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    Automatic Karyotype to SKYGRAM Converter

This tool will automatically convert the short form karyotype into a SKYGRAM image
(the full ideogram of a cell or clone, with each chromosome displayed in a different color,
with band overlay). The program will also incorporate the number of cells for each
structural abnormality which is displayed in brackets.

PARSER INTEGRATION TO THE DATABASE

  1. Register to submit data.
  2. Log on.
  3. Enter new case into database in "Case List Input Screen" and press Submit.
  4. Press SKY to advance to the "Karyotype Input Screen".
  5. Type (paste) in the short form karyotype in the karyotype window and press Submit.
  6. Press Convert under "Auto-conversion of Karyotype".

    Image highlighting the Convert Button in Karyotype Input Screen
  7. This brings up the "SKYGRAM and Report Screen" and
    automatically enters the chromosome
    data into the database.
  8. Examine the results and press the appropriate button:

    Edit/Review Chromosome Details:The data remains in the database and the "SKY Chromosome Input Screen" appears for
    additional editing of the SKYGRAM; e.g.,entering the number of cells and number of copies of each
    aberrant chromosome

    Discard Image/Proceed Manually:This deletes the newly added data and brings you to the next page for
    manual submission, "Number of Normal/Abnormal Chromosome Input Screen"

  9. Note:When editing is complete and submitted, press Reload or Refresh if changes are not visible in the SKYGRAM.

Sample page:

Karyotype Convertor Results
(scroll down for complete report)

Buttons:Edit/Review Chromosome Details Discard Image/Proceed Manually


Karyotype:46,XY,t(1;3)(p21;q21),del(9)(q22),t(1;18)

Note:Browsers tend to retain the previous image,
press Reload or Refresh if any further changes made to the karyotype are not visible in the SKYGRAM.

Image of Karyotype:46,XY,t(1;3)(p21;q21),del(9)(q22)

Karyotype Conversion Report


A.Count of Normal Chromosome

(deviatons from normal in red) 1:1 2:2 3:1 4:2 5:2 6:2 7:2 8:2 9:1 10:2 11:2 12:2 13:2 14:2 15:2 16:2 17:2 18:2 19:2 20:2
21:2 22:2 X:1 Y:1

B.Structurally Abnormal Chromosomes

Note:The chromosomes are listed in the order in which they appear in the karyotype; the
number preceding the colon indicates the chromosomal location in the SKYGRAM. The
default size for unknown chromosome/chromosome segments, which are indicated by "?"
in the karyotype, is 30% of the normal parent chromosome; please edit for size.
(described from top to bottom) 1:1pter->1q21H::3q21H->3qter
3:3pter->3q21H::1q21H->1qter
9:9pter->9q22H:

C.Problem Chromosomes

t(1;18) missing translocation breakpoints at t(1;18) Buttons:Edit/Review Chromosome Details Discard Image/Proceed Manually

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