Testing Status of Agents at NTP
(Chlorpyrifos)
CAS NO. 2921-88-2
| Route | Species/ Strain | # Per Dose Group/Sex | Dose | Study duration (days/# of doses) | Effects a | References |
| Oral | Cat/Domestic shorthair | 2/male | serial doses from 0.1-50.0 mg/kg (technical grade)b | 1/5 | reduced blood and plasma ChE; toxicosis and death (1 cat) at 50 mg/kg only | Hooser et al., 1988 |
| Oral | Cat/Domestic shorthair | 6/male | 40 mg/kg (technical gradeb | 56/1 | reduced blood and plasma ChE (P<0.001); toxicosis and reduced brain ChE and death (1 cat) | Hooser et al., 1988 |
| Oral | Goat/Nubian | 3/males and female | 150 mg/kg (48% technical gradec | 7/1 | clinical signs of toxicity; pulmonary, hepatic, intestinal, abomasal lesions; brain hemorrhage; changes in serum chemistry; death within 5 days | Mohamed et al., 1990 |
| Oral | Cow/Dairy Bred (new born) | 5/NS | 5, 10, or 25 mg/kg (technical grade) | 7/1 | dose-dependent reduction in blood ChE; severe toxicosis at 25 mg/kg | Palmer et al., 1980 |
| Dermal | Cow/Dairy Bred (new born) | 5/NS | sprayed with 0.02-0.12% emulsiond | 7/1 | dose-dependent reduction in blood ChE; toxicosis at 0.06 and 0.12%; death (1 calf) at 0.12% | Palmer et al., 1980 |
| Dermal | Cow/Angus and Brahman cross breed (4-6 months old) | 5/NS | sprayed with 0.25-2.30% emulsiond | 7/1 | dose-dependent reduction in blood ChE; toxicosis (1 calf) at 2.3% | Palmer et al., 1980 |
| Dermal | Cow/Holstein | 4/bulls (pretreated with testosterone) and Steers | 16ml | 86/2 (on days 28 and 56) | Bulls: decreased blood ChE (P<0.01) diarrhea, depression, anorexia after 2nd dose; Steers: Nonee | Haas et al., 1983 |
| Dermal | Cow/Brangus | 1/bull | Not reportedf | NR/1 | decreased blood ChE; general signs of toxicity | Scarratt and Bldgett, 1986 |
| Dermal | Cow/Limousin | 1/bull | Not reported (Dursban® 44) | NR/1 | diarrhea, anorexia, weakness, depression | Putnam and Edwards, 1984 |
| Dermal | Swine/NS (piglets) | 15/male and female | 2.5% aerosol spray | 20/1 (2 seconds) | decreased blood and brain ChE; toxicosis | Long et al., 1986; Scheidt et al., 1987 |
| Not specif. | Cat/Domestic shorthair | 2/male and female | unknown (home sprayed) | 18/6 applications | decreased ChE; general signs of toxicity | Jaggy and Oliver, 1990 |
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