2001

Smith MW, Lautenberger JA, Shin HD, Chretien JP, Shrestha S, Gilbert DK, O' Brien SJ:  Markers for mapping by admixture linkage disequilibrium in African American and Hispanic populations. Am. J. Hum. Genet. 2001 Nov., 69(5):1080-94    Abstract   MALD Index   MALD Map Primers (Table www.1)    MALD Map Allele Frequencies (Table www.2)    MALD Map Markers (Table www.3)  MALD Map Ratio Comparisons (Table www.4)

2000

An P, Martin MP, Nelson GW, Carrington M, Smith MW, Gong K, Vlahov' D, O'Brien SJ, Winkler CA (2000) Influence of CCR5 promoter haplotypes on AIDS progression in African- Americans. AIDS 14:2117-2122.  Abstract      Journal - click on “Online Articles"

Bream JH, Carrington M, O'Toole S, Dean M, Gerrard B, Shin HD, Kosack D, Modi W, Young HA, Smith MW (2000) Polymorphisms of the human IFNG gene noncoding regions. Immunogenetics 51:50-58.  Abstract      Reprint(PDF)

Lautenberger JA, Stephens JC, O'Brien SJ, Smith MW (2000) Significant admixture linkage disequilibrium across 30 cM around the FY locus in African Americans. Am. J. Hum. Genet. 66:969-978.  Abstract      Reprint(PDF)

O'Brien SJ, Dean M, Smith MW, Winkler C, Nelson GW, Martin MP, Carrington M (2000) The human genes that limit AIDS. In: Boulyhenkov V, Berg K, Christen Y (eds) Genes and Resistance to Diseases. Spinger-Verlag, Berlin, pp 9-17.  Book Information

O'Brien SJ, Nelson GW, Winkler CA, Smith MW (2000) Polygenic and multifactorial disease gene association in man: lessons from AIDS. Ann.34:563-591.  Abstract      Reprint(PDF)

Shin HD, Winkler C, Stephens JC, Bream J, Young H, Goedert JJ, O'Brien TR, Vlahov D, Buchbinder S, Giorgi J, Rinaldo C, Donfield S, Willoughby A, O'Brien SJ, Smith MW (2000) Genetic restriction of HIV-1 infection and AIDS by promoter alleles of interleukin 10. Proc. Natl. Acad. Sci. U S A 97:14467-14472.  Abstract      Reprint(PDF)

Shrestha S, Strathdee SA, Brahmbhatt H, Farzadegan H, Vlahov D, Smith MW (2000) Short tandem repeat methodology for genotypic identification of single- person versus multi-person use of syringes. AIDS 14:1507-1513. Abstract      Journal - click on “Online Articles"

1999

Bream JH, Young HA, Rice N, Martin MP, Smith MW, Carrington M, O'Brien SJ (1999) CCR5 Promoter Alleles and Specific DNA Binding Factors. Science 284:223a.  Reprint(PDF)

Huttley GA, Smith MW, Carrington M, O'Brien SJ (1999) A scan for linkage disequilibrium across the human genome. Genetics 152:1711-1722.  Abstract      Reprint(PDF)

Stephens JC, Smith MW, Shin HD, O'Brien SJ (1999) Tracking linkage disequilibrium in admixed populations with MALD using microsatellite loci. In: Goldstein DB, Schlotterer C (eds) Microsatellites: evolution and applications. Oxford University Press, Oxford, England, pp 211-224.  Book Information

Svard SG, Rafferty C, McCaffery JM, Smith MW, Reiner DS, Gillin FD (1999) A signal recognition particle receptor gene from the early-diverging eukaryote, Giardia lamblia. Mol. Biochem. Parasitol. 98:253-264.  Abstract      Reprint(PDF)

1998

Hendel H, Henon N, Lebuanec H, Lachgar A, Poncelet H, Caillat-Zucman S, Winkler CA, Smith MW, Kenefic L, O'Brien S, Lu W, Andrieu JM, Zagury D, Schachter F, Rappaport J, Zagury JF (1998) Distinctive effects of CCR5, CCR2, and SDF1 genetic polymorphisms in AIDS progression. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 19:381-386.  Abstract  

Martin MP, Dean M, Smith MW, Winkler C, Gerrard B, Michael NL, Lee B, Doms RW, Margolick J, Buchbinder S, Goedert JJ, O'Brien TR, Hilgartner MW, Vlahov D, O'Brien SJ, Carrington M (1998) Genetic acceleration of AIDS progression by a promoter variant of CCR5. Science 282:1907-1911.  Abstract      Reprint(PDF)

Roger AJ, Svard SG, Tovar J, Clark CG, Smith MW, Gillin FD, Sogin ML (1998) A mitochondrial-like chaperonin 60 gene in Giardia lamblia: evidence that diplomonads once harbored an endosymbiont related to the progenitor of mitochondria. Proc. Natl. Acad. Sci. U S A 95:229-234.  Abstract      Reprint(PDF)

Shriver MD, Smith MW, Jin L (1998) Reply to Brenner. Am. J. Hum. Genet. 62:1560-1561.  Reprint(PDF)

Smith MW, Aley SB, Sogin M, Gillin FD, Evans GA (1998) Sequence survey of the Giardia lamblia genome. Mol. Biochem. Parasitol. 95:267-280.  Abstract      Reprint(PDF)

Smith MW, Dean M, Carrington M, Winkler C, O'Brien SJ (1998) Progression to AIDS response. Science 280:1815.  Online Article

Stephens JC, Reich DE, Goldstein DB, Shin HD, Smith MW, Carrington M, Winkler C, Huttley GA, Allikmets R, Schriml L, Gerrard B, Malasky M, Ramos MD, Morlot S, Tzetis M, Oddoux C, di Giovine FS, Nasioulas G, Chandler D, Aseev M, Hanson M, Kalaydjieva L, Glavac D, Gasparini P, Dean M, O’Brien, SJ. (1998) Dating the origin of the CCR5-Delta32 AIDS-resistance allele by the coalescence of haplotypes. Am. J. Hum. Genet. 62:1507-1515.  Abstract      Reprint(PDF)  

Winkler C, Modi W, Smith MW, Nelson GW, Wu X, Carrington M, Dean M, Honjo T, Tashiro K, Yabe D, Buchbinder S, Vittinghoff E, Goedert JJ, O'Brien TR, Jacobson LP, Detels R, Donfield S, Willoughby A, Gomperts E, Vlahov D, Phair J, O'Brien SJ (1998) Genetic restriction of AIDS pathogenesis by an SDF-1 chemokine gene variant. Science 279:389-393.  Abstract      Reprint(PDF)

1997

Shriver MD, Smith MW, Jin L, Marcini A, Akey JM, Deka R, Ferrell RE (1997) Ethnic-affiliation estimation by use of population-specific DNA markers. Am. J. Hum. Genet. 60:957-964.  Abstract

Smith MW, Carrington M, Winkler C, Lomb D, Dean M, Huttley G, O'Brien SJ (1997) CCR2 chemokine receptor and AIDS progression. Nat. Med. 3:1052-1053.  Abstract

Smith MW, Dean M, Carrington M, Huttley GA, O'Brien SJ (1997) CCR5-delta 32 gene deletion in HIV-1 infected patients.  350:741-742.  Abstract      Reprint(PDF)

Smith MW, Dean M, Carrington M, Winkler C, Huttley GA, Lomb DA, Goedert JJ, O'Brien TR, Jacobson LP, Kaslow R, Buchbinder S, Vittinghoff E, Vlahov D, Hoots K, Hilgartner MW, O'Brien SJ (1997) Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression.. Science 277:959-965.  Abstract      Reprint(PDF)

1996

Dean M, Carrington M, Winkler C, Huttley GA, Smith MW, Allikmets R, Goedert JJ, Buchbinder SP, Vittinghoff E, Gomperts E, Donfield S, Vlahov D, Kaslow R, Saah A, Rinaldo C, Detels R, O'Brien SJ (1996) Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Science 273:1856-1862.  Abstract Online Article

Meng TC, Aley SB, Svard SG, Smith MW, Huang B, Kim J, Gillin FD (1996) Immunolocalization and sequence of caltractin/centrin from the early branching eukaryote Giardia lamblia. Mol. Biochem. Parasitol. 79:103-108.  Abstract      Reprint(PDF)

Roger AJ, Smith MW, Doolittle RF, Doolittle WF (1996) Evidence for the Heterolobosea from phylogenetic analysis of genes encoding glyceraldehyde-3-phosphate dehydrogenase. J. Eukaryot. Microbiol. 43:475-485.  Abstract

1995

Rozario C, Morin L, Roger AJ, Smith MW, Muller M (1996) Primary structure and phylogenetic relationships of glyceraldehyde-3- phosphate dehydrogenase genes of free-living and parasitic diplomonad flagellates. J. Eukaryot. Microbiol. 43:330-340.  Abstract

Kupfer K, Smith MW, Quackenbush J, Evans GA (1995) Physical mapping of complex genomes by sampled sequencing: a theoretical analysis. Genomics 27:90-100.  Abstract      Reprint(PDF)

Rozario C, Smith MW, Muller M (1995) Primary sequence of a putative pyrophosphate-linked phosphofructokinase gene of Giardia lamblia. Biochim. Biophys. Acta 1260:218-222.  Abstract      Reprint(PDF)

Selleri L, Smith MW, Holmsen AL, Romo AJ, Thomas SD, Paternotte C, Romberg LC, Wei YH, Evans GA (1995) High-resolution physical mapping of a 250-kb region of human chromosome 11q24 by genomic sequence sampling (GSS). Genomics 26:489-501.  Abstract      Reprint(PDF)

Classics

Smith MW, Holmsen AL, Wei YH, Peterson M, Evans GA (1994) Genomic sequence sampling: a strategy for high resolution sequence- based physical mapping of complex genomes. Nat. Genet. 7:40-47.  Abstract

Smith MW, Clark SP, Hutchinson JS, Wei YH, Churukian AC, Daniels LB, Diggle KL, Gen MW, Romo AJ, Lin Y, et al. (1993) A sequence-tagged site map of human chromosome 11. Genomics 17:699-725.  Abstract      Reprint(PDF)

Selleri L, Eubanks JH, Giovannini M, Hermanson GG, Romo A, Djabali M, Maurer S, McElligott DL, Smith MW, Evans GA (1992) Detection and characterization of "chimeric" yeast artificial chromosome clones by fluorescent in situ suppression hybridization. Genomics 14:536-541.  Abstract

Smith MW, Doolittle RF (1992) Anomalous phylogeny involving the enzyme glucose-6-phosphate isomerase. J. Mol. Evol. 34:544-545. 

Smith MW, Doolittle RF (1992) A comparison of evolutionary rates of the two major kinds of superoxide dismutase. J. Mol. Evol. 34:175-184.  Abstract

Smith MW, Feng DF, Doolittle RF (1992) Evolution by acquisition: the case for horizontal gene transfers. Trends Biochem. Sci. 17:489-493.  Abstract

Smith MW (1988) Structure of vertebrate genes: a statistical analysis implicating selection. J. Mol. Evol. 27:45-55.  Abstract

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Patents

Awarded:

Evans, G.A., Smith, M.W.: Method for Generation of Sequence Sampled Maps of Complex Genomes. U.S. Patent #5,851,760, Awarded December 22, 1998.

  Filed

Smith, M.W., Shin, H.D., O’Brien, S.J.: Method of Predicting Susceptibility to HIV Infection or Progression of HIV Disease. U.S. Provisional Patent Application, Serial # 60/128521, Filed April 9, 1999.

Dean, M., O’Brien, S.J., Smith, M., Carrington, M.: Delayed Progression to AIDS by a Missense Allele of the CCR2 Gene.  U.S. Provisional Patent Application, Serial 09/131,827, Filed August 10, 1998.