIDFHVFH RKD....... .SRNVFLFKL
CB2 SYLFIGSLAG ADFLASVVFA CSFVNFHVFH GVD....... .SKAVFLLKI
SSTR1 TNIYILNLAI ADELLMLSVP FLVTSTLLRH .WPFGA.... ...LLCRLVL
SSTR2 TNIYILNLAI ADELFMLGLP FLAMQVALVH .WPFGK.... ...AICRVVM
SSTR3 TNVYILNLAL ADELFMLGLP FLAAQNALSY .WPFGS.... ...LMCRLVM
SSTR4 TNIYLLNLAV ADELFMLSVP FVASSAALRH .WPFGS.... ...VLCRAVL
SSTR5 TNIYILNLAV ADVLYMLGLP FLATQNAASF .WPFGP.... ...VLCRLVM
IL8A TDVYLLNLAL ADLLFALTLP IWAA..SKVN GWIFGT.... ...FLCKVVS
IL8B TDVYLLNLAL ADLLFALTLP IWAA..SKVN GWIFGT.... ...FLCKVVS
AT1a ASVFLLNLAL ADLCFLLTLP LWAVYTAMEY RWPFGN.... ...YLCKIAS
AT1brat ASVFLLNLAL ADLCFLLTLP LWAVYTAMEY RWPFGN.... ...HLCKIAS
AT2 SSIYIFNLAV ADLLLLATLP LWATYYSYRY DWLFGP.... ...VMCKVFG
BK1 AEIYLANLAA SDLVFVLGLP FWAENIWNQF NWPFGA.... ...LLCRVIN
BK2 AEIYLGNLAA ADLILACGLP FWAITISNNF DWLFGE.... ...TLCRVVN
P2Y7 TALMVLNLAL ADLAVLLTAP FFLHFLAQGT WSFGLA.... ....GCRLCH
P2Y6 SAVYTLNLAL ADLLYACSLP LLIYNYARGD HWPFGD.... ...LACRLVR
P2Y5 TTTYMLNLAI SDLLFVFTLP FRIYYFVVRN .WPFGD.... ...VLCKISV
P2Y4 TATYMFHLAL SDTLYVVSLP TLIYYYAAHN HWPFGT.... ...EICKFVR
P2Y3chick TTIYMLNLAM ADLLYVCSLP LLIYNYTQKD YWPFGD.... ...FTCKFVR
P2Y2 STTYMFHLAV SDALYAASLP LLVYYYARGD HWPFST.... ...VLCKLVR
P2Y1 ISVYMFNLAL ADFLYVLTLP ALIFYYFNKT DWIFGD.... ...AMCKLQR
THRprec AVVYMLHLAT ADVLFVSVLP FKISYYFSGS DWQFGS.... ...ELCRFVT
C5a NAIWFLNLAV ADFLSCLALP ILFTSIVQHH WPFGGA.... ....ACSILP
GP01mouse MFLLIGSLAL ADLLAGLGLI INFVFAYLLQ ....SE.... ...ATKLVTI
R334rat MFLLIGSLAL ADLLAGLGLI INFVFAYLLQ ....SE.... ...ATKLVTI
GP21mouse MFLLVGSLAV ADLLAGLGLV LHFAADFCIG ....SP.... ...EMSLMLV
GCRCmouse TSLFIVNLAV ADIMITLLNT PFTLVRFVNS TWVFGK.... ...GMCHVSR
TXKR TNSFLVNLAF ADAAMAALNA LVNFIYALHG EWYFGA.... ...NYCRFQN
G10Drat LNLYILNMAV ADLGIILSLP VWMLEVMLEY TWLWGS.... ...FSCRFIH
RDC1 .HCYILNLAI ADLWVVLTIP VWVVSLVQHN QWPMGE.... ...LTCKVTH
BLR1 ..TFLFHLAV ADLLLVFILP FAVAEGSV.. GWVLGT.... ...FLCKTVI
CL5 .....LHLSV ADLLFVITLP FWAVDAVA.. NWYFGN.... ...FLCKAVH
LCR1 .....LHLSV ADLLFVITLP FWAVDAVA.. NWYFGN.... ...FLCKAVH
EBI1 ....LLNLAV ADILFLLTLP FWAYSAAK.. SWVFGV.... ...HFCKLIF
RBS1rat ....LLNLAL SDLLFVATLP FWTHYLIS.. HEGLHN.... ...AMCKLTT
EBI2 ....STNLVI SDILFTTALP TRIAYYAMGF DWRIGD.... ...ALCRITA
GCRTchick ....MLNLAI SDLLFVFTLP FRIYYFVVR. NWPFGD.... ...VLCKISV
APJ ..IFIASLAV ADLTFVVTLP LWATYTYRDY DWPFGT.... ...FFCKLSS
RTArat FSIYFLHLAS ADGIYLFSKA VIALLNMGTF LGSFPD.... ...YVRRVSR
UHRrat TNFLIGNLAL SDVLMCAACV PLTLAYAFEP RGWVFG.... ..GGLCHLVF
FMRL1 NTICYLNLAL ADFSFSAILP FRMVSVAMRE KWPFAS.... ...FLCKLVH
FMRL2 TTICYLNLAL ADFSFTATLP FLIVSMAMGE KWPFGW.... ...FLCKLIH
fMLP TTISYLNLAV ADFCFTSTLP FFMVRKAMGG HWPFGW.... ...FLCKFLF
OLF1catfish KYITVFNLAL SDLGGSSALI PKLIDTFLF. ......ENQV ISYEACLANM
OLF3catfish KYIAVFNLAL SDLCGSSALI PKLLDMLLF. ......ENQS ISYEACLSNM
OLF8catfish MCILIGLMAV VDLSMPIFCV PNMLLSFLF. ......NWKG ISLVGCLVQM
OLF32Acatfish KYMGIFNLAL SDFGETNVLI PSLVKTLFF. ......DSQY ISYDACLANM
OLF32Bcatfish KYMGIFNLAL SDFGETNALI PSLVKTLFF. ......DSQY ISYDACLANM
OLF32Ccatfish KYMGIFNLAL SDIGETNALI PSLVKTLFF. ......DSQY ISYDACLTNM
OLF32Dcatfish KYMGIFNLAL SDFGETNALI PSLVKTLFF. ......DSQY ISYDACLANM
OLF47catfish KFLAVFNLAV VDISINSVII PQMVPVFVF. ......NLNH ISFESCFSQM
OLF202catfish MYYIMLNLAA SDVLFSTTTL PKIIARYWF. ......GDGS ISFVGCFIQM
OLFCOR1chicken MYIFLQNLSF TDAAYSTVIT PKMLATFL.. .....EERKT ISYVGCILQY
OLFCOR2chicken MYIFLQNLSF TDAAYSTVIT PKMLATFL.. .....EERRT ISYVGCILQY
OLFCOR3chicken MYIFLQNLSF TDAAYSTVIT PKMLATFL.. .....EERKT ISYVGCILQY
OLFCOR4chicken MYIFLQNLSF TDAAYSTVIT PKMLATFL.. .....EERKT ISYVGCILQY
OLFCOR5chicken MYIFLQNLSF TDAAYSTVIT PKMLATFL.. .....EERRT ISYVGCILQY
OLFCOR6chicken MYIFLQNLSF TDAVYSTVIT PKMLATFL.. .....EETKT ISYVGCILQY
OLFdog MYLFLSNLSF SDLCFSSVTM PKLLQNMQ.. .....SQVPS IPYAGCLTQM
OLF07E VYFFLANLSF TDLFFVTNTI PKMLVNLQ.. .....SHNKA ISYAGCLTQL
OLF07I MYLFLSNLSF SDLCFSSVTI PKLLQNMQ.. .....NQDPS IPYADCLTQM
OLF07J MYFFLSMLST SETVYTLVIL PRMLSSLV.. .....GMSQP MSLAGCATQM
OLFOR3mouse MYFFLSNLSS LDLAFTTSSV PQMLKNLW.. .....GPDKT ISYGGCVTQL
OLFrat MYYFLSSLSF VDLCYSTVIT PKMLVNFL.. .....GKKNF ITYSECMAQF
OLFF3rat MYFFLSNLSF VDICFISTTV PKMLVNIQ.. .....TQNNV ITYAGCITQI
OLFF5rat MYFFLSNLSF VDVCFSSTTV PKVLANHI.. .....LGSQA ISFSGCLTQL
OLFF6rat MYFFLCNLSF LEIWFTTACV PKTLATF... ....APRGGV ISLAGCATQM
OLFF12rat MYFFLANLSF VDICFTSTTI PKMLVNIY.. .....TQSKS ITYEDCISQM
OLFI3rat MYLFLSNLSF SDLCFSSVTM PKLLQNMR.. .....SQDTS IPYGGCLAQT
OLFI7rat MYFFLANMSF LEIWYVTVTI PKMLAGFIG. ..SKENHGQL ISFEACMTQL
OLFI8rat MYLFLSNLSF SDLCFSSVTM LKLLQNIQ.. .....SQVPS ISYAGCLTQI
OLFI9rat MYLFLSNLSF ADLCFSSVTM PKLLQNMQ.. .....SQVPS IPYAGCLAQI
OLFI14rat MYLFLSNLSF SDLCFSSVTM PKLLQNMQ.. .....SQVPS ISYTGCLTQL
OLFI15rat MYLFLSNLSF SDLCFSSVTM PKLLQNMQ.. .....SQVPS IPFAGCLTQL
OLFOR17_40 MYFFLGNLSV LDVGCISVTV PSMLSRLL.. .....SRKRA VPCGACLTQL
GUST27rat MYFFLSNLSF VDICFISTTI PKMLVNIH.. .....SQTKD ISYIECLSQV
RPE CHLLVLSLAL ADSGISLNAL VAATSSLLRR WPYG...... ..SDGCQAHG
HHRF1 GDVYFINLAA ADLLFVCTLP LWMQYLLDHN SLA....... ..SVPCTLLT
HHRF2 SDTYICNLAV ADLLIVVGLP FFLEYAKHHP KLSR...... ..EVVCSGLN
HHRF3 PTIYMTNLYS TNFLTLTVLP FIVLSNQWLL PAG....... ..VASCKFLS
MCP-1A TDIYLLNLAI SDLLFLITLP LWAHSAANEW VFG....... ..NAMCKLFT
MCP-1B TDIYLLNLAI SDLLFLITLP LWAHSAANEW VFG....... ..NAMCKLFT
PPR1bovine TDVYILNLAV ADLFLLFTLP FWAVNAVHGW VLG....... ..KIMCKVTS
2222222222 2222222222 2222222222 3333333
3444444444 4555555555 5666666666 2222222
9012345678 9012345678 9012345678 3456789
201 250
GPCRAelegans FLAVFSSELS LFTLVMMTIE RFYAIVHAMH M.....NARL SFRKTVRFMI
GRH YLKLFSMYAP AFMMVVISLD RSLAITRPLA L..KSNSKVG .....QSMVG
TRH YLQYLGINAS SCSITAFTIE RYIAICHPIK .A....QFLC TFSRAKKIII
FSHprec FFTVFASELS VYTLTAITLE RWHTITHAMQ L....DCKVQ LR.HAASVMV
TSHprec FFTVFASELS VYTLTVITLE RWYAITFAMR L....DRKIR LR.HACAIMV
LH_CGprec FFTVFASELS VYTLTVITLE RWHTITYAIH L....DQKLR LR.HAILIML
PGE_EP1 GCMVFFGLCP LLLGCGMAVE RCVGVTRPLL HAARVSVARA R....L.ALA
PGE_EP2 FILLFFSLSG LSIICAMSVE RYLAINHAYF YSHYVDKR.. ..LAGL.TLF
PGE_EP3 FAMTFFSLAT MLMLFAMALE RYLSIGHPYF ...YQRRVSA ..SGGLAVLP
PGF ICMVFSGLCP LLLGSVMAIE RCIGVTKPIF HSTKITSKHV K....M.MLS
PGI FAMTFFGLAS MLILFAMAVE RCLALSHPYL YAQLDGPRCA R.....LALP
TXA2 VVMIFFGLSP LLLGAAMASE RYLGITRPFS RPAVASQRR. ...AWA.TVG
PAF CLFFINTYCS VAFLGVITYN RFQAVTRPIK TAQANTRKR. ...GIS.LSL
M2 ALDYVVSNAS VMNLLIISFD RYFCVTKPLT Y...PVKRTT .KMAGM.MIA
M4 ALDYVVSNAS VMNLLIISFD RYFCVTKPLT Y...PARRTT .KMAGL.MIA
M1 ALDYVASNAS VMNLLLISFD RYFSVTRPLS Y...RAKRTP .RRAAL.MIG
M3 AIDYVASNAS VMNLLVISFD RYFSITRPLT Y...RAKRTT .KRAGV.MIG
M5 ALDYVASNAS VMNLLVISFD RYFSITRPLT Y...RAKRTP .KRAGI.MIG
H1 SMDYVASTAS IFSVFILCID RYRSVQQPLR Y...LKYRTK .TRASA.TIL
H2 SLDVMLCTAS ILNLFMISLD RYCAVMDPLR Y...PVLVTP VR.VAI.SLV
5HT1A ALDVLCCTSS ILHLCAIALD RYWAITDPID Y...VNKRT. PRRAAA.LIS
5HT1B SSDITCCTAS ILHLCVIALD RYWAITDAVE Y...SAKRT. PKRAAV.MIA
5HT1D SSDITCCTAS ILHLCVIALD RYWAITDALE Y...SKRRT. AGHAAT.MIA
5HT1E SVDMTCCTCS ILHLCVIALD RYWAITNAIE Y...ARKRT. AKRAAL.MIL
5HT1F SVDITCCTCS ILHLSAIALD RYRAITDAVE Y...ARKRT. PKHAGI.MIT
5HT2A YLDVLFSTAS IMHLCAISLD RYVAIQNPIH H.SRFNSRTK .AFLK...II
5HT2B FLDVLFSTAS IMHLCAISVD RYIAIKKPIQ A.NQYNSRAT .AFIK...IT
5HT2C SLDVLFSTAS IMHLCAISLD RYVAIRNPIE H.SRFNSRTK .AIMK...IA
5HT5A ACDVLCCTAS IWNVTAIALD RYWSITRHME Y...TLRTR. KCVSNV.MIA
5HT5Brat SFDVLCCTAS IWNVAAIALD RYWTITRHLQ Y...TLRTR. RRASAL.MIA
5HT6rat AFDVMCCSAS ILNLCLISLD RYLLILSPLR Y...KLRMTA PR.ALA.LIL
5HT7 AMDVMCCTAS IMTLCVISID RYLGITRPLT Y...PVRQN. GKCMAK.MIL
alpha1A AVDVLCCTAS ILSLCTISVD RYVGVRHSLK Y...PAIMTE RK.AAA.ILA
alpha1B AVDVLCCTAS ILSLCAISID RYIGVRYSLQ Y...PTLVTR RK.AIL.ALL
alpha1C AVDVLCCTAS IMGLCIISID RYIGVTYPLR Y...PTIVTQ RR.GLM.ALL
alpha2A ALDVLFCTSS IVHLCAISLD RYWSITQAIE Y...NLKRT. PRRIKA.III
alpha2B ALDVLFCTSS IVHLCAISLD RYWAVSRALE Y...NSKRT. PRRIKC.IIL
alpha2C1 ALDVLFCTSS IVHLCAISLD RYWSVTQAVE Y...NLKRT. PRRVKA.TIV
alpha2C2 ALDVLFCTSS IVHLCAISLD RYWSVTQAVE Y...NLKRT. PRRVKA.TIV
beta1 SVDVLCVTAS IETLCVIALD RYLAITSPFR Y...QSLLTR AR.ARG.LVC
beta2 SIDVLCVTAS IETLCVIAVD RYFAITSPFK Y...QSLLTK NK.ARV.IIL
beta3 SVDVLCVTAS IETLCALAVD RYLAVTNPLR Y...GALVTK RC.ART.AVV
beta4turkey SLDVLCVTAS IETLCAIAVD RYLAITAPLQ Y...EALVTK GRA..WAVVC
D1A AFDIMCSTAS ILNLCVISVD RYWAISSPFR Y...ERK.MT PKAAFI.LIS
D2 TLDVMMCTAS ILNLCAISID RYTAVAMPML Y..NTRY.SS KRRVTV.MIS
D3 TLDVMMCTAS ILNLCAISID RYTAVVMPVH YQHGTGQ.SS CRRVAL.MIT
D4 AMDVMLCTAS IFNLCAISVD RFVAVAVPLR Y...NRQ.GG SRRQLL.LIG
D5 AFDIMCSTAS ILNLCVISVD RYWAISRPFR Y...KRK.MT QRMALV.MVG
A1 CPVLILTQSS ILALLAIAVD RYLRVKIPLR Y..KMVVTPR R...AAVAIA
A2a CFVLVLTQSS IFSLLAIAID RYIAIRIPLR Y..NGLVTGT RAK...GIIA
A2b CFVLVLTQSS IFSLLAVAVD RYLAICVPLR Y..KSLVTGT RAR...GVIA
A3 CLLLIFTHAS IMSLLAIAVD RYLRVKLTVR Y..KRVTTHR R...IWLALG
OCdrome TCDVLCCTSS ILNLCAIALD RYWAITDPIN Y.AQKR...T VGR.VLLLIS
ACTH SLFVLSLLGS IFSLSVIAAD RYITIFHALR Y..HSIVTMR R...TVVVLT
MSH VITCSSMLSS LCFLGAIAVD RYISIFYALR Y..HSIVTLP RAPR...AVA
MC3 SMICISLVAS ICNLLAIAVD RYVTIFYALR Y..HSIMTVR K...ALTLIV
MC4 SVICSSLLAS ICSLLSIAVD RYFTIFYALQ Y..HNIMTVK RV...GIIIS
MC5 SMICISVVAS MCSLLAIAVD RYVTIFYALR Y..HHIMTAR RS...GAIIA
melatonin FLMGLSVIGS IFNITGIAIN RYCYICHSLK YDKL.....Y SSKNSLCYVL
oxytocin YLQVVGMFAS TYLLLLMSLD RCLAICQPLR SLRR...... RTDR..LAVL
conopressinLs YFQVIAMYAS SYVLVMAAID RYLSICHPLT SQTL..SPKR ....VHLMIA
V1A HLQVFGMFAS AYMLVVMTAD RYIAVCHPLK T..LQQ.PAR R...SRLMIA
V1B YLQVLSMFAS TYMLLAMTLD RYLAVCHPLR SLQQ...... PGQSTYLLIA
V2 YLQMVGMYAS SYMILAMTLD RHRAICRPML A..YRHG..S .GAHWNRPVL
CCK_A YFMGTSVSVS TFNLVAISLE RYGAICKPLQ S..RVWQTKS ...HALKVIA
CCK_B YLMGVSVSVS TLSLVAIALE RYSAICRPLQ A..RVWQTRS ...HAARVIV
NPY1 FVQCVSITVS IFSLVLIAVE RHQLIINPRG W..RP..... NNRHAYVGIA
NTR FLRDACTYAT ALNVASLSVE RYLAICHPFK AKTLMSRS.. ...RTKKFIS
NK1 FFPIAAVFAS IYSMTAVAFD RYMAIIHPL. ...QPRLS.. .ATATKVVIC
NK2 LFPITAMFVS IYSMTAIAAD RYMAIVHPF. ...QPRLS.. .APSTKAVIA
NK3 FFPITAVFAS IYSMTAIAVD RYMAIIDPL. ...KPRLS.. .ATATKIVIG
blueops FLGTVAGLVT GWSLAFLAFE RYIVICKPF. G..NFRF... SSKHALTVVL
greenops YTVSLCGITG LWSLAIISWE RWMVVCKPF. G..NVRF... DAKLAIVGIA
redops YTVSLCGITG LWSLAIISWE RWLVVCKPF. G..NVRF... DAKLAIVGIA
rhodopsin FFATLGGEIA LWSLVVLAIE RYVVVCKPM. S..NFRF... GENHAIMGVA
violetopsGg FVGTHGGLVT GWSLAFLAFE RYIVICKPFG NFRF...... SSRHALLVVV
opsin_crab MAGSLFGCAS IWSMVMITLD RYNVIVRGMA AAPL...... THKKATLLLL
ET_Aprec FLQKSSVGIT VLNLCALSVD RYRAVASWSR V..Q...GIG IPLVTAIEIV
ET_Bprec FIQKASVGIT VLSLCALSID RYRAVASWSR I..K...GIG VPKWTAVEIV
ET_Cfrog LVHLYRARVY SLSLCALSID RYRAVASWNR I..R...SIG IPVRKAIELT
galanin YFFTVSMLVS IFTLAAMSVD RYVAIVHSRR S.....SSLR VSRNALLGVG
NMB VIQLTSVGVS VFTLTALSAD RYRAIVNPMD M..Q...TSG ALLRTCVKAM
GRP FIQLTSVGVS VFTLTALSAD RYKAIVRPMD I..Q...ASH ALMKICLKAA
BRS3 FIRLTSVGVS VFTLTILSAD RYKAVVKPLE R..Q...PSN AILKTCVKAG
deltaOP SIDYYNMFTS IFTLTMMSVD RYIAVCHPVK A..LDFRTPA KAK...LINI
kappaOP SIDYYNMFTS IFTLTMMSVD RYIAVCHPVK A..LDFRTPL KAK...IINI
muOP SIDYYNMFTS IFTLCTMSVD RYIAVCHPVK A..LDFRTPR NAK...IINV
OPRX AIDYYNMFTS TFTLTAMSVD RYVAICHPIR A..LDVRT.. SSK.AQAVNV
CB1 GGVTASFTAS VGSLFLTAID RYISIHRPLA Y..KRIVTRP ..K.AVVAFC
CB2 GSVTMTFTAS VGSLLLTAID RYLCLRYPPS Y..KALLTRG ..R.ALVTLG
SSTR1 SVDAVNMFTS IYCLTVLSVD RYVAVVHPIK A..ARYRRPT VAK...VVNL
SSTR2 TVDGINQFTS IFCLTVMSID RYLAVVHPIK S..AKWRRPR TAK...MITM
SSTR3 AVDGINQFTS IFCLTVMSVD RYLAVVHPTR S..ARWRTAP VAR...TVSA
SSTR4 SVDGLNMFTS VFCLTVLSVD RYVAVVHPLR A..ATYRRPS VAK...LINL
SSTR5 TLDGVNQFTS VFCLTVMSVD RYLAVVHPLS S..ARWRRPR VAK...LASA
IL8A LLKEVNFYSG ILLLACISVD RYLAIVHATR T...LTQKRH LVK...FVCL
IL8B LLKEVNFYSG ILLLACISVD RYLAIVHATR T...LTQKRY LVK...FICL
AT1a ASVSFNLYAS VFLLTCLSID RYLAIVHPMK S..RLRRTML VAK...VTCI
AT1brat ASVSFNLYAS VFLLTCLSID RYLAIVHPMK S..RLRRTML VAK...VTCI
AT2 SFLTLNMFAS IFFITCMSVD RYQSVIYPFL S..Q.RRNPW ...QASYIVP
BK1 GVIKANLFIS IFLVVAISQD RYRVLVHPMA S..GRQQRRR QAR...VTCV
BK2 AIISMNLYSS ICFLMLVSID RYLALVKTMS M..GRMRGVR WAK...LYSL
P2Y7 YVCGVSMYAS VLLITAMSLD RSLAVARPFV SQKLRTKAMA RR.....VLA
P2Y6 FLFYANLHGS ILFLTCISFQ RYLGICHPLA PWHKRGGRRA AW....VVCG
P2Y5 TLFYTNMYGS ILFLTCISVD RFLAIVHPFR SKTLRTK.RN AR....IVCV
P2Y4 FLFYWNLYCS VLFLTCISVH RYLGICHPLR AL.RWGRPRL AG....LLCL
P2Y3chick FQFYTNLHGS ILFLTCISVQ RYMGICHPLA SWHKKKGKKL TW....LVCA
P2Y2 FLFYTNLYCS ILFLTCISVH RCLGVLRPLR SL.RWGRARY AR....RVAG
P2Y1 FIFHVNLYGS ILFLTCISAH RYSGVVYPLK SLG.RLKKKN AI....CISV
THRprec AAFYCNMYAS ILLMTVISID RFLAVVYPMQ S..LSWR... TLGRASFTCL
C5a SLILLNMYAS ILLLATISAD RFLLVFKPIW CQNFR..... GAGLAWIACA
GP01mouse GLIVASFSAS VCSLLAITVD RYLSLYYALT YHSERT.... .VTFTYVMLV
R334rat GLIVASFSAS VCSLLAITVD RYLSLYYALT YHSERT.... .VTFTYVMLV
GP21mouse GVLAMAFTAS IGSLLAITVD RYLSLYNALT YYSETT.... .VTRTYVMLA
GCRCmouse FAQYCSLHVS ALTLTAIAVD RHQVIMHPLK P....RIS.. .ITKGVIYIA
TXKR FFPITAVFAS IYSMTAIAVD RYMAIIDPLK P....RLS.. .ATATRIVIG
G10Drat YFYLANMYSS IFFLTCLSID RYVTLTNTSP SWQRHQHRI. ..RR.AV.CA
RDC1 LIFSINLFSG IFFLTCMSVD RYLSITYFTN TPSSRKKMV. ..RR.VV.CI
BLR1 ALHKVNFYCS SLLLACIAVD RYLAIVHAVH AY..RHRRLL SIHIT...CG
CL5 VIYTVNLYSS VLILAFISLD RYLAIVHA.. TNSQRPRKLL AEK...VVYV
LCR1 VIYTVNLYSS VLILAFISLD RYLAIVHA.. TNSQRPRKLL AEK...VVYV
EBI1 AIYKMSFFSG MLLLLCISID RYVAIVQAVS AHRHRARVLL ISK...LSCV
RBS1rat AFFFIGFFGG IFFITVISID RYLAIVLA.. ANSMNNRTVQ .HGVT..ISL
EBI2 LVFYINTYAG VNFMTCLSID RFIAVVHPLR YNKIKRIE.. HAK...GVCI
GCRTchick TLFYTNMYGS ILFLTCISVD RFLAIVHPFR SKTLRTKR.. NAR...IVCV
APJ YLIFVNMYAS VFCLTGLSFD RYLAIVRPVA NARLRLR... .VS.GAVATA
RTArat IVGLCTFFAG VSLLPAISIE RCVSVIFPMW YWRRRPKR.. .LSAG..VCA
UHRrat FLQPVTVYVS VFTLTTIAVD RYVVLVHPL. ......RRRI SLKLSAYAVL
FMRL1 VMIDINLFVS VYLITIIALD RCICVLHPAW AQNHR..... TMSLAKRVMT
FMRL2 IVVDINLFGS VFLIGFIALD RCICVLHPVW AQNHR..... TVSLAMKVIV
fMLP TIVDINLFGS VFLIALIALD RCVCVLHPVW TQNHR..... TVSLAKKVII
OLF1catfish FFVLFFMTVQ SLTLLVMAYD RVVAICFPLR YNVIV..... TKEAMTLIIV
OLF3catfish FFVYCFMTLQ CLTLLALAYD RLIAICYPLR YHAIV..... TKAAMIFIIG
OLF8catfish FCIHCAGTFQ STILLWMALD RFFAICRPLY YQKYM..... GMPNFLKFII
OLF32Acatfish FLTFFFSSGQ ALTLVALAYD RFIAICLPLR YNAIV..... NNSFMFASLT
OLF32Bcatfish FFTFLFFGGQ ALTLVALAYD RFIAICLPLR YHAIV..... NNSFMFATLT
OLF32Ccatfish FFTFFFSGGQ ALTLVALAYD RFIAICLPLR YHAIV..... NNSFMFATLT
OLF32Dcatfish FFTFFFAGGQ ALTLVALAYD RFIAICLPLR YHAIV..... NNSFMFVTLI
OLF47catfish FFMHFFGDME SFSLALLAYD RLIAICFPLR YPTIN..... TNMRMVLIIA
OLF202catfish QFVHYFATVN ALVLAVMAFD RYVAVCNPLR YVNIV..... KESTILGLCV
OLFCOR1chicken FSFVLLTVTE SLLLAVMAYD RYVAICKPLL YPSIM..... TKAVCWRLVE
OLFCOR2chicken FSFVLLTTSE WLLLAVMAYD RYVAICKPLL YPSIM..... TKAVCWRLVK
OLFCOR3chicken FSFVLLTTSE CLLLAVMAYD RYVAICKPLL YPAIM..... TKAVCWRLVE
OLFCOR4chicken FSFVLLTTSE CLLLAVMAYD RYVAICKPLL YPAIM..... TKAVCWRLVE
OLFCOR5chicken FSFVLLTSSE CLLLAVMAYD RYVAICKPLL YPAIM..... TKAVCWRLVE
OLFCOR6chicken FSFVLLTVRE CLLLAVMAYD RYAAICKPLL YPAIM..... TKAVCWRLVK
OLFdog YFFLFFGDLE SFLLVAMAYD RYVAICFPLH YTTIM..... SPKLCFSLLV
OLF07E YFLVSLVALD NLILAVMAYD RYVAICCPLH YTTAM..... SPKLCILLLS
OLF07I YFFLLFGDLE SFLLVAMAYD RYVAICFPLH YTAIM..... SPMLCLALVA
OLF07J FFFVTFGITN CFLLTAMGYD RYVAICNPLR YMVIM..... NKRLRIQLVL
OLFOR3mouse YVFLWLGATE CILLVVMAFD RYVAVCRPLH YMTVM..... NPRLCWGLAA
OLFrat FFFAIFVVTE GYLLTVMAYD RYVAICRPLL YNVIM..... SSRICSLLVL
OLFF3rat YFFLLFVELD NFLLTIMAYD RYVAICHPMH YTVIM..... NYKLCGFLVL
OLFF5rat YFLAVFGNMD NFLLAVMSYD RFVAICHPLH YTTKM..... TRQLCVLLVV
OLFF6rat YFVFSLGCTE YFLLAVMAYD RYLAICLPLR YGGIM..... TPGLAMRLAL
OLFF12rat CVFLVFAELG NFLLAVMAYD RYVAXCHPLC YTVIV..... NHRLCILLLL
OLFI3rat YFFMVFGDME SFLLVAMAYD RYVAICFPLH YTSIM..... SPKLCTCLVL
OLFI7rat YFFLGLGCTE CVLLAVMAYD RYVAICHPLH YPVIV..... SSRLCVQMAA
OLFI8rat FFFLLFGYLG NFLLVAMAYD RYVAICFPLH YTNIM..... SHKLCTCLLL
OLFI9rat YFFLFFGDLG NFLLVAMAYD RYVAICFPLH YMSIM..... SPKLCVSLVV
OLFI14rat YFFMVFGDME SFLLVVMAYD RYVAICFPLR YTTIM..... STKFCASLVL
OLFI15rat YFYLYFADLE SFLLVAMAYD RYVAICFPLH YMSIM..... SPKLCVSLVV
OLFOR17_40 FFFHLFVGVD CFLLTAMAYD QFLAICRPLT YSTRM..... SQTVQRMLVA
GUST27rat YFLTTFGGMD NFLLTLMACD RYVAICHPLN YTVI.....M NLQLCALLIL
RPE FQGFVTALAS ICSSAAIAWG RYHHYC.... .....TRSQL AWNSAVSLVL
HHRF1 ACFYVAMFAS LCFITEIALD RYYAIVY... .MRYR..... PVKQACLFSI
HHRF2 ACFYICLFAG VCFLINLSMD RYCVIVWGVE LNRVR..... NNKRATCWVV
HHRF3 VIYYSSCTVG FATVALIAAD RYRVLHKRTY ARQSY..... RSTYMIL..L
MCP-1A GLYHIGYFGG IFFIILLTID RYLAIVHAVF ALKAR..... TVTFGVVTSV
MCP-1B GLYHIGYFGG IFFIILLTID RYLAIVHAVF ALKAR..... TVTFGVVTSV
PPR1bovine ALYTVNFVSG MQFLACISTD RYWAVTKAPS QSGVG..... ..KPCWVICF
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GPCRAelegans GGWIFALVMA VVPLTGVSGY SKVAI..... .....CLPFD VSDATSTAYV
GRH LAWILSSVFA GPQLYIF..R MIHLADSSGQ .......... .TKVFSQCVT
TRH FVWAFTSLYC MLWFFLLDLN ISTYKDAIVI SCGYK..... ..........
FSHprec MGWIFAFAAA LFPIFGISSY M......... .KVSICLPMD IDS.......
TSHprec GGWVCCFLLA LLPLVGISSY A......... .KVSICLPMD TET.......
LH_CGprec GGWLFSSLIA MLPLVGVSNY M......... .KVSICFPMD VET.......
PGE_EP1 AVAAVALAVA LLPLARVG.. .....RYELQ YPGTWCFIGL GPPG......
PGE_EP2 AVYASNVLFC ALPNMGLGSS .......RLQ YPDTWCFIDW TTNVT.....
PGE_EP3 VIYAVSLLFC SLPLLDYG.. .....QYVQY CPGTWCFIRH GRT.......
PGF GVCLFAVFIA LLPILG.... ...HRDYKIQ ASRTWCFYNT EDIK......
PGI AIYAFCVLFC ALPLLGLG.. ..QHQQY... CPGSWCFLRM RWAQ......
TXA2 LVWAAALALG LLPLLGVG.. .....RYTVQ YPGSWCFLTL GA........
PAF VIWVAIVGAA SYFLILDSTN .........T VPDSAGSG.N ..V.TR...C
M2 AAWVLSFILW APAILFW... .......... .........Q FIVGVRTVED
M4 AAWVLSFVLW APAILFW... .......... .........Q FVVGKRTVPD
M1 LAWLVSFVLW APAILFW... .......... .........Q YLVGERTVLA
M3 LAWVISFVLW APAILFW... .......... .........Q YFVGKRTVPP
M5 LAWLISFILW APAILCW... .......... .........Q YLVGKRTVPL
H1 GAWFLSFLWV IPILGWN... .......... .........H FMQQTSVRRE
H2 LIWVISITLS FLSIHLGWNS RNE....... .......... .TSKGNH...
5HT1A LTWLIGFLIS IPPMLGWRTP E......... .......... ...DRSDPDA
5HT1B LVWVFSISIS LPPFFWR.QA K......... .......... ...AEEEVSE
5HT1D IVWAISICIS IPPLFWR.QA K......... .......... ...AQEEMSD
5HT1E TVWTISIFIS MPPLFWRSHR R......... .......... ...LSPPPSQ
5HT1F IVWIISVFIS MPPLFWR..H Q......... .......... ...GTSRDDE
5HT2A AVWTISVGIS MPIPVFGLQD .......... .......... ...DSKVF.K
5HT2B VVWLISIGIA IPVPIKGIET .......... .......... ...DVDNPNN
5HT2C IVWAISIGVS VPIPVIGLRD .......... .......... ...EEKVFVN
5HT5A LTWALSAVIS LAPLLFGWGE T......... .......... ...YSEGSEE
5HT5Brat ITWALSALIA LAPLLFGWGE A......... .......... ...YDARLQR
5HT6rat GAWSLAALAS FLPLLLGWHE L......... ....GKARTP A.........
5HT7 SVWLLSASIT LPPLFGWAQN V......... .......... ...NDDKVC.
alpha1A LLWVVALVVS VGPL.LGWKE P......... .......... ....VPP...
alpha1B SVWVLSTVIS IGPL.LGWKE P......... .......... ....APN...
alpha1C CVWALSLVIS IGPL.FGWRQ P......... .......... ....APE...
alpha2A TVWVISAVIS FPPLISIEKK G......... .......... ...GGGGPQP
alpha2B TVWLIAAVIS LPPLIY...K G......... .......... ...DQGPQPR
alpha2C1 AVWLISAVIS FPPLVSLYRQ P......... .......... ...DGA....
alpha2C2 AVWLISAVIS FPPLVSLYRQ P......... .......... ...DGA....
beta1 TVWAISALVS FLPILMHWWR AES....... .......... .D.EARRCYN
beta2 MVWIVSGLTS FLPIQMHWYR ATH....... .......... .Q.EAINCYA
beta3 LVWVVSAAVS FAPIMSQWWR VGA....... .......... .DAEAQRCHS
beta4turkey MVWAISAFIS FLPIMNHWWR DGA....... .......... .DEQAVRCYD
D1A VAWTLSVLIS FIPVQLSWHK AKPTS..... .........P SDGNATSLAE
D2 IVWVLSFTIS CPLLFGLN.. .......... .......... ...NADQNEC
D3 AVWVLAFAVS CPLLFGFNT. .......... .......... ...TGDPTVC
D4 ATWLLSAAVA APVLCGLNDV R......... .......... ...GRDPAVC
D5 LAWTLSILIS FIPVQLNWHR DQAASWGGLD LPNNLANWTP WEEDFWEPDV
A1 GCWILSFVVG LTPMFGWNNL SAVERA.... ......WAAN GSMGE..PVI
A2a ICWVLSFAIG LTPMLGW... ....NNCG.. .QPKEGKNHS QGCGEG..QV
A2b VLWVLAFGIG LTPFLGWNSK DSATNNCT.. .EPWDGTTNE SCC.....LV
A3 LCWLVSFLVG LTPMFGWNMK LTSEYH.... ......RNV. .......TFL
OCdrome GVWLLSLLIS SPPLIGWN . DW........ .PDEFTSATP CE........
ACTH VIWTFCTGTG ITMVIFSHHV .......... .......... ..........
MSH AIWVASVVFS TLFIAYYDHV .......... .......... ..........
MC3 AIWVCCGVCG VVFIVYSESK .......... .......... ..........
MC4 CIWAACTVSG ILFIIYSDSS .......... .......... ..........
MC5 GIWAFCTGCG IVFILYSEST .......... .......... ..........
melatonin LIWLLTLAAV LPNLRAGTLQ YD........ .......... .......PRI
oxytocin ATWLGCLVAS APQVHIFSLR EVADG..VFD .......... .........C
conopressinLs LAWLISFLCA LPQVFIFSLQ AVGPD..QYD C......... ..........
V1A AAWVLSFVLS TPQYFVFSMI EVNNVTKARD C......... ..........
V1B APWLLAAIFS LPQVFIFSLR EVIQGSGVLD .......... .........C
V2 VAWAFSLLLS LPQLFIFAQR NVEGGSGVTD C......... ..........
CCK_A ATWCLSFTIM TPYPIYSNLV PFTKNNNQTA NMCRFLLPND VMQQSWH...
CCK_B ATWLLSGLLM VPYPVYTVVQ PVGPRVLQCV HR....WPSA RVRQTWS...
NPY1 VIWVLAVASS LPFLIYQVMT DEPFQNVTLD AYKDKYVCFD QFPSDSHRLS
NTR AIWLASALLT VPMLFTMGEQ NRSADGQHAG GLVCTPTIHT ATVKVV....
NK1 VIWVLALLLA FPQGY..YST TETMPSRVVC MIEWPEHPNK IYEKVYH...
NK2 GIWLVALALA SPQCF..YST VTMDQGATKC VVAWPEDSGG KTLLLYH...
NK3 SIWILAFLLA FPQCL..YSK TKVMPGRTLC FVQWPEGPKQ HF..TYH...
blueops ATWTIGIGVS IPPFFG.WSR FIPEGLQCSC GPDWYTVGTK YRSESYT...
greenops FSWIWAAVWT APPIFG.WSR YWPHGLKTSC GPDVFSGSSY PGVQSYM...
redops FSWIWSAVWT APPIFG.WSR YWPHGLKTSC GPDVFSGSSY PGVQSYM...
rhodopsin FTWVMALACA APPLAG.WSR YIPEGLQCSC GIDYYTLKPE VNNESFV...
violetopsGg ATWLIGVGVG LPPFFG.WSR YMPEGLQCSC G......... ........PD
opsin_crab FVWIWSGGWT ILPFFG.WSR YVPEGNLTSC T......... ........VD
ET_Aprec SIWILSFILA IPEAIGFVMV PFEYRGEQHK TCMLNATSK. ..........
ET_Bprec LIWVVSVVLA VPEAIGFDII TMDYKGSYLR ICLLHPVQK. ....TA....
ET_Cfrog LIWAVAIIVA VPEAIAFNLV ELDFRGQTIL VCMLPMEQ.. ....TS....
galanin CIWALSIAMA SPVAYHQGLF HPRASNQTFC WEQWPDPRHK ..........
NMB GIWVVSVLLA VPEAVFSEVA RI...SSLDN SSFTA..... ........CI
GRP FIWIISMLLA IPEAVFSDLH PF..HEESTN QTFI...... .......SCA
BRS3 CVWIVSMIFA LPEAIFSNVY TF..RDPNKN MTFE...... .......SCT
deltaOP CIWVLASGVG VPIMVMAVTR ..PRD..GAV VCMLQF.... ..........
kappaOP CIWLLSSSVG ISAIVLGGTK ..VREDVDVI ECSLQFPD.. ..DDY.....
muOP CNWILSSAIG LPVMFMATTK ..YRQ..GSI DCTLTF.... ....S.H...
OPRX AIWALASVVG VPVAIMGSAQ ..VEDEEIEC LVEIPT.... PQDYWGPVFA
CB1 LMWTIAIVIA VLPLLGWNCE K......... .......... ..........
CB2 IMWVLSALVS YLPLMGWTCC PR........ .......... ..........
SSTR1 GVWVLSLLVI LPIVVFSRT. ..AANSDGTV ACNMLMPE.. PAQRWLVGFV
SSTR2 AVWGVSLLVI LPIMIYAGLR ..SNQWGRS. SCTINWPG.. ESGAWYTGFI
SSTR3 AVWVASAVVV LPVVVFSGV. ....PRGMS. TCHMQWPE.. PAAAWRAGFI
SSTR4 GVWLASLLVT LPIAIFADTR ..PARGGQAV ACNLQWPH.. PA..WSAVFV
SSTR5 AAWVLSLCMS LPLLVFADV. ....QEG.G. TCNASWPE.. PVGLWGAVFI
IL8A GCWGLSMNLS LPFFLFRQA. ...YHPNNSS PVCYEVLG.. NDTAKWRMVL
IL8B SIWGLSLLLA LPVLLFRRT. ...VYSSNVS PACYEDMG.. NNTANWRMLL
AT1a IIWLLAGLAS LPAIIHRNV. .FFIENTNIT VCAFHYES.. QN.STL....
AT1brat IIWLMAGLAS LPAVIYRNV. .YFIENTNIT VCAFHYES.. QN.STL....
AT2 LVWCMACLSS LPTFYFRDV. .RTIEYLGVN ACIMAFPP.. EKYAQW....
BK1 LIWVVGGLLS IPTFLLRSIQ AVPD..LNIT ACILLLPH.. EAWHFAR...
BK2 VIWGCTLLLS SPMLVFRTMK EYSDEGHNVT ACVISYPS.. LIWEVFT...
P2Y7 GIWVLSFLLA TPVLAYRTVV PWKTNM.... SLCFPRYP.. SEGHRAFH..
P2Y6 VVWLVVTAQC LPTAVFAATG IQRNRT.... VCYDLSPP.. ILSTRYLP..
P2Y5 AVWITVLAGS TPASFFQSTN RQNNTEQR.. TCFENFPE.. STWKTYLSR.
P2Y4 AVWLVVAGCL VPNLFFVTTS TKGTTV.... LCHDTTRP.. EEFDHYVH..
P2Y3chick AVWFIVIAQC LPTFVFASTG TQRNRT.... VCYDLSPP.. DRSTSYF...
P2Y2 AVWVLVLACQ APVLYFVTTS ARG.PL.... TCHDTSAP.. ELFSRFVA..
P2Y1 LVWLIVVVAI SPILFYSGTG VRKNKTI... TCYDTTSD.. EYLRSYFI..
THRprec AIWALAIAGV VPLVLKEQT. .IQVPGLNIT TCHDVLNE.. TLLEGY....
C5a VAWGLALLLT IPSFLYRVV. REEYFPPKVL CGVDYSHD.. KRRER.....
GP01mouse MLWGTSICLG LLPVMGWNCL RDESTCSVVR PLTK...... ..........
R334rat MLWGTSTCLG LLLXMGWNCL RDESTCSVVR PLTK...... ..........
GP21mouse LVWVGALGLG LVPVLAWNCR DGLTTCGVVY PLSK...... ..........
GCRCmouse VIWVMATFFS LPHAICQKLF TFKYSEDIVR SLCLPDFPEP ADL.......
TXKR SIWILAFLLA FPQCLYSKIK VMP.....GR TLCYVQWPEG SRQHF.....
G10Drat GVWVLSAIIP LPEVVHIQLL DGS...EPMC LF...LAPFE TYSA......
RDC1 LVWLLAFCVS LPDTYYLKTV TSASNNETYC RS...FYPEH SIKE......
BLR1 TIWLVGFLLA LPEILFAKVS QGHHNNSLPR CT...FSQEN QAETH.....
CL5 GVWIPALLLT IPDFIFANV. .SEADDRYIC DR...FYPND L.........
LCR1 GVWIPALLLT IPDFIFANV. .SEADDRYIC DR...FYPND L.........
EBI1 GSAILATVLS IPELLYSDLQ RSSSEQAMRC SL...ITEHV E.........
RBS1rat GVWAAAILVA SPQFMFTKRK DNECLGDYP. .........E VLQEI.....
EBI2 FVWILVFAQT LPLLINPMSK QEAERITCME YP....NFEE T.KSL.....
GCRTchick AVWITVLAGS TPASFFQSTN RQNNTEQRTC FE...NFPES TWKTY.....
APJ VLWVLAALLA MPVMVLRTTG DLENTTKVQC YMDYSMVATV SSEWA.....
RTArat LLWLLSFLVT SIHNYFCMFL GHEASGTA.. .......... ....C.....
UHRrat GIWALSAVLA LPAAVHTYHV ELKPHDVRLC .......EEF WGSQE.....
FMRL1 GLWIFTITIV LTLPNFIFWT TISTTNGDTY CIFNFAFWGD TAVER.....
FMRL2 GPWILALALV LTLPVFLFLT TVTIPNGDTY CTFNFASWGG TPEER.....
fMLP GPWVMALALL LTLPVIIRVT TVPGKTGTVA CTFNFSPWTN DPKER.....
OLF1catfish ITWIFSISII ALLVALITRL SFCR...... .....SVIIN SYFCDHGPIL
OLF3catfish AMWVLSVSVN AVLVALITRL SFCR...... .....STTVY SYFCDHGPIY
OLF8catfish FPVIRNLFFI TTIVSWAGKL TFCE...... .....TNEID HCVCEHMALV
OLF32Acatfish AIWIFNVVMN GTLVVLITRL SFCK...... .....TNEIK SFFCDHGPVY
OLF32Bcatfish AIWVFNLVMI GTLVVLITRL SFCK...... .....TNEIK SFFCDHGPVY
OLF32Ccatfish AIWVFNLVIF GTTVVFITRL SFCK...... .....TNEIK SFFCDHGPVY
OLF32Dcatfish AIWVFNVVII GTTVVFITRL SFCK...... .....TNEIK SFFCDHGPVY
OLF47catfish SLWFLVFLIE LYPVALASGL SYCR...... .....SRVVP SCCCEHGPVY
OLF202catfish VSWLLAEPTV LTTVIRATSL PYCA...... .....SNTVI QCYCDHVSVT
OLFCOR1chicken SLYFLAFLNS LVHTSGLLKL SFCY...... .....SNVVN HFFCDISPLF
OLFCOR2chicken GLYSLAFLNS LVHTSGLLKL SFCS...... .....SNVVN HFFCDNRPLF
OLFCOR3chicken SLYFLAFLNS LVHTCGLLKL SFCY...... .....SNVVN HFFCDISPLF
OLFCOR4chicken SLYFLAFLNS LVHTCGLLKL SFCY...... .....SNVVN HFFCDISPLF
OLFCOR5chicken GLYSLAFLNS LVHTSGLLKL SFCS...... .....SNVVN HFFCDNSPLF
OLFCOR6chicken GLYSLAFLNF LVHTSGLLKL SFCS...... .....SNVVN HFFCDNSPLF
OLFdog LSWVLTMFHA VLHTLLMARL CFCA...... ......NTIP HFFCDMSALL
OLF07E LSWVLTTFHA MLHTLLMARL CFCA...... .....DNVIP HFFCDMSALL
OLF07I GACSIGLIVA ITQVTSVFRL PFCA...... ......RKVP HFFCDIRPVM
OLF07J LCWVLSVLYG LIHTLLMTRV TFCG...... .....SRKIH YIFCEMYVLL
OLFOR3mouse ISWLGGLGNS VIQSTFTLQL PFCG...... .....HRKVD NFLCEVPAMI
OLFrat VAFSLGLFSA VVHTSAMMNL SFCK...... .....SYIIS HYFCDALPLL
OLFF3rat VSWIVSVLHA LFQSLMMLAL PFCT...... .....HLEIP HYFCEPNQVI
OLFF5rat GSWVVANMNC LLHILLMARL SFCA...... .....DNMIP HFFCDGTPLL
OLFF6rat GSWLCGFSAI TVPATLIARL SFCG...... .....SRVIN HFFCDISPWI
OLFF12rat LSWVISIFHA FIQSLIVLQL TFCG...... .....DVKIP HFFCELNQLS
OLFI3rat LLWMLTTSHA MMHTLLAARL SFCE...... .....NNVVL NFFCDLFVLL
OLFI7rat GSWAGGFGIS MVKVFLISRL SYCG...... .....PNTIN HFFCDVSPLL
OLFI8rat VFWIMTSSHA MMHTLLAARL SFCE...... .....NNVLL NFFCDLFVLL
OLFI9rat LSWVLTTFHA MLHTLLMARL SFCE...... .....DSVIP HYFCDMSTLL
OLFI14rat LLWMLTMTHA LLHTLLIARL SFCE...... .....KNVIL HFFCDISALL
OLFI15rat LSWVLTTFHA MLHTLLMARL SFCA...... .....DNMIP HFFCDISPLL
OLFOR17_40 ASWACAFTNA LTHTVAMSTL NFCG...... .....PNVIN HFYCDLPQLF
GUST27rat MFWLIMFCVS LIHVLLMNEL NFS....... ....RGTEIP HFFCELAQVL
RPE FVWLSSAFWA ALPLLGWGHY DYEPLGTCCT .......... ........LD
HHRF1 FWWIFAVIIA IPHFMVVTKK DNQCMTDY.. .......... .........D
HHRF2 IFWILAVLMG MPHYLMYSHT NNECVGEF.. .......... ..........
HHRF3 LTWLAGLIFS VPAAVYTTVV MHH....... ...DANDTNN TNGHATCVLY
MCP-1A ITWLVAVFAS VPGIIFTKCQ KEDSVYV.... ......... ..........
MCP-1B ITWLVAVFAS VPGIIFTKCQ KEDSVYV.... ......... ..........
PPR1bovine CVWVAAILLS IPQLVFYTVN HKA....... .......... .....RCVPI
4444444444 4444444444 4444444444
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8901234567 8901234567 8901234567
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GPCRAelegans .AFLLLVNGA STSTAYVAFL LLVNGASFIS VMYLYSRMLY VVVSGGDMEG
GRH HCSFSQWWHQ AFYNFFTFSC LFIIPLFIML ICNAKIIFTL TRVL.HQDPH
TRH ....ISRNYY SPIYLMDFGV FYVVPMILAT VLYGFIARIL FLNPIPSDPK
FSHprec ........PL SQLYVMSLLV LNVLAFVVIC GCYIHIYLTV RNPNIVSSS.
TSHprec ........PL ALAYIVFVLT LNIVAFVIVC CCHVKIYITV RNPQYNPGD.
LH_CGprec ........TL SQVYILTILI LNVVAFFIIC ACYIKIYFAV RNPELMATN.
PGE_EP1 .GWRQ..... .ALLAGLFAS LGLVALLAAL VCNTLSGLAL HRARWRRRSR
PGE_EP2 .........A HAAYSYMYAG FSSFLILATV LCNVLVCGAL LRMHRQFMRR
PGE_EP3 .......... ..AYLQLYAT LLLLLIVSVL ACNFSVI... .LNL......
PGF .DWEDR.... ..FYLLLFSF LGLLALGVSL LCNAITGITL LRVKFK....
PGI ........PG GAAFSLAYAG LVALLVAAIF LCNGSVTLSL CRMYRQ....
TXA2 .ESGD..... .VAFGLLFSM LGGLSVGLSF LLNTVSVATL ..........
PAF FEHYEKGSVP VLIIHIFIVF SFFLVFLIIL FCNLVII... .RTLL.MQ..
M2 GECYIQFFSN AAVTFGTAIA AFYLPVIIMT VLYWHIS... .RASKSRIKK
M4 NHCFIQFLSN PAVTFGTAIA AFYLPVVIMT VLYIHIS... .LASRSRVHK
M1 GQCYIQFLSQ PIITFGTAMA AFYLPVTVMC TLYWRIY... .RETENRARE
M3 GECFIQFLSE PTITFGTAIA AFYMPVTIMT ILYWRIY... .KETEKRTKE
M5 DECQIQFLSE PTITFGTAIA AFYIPVSVMT ILYCRIY... .RETEKRTKD
H1 DKCETDFYDV TWFKVMTAII NFYLPTLLML WFYAKIY... .KAVRQHCQH
H2 TTSKCKVQVN EVYGLVDGLV TFYLPLLIMC ITYYRIF... .KVARDQAKR
5HT1A CTISKD...H .GYTIYSTFG AFYIPLLLML VLYGRIF... .RAARFRIRK
5HT1B CVVNTD...H ILYTVYSTVG AFYFPTLLLI ALYGRIY... .VEARSRILK
5HT1D CLVNTS...Q ISYTIYSTCG AFYIPSVLLI ILYGRIY... .RAARNRIL.
5HT1E CTIQHD...H VIYTIYSTLG AFYIPLTLIL ILYYRIY... .HAAKSLYQK
5HT1F CIIKHD...H IVSTIYSTFG AFYIPLALIL ILYYKIY... .RAAKTLYHK
5HT2A EGSCLLAD.. DNFVLIGSFV SFFIPLTIMV ITYFLTI... .KSLQKEATL
5HT2B ITCVLTKERF GDFMLFGSLA AFFTPLAIMI VTYFLT.... .IHALQKKAY
5HT2C NTTCVLND.. PNFVLIGSFV AFFIPLTIMV ITYCLTI... .YVLRRQALM
5HT5A CQVSRE...P .SYAVFSTVG AFYLPLCVVL FVYWKIY... .KAAKFRVGS
5HT5Brat CQVSQE...P .SYAVFSTCG AFYVPLAVVL FVYWKIY... .KAAKFRFGR
5HT6rat .PGQCRLLAS LPFVLVASGV TFFLPSGAIC FTYCRIL... .LAARKQAVQ
5HT7 ..LISQ...D FGYTIYSTAV AFYIPMSVML FMYYQIY... .KAARKSAAK
alpha1A DERFCGITEE AGYAVFSSVC SFYLPMAVIV VMYCRVY... .VVARSTTRS
alpha1B DDKECGVTEE PFYALFSSLG SFYIPLAVIL VMYCRVY... .IVAKRTTKN
alpha1C DETICQINEE PGYVLFSALG SFYLPLAIIL VMYCRVY... .VVAKRESRG
alpha2A AEPRCEINDQ KWYVISSCIG SFFAPCLIMI LVYVRIY... .QIAKRRTRV
alpha2B GRPQCKLNQE AWYILASSIG SFFAPCLIMI LVYLRIY... .LIAKRSNRR
alpha2C1 AYPQCGLNDE TWYILSSCIG SFFAPCLIMG LVYARIY... .RVAKRRTRT
alpha2C2 AYPQCGLNDE TWYILSSCIG SFFAPCLIMG LVYARIY... .RVAKLRTRT
beta1 DPKCCDFVTN RAYAIASSVV SFYVPLCIMA FVYLRVF... .REAQKQVKK
beta2 NETCCDFFTN QAYAIASSIV SFYVPLVIMV FVYSRVF... .QEAKRQLQK
beta3 NPRCCAFASN MPYVLLSSSV SFYLPLLVML FVYARVF... .VVATRQLRL
beta4turkey DPRCCDFVTN MTYAIVSSTV SFYVPLLVMI FVYVRVF... .AVATRHVQL
D1A TIDNCDSSLS RTYAISSSVI SFYIPVAIMI VTYTRIY... .RIAQKQIRR
D2 IIANPA.... ..FVVYSSIV SFYVPFIVTL LVYIKIY... .IVLR.RRRK
D3 SISNPD.... ..FVIYSSVV SFYLPFGVTV LVYARIY... .VVLKQRRRK
D4 RLEDRD.... ..YVVYSSVC SFFLPCPLML LLYWATF... .RGLQRWEVA
D5 NAENCDSSLN RTYAISSSLI SFYIPVAIMI VTYTRIY... .RIAQVQIRR
A1 KCEFEKVISM EYMVYFNFFV WVLPPLLLMV LIYLEVFY.. .LIRKQLNKK
A2a ACLFEDVVPM NYMVYFNFFA CVLVPLLLML GVYLRIFL.. .AARRQLKQM
A2b KCLFENVVPM SYMVYFNFFG CVLPPLLIML VIYIKIFL.. .VACRQLQRT
A3 SCQFVSVMRM DYMVYFSFLT WIFIPLVVMC AIYLDIFY.. .IIRNKLSLN
OCdrome ..LTSQ.... RGYVIYSSLG SFFIPLAIMT IVYIEIF... .....VATRR
ACTH .......... ..PTVITFTS LFPLMLVFIL CLYVHMFL.. .LARSHTRKI
MSH .......... ..AVLLCLVV FFLAMLVLMA VLYVHMLA.. .RACQHAQGI
MC3 .......... ..MVIVCLIT MFFAMMLLMG TLYVHMFL.. .FARLHVKRI
MC4 .......... ..AVIICLIT MFFTMLALMA SLYVHMFL.. .MARLHIKRI
MC5 .......... ..YVILCLIS MFFAMLFLLV SLYIHMFL.. .LARTHVKRI
melatonin YSCTFAQSVS SAYTIAVVVF HFLVPMIIVI FCYLRIWILV LQVRQRVKPD
oxytocin WAVFIQPWGP KAYITWITLA VYIVPVIVLA TCYGLISFKI WQNLRLKTAA
conopressinLs LATFEPDWGM QAYITWVFVA NYVIPFLLLA FCYGRICHVV WMSVAAKESA
V1A WATFIQPWGS RAYVTWMTGG IFVAPVVILG TCYGFICYNI WCNVRGKTAS
V1B WADFGFPWGP RAYLTWTTLA IFVLPVTMLT ACYSLICHEI CKNLKVKTQA
V2 WACFAEPWGR RTYVTWIALM VFVAPTLGIA ACQVLIFREI HASLVPGPSE
CCK_A .......... ....TFLLLI LFLIPGIVMM VAYGLISLEL YQGIKFEASQ
CCK_B .......... ....VLLLLL LFFIPGVVMA VAYGLISREL YLGLRFDGDS
NPY1 .......... ..YTTLLLVL QYFGPLCFIF ICYFKIYIRL KR........
NTR .......... ...IQVNTFM SFIFPMVVIS VLNTIIANKL TVMVRQAAEQ
NK1 .......... ....ICVTVL IYFLPLLVIG YAYTVVGITL W.........
NK2 .......... ....LVVIAL IYFLPLAVMF VAYSVIGLTL W.........
NK3 .......... ....IIVIIL VYCFPLLIMG ITYTIVGITL W.........
blueops .......... ....WFLFIF CFIVPLSLIC FSYTQLLRAL K.........
greenops .......... ....IVLMVT CCITPLSIIV LCYLQVWLAI R.........
redops .......... ....IVLMVT CCIIPLAIIM LCYLQVWLAI R.........
rhodopsin .......... ....IYMFVV HFTIPMIIIF FCYGQLVFTV K.........
violetopsGg WYTVGTKYRS EYYTWFLFIF CFIVPLSLII FSYSQLLSAL RAVAAQQQES
opsin_crab YLT..KDWSS ASYVVIYGLA VYFLPLITMI YCYFFIVHAV AEHEKQLREQ
ET_Aprec ....FMEFYQ DVKDWWLFGF YFCMPLVCTA IFYTLMTCEM L.........
ET_Bprec ....FMQFYK TAKDWWLFSF YFCLPLAITA FFYTLMTCEM L.........
ET_Cfrog ...DFMRFYQ EVKVWWLFGF YFCLPLACTG VFYTLMSCEM L.........
galanin .......... KAYVVCTFVF GYLLPLLLIC FCYAKVLNHL H.........
NMB PYPQTDELHP KIHSVLIFLV YFLIPLAIIS IYYYHIAKTL I.........
GRP PYPHSNELHP KIHSMASFLV FYVIPLSIIS VYYYFIAKNL I.........
BRS3 SYPVSKKLLQ EIHSLLCFLV FYIIPLSIIS VYYSLIARTL Y.........
deltaOP PSPSW..YWD TVTKICVFLF AFVVPILIIT VCYGLMLLRL R.........
kappaOP ...SWWD... LFMKICVFIF AFVIPVLIII VCYTLMILRL K.........
muOP ..PTW..YWE NLVKICVFIF AFIMPVLIIT VCYGLMILRL K.........
OPRX .......... ....ICIFLF SFIVPVLVIS VCYSLMIRRL R.........
CB1 LQSVCSDIFP HIDETYLMFW IGVTSVLLLF IVYAYMYILW KAHSHAVRMI
CB2 .PCSELFPLI PNDYLLSWLL FIAFLFSGII YTYGHVLWKA HQHVASLS..
SSTR1 .......... ....LYTFLM GFLLPVGAIC LCYVLIIAKM R.........
SSTR2 .......... ....IYTFIL GFLVPLTIIC LCYLFIIIKV K.........
SSTR3 .......... ....IYTAAL GFFGPLLVIC LCYLLIVVKV R.........
SSTR4 .......... ....VYTFLL GFLLPVLAIG LCYLLIVGKM R.........
SSTR5 .......... ....IYTAVL GFFAPLLVIC LCYLLIVVKV R.........
IL8A R......... ....ILPHTF GFIVPLFVML FCYGFTLRTL F.........
IL8B R......... ....ILPQSF GFIVPLLIML FCYGFTLRTL F.........
AT1a .........P IGLGLTKNIL GFLFPFLIIL TSYTLIWKAL K.........
AT1brat .........P IGLGLTKNIL GFVFPFLIIL TSYTLIWKAL K.........
AT2 .........S AGIALMKNIL GFIIPLIFIA TCYFGIRKHL L.........
BK1 .......... ...IVELNIL GFLLPLAAIV FFNYHILASL R.........
BK2 .......... ...NMLLNVV GFLLPLSVIT FCTMQIMQVL R.........
P2Y7 .......... ...LIFEAVT GFLLPFLAVV ASYSDIGRRL Q.........
P2Y6 .......... ..YGMALTVI GFLLPFTALL ACYCRMARRL CRQ.......
P2Y5 .......... ..IVIFIEIV GFFIPLILNV TCSTMVLRTL NKP.......
P2Y4 .......... ..FSSAVMGL LFGVPCLVTL VCYGLMARRL YQP.......
P2Y3chick .......... .PYGITLTIT GFLLPFAAIL ACYCSMARIL CQK.......
P2Y2 .......... ..YSSVMLGL LFAVPFAVIL VCYVLMARRL LKP.......
P2Y1 .......... ..YSMCTTVA MFCVPLVLIL GCYGLIVRAL IYK.......
THRprec .........Y AYYFSAFSAV FFFVPLIIST VCYVSIIRCL S.........
C5a .......... .AVAIVRLVL GFLWPLLTLT ICYTFILLRT WSRRAT....
GP01mouse .......... ..NNAAILSI SFLFMFALML QLYIQICKIV MRHAHQIALQ
R334rat .......... ..NNAAILSI SFLFMFALML QLYIQICKIV MRHAHQIALQ
GP21mouse .......... ..NHLVVLAI AFFMVFGIML QLYAQICRIV CRHAQQIALQ
GCRCmouse ........FW K..YLDLATL LYLLPLFIIS VAYARVAKKL WLCNTIGDVT
TXKR ........TY .HMIVIVFIL VYCFPLLIMG ITYTIVGITL WGGEIPGD.T
G10Drat ........WA LAVALSATIL GFLLPFPLIA VFNILSACRL RRQGQT....
RDC1 ........WL IGMELVSVVL GFAVPFSIIA VFYFLLARAI SASSDQ....
BLR1 ........AW FTSRFLYHVA GFLLPMLVMG WCYVGVVHRL RQAQRRP...
CL5 ........WV VVFQFQHIMV GLILPGIVIL SCYCIIISKL SHSKGH....
LCR1 ........WV VVFQFQHIMV GLILPGIVIL SCYCIIISKL SHSKGH....
EBI1 ........AF ITIQVAQMVI GFLVPLLAMS FCYLVIIRTL LQARNF....
RBS1rat ........WP VLRNSEVNIL GFVLPLLIMS FCYFRIVRTL FSCKNR....
EBI2 .......... PWILLGACFI GYVLPLIIIL ICYSQICCKL FRTAKQNPLT
GCRTchick .........L SRIVIFIEIV GFFIPLILNV TCSTMVLRTL NKPLTLSRNK
APJ ........WE VGLGVSSTTV GFVVPFTIML TCYFFIAQTI AGHFRKERIE
RTArat ........LN MDISLGILLF FLFCPLMVLP CLALILHVEC RARRRQRSAK
UHRrat ......RQRQ IYAWGLLLGT YLLPPLLAIL LSYVRVSVKL RNRVVPGSVT
FMRL1 ..LNVFITMA KVFLILHFII GFTVPMSIIT VCYGIIAAKI HRNHMI....
FMRL2 ..LKVAITML TARGIIRFVI GFSLPMSIVA ICYGLIAAKI HKKGMI....
fMLP ..INVAVAML TVRGIIRFII GFSAPMSIVA VSYGLIATKI HKQGLI....
OLF1catfish ILAGNDKFIN RVMAIGCFVV LDCVPFLLII VSYICIGIAL MNISHGLER.
OLF3catfish KLACNDNTIN SIMGNVCTAT LLYFPLILII ASYVCIGFAL QKIAHGVEQ.
OLF8catfish QLACGDISIN NALGLLTVFL TITADFIFIT ISYIVILVSI LR..SGKAC.
OLF32Acatfish TIACNDNSIN SFMAKLCTAV YLYAPLTAIV FSYLGILLAL TKITTWESR.
OLF32Bcatfish TIACNDNSIN SFMAKLCTAV YLYAPLTAIV LSYIGILLAL TKITTWESR.
OLF32Ccatfish TIACNDNSIN SFMAKLCTAV YLYAPLTAIV LSYIGILLAL TKITTWESR.
OLF32Dcatfish TIACNDNSIN SFMAYFCTAV YLYAPLTAIV LSYIGILLAL TKITTWESR.
OLF47catfish NLACGDISYN KRLALAKTLV VLLGPLTFII CSYVIVVVAV LRIASPTQC.
OLF202catfish KLACIDRTPY AFPALVSALV MLLTPLAFIL FSYGSIIVTV FRTSSTRGR.
OLFCOR1chicken QISSSSIAIS ELLVIISGSL FVMSSIIIIL ISYVFIILTV VMIRSKDGK.
OLFCOR2chicken QISSSSTTLN ELLVIISGSL FVMSSIITIL ISYVFIILTV VMIRSKDGK.
OLFCOR3chicken QISSSSIAIS ELLVIISGSL FVMSSIIIIL ISYVFIILTV VMIRSKDGK.
OLFCOR4chicken QISSSSIAIS ELLVIISGSL FVMSSIIIIL ISYVFIILTV VMIRSKDGK.
OLFCOR5chicken QISSSSTTLN ELLVFIFGSW FAMSSIITTP ISYVFIILTV VRIRSKDGK.
OLFCOR6chicken QISSSSTALN ELLVFIFGSL FVMSSIITIL ISYVFIILTV VRIRSKERK.
OLFdog KLACSDTQVN ELVIFIMGGL ILVIPFLLII TSYARIVSSI LKVPSAIGI.
OLF07E KLAFSDTRVN EWVIFIMGGL ILVIPFLLIL GSYARIVSSI LKVPSSKGI.
OLF07I KLSCIDTTVN EILTLIISVL VLVVPMGLVF ISYVLIISTI LKIASVEGR.
OLF07J RMACSNIQIN HTVLIATGCF IFLIPFGFVI ISYVLIIRAI LRIPSVSKK.
OLFOR3mouse KLACGDTSLN EAVLNGVCTF FTVVPVSVIL VSYCFIAQAV MKIRSVEGR.
OLFrat KLACSNTHLN ELLIFIIGGL NTLVPTLAVA ISYVFIFCSI LRIRSSEGR.
OLFF3rat QLTCSDAFLN DLVIYFTLVL LATVPLAGIF YSYFKIVSSI CAISSVHGK.
OLFF5rat KLSCSDTHLN ELMILTEGAV VMVTPFVCIL ISYIHITCAV LRVSSPRGG.
OLFF6rat VLSCTDTQVV ELVSFGIAFC VILGSCGITL VSYAYIITTI IKIPSARGR.
OLFF12rat QLTCSDNFPS HLIMNLVPVM LAAISFSGIL YSYFKIVSSI HSISTVQGK.
OLFI3rat KLACSDTYIN ELMIFIMSTL LIIIPFFLIV MSYARIISSI LKVPSTQGI.
OLFI7rat NLSCTDMSTA ELTDFVLAIF ILLGPLSVTG ASYMAITGAV MRIPSAAGR.
OLFI8rat KLACSDTYVN ELMIHIMGVI IIVIPFVLIV ISYAKIISSI LKVPSTQSI.
OLFI9rat KVACSDTHDN ELAIFILGGP IVVLPFLLII VSYARIVSSI FKVPSSQSI.
OLFI14rat KLSCSDIYVN ELMIYILGGL IIIIPFLLIV MSYVRIFFSI LKFPSIQDI.
OLFI15rat KLSCSDTHVN ELVIFVMGGL VIVIPFVLII VSYARVVASI LKVPSVRGI.
OLFOR17_40 QLSCSSTQLN ELLLFAVGFI MAGTPMALIV ISYIHVAAAV LRIRSVEGR.
GUST27rat KVANSDTHIN NVFMYVVTSL LGLIPMTGIL MSYSQIASSL LKMSSSV...
RPE ..YSKGDRNF TSFLFTMSFF NFAMPLFITI TSYSLMEQKL GK SGHLQVN
HHRF1 ..YLEV.SYP IILNVELMLG AFVIPLSVIS YCYYRISRI. ..........
HHRF2 .ANETSGWFP VFLNTKVNIC GYLAPIALMA YTYNRMVRF. ..........
HHRF3 FVAEEVHTVL LSWKVLLTMV WGAAPVIMMT WFY....... ..........
MCP-1A CGPYFPRGWN NFHTIMRNIL GLVLPLLIMV ICYSGILKT. ..........
MCP-1B CGPYFPRGWN NFHTIMRNIL GLVLPLLIMV ICYSGILKT. ..........
PPR1bovine FPYHLGTSMK ASIQILEICI GFIIPFLIMA VCYFITAKT. ..........
5 5555555555 5555555555 5555555555 5
3 3333444444 4444555555 5555666666 6
5 6789012345 6789012345 6789012345 6
351 400
GPCRAelegans .......... .......... .......... .......... ..........
GRH EL........ .......... .......... .......... ..........
TRH ENSKTWKNDS THQNTNLNVN TSNRCFNSTV S......... ..........
FSHprec .......... .......... .......... .......... ..........
TSHprec .......... .......... .......... .......... ..........
LH_CGprec .......... .......... .......... .......... ..........
PGE_EP1 RPPPASGPDS RRRWGAHGPR SASASSASSI ASASTFFGGS RSSGSARRAR
PGE_EP2 TSLGTEQHH. .....AAAAA SVASRGHPAA SPALPRLSDF RRRRSFRRIA
PGE_EP3 .......... .......... ........IR MHRRSRRSRC GPSLGSGRGG
PGF .......... .......... .......... .......... ..SQQHRQGR
PGI .......... .......... .......... .......... ..QKRHQGSL
TXA2 .......... .......... .......... ..CHVYHGQE AAQQRPRDSE
PAF .......... .......... .......... .......... .PVQQQRRNA
M2 DKKEPVANQD PVSPSLVQGR IVKPNNNNMP SSDDGLEHNK IQN.GKAPRD
M4 HRPEGPKEKK AKTLAFLKSP LMKQSVKKPP PGEAAREELR NGKLEEAPPP
M1 LAALQGSET. ........PG KGGGSSSSSE RSQPGAEGSP ETPPGRC...
M3 LAGLQASGTE AETENFVHPT GSSRSCSSYE LQQQSMKRSN RRKYGRCHFW
M5 LADLQGSDSV TKAEK.RKPA HRALFRSCLR CPRPTLAQRE RNQASWSSSR
H1 .......... .......... .......... .....RELIN RSLPSFSEIK
H2 IN........ .......... .......... .......... ..........
5HT1A TVKKVEKTGA DTRHGASPAP QPKKS..... .......... ..........
5HT1B ..QTPNRTGK RLTRAQLITD SPGST..... .......... ..........
5HT1D ..NPPSLYGK RFTTAHLITG SAG....... .......... ..........
5HT1E ..RGSSRHLS NRSTDS...Q NSFAS..... .......... ..........
5HT1F ..RQASRIAK EEVNGQVLLE SGEKS..... .......... ..........
5HT2A CVSDLGTRAK LASFSFL... .......... ..PQSSLSSE KLFQRSIH..
5HT2B VKNKPPQRLT WLTVSTVFQR DETPCSSPEK VAMLDGSRKD KALPNSGDET
5HT2C LLHGHTEEPP GLSLDFLK.. .....CCKRN TAEEENSANP NQDQNARR..
5HT5A RKTNSVSPIS EAVEVKDSAK QPQMV..... .......... ..........
5HT5Brat RR.RAVVPLP ATTQAKEAPQ ESETV..... .......... ..........
5HT6rat VAS....... .......... ...LTTGTAG QALETLQVPR TPRPGMESA.
5HT7 HKFPGFPRVE PDSVIALNGI VKLQK..... .......... ..........
alpha1A LEAGVKR... ...ERGKASE VVLRIHCRGA ATGADGAHGM RSAKGHTFR.
alpha1B LEAGVMK... ...EMSNSKE LTLRIHSKNF ...HEDTLSS TKAKGHNPR.
alpha1C LKSGLKT... ...DKSDSEQ VTLRIHRKNA ...PAGGSGM ASAKT...K.
alpha2A PPSRRGPDAV AAPPGGTERR PNGLGPERSA GPGGAEAEPL PTQLNGAPGE
alpha2B GPRAKGGPGQ GESKQPRPDH GGALASAKLP ALASVASARE VNGHSKSTGE
alpha2C1 LSEKRAPVGP DGASPTTE.. .NGLGAAAGE ARTG.TARPR PPTWSRTRAA
alpha2C2 LSEKRAPVGP DGASPTTE.. .NGLGAAAGA GENGHCAPPP ADVEPDESSA
beta1 IDSCERRFLG GPARPPSPSP SPVPAPAPPP GPPRPAAAAA TAPLANGRA.
beta2 IDKSEGRFHV QNLSQVEQDG RTGHGL.... .......... ..........
beta3 LRGELGRF.. .......... PPEESPPAPS RSLAPAPVGT CAPPEGVPA.
beta4turkey IGKDKVRFLQ ENPSLSSRGG RWR....... .......... ..........
D1A IAA....... .......... .....LERAA VHAKNCQTTT GNGKPVECS.
D2 RVNTKRSSRA FRAHLRAPLK GNCTHPEDMK LCTVIMKSNG SFPVNRRRVE
D3 RILTRQNSQC NSVRPGFPQQ TLSPDPAHLE L.......KR YYSICQDTAL
D4 RRAKLHGRAP RRPSGPGP.. .......... .......... ..........
D5 ISS....... .......... .....LERAA EHAQSCRSSA A.......C.
A1 .......... .......... .......... .......... ..........
A2a ESQPLP.... .......... .......... .......... ..........
A2b ELM....... .......... .......... .......... ..........
A3 .......... .......... .......... .......... ..........
OCdrome RLR.ERARA. NKLNTIALKS TELEPMANSS PVAASNSGSK SRLLASWLCC
ACTH STLP...... .......... .......... .......... ..........
MSH ARLH...... .......... .......... .......... ..........
MC3 AALP...... .......... .......... .......... ..........
MC4 AVLP...... .......... .......... .......... ..........
MC5 AALP...... .......... .......... .......... ..........
melatonin WRVGGGGWRT WDR....... .......... .......... ..........
oxytocin .......... .......... .......... .......... ..........
conopressinLs AYSSMRNGCT ESSRPIKMRI SFHRRRDNTN ATLTS..... ..........
V1A RQSKGAEQAG VAF....... .......... .......... ..........
V1B .......... .......... .......... .......... ..........
V2 RPGG...... .......... .......... .......... ..........
CCK_A KKSAKER... .......... .......... .......... ..........
CCK_B DSDSQSR... .......... .......... .......... ..........
NPY1 .......... .......... .......... .......... ..........
NTR G......... .......... .......... .......... ..........
NK1 .......... .......... .......... .......... ..........
NK2 .......... .......... .......... .......... ..........
NK3 .......... .......... .......... .......... ..........
blueops .......... .......... .......... .......... ..........
greenops .......... .......... .......... .......... ..........
redops .......... .......... .......... .......... ..........
rhodopsin .......... .......... .......... .......... ..........
violetopsGg .......... .......... .......... .......... ..........
opsin_crab .......... .......... .......... .......... ..........
ET_Aprec .......... .......... .......... .......... ..........
ET_Bprec .......... .......... .......... .......... ..........
ET_Cfrog .......... .......... .......... .......... ..........
galanin .......... .......... .......... .......... ..........
NMB .......... .......... .......... .......... ..........
GRP .......... .......... .......... .......... ..........
BRS3 .......... .......... .......... .......... ..........
deltaOP .......... .......... .......... .......... ..........
kappaOP .......... .......... .......... .......... ..........
muOP .......... .......... .......... .......... ..........
OPRX .......... .......... .......... .......... ..........
CB1 QRGTQKSI.. .......... .......... .......... ..........
CB2 .......... .......... .......... .......... ..........
SSTR1 .......... .......... .......... .......... ..........
SSTR2 .......... .......... .......... .......... ..........
SSTR3 .......... .......... .......... .......... ..........
SSTR4 .......... .......... .......... .......... ..........
SSTR5 .......... .......... .......... .......... ..........
IL8A .......... .......... .......... .......... ..........
IL8B .......... .......... .......... .......... ..........
AT1a .......... .......... .......... .......... ..........
AT1brat .......... .......... .......... .......... ..........
AT2 .......... .......... .......... .......... ..........
BK1 .......... .......... .......... .......... ..........
BK2 .......... .......... .......... .......... ..........
P2Y7 .......... .......... .......... .......... ..........
P2Y6 .......... .......... .......... .......... ..........
P2Y5 .......... .......... .......... .......... ..........
P2Y4 .......... .......... .......... .......... ..........
P2Y3chick .......... .......... .......... .......... ..........
P2Y2 .......... .......... .......... .......... ..........
P2Y1 .......... .......... .......... .......... ..........
THRprec .......... .......... .......... .......... ..........
C5a .......... .......... .......... .......... ..........
GP01mouse HHFLATSHYV T......... .......... .......... ..........
R334rat HHFLATSHYV T......... .......... .......... ..........
GP21mouse RHLLPASHYV A......... .......... .......... ..........
GCRCmouse TEQYLALRRK K......... .......... .......... ..........
TXKR CDKYQEQLKA K......... .......... .......... ..........
G10Drat ESRRHCLL.. .......... .......... .......... ..........
RDC1 EKHSSRK... .......... .......... .......... ..........
BLR1 QRQKAVR... .......... .......... .......... ..........
CL5 QKRKALK... .......... .......... .......... ..........
LCR1 QKRKALK... .......... .......... .......... ..........
EBI1 ERNKAIK... .......... .......... .......... ..........
RBS1rat KKARAIR... .......... .......... .......... ..........
EBI2 EKSGVNKK.. .......... .......... .......... ..........
GCRTchick LSKKKVLK.. .......... .......... .......... ..........
APJ GLRKRRR... .......... .......... .......... ..........
RTArat LNHVVLAIVS V......... .......... .......... ..........
UHRrat QSQADWDRAR RRRT...... .......... .......... ..........
FMRL1 .......... .......... .......... .......... ..........
FMRL2 .......... .......... .......... .......... ..........
fMLP .......... .......... .......... .......... ..........
OLF1catfish .......... .......... .......... .......... ..........
OLF3catfish .......... .......... .......... .......... ..........
OLF8catfish .......... .......... .......... .......... ..........
OLF32Acatfish .......... .......... .......... .......... ..........
OLF32Bcatfish .......... .......... .......... .......... ..........
OLF32Ccatfish .......... .......... .......... .......... ..........
OLF32Dcatfish .......... .......... .......... .......... ..........
OLF47catfish .......... .......... .......... .......... ..........
OLF202catfish .......... .......... .......... .......... ..........
OLFCOR1chicken .......... .......... .......... .......... ..........
OLFCOR2chicken .......... .......... .......... .......... ..........
OLFCOR3chicken .......... .......... .......... .......... ..........
OLFCOR4chicken .......... .......... .......... .......... ..........
OLFCOR5chicken .......... .......... .......... .......... ..........
OLFCOR6chicken .......... .......... .......... .......... ..........
OLFdog .......... .......... .......... .......... ..........
OLF07E .......... .......... .......... .......... ..........
OLF07I .......... .......... .......... .......... ..........
OLF07J .......... .......... .......... .......... ..........
OLFOR3mouse .......... .......... .......... .......... ..........
OLFrat .......... .......... .......... .......... ..........
OLFF3rat .......... .......... .......... .......... ..........
OLFF5rat .......... .......... .......... .......... ..........
OLFF6rat .......... .......... .......... .......... ..........
OLFF12rat .......... .......... .......... .......... ..........
OLFI3rat .......... .......... .......... .......... ..........
OLFI7rat .......... .......... .......... .......... ..........
OLFI8rat .......... .......... .......... .......... ..........
OLFI9rat .......... .......... .......... .......... ..........
OLFI14rat .......... .......... .......... .......... ..........
OLFI15rat .......... .......... .......... .......... ..........
OLFOR17_40 .......... .......... .......... .......... ..........
GUST27rat RKPK...... .......... .......... .......... ..........
RPE .......... .......... .......... .......... ..........
HHRF1 .......... .......... .......... .......... ..........
HHRF2 .......... .......... .......... .......... ..........
HHRF3 .......... .......... .......... .......... ..........
MCP-1A .......... .......... .......... .......... ..........
MCP-1B .......... .......... .......... .......... ..........
PPR1bovine .......... .......... .......... .......... ..........
401 450
GPCRAelegans .......... .......... .......... .......... ..........
GRH .......... .......... .......... .......... ..........
TRH .......... .......... .......... .......... ..........
FSHprec .......... .......... .......... .......... ..........
TSHprec .......... .......... .......... .......... ..........
LH_CGprec .......... .......... .......... .......... ..........
PGE_EP1 AHDVE..... .......... .......... .......... ..........
PGE_EP2 GAE....... .......... .......... .......... ..........
PGE_EP3 PGARR..... .......... .......... .......... ..........
PGF SHHLE..... .......... .......... .......... ..........
PGI GPRPRTGEDE .......... .......... .......... ..........
TXA2 ...VE..... .......... .......... .......... ..........
PAF EVKRR..... .......... .......... .......... ..........
M2 PVTENCVQGE EKESSNDSTS VSAV...... .ASNMRDDEI TQDENTVSTS
M4 ALPPPPRPVA DKDTSNESSS GSATQNTKER PATELSTTEA TTPAMPAPPL
M1 ....CRCCRA PRLLQAYSWK E..EEEEDEG SMESLTSSEG EEPGSE....
M3 FTTKSWKPSS EQMDQDHSSS DSWNNNDAAA SLENSASSDE EDIGSETRAI
M5 RST....STT GKPSQATGPS ANWAKAEQLT TCSSYPSSED EDKPATDPVL
H1 LRPENPKGDA KKPGKESPWE VLKRKPKDAG GGSVLKSPSQ TPKEMKSPVV
H2 .......... .......... .......... .......... ..........
5HT1A .......... .......... ....VNGESG SRNWRLGVES KAGGALCANG
5HT1B .......... .......... ....SSVTSI NSRVPDVPSE S.GSPVYVNQ
5HT1D .......... .......... ....SSLCSL NSSLHEGHSH SAGSPLFFNH
5HT1E .......... .......... ....CKLTQT FCVSDFSTSD PTTEFEKFHA
5HT1F .......... .......... ....TKSVST SYVLEKSLSD PSTDFDKIHS
5HT2A .REPG..... .......... .......... .......... ..........
5HT2B LMRRT..... .......... .......... .......... ..........
5HT2C .RKKK..... .......... .......... .......... ..........
5HT5A .......... .......... ....FTVR.H ATVTFQPEGD TWRE......
5HT5Brat .......... .......... ....FTARCR ATVAFQTSGD SWRE......
5HT6rat .......... .......... .......... .......... ..........
5HT7 .......... .......... ....EVEECA NLSRLLKHER KNISIF....
alpha1A .......... .......... .......... .......... ..........
alpha1B .......... .......... .......... .......... ..........
alpha1C .......... .......... .......... .......... ..........
alpha2A PAPAG..... .......... ..PRDTDALD LEESSSSDHA ERPPGPRRPE
alpha2B KEEGETPEDT GTRALPPSWA ALPNSGQGQK EGVCGASPED EAEEEEEEEE
alpha2C1 QRPRG..... .......... ..GAPGPLRR GGRRRAGAEG GAGGADGQGA
alpha2C2 AAERR..... .......... ..RRRGALRR GGRRRAGAEG GAGGADGQ..
beta1 .......... .......... .......... .......... ..........
beta2 .......... .......... .......... .......... ..........
beta3 .......... .......... .......... .......... ..........
beta4turkey .......... .......... .......... .......... ..........
D1A .......... .......... .......... .......... ..........
D2 AARRAQELEM EMLSSTSPPE RTRYSPIPPS HHQLTLPDPS HHGLHSTPDS
D3 GGPGFQERGG EL....KREE KTRNSLSPTI APKLSL.... ..........
D4 .......... .......... ....PSPTPP APRLPQDPCG PDCAPPAPGL
D5 .......... .......... .......... .......... ..........
A1 .......... .......... .......... .......... ..........
A2a .......... .......... .......... .......... ..........
A2b .......... .......... .......... .......... ..........
A3 .......... .......... .......... .......... ..........
OCdrome GRDRAQFATP MIQNDQESIS SETHQPQDSS KAGPHGNSDP QQQHVVVLVK
ACTH .......... .......... .......... .......... ..........
MSH .......... .......... .......... .......... ..........
MC3 .......... .......... .......... .......... ..........
MC4 .......... .......... .......... .......... ..........
MC5 .......... .......... .......... .......... ..........
melatonin .......... .......... .......... .......... ..........
oxytocin .......... .......... .......... .......... ..........
conopressinLs .......... .......... .......... .......... ..........
V1A .......... .......... .......... .......... ..........
V1B .......... .......... .......... .......... ..........
V2 .......... .......... .......... .......... ..........
CCK_A .......... .......... .......... .......... ..........
CCK_B .......... .......... .......... .......... ..........
NPY1 .......... .......... .......... .......... ..........
NTR .......... .......... .......... .......... ..........
NK1 .......... .......... .......... .......... ..........
NK2 .......... .......... .......... .......... ..........
NK3 .......... .......... .......... .......... ..........
blueops .......... .......... .......... .......... ..........
greenops .......... .......... .......... .......... ..........
redops .......... .......... .......... .......... ..........
rhodopsin .......... .......... .......... .......... ..........
violetopsGg .......... .......... .......... .......... ..........
opsin_crab .......... .......... .......... .......... ..........
ET_Aprec .......... .......... .......... .......... ..........
ET_Bprec .......... .......... .......... .......... ..........
ET_Cfrog .......... .......... .......... .......... ..........
galanin .......... .......... .......... .......... ..........
NMB .......... .......... .......... .......... ..........
GRP .......... .......... .......... .......... ..........
BRS3 .......... .......... .......... .......... ..........
deltaOP .......... .......... .......... .......... ..........
kappaOP .......... .......... .......... .......... ..........
muOP .......... .......... .......... .......... ..........
OPRX .......... .......... .......... .......... ..........
CB1 .......... .......... .......... .......... ..........
CB2 .......... .......... .......... .......... ..........
SSTR1 .......... .......... .......... .......... ..........
SSTR2 .......... .......... .......... .......... ..........
SSTR3 .......... .......... .......... .......... ..........
SSTR4 .......... .......... .......... .......... ..........
SSTR5 .......... .......... .......... .......... ..........
IL8A .......... .......... .......... .......... ..........
IL8B .......... .......... .......... .......... ..........
AT1a .......... .......... .......... .......... ..........
AT1brat .......... .......... .......... .......... ..........
AT2 .......... .......... .......... .......... ..........
BK1 .......... .......... .......... .......... ..........
BK2 .......... .......... .......... .......... ..........
P2Y7 .......... .......... .......... .......... ..........
P2Y6 .......... .......... .......... .......... ..........
P2Y5 .......... .......... .......... .......... ..........
P2Y4 .......... .......... .......... .......... ..........
P2Y3chick .......... .......... .......... .......... ..........
P2Y2 .......... .......... .......... .......... ..........
P2Y1 .......... .......... .......... .......... ..........
THRprec .......... .......... .......... .......... ..........
C5a .......... .......... .......... .......... ..........
GP01mouse .......... .......... .......... .......... ..........
R334rat .......... .......... .......... .......... ..........
GP21mouse .......... .......... .......... .......... ..........
GCRCmouse .......... .......... .......... .......... ..........
TXKR .......... .......... .......... .......... ..........
G10Drat .......... .......... .......... .......... ..........
RDC1 .......... .......... .......... .......... ..........
BLR1 .......... .......... .......... .......... ..........
CL5 .......... .......... .......... .......... ..........
LCR1 .......... .......... .......... .......... ..........
EBI1 .......... .......... .......... .......... ..........
RBS1rat .......... .......... .......... .......... ..........
EBI2 .......... .......... .......... .......... ..........
GCRTchick .......... .......... .......... .......... ..........
APJ .......... .......... .......... .......... ..........
RTArat .......... .......... .......... .......... ..........
UHRrat .......... .......... .......... .......... ..........
FMRL1 .......... .......... .......... .......... ..........
FMRL2 .......... .......... .......... .......... ..........
fMLP .......... .......... .......... .......... ..........
OLF1catfish .......... .......... .......... .......... ..........
OLF3catfish .......... .......... .......... .......... ..........
OLF8catfish .......... .......... .......... .......... ..........
OLF32Acatfish .......... .......... .......... .......... ..........
OLF32Bcatfish .......... .......... .......... .......... ..........
OLF32Ccatfish .......... .......... .......... .......... ..........
OLF32Dcatfish .......... .......... .......... .......... ..........
OLF47catfish .......... .......... .......... .......... ..........
OLF202catfish .......... .......... .......... .......... ..........
OLFCOR1chicken .......... .......... .......... .......... ..........
OLFCOR2chicken .......... .......... .......... .......... ..........
OLFCOR3chicken .......... .......... .......... .......... ..........
OLFCOR4chicken .......... .......... .......... .......... ..........
OLFCOR5chicken .......... .......... .......... .......... ..........
OLFCOR6chicken .......... .......... .......... .......... ..........
OLFdog .......... .......... .......... .......... ..........
OLF07E .......... .......... .......... .......... ..........
OLF07I .......... .......... .......... .......... ..........
OLF07J .......... .......... .......... .......... ..........
OLFOR3mouse .......... .......... .......... .......... ..........
OLFrat .......... .......... .......... .......... ..........
OLFF3rat .......... .......... .......... .......... ..........
OLFF5rat .......... .......... .......... .......... ..........
OLFF6rat .......... .......... .......... .......... ..........
OLFF12rat .......... .......... .......... .......... ..........
OLFI3rat .......... .......... .......... .......... ..........
OLFI7rat .......... .......... .......... .......... ..........
OLFI8rat .......... .......... .......... .......... ..........
OLFI9rat .......... .......... .......... .......... ..........
OLFI14rat .......... .......... .......... .......... ..........
OLFI15rat .......... .......... .......... .......... ..........
OLFOR17_40 .......... .......... .......... .......... ..........
GUST27rat .......... .......... .......... .......... ..........
RPE .......... .......... .......... .......... ..........
HHRF1 .......... .......... .......... .......... ..........
HHRF2 .......... .......... .......... .......... ..........
HHRF3 .......... .......... .......... .......... ..........
MCP-1A .......... .......... .......... .......... ..........
MCP-1B .......... .......... .......... .......... ..........
PPR1bovine .......... .......... .......... .......... ..........
451 500
GPCRAelegans .......... .......... .......... .......... ..........
GRH .......... .......... .......... .......... ..........
TRH .......... .......... .......... .......... ..........
FSHprec .......... .......... .......... .......... ..........
TSHprec .......... .......... .......... .......... ..........
LH_CGprec .......... .......... .......... .......... ..........
PGE_EP1 .......... .......... .......... .......... ..........
PGE_EP2 .......... .......... .......... .......... ..........
PGE_EP3 .......... .......... .......... .......... ..........
PGF .......... .......... .......... .......... ..........
PGI .......... .......... .......... .......... ..........
TXA2 .......... .......... .......... .......... ..........
PAF .......... .......... .......... .......... ..........
M2 LGHSKDENSK QTCIRIGTKT PKSDSCTPTN TTVEVVGSSG QNGDEKQNIV
M4 QPRALNPASR WSKIQIVTKQ TGNECVTA.. ..IEIVPATP AGMRPAANVA
M1 ..VVIKMP.. .......... .......... ...MVDPEAQ APTKQPPRSS
M3 YSIVLKLPGH STILNSTKLP SSDNLQVPEE ELGMVDLERK ADKLQAQKSV
M5 QVVYKSQGKE SP.......G EEFSAEETEE TFVKAETEKS DYDTPNYLLS
H1 FSQEDDREVD KLYCFPLDIV HMQAAAEGSS RDYVAVNRSH GQLKTDEQGL
H2 .......... .......... .......... .......... .........H
5HT1A AVRQGDDGAA LEVIEVHRVG NSKEHLPLPS EAGPTPCAPA SFERKNERNA
5HT1B VKVRVS.... .D........ .......... .......... ........AL
5HT1D VKIKLA.... .D........ .......... .......... ........SA
5HT1E SIRIPPFDND LD........ .......... .......... ........HP
5HT1F TVRSLRSEFK HE........ .......... .......... ........KS
5HT2A .......... .......... .......... .......... .......SYT
5HT2B .......... .......... .......... .......... .......STI
5HT2C .......... .......... .......... .......... .......ERR
5HT5A .......... .......... .......... .......... ..........
5HT5Brat .......... .......... .......... .......... ..........
5HT6rat .......... .......... .......... .......... ........DS
5HT7 .......... .......... .......... .......... ..........
alpha1A .......... .......... .......... .......... ........SS
alpha1B .......... .......... .......... .......... ........SS
alpha1C .......... .......... .......... .......... ........TH
alpha2A RGPRGKGKAR ASQVKPGDSL RGAGRGRRGS GRRLQGRGRS ASGL....PR
alpha2B EEEECEPQAV PVSPASACSP PLQQPQGSRV LATLRGQVLL GRGVGAIGGQ
alpha2C1 GPGAAQSGAL TASRSPGPGG RLSRASSRSV EFFLSRRRRA RSSV....CR
alpha2C2 ..GAAESGAL TASRSPGPGG RLSRASSRSV EFFLSRRRRA RSSV....CR
beta1 .......... .......... .......... .......... ........GK
beta2 .......... .......... .......... .......... ..........
beta3 .......... .......... .......... .......... ........CG
beta4turkey .......... .......... .......... .......... ..........
D1A .......... .......... .......... .......... ........QP
D2 PAKPEKNGHA KDHPKIAKIF EIQTMPNGKT RTSLKTMS.R RKLS......
D3 .......... .......... EVRKKSNGRL STSLKLGPLQ PRGV......
D4 PPDPCGSNCA PPDAVRAAAL PPQTPPQTRR RRRAKITG.. ..........
D5 .......... .......... .......... .......... ........AP
A1 .......... .......... .......... .......... ..........
A2a .......... .......... .......... .......... ..........
A2b .......... .......... .......... .......... ..........
A3 .......... .......... .......... .......... ..........
OCdrome KSRRAKTKDS IKHGKTRGGR KSQSSSTCEP HGEQQLLPAG GDGGSCQPGG
ACTH .......... .......... .......... .......... ..........
MSH .......... .......... .......... .......... ..........
MC3 .......... .......... .......... .......... ..........
MC4 .......... .......... .......... .......... ..........
MC5 .......... .......... .......... .......... ..........
melatonin .......... .......... .......... .......... ..........
oxytocin .......... .......... .......... .......... ..........
conopressinLs .......... .......... .......... .......... ..........
V1A .......... .......... .......... .......... ..........
V1B .......... .......... .......... .......... ..........
V2 .......... .......... .......... .......... ..........
CCK_A .......... .......... .......... .......... ......KPST
CCK_B .......... .......... .......... .VRNQGGLPG AVHQNGRCRP
NPY1 .......... .......... .......... .......... ..........
NTR .......... .......... .......... .......... ..........
NK1 .......... .......... .......... .......... ..........
NK2 .......... .......... .......... .......... ..........
NK3 .......... .......... .......... .......... ..........
blueops .......... .......... .......... .......... ..........
greenops .......... .......... .......... .......... ..........
redops .......... .......... .......... .......... ..........
rhodopsin .......... .......... .......... .......... ..........
violetopsGg .......... .......... .......... .......... ..........
opsin_crab .......... .......... .......... .......... ..........
ET_Aprec .......... .......... .......... .......... ..........
ET_Bprec .......... .......... .......... .......... ..........
ET_Cfrog .......... .......... .......... .......... ..........
galanin .......... .......... .......... .......... ..........
NMB .......... .......... .......... .......... ..........
GRP .......... .......... .......... .......... ..........
BRS3 .......... .......... .......... .......... ..........
deltaOP .......... .......... .......... .......... ..........
kappaOP .......... .......... .......... .......... ..........
muOP .......... .......... .......... .......... ..........
OPRX .......... .......... .......... .......... ..........
CB1 .......... .......... .......... .......... ..........
CB2 .......... .......... .......... .......... ..........
SSTR1 .......... .......... .......... .......... ..........
SSTR2 .......... .......... .......... .......... ..........
SSTR3 .......... .......... .......... .......... ..........
SSTR4 .......... .......... .......... .......... ..........
SSTR5 .......... .......... .......... .......... ..........
IL8A .......... .......... .......... .......... ..........
IL8B .......... .......... .......... .......... ..........
AT1a .......... .......... .......... .......... ..........
AT1brat .......... .......... .......... .......... ..........
AT2 .......... .......... .......... .......... ..........
BK1 .......... .......... .......... .......... ..........
BK2 .......... .......... .......... .......... ..........
P2Y7 .......... .......... .......... .......... ..........
P2Y6 .......... .......... .......... .......... ..........
P2Y5 .......... .......... .......... .......... ..........
P2Y4 .......... .......... .......... .......... ..........
P2Y3chick .......... .......... .......... .......... ..........
P2Y2 .......... .......... .......... .......... ..........
P2Y1 .......... .......... .......... .......... ..........
THRprec .......... .......... .......... .......... ..........
C5a .......... .......... .......... .......... ..........
GP01mouse .......... .......... .......... .......... ..........
R334rat .......... .......... .......... .......... ..........
GP21mouse .......... .......... .......... .......... ..........
GCRCmouse .......... .......... .......... .......... ..........
TXKR .......... .......... .......... .......... ..........
G10Drat .......... .......... .......... .......... ..........
RDC1 .......... .......... .......... .......... ..........
BLR1 .......... .......... .......... .......... ..........
CL5 .......... .......... .......... .......... ..........
LCR1 .......... .......... .......... .......... ..........
EBI1 .......... .......... .......... .......... ..........
RBS1rat .......... .......... .......... .......... ..........
EBI2 .......... .......... .......... .......... ..........
GCRTchick .......... .......... .......... .......... ..........
APJ .......... .......... .......... .......... ..........
RTArat .......... .......... .......... .......... ..........
UHRrat .......... .......... .......... .......... ..........
FMRL1 .......... .......... .......... .......... ..........
FMRL2 .......... .......... .......... .......... ..........
fMLP .......... .......... .......... .......... ..........
OLF1catfish .......... .......... .......... .......... ..........
OLF3catfish .......... .......... .......... .......... ..........
OLF8catfish .......... .......... .......... .......... ..........
OLF32Acatfish .......... .......... .......... .......... ..........
OLF32Bcatfish .......... .......... .......... .......... ..........
OLF32Ccatfish .......... .......... .......... .......... ..........
OLF32Dcatfish .......... .......... .......... .......... ..........
OLF47catfish .......... .......... .......... .......... ..........
OLF202catfish .......... .......... .......... .......... ..........
OLFCOR1chicken .......... .......... .......... .......... ..........
OLFCOR2chicken .......... .......... .......... .......... ..........
OLFCOR3chicken .......... .......... .......... .......... ..........
OLFCOR4chicken .......... .......... .......... .......... ..........
OLFCOR5chicken .......... .......... .......... .......... ..........
OLFCOR6chicken .......... .......... .......... .......... ..........
OLFdog .......... .......... .......... .......... ..........
OLF07E .......... .......... .......... .......... ..........
OLF07I .......... .......... .......... .......... ..........
OLF07J .......... .......... .......... .......... ..........
OLFOR3mouse .......... .......... .......... .......... ..........
OLFrat .......... .......... .......... .......... ..........
OLFF3rat .......... .......... .......... .......... ..........
OLFF5rat .......... .......... .......... .......... ..........
OLFF6rat .......... .......... .......... .......... ..........
OLFF12rat .......... .......... .......... .......... ..........
OLFI3rat .......... .......... .......... .......... ..........
OLFI7rat .......... .......... .......... .......... ..........
OLFI8rat .......... .......... .......... .......... ..........
OLFI9rat .......... .......... .......... .......... ..........
OLFI14rat .......... .......... .......... .......... ..........
OLFI15rat .......... .......... .......... .......... ..........
OLFOR17_40 .......... .......... .......... .......... ..........
GUST27rat .......... .......... .......... .......... ..........
RPE .......... .......... .......... .......... ..........
HHRF1 .......... .......... .......... .......... ..........
HHRF2 .......... .......... .......... .......... ..........
HHRF3 .......... .......... .......... .......... ..........
MCP-1A .......... .......... .......... .......... ..........
MCP-1B .......... .......... .......... .......... ..........
PPR1bovine .......... .......... .......... .......... ..........
501 550
GPCRAelegans .......... .......... .......... .......... ..........
GRH .......... .......... .......... .......... ..........
TRH .......... .......... .......... .......... ..........
FSHprec .......... .......... .......... .......... ..........
TSHprec .......... .......... .......... .......... ..........
LH_CGprec .......... .......... .......... .......... ..........
PGE_EP1 .......... .......... .......... .......... ..........
PGE_EP2 .......... .......... .......... .......... ..........
PGE_EP3 .......... .......... .......... .......... ..........
PGF .......... .......... .......... .......... ..........
PGI .......... .......... .......... .......... ..........
TXA2 .......... .......... .......... .......... ..........
PAF .......... .......... .......... .......... ..........
M2 ARKIVKMTKQ .......... .......... .......... ..........
M4 RKFASIARNQ .......... .......... .......... ..........
M1 PNTVKRP... .......... .......TKK GRDRAGKGQK .P........
M3 DDGGSFPKSF SK.....LPI QLESAVDTAK TSDVNSSVGK .STATLPLSF
M5 PAAAHRPKSQ K.....CVAY KFRLVVKADG NQETNNGCHK VKIMPCPFPV
H1 NTHGASEISE DQ.....MLG DSQSFSRTDS DTTTETAPGK GKLRSGSNTG
H2 I......... .......... .......... .......... ..........
5HT1A E......... .......... .......... .......... ..........
5HT1B L......... .......... .......... .......... ..........
5HT1D L......... .......... .......... .......... ..........
5HT1E G......... .......... .......... .......... ..........
5HT1F W......... .......... .......... .......... ..........
5HT2A G......... .......... .......... .......... ..........
5HT2B G......... .......... .......... .......... ..........
5HT2C P......... .......... .......... .......... ..........
5HT5A .......... .......... .......... .......... ..........
5HT5Brat .......... .......... .......... .......... ..........
5HT6rat R......... .......... .......... .......... ..........
5HT7 .......... .......... .......... .......... ..........
alpha1A L......... .......... .......... .......... ..........
alpha1B I......... .......... .......... .......... ..........
alpha1C F......... .......... .......... .......... ..........
alpha2A R......... .......... .......... .......... ..........
alpha2B W......... .......... .......... .......... ..........
alpha2C1 R......... .......... .......... .......... ..........
alpha2C2 R......... .......... .......... .......... ..........
beta1 R......... .......... .......... .......... ..........
beta2 .......... .......... .......... .......... ..........
beta3 R......... .......... .......... .......... ..........
beta4turkey .......... .......... .......... .......... ..........
D1A E......... .......... .......... .......... ..........
D2 .......... .......... .......... .......... ..........
D3 .......... .......... .......... .......... ..........
D4 .......... .......... .......... .......... ..........
D5 D......... .......... .......... .......... ..........
A1 .......... .......... .......... .......... ..........
A2a .......... .......... .......... .......... ..........
A2b .......... .......... .......... .......... ..........
A3 .......... .......... .......... .......... ..........
OCdrome GHSGGGKSDA EISTESGSDP KGCIQVCVTQ ADEQTSLKLT PPQSSTGVAA
ACTH .......... .......... .......... .......... ..........
MSH .......... .......... .......... .......... ..........
MC3 .......... .......... .......... .......... ..........
MC4 .......... .......... .......... .......... ..........
MC5 .......... .......... .......... .......... ..........
melatonin .......... .......... .......... .......... ..........
oxytocin .......... .......... .......... .......... ..........
conopressinLs .......... .......... .......... .......... ..........
V1A .......... .......... .......... .......... ..........
V1B .......... .......... .......... .......... ..........
V2 .......... .......... .......... .......... ..........
CCK_A TSSGKYEDSD GCYLQ..... KTRPPRKLEL RQLSTG.... ..........
CCK_B ETGAVGEDSD GCYVQ..... LPRSRPALEL TALTAP.... ..........
NPY1 .......... .......... .......... .......... ..........
NTR .......... .......... .......... .......... ..........
NK1 .......... .......... .......... .......... ..........
NK2 .......... .......... .......... .......... ..........
NK3 .......... .......... .......... .......... ..........
blueops .......... .......... .......... .......... ..........
greenops .......... .......... .......... .......... ..........
redops .......... .......... .......... .......... ..........
rhodopsin .......... .......... .......... .......... ..........
violetopsGg .......... .......... .......... .......... ..........
opsin_crab .......... .......... .......... .......... ..........
ET_Aprec .......... .......... .......... .......... ..........
ET_Bprec .......... .......... .......... .......... ..........
ET_Cfrog .......... .......... .......... .......... ..........
galanin .......... .......... .......... .......... ..........
NMB .......... .......... .......... .......... ..........
GRP .......... .......... .......... .......... ..........
BRS3 .......... .......... .......... .......... ..........
deltaOP .......... .......... .......... .......... ..........
kappaOP .......... .......... .......... .......... ..........
muOP .......... .......... .......... .......... ..........
OPRX .......... .......... .......... .......... ..........
CB1 .......... .......... .......... .......... ..........
CB2 .......... .......... .......... .......... ..........
SSTR1 .......... .......... .......... .......... ..........
SSTR2 .......... .......... .......... .......... ..........
SSTR3 .......... .......... .......... .......... ..........
SSTR4 .......... .......... .......... .......... ..........
SSTR5 .......... .......... .......... .......... ..........
IL8A .......... .......... .......... .......... ..........
IL8B .......... .......... .......... .......... ..........
AT1a .......... .......... .......... .......... ..........
AT1brat .......... .......... .......... .......... ..........
AT2 .......... .......... .......... .......... ..........
BK1 .......... .......... .......... .......... ..........
BK2 .......... .......... .......... .......... ..........
P2Y7 .......... .......... .......... .......... ..........
P2Y6 .......... .......... .......... .......... ..........
P2Y5 .......... .......... .......... .......... ..........
P2Y4 .......... .......... .......... .......... ..........
P2Y3chick .......... .......... .......... .......... ..........
P2Y2 .......... .......... .......... .......... ..........
P2Y1 .......... .......... .......... .......... ..........
THRprec .......... .......... .......... .......... ..........
C5a .......... .......... .......... .......... ..........
GP01mouse .......... .......... .......... .......... ..........
R334rat .......... .......... .......... .......... ..........
GP21mouse .......... .......... .......... .......... ..........
GCRCmouse .......... .......... .......... .......... ..........
TXKR .......... .......... .......... .......... ..........
G10Drat .......... .......... .......... .......... ..........
RDC1 .......... .......... .......... .......... ..........
BLR1 .......... .......... .......... .......... ..........
CL5 .......... .......... .......... .......... ..........
LCR1 .......... .......... .......... .......... ..........
EBI1 .......... .......... .......... .......... ..........
RBS1rat .......... .......... .......... .......... ..........
EBI2 .......... .......... .......... .......... ..........
GCRTchick .......... .......... .......... .......... ..........
APJ .......... .......... .......... .......... ..........
RTArat .......... .......... .......... .......... ..........
UHRrat .......... .......... .......... .......... ..........
FMRL1 .......... .......... .......... .......... ..........
FMRL2 .......... .......... .......... .......... ..........
fMLP .......... .......... .......... .......... ..........
OLF1catfish .......... .......... .......... .......... ..........
OLF3catfish .......... .......... .......... .......... ..........
OLF8catfish .......... .......... .......... .......... ..........
OLF32Acatfish .......... .......... .......... .......... ..........
OLF32Bcatfish .......... .......... .......... .......... ..........
OLF32Ccatfish .......... .......... .......... .......... ..........
OLF32Dcatfish .......... .......... .......... .......... ..........
OLF47catfish .......... .......... .......... .......... ..........
OLF202catfish .......... .......... .......... .......... ..........
OLFCOR1chicken .......... .......... .......... .......... ..........
OLFCOR2chicken .......... .......... .......... .......... ..........
OLFCOR3chicken .......... .......... .......... .......... ..........
OLFCOR4chicken .......... .......... .......... .......... ..........
OLFCOR5chicken .......... .......... .......... .......... ..........
OLFCOR6chicken .......... .......... .......... .......... ..........
OLFdog .......... .......... .......... .......... ..........
OLF07E .......... .......... .......... .......... ..........
OLF07I .......... .......... .......... .......... ..........
OLF07J .......... .......... .......... .......... ..........
OLFOR3mouse .......... .......... .......... .......... ..........
OLFrat .......... .......... .......... .......... ..........
OLFF3rat .......... .......... .......... .......... ..........
OLFF5rat .......... .......... .......... .......... ..........
OLFF6rat .......... .......... .......... .......... ..........
OLFF12rat .......... .......... .......... .......... ..........
OLFI3rat .......... .......... .......... .......... ..........
OLFI7rat .......... .......... .......... .......... ..........
OLFI8rat .......... .......... .......... .......... ..........
OLFI9rat .......... .......... .......... .......... ..........
OLFI14rat .......... .......... .......... .......... ..........
OLFI15rat .......... .......... .......... .......... ..........
OLFOR17_40 .......... .......... .......... .......... ..........
GUST27rat .......... .......... .......... .......... ..........
RPE .......... .......... .......... .......... ..........
HHRF1 .......... .......... .......... .......... ..........
HHRF2 .......... .......... .......... .......... ..........
HHRF3 .......... .......... .......... .......... ..........
MCP-1A .......... .......... .......... .......... ..........
MCP-1B .......... .......... .......... .......... ..........
PPR1bovine .......... .......... .......... .......... ..........
551 600
GPCRAelegans .......... .......... ..APKRNDSK VAKRMAILVF TDMLCWAPIA
GRH .......... .....QLNQS KNNIPRARLK TLKMTVAFAT SFTVCWTPYY
TRH .......... .......... ......SRKQ VTKMLAVVVI LFALLWMPYR
FSHprec .......... .......... ......SDTR IAKRMAMLIF TDFLCMAPIS
TSHprec .......... .......... ......KDTK IAKRMAVLIF TDFICMAPIS
LH_CGprec .......... .......... ......KDTK IAKKMAILIF TDFTCMAPIS
PGE_EP1 .......... .......... .......... MVGQLVGIMV VSCICWSPML
PGE_EP2 .......... .......... ........IQ MVILLIATSL VVLICSIPLV
PGE_EP3 .......... ........RG ERVSMAEETD HLILLAIMTI TFAVCSLPFT
PGF .......... .......... .......... MVIQLLAIMC VSCICWSPFL
PGI .......... .......... ........VD HLILLALMTV VMAVCSLPLT
TXA2 .......... .......... .......... MMAQLLGIMV VASVCWLPLL
PAF .......... .......... .......... ALWMVCTVLA VFIICFVPHH
M2 .......... .......PAK KKPPPSREKK VTRTILAILL AFIITWAPYN
M4 .......... .......VRK KRQMAARERK VTRTIFAILL AFILTWTPYN
M1 .......... .RGKEQLAKR KTFSLVKEKK AARTLSAILL AFILTWTPYN
M3 KEATLAKRFA LKTRSQITKR KRMSLVKEKK AAQTLSAILL AFIITWTPYN
M5 AKEPSTKGLN PNPSHQMTKR KRVVLVKERK AAQTLSAILL AFIITWTPYN
H1 LDYIKFTWKR LRSHSRQYV. SGLHMNRERK AAKQLGFIMA AFILCWIPYF
H2 .......... ........SS WKAATIREHK ATVTLAAVMG AFIICWFPYF
5HT1A .......... ........AK RKMALARERK TVKTLGIIMG TFILCWLPFF
5HT1B .......... ........EK KKLMAARERK ATKTLGIILG AFIVCWLPFF
5HT1D .......... ........ER KRISAARERK ATKILGIILG AFIICWLPFF
5HT1E .......... ........ER QQISSTRERK AARILGLILG AFILSWLPFF
5HT1F .......... ........RR QKISGTRERK AATTLGLILG AFVICWLPFF
5HT2A .......... ........RR TMQSISNEQK ACKVLGIVFF LFVVMWCPFF
5HT2B .......... ........KK SVQTISNEQR ASKVLGIVFF LFLLMWCPFF
5HT2C .......... ........RG TMQAINNERK ASKVLGIVFF VFLIMWCPFF
5HT5A .......... .......... .....QKEQR AALMVGILIG VFVLCWIPFF
5HT5Brat .......... .......... .....QKEKR AAMMVGILIG VFVLCWIPFF
5HT6rat .......... ........RL ATKHSRKALK ASLTLGILLG MFFVTWLPFF
5HT7 .......... .......... .....KREQK AATTLGIIVG AFTVCWLPFF
alpha1A .......... ........SV RLLKFSREKK AAKTLAIVVG VFVLCWFPFF
alpha1B .......... ........AV KLFKFSREKK AAKTLGIVVG MFILCWLPFF
alpha1C .......... ........SV RLLKFSREKK AAKTLGIVVG CFVLCWLPFF
alpha2A .......... ........RA GAGGQNREKR FTFVLAVVIG VFVVCWFPFF
alpha2B .......... ........WR RRAHVTREKR FTFVLAVVIG VFVLCWFPFF
alpha2C1 .......... ........K. ..VAQAREKR FTFVLAVVMG VFVLCWFPFF
alpha2C2 .......... ........K. ..VAQAREKR FTFVLAVVMG VFVLCWFPFF
beta1 .......... ........RP SRLVALREQK ALKTLGIIMG VFTLCWLPFF
beta2 .......... ........RR SSKFCLKEHK ALKTLGIIMG TFTLCWLPFF
beta3 .......... ........RP ARLLPLREHR ALCTLGLIMG TFTLCWLPFF
beta4turkey .......... ........RP SRLLAIKEHK ALKTLGIIMG TFTLCWLPFF
D1A .......... ........SS FKMSFKRETK VLKTLSVIMG VFVCCWLPFF
D2 .......... .......... ....QQKEKK ATQMLAIVLG VFIICWLPFF
D3 .......... .......... ....PLREKK ATQMVAIVLG AFIVCWLPFF
D4 .......... .......... ......RERK AMRVLPVVVG AFLLCWTPFF
D5 .......... ........TS LRASIKKETK VLKTLSVIMG VFVCCWLPFF
A1 .......... ...VSASSGD PQKYYGKELK IAKSLALILF LFALSWLPLH
A2a .......... .......GER ARSTLQKEVH AAKSLAIIVG LFALCWLPLH
A2b .......... ........DH SRTTLQREIH AAKSLAMIVG IFALCWLPVH
A3 .......... ...LSNSK.E TGAFYGREFK TAKSLFLVLF LFALSWLPLS
OCdrome VSVTPLQKKT SGVNQFIEEK QKISLSKERR AARTLGIIMG VFVICWLPFF
ACTH .......... .......... .....RANMK GAITLTILLG VFIFCWAPFV
MSH .......... ......KRQR .PVHQGFGLK GAVTLTILLG IFFLCWGPFF
MC3 .......... ......PADG VAPQQHSCMK GAVTITILLG VFIFCWAPFF
MC4 .......... ......GTGA I..RQGANMK GAITLTILIG VFVVCWAPFF
MC5 .......... ......GASS A..RQRTSMQ GAVTVTMLLG VFTVCWAPFF
melatonin .......... .......... ...LKPQDFR NFVTMFVVFV LFAICWAPLN
oxytocin .PEGAAAGDG GRVALARVSS VKLISKAKIR TVKMTFIIVL AFIVCWTPFF
conopressinLs LDRHDASAVT SSDSKKPRGH QRGVSKSKMK TIKLTLTVVL CYLFCWAPFF
V1A ........QK GFLLAPCVSS VKSISRAKIR TVKMTFVIVT AYIVCWAPFF
V1B .PSPSTLAAT TRGLPSRVSS INTISRAKIR TVKMTFVIVL AYIACWAPFF
V2 ........RR RGRRTGSPGE GAHVSAAVAK TVRMTLVIVV VYVLCWAPFF
CCK_A ....... SS SRANRIRSNS SAANLMAKKR VIRMLIVIVV LFFLCWMPIF
CCK_B ........GP GSGSR....P TQAKLLAKKR VVRMLLVIVV LFFLCWLPVY
NPY1 .......... RNNMMDKMRD NKYRSSETKR INIMLLSIVV AFAVCWLPLT
NTR ....QVCTVG GEHSTFSMAI EPGRVQALRH GVRVLRAVVI AFVVCWLPYH
NK1 ........AS EIPG.DSSDR YHEQVSAKRK VVKMMIVVVC TFAICWLPFH
NK2 ........RR AVPGHQAHGA NLRHLQAKKK FVKTMVLVVL TFAICWLPYH
NK3 ........GG EIPG.DTCDK YHEQLKAKRK VVKMMIIVVM TFAICWLPYH
blueops ........AV AAQQQESATT ....QKAERE VSRMVVVMVG SFCVCYVPYA
greenops ........AV AKQQKESEST ....QKAEKE VTRMVVVMVL AFCFCWGPYA
redops ........AV AKQQKESEST ....QKAEKE VTRMVVVMIF AYCVCWGPYT
rhodopsin ........EA AAQQQESATT ....QKAEKE VTRMVIIMVI AFLICWVPYA
violetopsGg .......AT. .......... ...TQKAERE VSRMVVVMVG SFCLCYVPYA
opsin_crab .......AKK MNVASLRANA DQQKQSAECR LAKVAMMTVG LWFMAWTPYL
ET_Aprec .......NRR N...GSLRIA LSEHLKQRRE VAKTVFCLVV IFALCWFPLH
ET_Bprec ........RK K...SGMQIA LNDHLKQRRE VAKTVFCLVL VFALCWLPLH
ET_Cfrog ........SI K...NGMRIA LNDHMKQRRE VAKTVFCLVV IFALCWLPLH
galanin .......... ....KKLKNM SKKSEASKKK TAQTVLVVVV VFGISWLPHH
NMB .......KSA HNLPGEYNEH TKKQMETRKR LAKIVLVFVG CFIFCWFPNH
GRP .......QSA YNLPVEGNIH VKKQIESRKR LAKTVLVFVG LFAFCWLPNH
BRS3 .......KST LNIPTEEQSH ARKQIESRKR IARTVLVLVA LFALCWLPNH
deltaOP .......SVR LLSGS..... .KEKDRSLRR ITRMVLVVVG AFVVCWAPIH
kappaOP .......SVR LLSGS..... .REKDRNLRR ITRLVLVVVA VFVVCWTPIH
muOP .......SVR MLSGS..... .KEKDRNLRR ITRMVLVVVA VFIVCWTPIH
OPRX .......GVR LLSGS..... .REKDRNLRR ITRLVLVVVA VFVGCWTPVQ
CB1 .......IIH TSEDGKVQVT RPDQARMDIR LAKTLVLILV VLIICWGPLL
CB2 .......... ..GHQDRQVP GMARMRLDVR LAKTLGLVLA VLLICWFPVL
SSTR1 .......MVA LKAG...... WQQRKRSERK ITLMVMMVVM VFVICWMPFY
SSTR2 .......SSG IRVGSS.... ..KRKKSEKK VTRMVSIVVA VFIFCWLPFY
SSTR3 .......SAG RRVWAP...S CQRRRRSERR VTRMVVAVVA LFVLCWMPFY
SSTR4 .......AVA LRAG...... WQQRRRSEKK ITRLVLMVVV VFVLCWMPFY
SSTR5 .......AAG VRVGCV.... ...RRRSERK VTRMVLVVVL VFAGCWLPFF
IL8A .......KAH MGQ....... .......KHR AMRVIFAVVL IFLLCWLPYN
IL8B .......KAH MGQ....... .......KHR AMRVIFAVVL IFLLCWLPYN
AT1a .......KAY EIQ....... ..KNKPRNDD IFKIIMAIVL FFFFSWIPHQ
AT1brat .......KAY KIQ....... ..KNTPRNDD IFRIIMAIVL FFFFSWVPHQ
AT2 .......KTN SYG....... ..KNRITRDQ VLKMAAAVVL AFIICWLPFH
BK1 .......TRE EVSRT..... .RVRGPKDSK TTALILTLVV AFLVCWAPYH
BK2 .......NNE MQKF...... ..KEIQTERR ATVLVLVVLL LFIICWLPFQ
P2Y7 .......... .......... .ARRFRRSRR TGRLVVLIIL TFAAFWLPYH
P2Y6 .......... .......DGP AGPVAQRRSK AARMAVVVAA VFVISFLPFH
P2Y5 .......... ........LT LSRNKLSKKK VLKMIFVHLV IFCFCFVPYN
P2Y4 .......... ........LP GAAQSSSRLR SLRTIAVVLT VFAVCFVPFH
P2Y3chick .......... ......DELI GLAVHKKKDK AVRMIIIVVI VFSISFFPFH
P2Y2 .......... ......AYGT SGGLPRAKRK SVRTIAVVLA VFALCFLPFH
P2Y1 .......... .......... DLDNSPLRRK SIYLVIIVLT VFAVSYIPFH
THRprec .......SSA VANRS..... ..K....KSR ALFLSAAVFC IFIICFGPTN
C5a .......... .......... ......RSTK TLKVVVAVVA SFFIFWLPYQ
GP01mouse .......... .......... .......TRK GVSTLALILG TFAACWMPFT
R334rat .......... .......... .......TRK GISTLALILG TFAACWMPFT
GP21mouse .......... .......... .......TRK GIATLAVVLG AFAACWLPFT
GCRCmouse .......... .......... .......KTT VK.MLVLVVV LFALVWCPLN
TXKR .......... .......... .......RKV VK.MMIIVVV TFAICWLPYH
G10Drat .......... .......... .......... ....MWAYIV VFAICWLPYH
RDC1 .......... .......... .......... ...IIFSYVV VFLVCWLPYH
BLR1 .......... .......... .......... ...VAILVTS IFFLCWSPYH
CL5 .......... .......... .......... ...TTVILIL AFFACWLPYY
LCR1 .......... .......... .......... ...TTVILIL AFFACWLPYY
EBI1 .......... .......... .......... ...VIIAVVV VFIVFQLPYN
RBS1rat .......... .......... .......... ...LILLVVV VFFLFWTPYN
EBI2 .......... .......... .......... ALNTIILIIV VFVLCFTPYH
GCRTchick .......... .......... .......... ...MIFVHLV IFCFCFVPYN
APJ .......... .......... .......... LLSIIVVLVV TFALCWMPYH
RTArat .......... .......... .......FLV SSIYLGIDWF LFWVFQIPAP
UHRrat .......... .......... .......... .FCLLVVVVV VFALCWLPLH
FMRL1 .......... .......... ......KSSR PLRVFAAVVA SFFICWFPYE
FMRL2 .......... .......... ......KSSR PLRVLTAVVA SFFICWFPFQ
fMLP .......... .......... ......KSSR PLRVLSFVAA AFFLCWSPYQ
OLF1catfish .......... .......... ........RK AMKTCTSHLI LVALFYLPFI
OLF3catfish .......... .......... ........VK AMKTCTSHLI LVAMFYLPII
OLF8catfish .......... .......... ........LK AVNTCITHII VMTVSLTFAL
OLF32Acatfish .......... .......... ........LK ALKTCISHLL VVGVFFLPIV
OLF32Bcatfish .......... .......... ........LK ALKTCISHLL VVGVFFLPIV
OLF32Ccatfish .......... .......... ........LK ALKTCISHLL VVGVFFLPIV
OLF32Dcatfish .......... .......... ........LK ALKTCISHLL VVGVFFLPIV
OLF47catfish .......... .......... ........WK AFNTCLTHMI LVLIYYLPII
OLF202catfish .......... .......... ........LK TLSTCSSQLI IITLFFLPRC
OLFCOR1chicken .......... .......... ........YK AFSTCTSHLM AVSLFHGTVI
OLFCOR2chicken .......... .......... ........YK AFSTCTSHLM AVSLFHGTVI
OLFCOR3chicken .......... .......... ........YK AFSTCTSHLM AVSLFHGTVI
OLFCOR4chicken .......... .......... ........YK AFSTCTSHLM AVSLFHGTVI
OLFCOR5chicken .......... .......... ........YK AFSTCTSHLM AVSLFHGTVI
OLFCOR6chicken .......... .......... ........YK AFSTCTSHLM AVSLFHGTIV
OLFdog .......... .......... ........CK VFSTCGSHLS VVSLFYGTVI
OLF07E .......... .......... ........YK AFSTCASHLG AVSLFYGTLC
OLF07I .......... .......... ........CK AFSTCGSHLS VVSLFYGTVI
OLF07J .......... .......... ........KK AFATCASHLT VVIVHYSCAS
OLFOR3mouse .......... .......... ........RK AFNTCVSHLV VVFLFYGSAI
OLFrat .......... .......... ........SK AFGTCSSHLM AVGIFFGSIT
OLFF3rat .......... .......... ........YK AFSTCASHLS VVSLFYCTGL
OLFF5rat .......... .......... ........WK SFSTCGSHLA VVCLFYGTVI
OLFF6rat .......... .......... ........HR AFSTCSSHLT VVLIWYGSTI
OLFF12rat .......... .......... ........YK AFSTCASHLS IVSLFYSTGL
OLFI3rat .......... .......... ........CK VFSTCGSHLS VVSLFYGTII
OLFI7rat .......... .......... ........HK AFSTCASHLT VVIIFYAASI
OLFI8rat .......... .......... ........HK VFSTCGSHLS VVSLFYGTII
OLFI9rat .......... .......... ........HK AFSTCGSHLS VVSLFYGTVI
OLFI14rat .......... .......... ........YK VFSTCGSHLS VVTLFYGTIF
OLFI15rat .......... .......... ........HK IFSTCGSHLS VVSLFYGTII
OLFOR17_40 .......... .......... ........KK AFSTCGSHLT VVAIFYGSGI
GUST27rat .......... .......... ......SKYK AFSTCGSHLC VVSLFYGSAT
RPE .......T.. .......... .......... ......LPAR TLLLGWGPYA
HHRF1 .......... ....VAVSQS .....RHKGR IVRVLIAVVL VFIIFWLPYH
HHRF2 .......... ....IINYVG .....KWHMQ TLHVLLVVVV SFASFWFPFN
HHRF3 .......... ...AFFYSTV QRTSQKQRSR TLTFVSVLLI SFVALQTPYV
MCP-1A .......... ....LLRC.. ..RNEKKRHR AVRVIFTIMI VYFLFWTPYN
MCP-1B .......... ....LLRC.. ..RNEKKRHR AVRVIFTIMI VYFLFWTPYN
PPR1bovine .......... ....LIKM.. ..PNIKKSQ. PLKVLFTVVI VFIVTQLPYN
6666666666 6666666666 6666666666
2222222333 3333333444 4444444555
3456789012 3456789012 3456789012
601 650
GPCRAelegans FFGLLAAF.. .......... GQTLLTVTQS KILLVFFFPI NSICNPFLYA
GRH VLGIWYWF.. ........DP EMLNRLSDPV NHFFFLFAFL NPCFDPLIYG
TRH TLVVV..... .......NSF LSSPFQENWF LLFCRICIYL NSAINPVIYN
FSHprec FFAISASLKV P......... ...LITVSKA KILLVLFHPI NSCANPFLYA
TSHprec FYALSAILNK P......... ...LITVSNS KILLVLFYPL NSCANPFLYA
LH_CGprec FFAISAAFKV P......... ...LITVTNS KVLLVLFYPI NSCANPFLYA
PGE_EP1 VLVA.LAV.. .......GGW SSTSLQ..RP LFLAVRLASW NQILDPWVYI
PGE_EP2 VRVFVNQLYQ PS.......L EREVSKN..P DLQAIRIASV NPILDPWIYI
PGE_EP3 IFAYMNE... TS........ .SRKEK...W DLQALRFLSI NSIIDPWVFA
PGF VTMANIGI.. .......NGN HSLETCE..T TLFALRMATW NQILDPWVYI
PGI IRCFTQ.... .........A VAPDSSSEMG DLLAFRFYAF NPILDPWVFI
TXA2 WFIAQTVLRN PPAMSPAGQL SRTTEKE... LLIYLRVATW NQILDPWVYI
PAF VVQLPWTLAE LGFQDSKFHQ AI.ND....A HQVTLCLLST NCVLDPVIYC
M2 VMVLINTFCA P......... ....CIPNTV WTIGYWLCYI NSTINPACYA
M4 VMVLVNTFCQ S......... ....CIPDTV WSIGYWLCYV NSTINPACYA
M1 IMVLVSTFCK D......... ....CVPETL WELGYWLCYV NSTINPMCYA
M3 IMVLVNTFCD S......... ....CIPKTF WNLGYWLCYI NSTVNPVCYA
M5 IMVLVSTFCD K......... ....CVPVTL WHLGYWLCYV NSTVNPICYA
H1 IFFMVIAFCK N......... ....CCNEHL HMFTIWLGYI NSTLNPLIYP
H2 TAFVYRGLRG DDA....... .....INEVL EAIVLWLGYA NSALNPILYA
5HT1A IVALVLPF.. CESSCH.... .....MPTLL GAIINWLGYS NSLLNPVIYA
5HT1B IISLVMPI.. CKDACW.... .....FHLAI FDFFTWLGYL NSLINPIIYT
5HT1D VVSLVLPI.. CRDSCW.... .....IHPAL FDFFTWLGYL NSLINPIIYT
5HT1E IKELIVGL.. S..IYT.... .....VSSEV ADFLTWLGYV NSLINPLLYT
5HT1F VKELVVNV.. C.DKCK.... .....ISEEM SNFLAWLGYL NSLINPLIYT
5HT2A ITNIMAVI.. ....CKESCN ED...VIGAL LNVFVWIGYL SSAVNPLVYT
5HT2B ITNITLVL.. ....C.DSCN QT...TLQML LEIFVWIGYV SSGVNPLVYT
5HT2C ITNILSVL.. ....CEKSCN QK...LMEKL LNVFVWIGYV CSGINPLVYT
5HT5A LTELISPL.. C..SCD.... .....IPAIW KSIFLWLGYS NSFFNPLIYT
5HT5Brat LTELVSPL.. C..ACS.... .....LPPIW KSIFLWLGYS NSFFNPLIYT
5HT6rat VANIAQAVCD .......... ....CISPGL FDVLTWLGYC NSTMNPIIYP
5HT7 LLSTARPFIC GTSCSC.... .....IPLWV ERTFLWLGYA NSLINPFIYA
alpha1A FVLPLGSLFP QLK....... .....PSEGV FKVIFWLGYF NSCVNPLIYP
alpha1B IALPLGSLFS TLK....... .....PPDAV FKVVFWLGYF NSCLNPIIYP
alpha1C LVMPIGSFFP DFK....... .....PSETV FKIVFWLGYL NSCINPIIYP
alpha2A FTYTLTAV.. ...GCS.... .....VPRTL FKFFFWFGYC NSSLNPVIYT
alpha2B FSYSLGAI.. CPKHCK.... .....VPHGL FQFFFWIGYC NSSLNPVIYT
alpha2C1 FIYSLYGI.. CREACQ.... .....VPGPL FKFFFWIGYC NSSLNPVIYT
alpha2C2 FSYSLYGI.. CREACQ.... .....VPGPL FKFFFWIGYC NSSLNPVIYT
beta1 LANVVKAF.H REL.....VP DR.......L FVFFNWLGYA NSAFNPIIY.
beta2 IVNIVHVI.Q DNL....... IRK.....EV YILLNWIGYV NSGFNPLIY.
beta3 LANVLRALGG PSL....... .....VPGPA FLALNWLGYA NSAFNPLIY.
beta4turkey VANIIKVFCR PL........ .....VPDQL FLFLNWLGYV NSAFNPIIYC
D1A ILNCILPFCG SGETQP.... ...FCIDSNT FDVFVWFGWA NSSLNPIIY.
D2 ITHILNIH.. C.D.CN.... .....IPPVL YSAFTWLGYV NSAVNPIIYT
D3 LTHVLNTH.. C.QTCH.... .....VSPEL YSATTWLGYV NSALNPVIYT
D4 VVHITQAL.. C.PACS.... .....VPPRL VSAVTWLGYV NSALNPVIYT
D5 ILNCMVPFCS GHPEGPPAGF P...CVSETT FDVFVWFGWA NSSLNPVIY.
A1 ILNCITLFCP .......... .SCHKPSILT Y.IAIFLTHG NSAMNPIVYA
A2a IINCFTFFCP .......... DCSHAPLWLM Y.LAIVLSHT NSVVNPFIYA
A2b AVNCVTLFQP A......... QGKNKPKWAM N.MAILLSHA NSVVNPIVYA
A3 IINCIIYF.. .......... .NGEVPQLVL Y.MGILLSHA NSMMNPIVYA
OCdrome LMYVILPF.. C...Q..... ..TCCPTNKF KNFITWLGYI NSGLNPVIYT
ACTH LHVLLMTFCP S......... NPYCACYMSL FQVNGMLIMC NAVIDPFIYA
MSH LHLTLIVLCP E......... HPTCGCIFKN FNLFLALIIC NAIIDPLIYA
MC3 LHLVLIITCP T......... NPYCTCYTAH FNTYLVLIMC NSVIDPLIYA
MC4 LHLIFYISCP Q......... NPYCVCFMSH FNLYLILIMC NSIIDPLIYA
MC5 LHLTLMLSCP Q......... NLYCSRFMSH FNMYLILIMC NSVMDPLIYA
melatonin F......... FGLLAAFGQT LLTVTQSKIL LV...FFFPI NSICNPFLYA
oxytocin F......... FACFAA...A NPGYPFHPLM AALPAFFAKS ATIYNPVIYV
conopressinLs VVQMWSAF.. .......... DDDSGIEHPV TVICMLLASL NSCTNPWIYL
V1A IIQMWSVW.. ......DPMS VWT.ESENPT ITITALLGSL NSCCNPWIYM
V1B S......... VQMWSVWDAN APKEAS...A FIIVMLLASL NSCCNPWIYM
V2 LVQLWAAW.. ......DPEA PL....EGAP FVLLMLLASL NSCTNPWIYA
CCK_A SANAWRAY.. ......DTAS AERR.LSGTP ISFILLLSYT SSCVNPIIYC
CCK_B SANTWRAF.. ......DGPG AHR.ALSGAP ISFIHLLSYA SACVNPLVYC
NPY1 IFNTVFDW.. .......NHQ IIATCNHNLL FLLCHLTAMI STCVNPIFYG
NTR VRRLMFCYI. ....SDEQWT PFLYDFYHYF YMVTNALFYV SSTINPILYN
NK1 IFFLLPYI.. ......NPDL YLKK.FIQQV YLAIMWLAMS STMYNPIIYC
NK2 LYFILGSF.. ......QEDI YCHK.FIQQV YLALFWLAMS STMYNPIIYC
NK3 IYFILTAI.. ......YQQL NRWK.YIQQV YLASFWLAMS STMYNPIIYC
blueops AFAMYMVN.. ......NRNH GLDLRLVTI. ...PSFFSKS ACIYNPIIYC
greenops FFACFAAA.. ......NPGY PFHPLMAAL. ...PAFFAKS ATIYNPVIYV
redops FFACFAAA.. ......NPGY AFHPLMAAL. ...PAYFAKS ATIYNPVIYV
rhodopsin SVAFYIFT.. ......HQGS NFGPIFMTI. ...PAFFAKS AAIYNPVIYI
violetopsGg A......... VAFYIF...T HQGSNFGPIF MTIPAFFAKS AAIYNPVIYI
opsin_crab I......... LYLYAV...I ADVTSISPKL QMVPALIAKM VPTINAINYA
ET_Aprec LSRILKKTVY NEM..DKNRC EL.LSFLLLM DYIGINLATM NSCINPIALY
ET_Bprec LSRILKLTLY NQN..DPNRC EL.LSFLLVL DYIGINMASL NSCINPIALY
ET_Cfrog VSSI...... ....QLLMVM NYTGINMASL NSCIGPVALY
galanin IIHLWAEFGV FP........ ..LTPASFLF RITAHCLAYS NSSVNPIIYA
NMB ILYMYRSFNY NEI..DPSLG H......MIV TLVARVLSFG NSCVNPFALY
GRP VIYLYRSYHY SEV..DTSML H......FVT SICARLLAFT NSCVNPFALY
BRS3 LLYLYHSFTS QT.YVDPSAM H......FIF TIFSRVLAFS NSCVNPFALY
deltaOP IFVIVWTLVD ID........ RRDPL.VVAA LHLCIALGYA NSSLNPVLYA
kappaOP IFILVEALGS TS........ HSTA..ALSS YYFCIALGYT NSSLNPILYA
muOP IYVIIKALVT I......... PETTFQT.VS WHFCIALGYT NSCLNPVLYA
OPRX VFVLAQGLGV Q......... PSS.ETAVAI LRFCTALGYV NSCLNPILYA
CB1 AIMVYDVFGK .......... ..MNKLIKTV FAFCSMLCLL NSTVNPIIYA
CB2 ALMAHSLATT .......... ..LSDQVKKA FAFCSMLCLI NSMVNPVIYA
SSTR1 VVQLVNVFA. .......... .EQDDATV.. SQLSVILGYA NSCANPILYG
SSTR2 IFNVSSVSMA IS........ PTPALKGM.. FDFVVVLTYA NSCANPILYA
SSTR3 VLNIVNVVCP LP........ EEPAFFGL.. YFLVVALPYA NSCANPILYG
SSTR4 VVQLLNLVV. .......... .TSLDATV.. NHVSLILSYA NSCANPILYG
SSTR5 TVNIVNLAVA LP........ QEPASAGL.. YFFVVILSYA NSCANPVLYG
IL8A LVLLADTLMR TQVI..QET. CERRNNIGRA LDATEILGFL HSCLNPIIYA
IL8B LVLLADTLMR TQVI..QET. CERRNHIDRA LDATEILGIL HSCLNPLIYA
AT1a IFTFLDVLIQ LGII..RD.. CRIADIVDTA MPITICIAYF NNCLNPLFYG
AT1brat IFTFLDVLIQ LGII..RD.. CEIADIVDTA MPITICIAYF NNCLNPLFYG
AT2 VLTFLDALAW MGVI..NS.. CEVIAVIDLA LPFAILLGFT NSCVNPFLYC
BK1 FFAFLEFLFQ VQAV..RG.. CFWEDFIDLG LQLANFFAFT NSSLNPVIYV
BK2 ISTFLDTLHR LGIL..SS.. CQDERIIDVI TQIASFMAYS NSCLNPLVYV
P2Y7 VVNLAEAGRA L..AGQAAGL GLVGKRLSLA RNVLIVLAFL SSSVNPVLYA
P2Y6 ITKTAYLAVR S....TPGVS CPVLETFAAA YKGTRPFASA NSVLDPILFY
P2Y5 ITLILYSLMR T....QTWIN CSVVTAVRTM YPVTLCIAVS NCCFDPIVYY
P2Y4 ITRTIYYLAR L....L.EAD CRVLNIVNVV YKVTRPLASA NSCLDPVLYL
P2Y3chick LTKTIYLIVR S....SASLP CPTLQAFAIA YKCTRPFASM NSVLDPILFY
P2Y2 VTRTLYYSFR S....L.DLS CHTLNAINMA YKVTRPLASA NSCLDPVLYF
P2Y1 VMKTMNLRAR L..DFQTPAM CAFNDRVYAT YQVTRGLASL NSCVDPILYF
THRprec VLLIAHYSFL SHTSTTEA.. .....A.YFA YLLCVCVSSI SSCIDPLIYY
C5a VTGIMMSFLE PSSPTF.... ....LLLNKL DSLCVSFAYI NCCINPIIYV
GP01mouse LYSLIADYTY PSIYTY.... .......... ..ATLLPATY NSIINPVIYA
R334rat LYSLIADYTY PSIYTY.... .......... ..ATLLPATY NSIINPVIYA
GP21mouse VYCLLGDADS PRLYTY.... .......... ..LTLLPATY NSMINPVIYA
GCRCmouse CYVLLLSSKA IHTN....NA LYF....... ..AFHWFAMS STCYNPFIYC
TXKR IYFILTAIYQ QLNRWKYIQQ VYL....... ..ASFWLAMS STMYNPIIYC
G10Drat VTMLLLTLHT TH.IFL.HC. .NLVNFLYFF YEIIDCFSML HCVANPILYN
RDC1 VAVLLDIFSI LHYIPF.TC. .RLEHALFTA LHVTQCLSLV HCCVNPVLYS
BLR1 IVIFLDTLAR LKAVD.NTC. .KLNGSLPVA ITMCEFLGLA HCCLNPMLYT
CL5 IGISIDSFIL LEIIK.QGC. .EFENTVHKW ISITEALAFF HCCLNPILYA
LCR1 IGISIDSFIL LEIIK.QGC. .EFENTVHKW ISITEALAFF HCCLNPILYA
EBI1 GVVLAQTVAN FNITS.STC. .ELSKQLNIA YDVTYSLACV RCCVNPFLYA
RBS1rat IVIFLETLKF YNFF..PSC. .GMKRDLRWA LSVTETVAFS HCCLNPFIYA
EBI2 VAIIQHMIKK LRFSNFLEC. .SQRHSFQIS LHFTVCLMNF NCCMDPFIYF
GCRTchick ITLI..LYSL MRTQTWINC. .SVVTAVRTM YPVTLCIAVS NCCFDPIVYY
APJ LVKTLYMLGS LLHWPCDFD. .LFL...MNI FPYCTCISYV NSCLNPFLYA
RTArat FPEYV..... .......... .......... ...TDLCICI NSSAKPIVYF
UHRrat IFNLL..... RD....LDPR AIDPYAFGLV QLLCHWLAMS SACYNPFIYA
FMRL1 LIGILMAVWL KE.....MLL NGKYKIILVL INPTSSLAFF NSCLNPILYV
FMRL2 LVALLGTVWL KE.....MLF YGKYKIIDIL VNPTSSLAFF NSCLNPMLYV
fMLP VVALIATVRI RE......LL QGMYKEIGIA VDVTSALAFF NSCLNPMLYV
OLF1catfish GTN....... .......ITS LTSSINANDR ILNSTLTQII PPMLNPIIYT
OLF3catfish SVY....... .......TVA LTTRIDTNIR IINTALTQTI PPMLNPIIYT
OLF8catfish IAFL...... ........SY RIRNFSPSSR VFLSTMYLFI PSCFNPIIYG
OLF32Acatfish GTY....... .......LAA VTFSLHPNAR IINTSLSRTI PPMLNPIIYV
OLF32Bcatfish GTY....... .......LAA LTFSLHPNAR IINTSLSRTI PPMLNPIIYV
OLF32Ccatfish GTY....... .......LAA LTFSLHPNAR IINTSLSRTI PPMLNPIIYV
OLF32Dcatfish GTY....... .......LAA VTFSLHPNAR IINTSLSRTI PPMLNPIIYV
OLF47catfish LAYILGN... .......... LKLLQSADLY TAGLTVCVTL PAMLNPIIYS
OLF202catfish LNYLSSS... .......... LGIHINADIQ ILVIMLYSLL PPMINPVIYC
OLFCOR1chicken FMYLRPV... .......... ..KLFSLDTD KIASLFYTVV IPMLNPLIYS
OLFCOR2chicken FMYLRSV... .......... ..KLFSLDTD KIASLFYTVV IPMLNPLIYS
OLFCOR3chicken FMYLRPV... .......... ..KLFSLDTD KIASLFYTVV IPMLNPLIYS
OLFCOR4chicken FMYLRPV... .......... ..KLFSLDTD KIASLFYTVV IPMLNPLIYS
OLFCOR5chicken FMYLRPV... .......... ..KLFSLDTD KIASLFYTVV IPMLNPLIYS
OLFCOR6chicken FMYFQPA... .......... ..NNFSLDKD KIMSLFYTVV IPMLNPLIYS
OLFdog GLYLCPS... .......... ..ANNSTVKE TIMAMMYTVV TPMLNPFIYS
OLF07E MVYLKP.... .......... ..LHTYSVKD SVATVMYAVV TPMMNPFIYS
OLF07I GLYLCSS... .......... ..ANSSTLKD TVMAMMYTVV TPMLNPFIYS
OLF07J IAYLKPK... .......... ..SENTREHD QLISVTYTVI TPLLNPVVYT
OLFOR3mouse YGYLLPA... .......... ..KSSNQSQG KFISLFYSVV TPMVNPLIYT
OLFrat FMYLKPS... .......... ..SSNSLEQE KVSSVFYTTV IPMLNPLIYS
OLFF3rat GVYLSSA... .......... ..ANNSSQAS ATASVMYTVV TPMVNPFIYS
OLFF5rat AVYFNPS... .......... ..SSHLAGRD MAAAVMYAVV TPMLNPFIYS
OLFF6rat FLHVRTS... .......... ..VESSLDLT KAITVLNTIV TPVLNPFIYT
OLFF12rat GVYVSSA... .......... ..VVQSSHSA ASASVMYTVV TPMLNPFIYS
OLFI3rat GLYLCPA... .......... ..GNNSTVKE MVMAMMYTVV TPMLNPFIYS
OLFI7rat FIYARPK... .......... ..ALSAFDTN KLVSVLYAVI VPLFNPIIYC
OLFI8rat GLYLCPS... .......... ..GDNFSLKG SAMAMMYTVV TPMLNPFIYS
OLFI9rat GLYLCPS... .......... ..ANNSTVKE TVMSLMYTMV TPMLNPFIYS
OLFI14rat GIYLCPS... .......... ..GNNSTVKE IAMAMMYTVV TPMLNPFIYS
OLFI15rat GLYLCPS... .......... ..ANNSTVKE TVMAMMYTVV TPMLNPFIYS
OLFOR17_40 FNYMRLG... .......... ..STKLSDKD KAVGIFNTVI NPMLNPIIYS
GUST27rat IVYF...... IGLAVASDPA SMVPRIPEWL FVASYYMAYF NSCLNAIIYG
RPE ITLFVDTLKL LKWISSS... CEFERSLKRA LILTESLAFC HCCLNPLLYV
HHRF1 LALFLESIRL LAGV....YN DTLQNVIIFC LYVGQFLAYV RACLNPGIYI
HHRF2 LVILLNTFQE FFGL....SN CESTSQLDQA TQVTETLGMT HCCINPIIYA
HHRF3 SLMIFNSYAT TAW....PMQ CEHLTLRRTI GTLARVVPHL HCLINPILYA
MCP-1A IVILLNTFQE FFGL....SN CESTSQLDQA TQVTETLGMT HCCINPIIYA
MCP-1B IVKFCQAIDI IYSLI...TD CDMSKRMDVA IQITESIALF HSCLNPVLYV
PPR1bovine ILTFLDALA. ..WM.GVINS CEVIAVIDLA LPFAILLGFT NSCVNPFLYC
6666666666 6666 77 7777777777 7777777777
5555555666 6666 33 3333344444 4444455555
3456789012 3456 34 5678901234 5678901234
651 700
GPCRAelegans FFTKAFKREL FTALSRIGFC KFRALKYNGT LSSFLYSRSR RHHSTVNAEH
GRH YFSL...... .......... .......... .......... ..........
TRH LMSQKFRAAF RKLCNCKQKP TEKPANYSVA LNYSVIKESD HFSTELDDIT
FSHprec IFTKNFRRDF FILLSKC... ..GCYEMQAQ IYRTETSSTV ...HNTHPRN
TSHprec IFTKAFQRDV FILLSKF... ..GICKRQAQ AYRGQRVPPK ...NSTDIQV
LH_CGprec IFTKTFQRDF FLLLSKF... ..GCCKRRAE LYRRKDFSAY ...TSNCKNG
PGE_EP1 LLRQAVLRQ. .......LLR LLPPRAGAKG GPAGLGLTPS AWEASSLRSS
PGE_EP2 LLRKTVLSKA IEKIKCLFCR IGGSRRERSG QHCSDSQRTS SAMSGHSRSF
PGE_EP3 ILRPPVLRL. ........MR SVLCCRISLR TQDATQTSCS TQSDASKQAD
PGF LLRKAVLKN. .......L.. YKLASQCCGV HVISLHIWEL SSIKNSLKVA
PGI LFRKAVFQRL KLWVCCLCLG PAHGDSQTPL SQLASGRRDP RAPSAPVGKE
TXA2 LFRRAVLRR. .......L.Q PRLSTRPRSL SLQPQLTQRS GLQ.......
PAF FLTKKFRKHL TEKFYSMRSS RKCSRATTDT VTEVVVPFNQ IPGNSLKN..
M2 LCNATFKKTF KHLLMCHYKN IGATR..... .......... ..........
M4 LCNATFKKTF RHLLLCQYRN IGTAR..... .......... ..........
M1 LCNKAFRDTF RLLLLCRWDK RRWRK...IP KRPGSVHRTP SRQC......
M3 LCNKTFRTTF KMLLLCQCDK KKRRKQQYQQ RQSVIFHKRA PEQAL.....
M5 LCNRTFRKTF KMLLLCRWKK KKVEEKLYWQ GNSKLP.... ..........
H1 LCNENFKKTF KRILHIRS.. .......... .......... ..........
H2 ALNRDFRTGY QQLFCCRLAN RNSHKTSLRS NASQLSRTQS REPRQQEEKP
5HT1A YFNKDFQNAF KKIIKCKFCR Q......... .......... ..........
5HT1B MSNEDFKQAF HKLIRFKCTS .......... .......... ..........
5HT1D VFNEEFRQAF QKIVPFRKAS .......... .......... ..........
5HT1E SFNEDFKLAF KKLIRCREHT .......... .......... ..........
5HT1F IFNEDFKKAF QKLVRCRC.. .......... .......... ..........
5HT2A LFNKTYRSAF SRYIQCQYKE NKKPLQLILV NTIPALAYKS SQLQMGQKKN
5HT2B LFNKTFRDAF GRYITCNYRA TKSVKTLRKR SSKIYFRNPM AENSKFFKKH
5HT2C LFNKIYRRAF SNYLRCNYKV EKKP.PVRQI PRVAATALSG RELNVNIYRH
5HT5A AFNKNYNSAF KNFFSRQH.. .......... .......... ..........
5HT5Brat AFNKNYNNAF KSLFTKQR.. .......... .......... ..........
5HT6rat LFMRDFKRAL GRFLHASTVP RSTGQPCLPL HVDLSQRCQT RPQLQQVLAL
5HT7 FFNRDLRTTY RSLLQCQYRN INRKLSAAGM HEALKLAERP ERPEFVLQNA
alpha1A CSSREFKRAF LRLLRCQC.. RRRRRRRPLW RVYGHHWRAS TSGLRQDCAP
alpha1B CSSKEFKRAF VRILGCQCRG RRRRRRRRRL GGCAYTYRPW TRGGSLERSQ
alpha1C CSSQEFKKAF QNVLRIQCLC RKQSSKH... .ALGYPLHPP SQAVEGQHKD
alpha2A IFNHDFRRAF KKILCRGDRK RIV....... .......... ..........
alpha2B IFNQDFRRAF RRILCRPWTQ TAW....... .......... ..........
alpha2C1 VFNQDFRPSF KHILFRRRRR GFRQ...... .......... ..........
alpha2C2 VFNQDFRRSF KHILFRRRRR GFRQ...... .......... ..........
beta1 CRSPDFRKAF QGLLC...CA RRAARRRHAT HGDRPRASGC LARPGPPPSP
beta2 CRSPDFRIAF QELLCLRRSS LKAYGNGYSS NGNTGEQSGY HVEQEKENKL
beta3 CRSPDFRSAF RRLLC..RCG RRLPPEPCAA ARPALFPSGV PAARSSPAQP
beta4turkey RSPDFRSAFR KLLCCPRRAD RRLHAAPQDP QHCSCAFSPR GDPMEDSKAV
D1A AFNADFRKAF STLLGCYRLC PATNNAIETV SINNNGAAMF SSHHEPRGSI
D2 TFNIEFRKAF LKILHC.... .......... .......... ..........
D3 TFNIEFRKAF LKILSC.... .......... .......... ..........
D4 VFNAEFRNVF RKALRACC.. .......... .......... ..........
D5 AFNADFQKVF AQLLGCSHFC SRT..PVETV NISNE...LI SYNQDIVFHK
A1 FRIQKFRVTF LKIWNDHFRC QPAPPIDEDL PEERPDD... ..........
A2a YRIREFRQTF RKIIRSHVLR QQEPFKAAGT SARVLAAHGS DGEQVSLRLN
A2b YRNRDFRYTF HKIISRYLLC QAD.VKSGNG QAGVQPALGV GL........
A3 YKIKKFKETY LLILKACVVC HPSDSLDTSI EKNSE..... ..........
OCdrome IFNLDYRRAF KRLLGLN... .......... .......... ..........
ACTH FRSPELRDAF KKMIFCSRYW .......... .......... ..........
MSH FHSQELRRTL KEVLTCSW.. .......... .......... ..........
MC3 FRSLELRNTF REILCGCNGM NLG....... .......... ..........
MC4 LRSQELRKTF KEIICCYPLG GLCDLSSRY. .......... ..........
MC5 FRSQEMRKTF KEIICCRGFR IACSFPRRD. .......... ..........
melatonin FFTKNFRKEY RRIIVSLCTA RVFFVDSSND VADRVKWKPS PLMTNNNVVK
oxytocin FMNRHLFHEL VQRFLCCSAS YLK.GRRLGE TSASKK.... ..........
conopressinLs AFSGRTCQRN HANRNTSRSW GPSTHVTSGG DSHEFKTRSS FIDLSHARMN
V1A FFSGHLLQDC VQSFPCCQNM KEKFNKEDTD SMSRRQTFYS NNRSPTNSTG
V1B LFTGHLLPRP LRHLACCGGP QPRMRRRLSD GSLSSRHTTL LTRSSCPATL
V2 SFSSSVSSEL RSLLCCARGR TPPSLGPQDE SCTTASSSLA KDTSS.....
CCK_A FMNKRFRLGF MATFPCCPNP GPPGARGEVG EEEEGGTTGA SLSRFSYSHM
CCK_B FMHRRFRQAC LETCARCCPR PPRARPRALP DEDPPTPSIA SLSRLSYTTI
NPY1 FLNKNFQRDL QFFFNFCDFR SRDDDYETIA MSTMHTDVSK TSLKQASPVA
NTR LVSANFRHIF LATLACLCPV WRRRRKRPAF SRKADSVSSN HTLSSNATRE
NK1 CLNDRFRLGF KHAFRCCPFI SAGDYEGLEM KSTRYLQT.Q GSVYKVSRLE
NK2 CLNHRFRSGF RLAFRCCPWV TPTKEDKLEL TPTTSLSTR. ..VNRCHTKE
NK3 CLNKRFRAGF KRAFRWCPFI KVSSYDELEL KTTRFHPNRQ SSMYTVTRME
blueops FMNKQFQACI MKMVCG..KA MTDESDTCSS QKTEVSTVSS TQVGPN....
greenops FMNRQFRNCI LQLFG...KK VDDGSELSSA SKTEVSSVSS VSPA......
redops FMNRQFRNCI LQLFG...KK VDDGSELSSA SKTEVSSVSS VSPA......
rhodopsin MMNKQFRNCM LTTICCGKNP LGDDEASATV SKTETSQVAP A.........
violetopsGg MMNKQFRACI METV.CGKPL TDDSDASTSA QRTEVSSVSS SQVGPT....
opsin_crab LGNERYKAAL YQRFPSLACG SGESGSDVKS EASATTTMEE KPKIPEA...
ET_Aprec FVSKKFKNCF QSCLCCCCYQ SKSLMTSVPM NGTSIQWKNH DQNNHNTDRS
ET_Bprec LVSKRFKNCF KSCLCCWC.Q SFEEKQSLEE KQSCLKFKAN DHGYDNFRSS
ET_Cfrog FVSRKFKNCF QSCLCCWCHR PTLTITPMDE KGSGGKWKAN GHDLDLDRSS
galanin FLSENFRKAY KQVFKCHIRK DSHLSDTKEN KSRIDTPPST NCTHV.....
NMB LLSESFRRHF NSQLCCGRKS YQERGTSYLL SSSAVRMTSL KSNAKNMVTN
GRP LLSKSFRKQF NTQLLCCQPG LIIRSHSTGR STTCMTSLKS TNPSVATFSL
BRS3 WLSKSFQKHF KAQLFCCKAE RPEPPVADTS LTTLAVMGTV PGTGSIQMSE
deltaOP FLDENFKRCF RQLCRKPCGR PDPSSFSRPR EATARERVTA CTPSDGPGGG
kappaOP FLDENFKRCF RDFCFPLKMR MERQSTSRVR NTVQDPAYLR DIDGMNKPV.
muOP FLDENFKRCF REFCIPTSSN IEQQNSTRIR QNTRDHPSTA NTVDRTNHQL
OPRX FLDENFKACF RKFCCASALR RDVQVSDRVR SIAKDVALAC KTSETVPRPA
CB1 LRSKDLRHAF RSMFPSCEGT AQPLDNSMGD SDCLHKHANN AASVHRAAES
CB2 LRSGEIRSSA HHCLAHWKKC VRGLGSEAKE EAPRSSVTET EADGKITPWP
SSTR1 FLSDNFKRSF QRILCLSWMD NAAEEPVDYY ATALKSRA.. ........YS
SSTR2 FLSDNFKKSF QNVLCLVKVS GTDDGERSDS KQDKSRL..N ETTETQRTLL
SSTR3 FLSYRFKQGF RRVLLRPSRR VRSQEPTVGP PEKTEEEDEE EEDGEESRE.
SSTR4 FLSDNFRRSF QRVLCLRCCL LEGAGGAEEE PLDYYATALK SKGGAGCMCP
SSTR5 FLSDNFRQSF QKVLCLRKGS GAKDADATEP RPDRIRQQQE ATPPAHRAAA
IL8A FIGQNFRHGF LKILAMHGLV SKEFLARHRV TSYTSSSVNV SSNL......
IL8B FIGQKFRHGL LKILAIHGLI SKDSLPKDSR PSFVGSSSGH TSTTL.....
AT1a FLGKKFKRYF LQLLKYIPPK AKSHSNLSTK MSTLSYRPSD NVSSSTKKPA
AT1brat FLGKKFKKYF LQLLKYIPPT AKSHAGLSTK MSTLSYRPSD NMSSSAKKSA
AT2 FVGNRFQQKL RSVFRVPITW LQGKRESMSC RKSSSLREME TFVS......
BK1 FVGRLFRTKV WELYKQCTPK SLAPISSSHR KEIFQLFWRN ..........
BK2 IVGKRFRKKS WEVYQGVCQK GGCRSEPIQM ENSMGTLRTS ISVERQIHKL
P2Y7 CAGGGLVRSA GVGFVAKLLE GTGSEASSTR RGGSLGQTAR SGPAALEPGP
P2Y6 FTQQKFRRQP HDLLQKLTAK WQRQRV.... .......... ..........
P2Y5 FTSDTNSELD KKQQVHQNT. .......... .......... ..........
P2Y4 LTGDKYRRQL RQLCGGGKPQ PRTAASSLAL VSLPEDSSCR WAATPQDSSC
P2Y3chick FTQRKFREST RYLLDKMSSK WRQDHCISYG S......... ..........
P2Y2 LAGQRLVRFA RDAKPPTGPS PATPARRTLG LRRSDRTDMQ RIGDVLGSSE
P2Y1 LAGDTFRRRL SRATRKASRR SEANLQSKSE DMTLNILPEF KQNGDTSL..
THRprec YASSECQRYV YSILCCKESS DPSSYNSSGQ LMASKMDTCS SNLNNSIYKK
C5a VAGQGFQGRL RKSLPSLLRN VLTEESVVRE SKSFTRSTVD TMAQKTQAV.
GP01mouse FRNQEIQKAL CLICCGCIPS SLSQRARSPS DV........ ..........
R334rat FRNQEIQKAL CLICCGCIPN TLSQRARSPS DV........ ..........
GP21mouse FRNQDVQKVL WAICCCCSTS KIPFRSRSPS DV........ ..........
GCRCmouse WLNENFRVEL KALLSMCQRP PKPQEDRLPS PVPSFRVAWT EKSHG.RRAP
TXKR CLNKRFRAGF KRAFRWCPFI HVSSYDELEL KATRLHPMRQ SSLYTVTRME
G10Drat FLSPSFRGRL LSLVVRYLPK EQARAAGGRA SSSSSTQHSI IITKEGSLPL
RDC1 FINRNYRYEL MKAFIFKYSA KTGLTKLIDA SRVSETEYSA LEQNAK....
BLR1 FAGVKFRSDL SRLLTKLGCT GPASLCQLFP SWRRSSLSES ENATSLTTF.
CL5 FLGAKFKTSA QHALTSVSRG S..SLKILSK GKRGGHSSVS TESESSSFHS
LCR1 FLGAKFKTSA QHALTSVSRG S..SLKILSK GKRGGHSSVS TESESSSFHS
EBI1 FIGVKFRNDI FKLFKDLGCL SQEQLRQWSS CRHIRRSSMS VEAETTTTFS
RBS1rat FAGEKFRRYL RHLYNKCLAV LCGRPVHAGF STESQRSRQD SILSSLTHYT
EBI2 FACKGYKRKV MRMLKRQVSV SISSAVKSAP EENSREMTET QMMIHSKSSN
GCRTchick FTSDTNSELD KKQQVHQNT. .......... .......... ..........
APJ FFDPRFRQAC TSMLCCGQSR CAGTSHSSSG EKSASYSSGH SQGPGPNMGK
RTArat LAGRDKSQRL WEPLRVVFQR ALRDGAEPGD AASSTPNTVT MEMQCPSGNA
UHRrat WLHDSFREEL RKMLLSWPRK IVPHGQNMTV SVVI...... ..........
FMRL1 FMGRNFQERL IRSLPTSLER ALTEVPDSAQ TSNTHTTSAS PPEETELQAM
FMRL2 FVGQDFRERL IHSLPTSLER ALSE..DSAP TNDTAANSAS PPAETELQAM
fMLP FMGQDFRERL IHALPASLER ALTE..DSTQ TSDTATNSTL PSAEVALQAK
OLF1catfish LKTEEVMQAV KVLYKRAKAV VICDIPNGQV FQPWVGVDSK KKTFC.....
OLF3catfish LKTEEVMQAI KLLYKHIR.. .......... .......... ..........
OLF8catfish VRTKEIREQF LKLMKYVKVF PK........ .......... ..........
OLF32Acatfish LNTKDFRVFI VKMLKKKTTI ISQVHALAK. .......... ..........
OLF32Bcatfish LNTKDFRVFI VKMLKKKTTK ISQVHALAK. .......... ..........
OLF32Ccatfish LNTKDFRVFI VKMLKKKTTK ISQVHALAK. .......... ..........
OLF32Dcatfish LNTKDFRVFI VKMLKKKTTI ISQVHALAK. .......... ..........
OLF47catfish LKTEELQDKL LKFIKPQKVS NTV....... .......... ..........
OLF202catfish LRTKEAKECL KRSLNRSSFV QFLKINVQVS TLSN...... ..........
OLFCOR1chicken WRNKEVKDAL RRLTATTFGF IDSKAVQ... .......... ..........
OLFCOR2chicken WRNKEVKDAL RRLTATSVWL H......... .......... ..........
OLFCOR3chicken WRNKEVKDAL RRLTATTFGF IDSKAVQ... .......... ..........
OLFCOR4chicken WRNKEVKDAL RRLTATTFGF IDSKAVQ... .......... ..........
OLFCOR5chicken WRNKEVKDAL RRVIATNVWI H......... .......... ..........
OLFCOR6chicken WRNKEVKDAL HRAIATAVLF H......... .......... ..........
OLFdog LRNKDMKGAL RRVICRKKIT FSV....... .......... ..........
OLF07E LRNKDMHGAL GRLLDKHFKR LT........ .......... ..........
OLF07I LRNRDMKGAL SRVIHQKKTF FSL....... .......... ..........
OLF07J LRNKEVKDAL CRAVGGKFS. .......... .......... ..........
OLFOR3mouse LRNKEVKGAL GRLLGKGRGA S......... .......... ..........
OLFrat LRNKDVKKAL GRFSVRS... .......... .......... ..........
OLFF3rat LRNKDVKSVL KKTLCEEVIR SPPSLLHFFL VLCHLPCFIF CY........
OLFF5rat LRNSDMKAAL RKVLAMRFPS KQ........ .......... ..........
OLFF6rat LRNKDVKEAL RRTVKGK... .......... .......... ..........
OLFF12rat LRNKDVKRAL ERLLEGNCKV HHWTG..... .......... ..........
OLFI3rat LRNRDMKRAL IRVICSMKIT L......... .......... ..........
OLFI7rat LRNQDVKRAL RRTLHLAQDQ EANTNKGSKI G......... ..........
OLFI8rat LRNRDMKQAL IRVTCSKKIS LPW....... .......... ..........
OLFI9rat LRNRDIKDAL EKIMCKKQIP SFL....... .......... ..........
OLFI14rat LRNRDMKRAL IRVICTKKIS L......... .......... ..........
OLFI15rat LRNRDMKEAL IRVLCKKKIT FCL....... .......... ..........
OLFOR17_40 FRNPDVQSAI WRMLTGRRSL A......... .......... ..........
GUST27rat LLNQDVKGAL GKLFIRVASC PLWSKDFRPK FILKPERQSL ..........
RPE FVGTMVCRGI WQCLSPQKRE KDRTK..... .......... ..........
HHRF1 LVGTKFRKNY TVCWPSFASD SFPAMYPGTT A......... ..........
HHRF2 FVGEQMRKDM WTTLRVFACC CVKQEIPYQD IDIELQKDIQ RRAKHTKRTH
HHRF3 DFLQRMRQCF RGQLLDRRAF LRSQQNQRAT AETNLAAGNN SQSVAT....
MCP-1A FVGEKFRSLF HIALGCRIAP LQKPVCGGPG VRPGKNVKVT TQGLLDGRGK
MCP-1B FMGTKFRRYL SVFFRKHITK RFCKQCPVFY RETVDGVTST NTPSTGEQEV
PPR1bovine FVGNSFKNYI MKVAKKYGSW RRQRQNVEEI PFESEDATEP TSTFSI....
7777777777 7777777777
5555566666 6666677777
5678901234 5678901234
701 750
GPCRAelegans STPKSKHAST MSLRQSHQDL YRKESKTAES LNGICNAGFN AHEETRTSPG
GRH .......... .......... .......... .......... ..........
TRH VTDTYLSATK VSFDDTCLAS EVSFSQS... .......... ..........
FSHprec GHCSSAPRVT NGSTYILVPL SHLAQN.... .......... ..........
TSHprec QKVTHDMRQG LHNMEDVYEL IENSHLTPKK QGQISEEYMQ TVL.......
LH_CGprec FTGSNKPSQS TLKLSTLHCQ GTALLDKTRY TEC....... ..........
PGE_EP1 RHSGLSHF.. .......... .......... .......... ..........
PGE_EP2 ISRELKEISS TSQTLLPDLS LPDLSENGLG GRNLLPGVPG MGLAQEDTTS
PGE_EP3 L......... .......... .......... .......... ..........
PGF AISESPVAEK SAST...... .......... .......... ..........
PGI GSCVPLSAWG EGQVEPLPPT QQSSGSAVGT SSKAEASVAC SLC.......
TXA2 .......... .......... .......... .......... ..........
PAF .......... .......... .......... .......... ..........
M2 .......... .......... .......... .......... ..........
M4 .......... .......... .......... .......... ..........
M1 .......... .......... .......... .......... ..........
M3 .......... .......... .......... .......... ..........
M5 .......... .......... .......... .......... ..........
H1 .......... .......... .......... .......... ..........
H2 LKLQVWSGTE VTAPQGATDR .......... .......... ..........
5HT1A .......... .......... .......... .......... ..........
5HT1B .......... .......... .......... .......... ..........
5HT1D .......... .......... .......... .......... ..........
5HT1E .......... .......... .......... .......... ..........
5HT1F .......... .......... .......... .......... ..........
5HT2A SKQDAKTTDN DCSMVALGKQ HSEEASK... ......DNSD GVNEKVSCV.
5HT2B GIRNGINPAM YQSPMRLRSS TIQSSSIILL DTLLLTENEG DKTEEQVSYV
5HT2C TNEPVIEKAS DNEPGIEMQV ENLELPV... ......NPSS VVSERISSV.
5HT5A .......... .......... .......... .......... ..........
5HT5Brat .......... .......... .......... .......... ..........
5HT6rat PLPPNSDSDS ASGGTSGLQL TAQLLLPGEA TRDPPPPTRA TTVVNFFVTD
5HT7 DYCRKKGHDS .......... .......... .......... ..........
alpha1A SSGDAPPGAP LAL.TALPDP DPEPPGTPEM QAPVASRRSH PAPSASGGCW
alpha1B SRKDSLDDSG SCLSGSQRTL PSASPSPGYL GRGAP....P PVELCAFPEW
alpha1C MVRIPVGSRE TFYRISKTDG VCEWKFFSSM PRGSARITVS KDQSSCTTAR
alpha2A .......... .......... .......... .......... ..........
alpha2B .......... .......... .......... .......... ..........
alpha2C1 .......... .......... .......... .......... ..........
alpha2C2 .......... .......... .......... .......... ..........
beta1 GAASDDDDDD VVGATPPARL LEPWAGCNGG AAADSDSSLD EPCRPGFASE
beta2 LCEDLPGTED FVG..HQGTV PSDNIDSQGR NCSTNDSLL. ..........
beta3 RLCQRLDGAS WGVS...... .......... .......... ..........
beta4turkey DPGHLREDSE VQGSGRREEN ASSHGGGHQQ RPLGECWLQG MQSMLCEQLD
D1A SKECNLVYLI PHAV..GSSE DLKKEEAAGI ARPLEKLSPA LSV.......
D2 .......... .......... .......... .......... ..........
D3 .......... .......... .......... .......... ..........
D4 .......... .......... .......... .......... ..........
D5 EIAAAYIHMM PNAVTPGNRE VDNDEEEGPF DRMFQIYQTS PDGDPVAESV
A1 .......... .......... .......... .......... ..........
A2a GHPPGVWANG SAPHPERRPN GYALGLVSGG SAQESQGNTG LPDVELLSHE
A2b .......... .......... .......... .......... ..........
A3 .......... .......... .......... .......... ..........
OCdrome .......... .......... .......... .......... ..........
ACTH .......... .......... .......... .......... ..........
MSH .......... .......... .......... .......... ..........
MC3 .......... .......... .......... .......... ..........
MC4 .......... .......... .......... .......... ..........
MC5 .......... .......... .......... .......... ..........
melatonin VDSV...... .......... .......... .......... ..........
oxytocin SNSSSFVLSH RSSSQRSCSQ PSTA...... .......... ..........
conopressinLs ARSSSPRFSE MNKLNHSKC. .......... .......... ..........
V1A MWKDSPKSSK SIKFIPVST. .......... .......... ..........
V1B SLSLSLTLSG RPRPEESPRD LELADGEGTA ETIIF..... ..........
V2 .......... .......... .......... .......... ..........
CCK_A SASVPPQ... .......... .......... .......... ..........
CCK_B STLGPG.... .......... .......... .......... ..........
NPY1 FKKINNNDDN EKI....... .......... .......... ..........
NTR TLY....... .......... .......... .......... ..........
NK1 TTISTVVGAH EEEPEDGPKA TPSSLDLTSN CSSRSDSKTM TESFSFSSNV
NK2 TLFMAGDTAP SEATSGEAGR PQDGSGLWFG YGLLAPTKTH VEI.......
NK3 SMTVVFDPND ADTTRSSRKK RATPRDPSFN GCSRRNSKSA SATSSFISSP
blueops .......... .......... .......... .......... ..........
greenops .......... .......... .......... .......... ..........
redops .......... .......... .......... .......... ..........
rhodopsin .......... .......... .......... .......... ..........
violetopsGg .......... .......... .......... .......... ..........
opsin_crab .......... .......... .......... .......... ..........
ET_Aprec SHKDSMN... .......... .......... .......... ..........
ET_Bprec NKYSSS.... .......... .......... .......... ..........
ET_Cfrog SRLSNKYSSS .......... .......... .......... ..........
galanin .......... .......... .......... .......... ..........
NMB SVLLNGHSMK QEMAM..... .......... .......... ..........
GRP INGNICHERY V......... .......... .......... ..........
BRS3 ISVTSFTGCS VKQAEDRF.. .......... .......... ..........
deltaOP RAA....... .......... .......... .......... ..........
kappaOP .......... .......... .......... .......... ..........
muOP ENLEAETAPL P......... .......... .......... ..........
OPRX .......... .......... .......... .......... ..........
CB1 CIKSTVKIAK VTMSVSTDTS AEAL...... .......... ..........
CB2 DSRDLDLSDC .......... .......... .......... ..........
SSTR1 VEDFQPENLE SGGVFRNGTC TSRITTL... .......... ..........
SSTR2 NGDLQTSI.. .......... .......... .......... ..........
SSTR3 GGKGKEMNGR VSQITQPGTS GQERPPSRVA SKEQQLLPQE ASTGEKSSTM
SSTR4 PLPCQQEALQ PEPG.RKRIP LTRTTTF... .......... ..........
SSTR5 NGLMQTSKL. .......... .......... .......... ..........
IL8A .......... .......... .......... .......... ..........
IL8B .......... .......... .......... .......... ..........
AT1a PCFEVE.... .......... .......... .......... ..........
AT1brat SFFEVE.... .......... .......... .......... ..........
AT2 .......... .......... .......... .......... ..........
BK1 .......... .......... .......... .......... ..........
BK2 QDWAGSRQ.. .......... .......... .......... ..........
P2Y7 SESLTASSPL KLNELN.... .......... .......... ..........
P2Y6 .......... .......... .......... .......... ..........
P2Y5 .......... .......... .......... .......... ..........
P2Y4 STPRADRL.. .......... .......... .......... ..........
P2Y3chick .......... .......... .......... .......... ..........
P2Y2 DSRRTESTPA GSENTKDIRL .......... .......... ..........
P2Y1 .......... .......... .......... .......... ..........
THRprec LLT....... .......... .......... .......... ..........
C5a .......... .......... .......... .......... ..........
GP01mouse .......... .......... .......... .......... ..........
R334rat .......... .......... .......... .......... ..........
GP21mouse .......... .......... .......... .......... ..........
GCRCmouse LPNHHLPSSQ IQSGKTDLSS VEPVVAMS.. .......... ..........
TXKR SMSVVFDSND GDSARSSHQK RGTTRDVGSN VCSRRNSKST STTASFVSSS
G10Drat QRICTPTPSE TCRPPLCLRT PHLHSAIP.. .......... ..........
RDC1 .......... .......... .......... .......... ..........
BLR1 .......... .......... .......... .......... ..........
CL5 S......... .......... .......... .......... ..........
LCR1 S......... .......... .......... .......... ..........
EBI1 P......... .......... .......... .......... ..........
RBS1rat SEGEGSLLL. .......... .......... .......... ..........
EBI2 GK........ .......... .......... .......... ..........
GCRTchick .......... .......... .......... .......... ..........
APJ GGEQMHEKSI PYSQETLVVD .......... .......... ..........
RTArat S......... .......... .......... .......... ..........
UHRrat .......... .......... .......... .......... ..........
FMRL1 .......... .......... .......... .......... ..........
FMRL2 .......... .......... .......... .......... ..........
fMLP .......... .......... .......... .......... ..........
OLF1catfish .......... .......... .......... .......... ..........
OLF3catfish .......... .......... .......... .......... ..........
OLF8catfish .......... .......... .......... .......... ..........
OLF32Acatfish .......... .......... .......... .......... ..........
OLF32Bcatfish .......... .......... .......... .......... ..........
OLF32Ccatfish .......... .......... .......... .......... ..........
OLF32Dcatfish .......... .......... .......... .......... ..........
OLF47catfish .......... .......... .......... .......... ..........
OLF202catfish .......... .......... .......... .......... ..........
OLFCOR1chicken .......... .......... .......... .......... ..........
OLFCOR2chicken .......... .......... .......... .......... ..........
OLFCOR3chicken .......... .......... .......... .......... ..........
OLFCOR4chicken .......... .......... .......... .......... ..........
OLFCOR5chicken .......... .......... .......... .......... ..........
OLFCOR6chicken .......... .......... .......... .......... ..........
OLFdog .......... .......... .......... .......... ..........
OLF07E .......... .......... .......... .......... ..........
OLF07I .......... .......... .......... .......... ..........
OLF07J .......... .......... .......... .......... ..........
OLFOR3mouse .......... .......... .......... .......... ..........
OLFrat .......... .......... .......... .......... ..........
OLFF3rat .......... .......... .......... .......... ..........
OLFF5rat .......... .......... .......... .......... ..........
OLFF6rat .......... .......... .......... .......... ..........
OLFF12rat .......... .......... .......... .......... ..........
OLFI3rat .......... .......... .......... .......... ..........
OLFI7rat .......... .......... .......... .......... ..........
OLFI8rat .......... .......... .......... .......... ..........
OLFI9rat .......... .......... .......... .......... ..........
OLFI14rat .......... .......... .......... .......... ..........
OLFI15rat .......... .......... .......... .......... ..........
OLFOR17_40 .......... .......... .......... .......... ..........
GUST27rat .......... .......... .......... .......... ..........
RPE .......... .......... .......... .......... ..........
HHRF1 .......... .......... .......... .......... ..........
HHRF2 YDRKNAPMES GEEEFLL... .......... .......... ..........
HHRF3 SLDTNSKNYN QHAKRSVSFN FPSGTWKGGQ KTASNDTSTK IPHRLSQSHH
MCP-1A GKSIGRAPEA SLQDKEGA.. .......... .......... ..........
MCP-1B SAGL...... .......... .......... .......... ..........
PPR1bovine .......... .......... .......... .......... ..........
751 800
GPCRAelegans SVRYVRSLRG VTKSSSPPHL KLQKQKILQS PS........ ..........
GRH .......... .......... .......... .......... ..........
TRH .......... .......... .......... .......... ..........
FSHprec .......... .......... .......... .......... ..........
TSHprec .......... .......... .......... .......... ..........
LH_CGprec .......... .......... .......... .......... ..........
PGE_EP1 .......... .......... .......... .......... ..........
PGE_EP2 LRTLRISETS DSSQGQDSES VLLVDEAGGS GRAGPAPKGS SLQVTFPSET
PGE_EP3 .......... .......... .......... .......... ..........
PGF .......... .......... .......... .......... ..........
PGI .......... .......... .......... .......... ..........
TXA2 .......... .......... .......... .......... ..........
PAF .......... .......... .......... .......... ..........
M2 .......... .......... .......... .......... ..........
M4 .......... .......... .......... .......... ..........
M1 .......... .......... .......... .......... ..........
M3 .......... .......... .......... .......... ..........
M5 .......... .......... .......... .......... ..........
H1 .......... .......... .......... .......... ..........
H2 .......... .......... .......... .......... ..........
5HT1A .......... .......... .......... .......... ..........
5HT1B .......... .......... .......... .......... ..........
5HT1D .......... .......... .......... .......... ..........
5HT1E .......... .......... .......... .......... ..........
5HT1F .......... .......... .......... .......... ..........
5HT2A .......... .......... .......... .......... ..........
5HT2B .......... .......... .......... .......... ..........
5HT2C .......... .......... .......... .......... ..........
5HT5A .......... .......... .......... .......... ..........
5HT5Brat .......... .......... .......... .......... ..........
5HT6rat SVEPEIRPHP LSSPVN.... .......... .......... ..........
5HT7 .......... .......... .......... .......... ..........
alpha1A GRSGDPRPSC APKSPACRTR SPPGARSAQR QRAPSAQRWR LCP.......
alpha1B KAPGALLSLP APEPPGRRGR HDSGPLFTFK LLTEPESPGT DGGASNGGCE
alpha1C VRSKSFLQVC CCVGPSTPCL DKNHQVPTIK VHTISLSENG EEV.......
alpha2A .......... .......... .......... .......... ..........
alpha2B .......... .......... .......... .......... ..........
alpha2C1 .......... .......... .......... .......... ..........
alpha2C2 .......... .......... .......... .......... ..........
beta1 SKV....... .......... .......... .......... ..........
beta2 .......... .......... .......... .......... ..........
beta3 .......... .......... .......... .......... ..........
beta4turkey EFTSTEMPAG PSV....... .......... .......... ..........
D1A .ILDYDTDVS LEKIQPITQN GQHPT..... .......... ..........
D2 .......... .......... .......... .......... ..........
D3 .......... .......... .......... .......... ..........
D4 .......... .......... .......... .......... ..........
D5 WELDCEGEIS LDKITPFTPN GFH....... .......... ..........
A1 .......... .......... .......... .......... ..........
A2a LKGVCPEPPG LDDPLAQDGA GVS....... .......... ..........
A2b .......... .......... .......... .......... ..........
A3 .......... .......... .......... .......... ..........
OCdrome .......... .......... .......... .......... ..........
ACTH .......... .......... .......... .......... ..........
MSH .......... .......... .......... .......... ..........
MC3 .......... .......... .......... .......... ..........
MC4 .......... .......... .......... .......... ..........
MC5 .......... .......... .......... .......... ..........
melatonin .......... .......... .......... .......... ..........
oxytocin .......... .......... .......... .......... ..........
conopressinLs .......... .......... .......... .......... ..........
V1A .......... .......... .......... .......... ..........
V1B .......... .......... .......... .......... ..........
V2 .......... .......... .......... .......... ..........
CCK_A .......... .......... .......... .......... ..........
CCK_B .......... .......... .......... .......... ..........
NPY1 .......... .......... .......... .......... ..........
NTR .......... .......... .......... .......... ..........
NK1 LS........ .......... .......... .......... ..........
NK2 .......... .......... .......... .......... ..........
NK3 YTSVDEYS.. .......... .......... .......... ..........
blueops .......... .......... .......... .......... ..........
greenops .......... .......... .......... .......... ..........
redops .......... .......... .......... .......... ..........
rhodopsin .......... .......... .......... .......... ..........
violetopsGg .......... .......... .......... .......... ..........
opsin_crab .......... .......... .......... .......... ..........
ET_Aprec .......... .......... .......... .......... ..........
ET_Bprec .......... .......... .......... .......... ..........
ET_Cfrog .......... .......... .......... .......... ..........
galanin .......... .......... .......... .......... ..........
NMB .......... .......... .......... .......... ..........
GRP .......... .......... .......... .......... ..........
BRS3 .......... .......... .......... .......... ..........
deltaOP .......... .......... .......... .......... ..........
kappaOP .......... .......... .......... .......... ..........
muOP .......... .......... .......... .......... ..........
OPRX .......... .......... .......... .......... ..........
CB1 .......... .......... .......... .......... ..........
CB2 .......... .......... .......... .......... ..........
SSTR1 .......... .......... .......... .......... ..........
SSTR2 .......... .......... .......... .......... ..........
SSTR3 RISYL..... .......... .......... .......... ..........
SSTR4 .......... .......... .......... .......... ..........
SSTR5 .......... .......... .......... .......... ..........
IL8A .......... .......... .......... .......... ..........
IL8B .......... .......... .......... .......... ..........
AT1a .......... .......... .......... .......... ..........
AT1brat .......... .......... .......... .......... ..........
AT2 .......... .......... .......... .......... ..........
BK1 .......... .......... .......... .......... ..........
BK2 .......... .......... .......... .......... ..........
P2Y7 .......... .......... .......... .......... ..........
P2Y6 .......... .......... .......... .......... ..........
P2Y5 .......... .......... .......... .......... ..........
P2Y4 .......... .......... .......... .......... ..........
P2Y3chick .......... .......... .......... .......... ..........
P2Y2 .......... .......... .......... .......... ..........
P2Y1 .......... .......... .......... .......... ..........
THRprec .......... .......... .......... .......... ..........
C5a .......... .......... .......... .......... ..........
GP01mouse .......... .......... .......... .......... ..........
R334rat .......... .......... .......... .......... ..........
GP21mouse .......... .......... .......... .......... ..........
GCRCmouse .......... .......... .......... .......... ..........
TXKR HMSVEEGS.. .......... .......... .......... ..........
G10Drat .......... .......... .......... .......... ..........
RDC1 .......... .......... .......... .......... ..........
BLR1 .......... .......... .......... .......... ..........
CL5 .......... .......... .......... .......... ..........
LCR1 .......... .......... .......... .......... ..........
EBI1 .......... .......... .......... .......... ..........
RBS1rat .......... .......... .......... .......... ..........
EBI2 .......... .......... .......... .......... ..........
GCRTchick .......... .......... .......... .......... ..........
APJ .......... .......... .......... .......... ..........
RTArat .......... .......... .......... .......... ..........
UHRrat .......... .......... .......... .......... ..........
FMRL1 .......... .......... .......... .......... ..........
FMRL2 .......... .......... .......... .......... ..........
fMLP .......... .......... .......... .......... ..........
OLF1catfish .......... .......... .......... .......... ..........
OLF3catfish .......... .......... .......... .......... ..........
OLF8catfish .......... .......... .......... .......... ..........
OLF32Acatfish .......... .......... .......... .......... ..........
OLF32Bcatfish .......... .......... .......... .......... ..........
OLF32Ccatfish .......... .......... .......... .......... ..........
OLF32Dcatfish .......... .......... .......... .......... ..........
OLF47catfish .......... .......... .......... .......... ..........
OLF202catfish .......... .......... .......... .......... ..........
OLFCOR1chicken .......... .......... .......... .......... ..........
OLFCOR2chicken .......... .......... .......... .......... ..........
OLFCOR3chicken .......... .......... .......... .......... ..........
OLFCOR4chicken .......... .......... .......... .......... ..........
OLFCOR5chicken .......... .......... .......... .......... ..........
OLFCOR6chicken .......... .......... .......... .......... ..........
OLFdog .......... .......... .......... .......... ..........
OLF07E .......... .......... .......... .......... ..........
OLF07I .......... .......... .......... .......... ..........
OLF07J .......... .......... .......... .......... ..........
OLFOR3mouse .......... .......... .......... .......... ..........
OLFrat .......... .......... .......... .......... ..........
OLFF3rat .......... .......... .......... .......... ..........
OLFF5rat .......... .......... .......... .......... ..........
OLFF6rat .......... .......... .......... .......... ..........
OLFF12rat .......... .......... .......... .......... ..........
OLFI3rat .......... .......... .......... .......... ..........
OLFI7rat .......... .......... .......... .......... ..........
OLFI8rat .......... .......... .......... .......... ..........
OLFI9rat .......... .......... .......... .......... ..........
OLFI14rat .......... .......... .......... .......... ..........
OLFI15rat .......... .......... .......... .......... ..........
OLFOR17_40 .......... .......... .......... .......... ..........
GUST27rat .......... .......... .......... .......... ..........
RPE .......... .......... .......... .......... ..........
HHRF1 .......... .......... .......... .......... ..........
HHRF2 .......... .......... .......... .......... ..........
HHRF3 NLSGV..... .......... .......... .......... ..........
MCP-1A .......... .......... .......... .......... ..........
MCP-1B .......... .......... .......... .......... ..........
PPR1bovine .......... .......... .......... .......... ..........
801 822
GPCRAelegans .......... .......... ..
GRH .......... .......... ..
TRH .......... .......... ..
FSHprec .......... .......... ..
TSHprec .......... .......... ..
LH_CGprec .......... .......... ..
PGE_EP1 .......... .......... ..
PGE_EP2 .......... .......... ..
PGE_EP3 .......... .......... ..
PGF .......... .......... ..
PGI .......... .......... ..
TXA2 LNLSEKCI.. .......... ..
PAF .......... .......... ..
M2 .......... .......... ..
M4 .......... .......... ..
M1 .......... .......... ..
M3 .......... .......... ..
M5 .......... .......... ..
H1 .......... .......... ..
H2 .......... .......... ..
5HT1A .......... .......... ..
5HT1B .......... .......... ..
5HT1D .......... .......... ..
5HT1E .......... .......... ..
5HT1F .......... .......... ..
5HT2A .......... .......... ..
5HT2B .......... .......... ..
5HT2C .......... .......... ..
5HT5A .......... .......... ..
5HT5Brat .......... .......... ..
5HT6rat .......... .......... ..
5HT7 .......... .......... ..
alpha1A .......... .......... ..
alpha1B .......... .......... ..
alpha1C .......... .......... ..
alpha2A .......... .......... ..
alpha2B PRHVANGQPG FKSNMPLAPG QF
alpha2C1 .......... .......... ..
alpha2C2 .......... .......... ..
beta1 .......... .......... ..
beta2 .......... .......... ..
beta3 .......... .......... ..
beta4turkey .......... .......... ..
D1A .......... .......... ..
D2 .......... .......... ..
D3 .......... .......... ..
D4 .......... .......... ..
D5 .......... .......... ..
A1 .......... .......... ..
A2a .......... .......... ..
A2b .......... .......... ..
A3 .......... .......... ..
OCdrome .......... .......... ..
ACTH .......... .......... ..
MSH .......... .......... ..
MC3 .......... .......... ..
MC4 .......... .......... ..
MC5 .......... .......... ..
melatonin .......... .......... ..
oxytocin .......... .......... ..
conopressinLs .......... .......... ..
V1A .......... .......... ..
V1B .......... .......... ..
V2 .......... .......... ..
CCK_A .......... .......... ..
CCK_B .......... .......... ..
NPY1 .......... .......... ..
NTR .......... .......... ..
NK1 .......... .......... ..
NK2 .......... .......... ..
NK3 .......... .......... ..
blueops .......... .......... ..
greenops .......... .......... ..
redops .......... .......... ..
rhodopsin .......... .......... ..
violetopsGg .......... .......... ..
opsin_crab .......... .......... ..
ET_Aprec .......... .......... ..
ET_Bprec .......... .......... ..
ET_Cfrog .......... .......... ..
galanin .......... .......... ..
NMB .......... .......... ..
GRP .......... .......... ..
BRS3 .......... .......... ..
deltaOP .......... .......... ..
kappaOP .......... .......... ..
muOP .......... .......... ..
OPRX .......... .......... ..
CB1 .......... .......... ..
CB2 .......... .......... ..
SSTR1 .......... .......... ..
SSTR2 .......... .......... ..
SSTR3 .......... .......... ..
SSTR4 .......... .......... ..
SSTR5 .......... .......... ..
IL8A .......... .......... ..
IL8B .......... .......... ..
AT1a .......... .......... ..
AT1brat .......... .......... ..
AT2 .......... .......... ..
BK1 .......... .......... ..
BK2 .......... .......... ..
P2Y7 .......... .......... ..
P2Y6 .......... .......... ..
P2Y5 .......... .......... ..
P2Y4 .......... .......... ..
P2Y3chick .......... .......... ..
P2Y2 .......... .......... ..
P2Y1 .......... .......... ..
THRprec .......... .......... ..
C5a .......... .......... ..
GP01mouse .......... .......... ..
R334rat .......... .......... ..
GP21mouse .......... .......... ..
GCRCmouse .......... .......... ..
TXKR .......... .......... ..
G10Drat .......... .......... ..
RDC1 .......... .......... ..
BLR1 .......... .......... ..
CL5 .......... .......... ..
LCR1 .......... .......... ..
EBI1 .......... .......... ..
RBS1rat .......... .......... ..
EBI2 .......... .......... ..
GCRTchick .......... .......... ..
APJ .......... .......... ..
RTArat .......... .......... ..
UHRrat .......... .......... ..
FMRL1 .......... .......... ..
FMRL2 .......... .......... ..
fMLP .......... .......... ..
OLF1catfish .......... .......... ..
OLF3catfish .......... .......... ..
OLF8catfish .......... .......... ..
OLF32Acatfish .......... .......... ..
OLF32Bcatfish .......... .......... ..
OLF32Ccatfish .......... .......... ..
OLF32Dcatfish .......... .......... ..
OLF47catfish .......... .......... ..
OLF202catfish .......... .......... ..
OLFCOR1chicken .......... .......... ..
OLFCOR2chicken .......... .......... ..
OLFCOR3chicken .......... .......... ..
OLFCOR4chicken .......... .......... ..
OLFCOR5chicken .......... .......... ..
OLFCOR6chicken .......... .......... ..
OLFdog .......... .......... ..
OLF07E .......... .......... ..
OLF07I .......... .......... ..
OLF07J .......... .......... ..
OLFOR3mouse .......... .......... ..
OLFrat .......... .......... ..
OLFF3rat .......... .......... ..
OLFF5rat .......... .......... ..
OLFF6rat .......... .......... ..
OLFF12rat .......... .......... ..
OLFI3rat .......... .......... ..
OLFI7rat .......... .......... ..
OLFI8rat .......... .......... ..
OLFI9rat .......... .......... ..
OLFI14rat .......... .......... ..
OLFI15rat .......... .......... ..
OLFOR17_40 .......... .......... ..
GUST27rat .......... .......... ..
RPE .......... .......... ..
HHRF1 .......... .......... ..
HHRF2 .......... .......... ..
HHRF3 .......... .......... ..
MCP-1A .......... .......... ..
MCP-1B .......... .......... ..
PPR1bovine .......... .......... ..
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Chief: Dr. Kenneth Jacobson
The Molecular Recognition Section (MRS) is in the Laboratory of Bioorganic Chemistry at the
National Institute of Diabetes and Digestive and Kidney Diseases
which is part of the National Institutes of Health, Bethesda, MD, USA. General inquiries may be addressed to NIDDK, NIH, Building 31, Room 9A04, 31 Center Drive, MSC 2560, Bethesda, MD 20892-2560, USA.
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