NTP Experiment-Test: 56348-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY CITRAL Date: 07/05/01 Route: DOSED FEED Time: 08:02:05 Facility: Battelle Columbus Laboratory Chemical CAS #: 5392-40-5 Lock Date: 01/02/96 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Page 1 NTP Experiment-Test: 56348-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY CITRAL Date: 07/05/01 Route: DOSED FEED Time: 08:02:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | UNTREAT | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Inflammation, Chronic | 1 2 1 1 1 1 2 1 1 | 9 1.2| |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | Cardiomyopathy | 1 1 1 | 3 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 2 NTP Experiment-Test: 56348-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY CITRAL Date: 07/05/01 Route: DOSED FEED Time: 08:02:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | UNTREAT | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + | 10 | Inflammation | 1 1 | 2 1.0| |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 10 | Cyst | 1 2 | 2 1.5| |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 3 NTP Experiment-Test: 56348-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY CITRAL Date: 07/05/01 Route: DOSED FEED Time: 08:02:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | UNTREAT | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | Spleen | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | Inflammation, Chronic | 1 1 | 2 1.0| Alveolus, Infiltration Cellular, | | | Histiocyte | 1 | 1 1.0| |__________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | Inflammation | 1 1 1 1 | 4 1.0| |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | Inflammation | 1 1 1 1 1 | 5 1.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 4 NTP Experiment-Test: 56348-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY CITRAL Date: 07/05/01 Route: DOSED FEED Time: 08:02:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | UNTREAT | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Mineralization | 1 1 1 1 1 | 5 1.0| Renal Tubule, Regeneration | 1 1 1 | 3 1.0| |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 5 NTP Experiment-Test: 56348-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY CITRAL Date: 07/05/01 Route: DOSED FEED Time: 08:02:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | VEHICLE | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Hepatodiaphragmatic Nodule | X | 1 | Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 | 9 1.0| |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | Mineralization | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | Cardiomyopathy | 1 1 1 | 3 1.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 6 NTP Experiment-Test: 56348-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY CITRAL Date: 07/05/01 Route: DOSED FEED Time: 08:02:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | VEHICLE | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + M + + + M | 8 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + | 10 | Inflammation | 1 1 1 1 1 | 5 1.0| |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 7 NTP Experiment-Test: 56348-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY CITRAL Date: 07/05/01 Route: DOSED FEED Time: 08:02:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | VEHICLE | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | Inflammation, Chronic | 1 1 1 1 | 4 1.0| Alveolus, Infiltration Cellular, | | | Histiocyte | 1 | 1 1.0| |__________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | Inflammation | 1 1 1 | 3 1.0| |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | Inflammation | 1 1 1 | 3 1.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 8 NTP Experiment-Test: 56348-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY CITRAL Date: 07/05/01 Route: DOSED FEED Time: 08:02:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | VEHICLE | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM - cont | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Mineralization | 1 1 1 1 1 1 1 1 1 | 9 1.0| Renal Tubule, Regeneration | 1 1 | 2 1.0| |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | Inflammation | 1 | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 9 NTP Experiment-Test: 56348-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY CITRAL Date: 07/05/01 Route: DOSED FEED Time: 08:02:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 3900 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Liver | + | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 10 NTP Experiment-Test: 56348-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY CITRAL Date: 07/05/01 Route: DOSED FEED Time: 08:02:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 3900 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 11 NTP Experiment-Test: 56348-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY CITRAL Date: 07/05/01 Route: DOSED FEED Time: 08:02:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | A | 7800 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Intestine Large, Colon | + | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 12 NTP Experiment-Test: 56348-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY CITRAL Date: 07/05/01 Route: DOSED FEED Time: 08:02:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | A | 7800 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 13 NTP Experiment-Test: 56348-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY CITRAL Date: 07/05/01 Route: DOSED FEED Time: 08:02:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 15600 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 10 | Parasite Metazoan | X X X | 3 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Inflammation, Chronic | 1 1 1 1 1 | 5 1.0| |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | Atrophy | 1 | 1 1.0| |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | Cardiomyopathy | 1 1 1 1 | 4 1.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 14 NTP Experiment-Test: 56348-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY CITRAL Date: 07/05/01 Route: DOSED FEED Time: 08:02:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 15600 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + | 10 | Inflammation | 1 1 1 1 1 1 1 | 7 1.0| |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | Atrophy | 1 1 1 1 1 1 1 1 | 8 1.0| |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 15 NTP Experiment-Test: 56348-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY CITRAL Date: 07/05/01 Route: DOSED FEED Time: 08:02:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 15600 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | Spleen | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | Inflammation, Chronic | 1 | 1 1.0| |__________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | Inflammation | 1 1 | 2 1.0| |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | Inflammation | 1 1 1 | 3 1.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 16 NTP Experiment-Test: 56348-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY CITRAL Date: 07/05/01 Route: DOSED FEED Time: 08:02:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 15600 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM - cont | | | Kidney | + + + + + + + + + + | 10 | Mineralization | 1 1 1 1 | 4 1.0| Renal Tubule, Regeneration | 1 | 1 1.0| |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | Inflammation | 1 | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 17 NTP Experiment-Test: 56348-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY CITRAL Date: 07/05/01 Route: DOSED FEED Time: 08:02:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 31300 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Hepatodiaphragmatic Nodule | X | 1 | Inflammation, Chronic | 1 1 | 2 1.0| |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | Hyperkeratosis | 2 1 1 2 | 4 1.5| Epithelium, Hyperplasia | 2 1 1 1 | 4 1.3| |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 18 NTP Experiment-Test: 56348-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY CITRAL Date: 07/05/01 Route: DOSED FEED Time: 08:02:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 31300 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Parathyroid Gland | M + + + + + + + M + | 8 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | Atrophy | 3 1 1 1 | 4 1.5| Hemorrhage | 1 3 1 3 3 1 2 3 2 | 9 2.1| |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 19 NTP Experiment-Test: 56348-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY CITRAL Date: 07/05/01 Route: DOSED FEED Time: 08:02:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 31300 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | Spleen | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | Atrophy | 4 3 2 2 | 4 2.8| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + M M + + | 8 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | Inflammation | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | Inflammation | 1 | 1 1.0| |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 20 NTP Experiment-Test: 56348-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY CITRAL Date: 07/05/01 Route: DOSED FEED Time: 08:02:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 31300 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM - cont | | | Kidney | + + + + + + + + + + | 10 | Mineralization | 1 1 1 1 | 4 1.0| |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 21 NTP Experiment-Test: 56348-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY CITRAL Date: 07/05/01 Route: DOSED FEED Time: 08:02:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | UNTREAT | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Hepatodiaphragmatic Nodule | X | 1 | Inflammation, Chronic | 1 1 1 1 1 1 1 1 | 8 1.0| |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | Mineralization | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | Cardiomyopathy | 1 2 1 1 1 1 1 1 | 8 1.1| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 22 NTP Experiment-Test: 56348-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY CITRAL Date: 07/05/01 Route: DOSED FEED Time: 08:02:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | UNTREAT | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Pituitary Gland | + M + + + + + + + + | 9 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + | 10 | Inflammation | 1 1 | 2 1.0| |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 23 NTP Experiment-Test: 56348-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY CITRAL Date: 07/05/01 Route: DOSED FEED Time: 08:02:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | UNTREAT | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + M + | 9 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | Alveolus, Infiltration Cellular, | | | Histiocyte | 1 1 | 2 1.0| |__________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | Inflammation | 1 1 1 1 1 1 1 1 1 | 9 1.0| |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | Inflammation | 1 1 1 | 3 1.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 24 NTP Experiment-Test: 56348-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY CITRAL Date: 07/05/01 Route: DOSED FEED Time: 08:02:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | UNTREAT | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Mineralization | 1 1 1 1 1 1 | 6 1.0| Renal Tubule, Regeneration | 1 1 1 1 1 1 1 1 | 8 1.0| |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 25 NTP Experiment-Test: 56348-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY CITRAL Date: 07/05/01 Route: DOSED FEED Time: 08:02:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | VEHICLE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 10 | Parasite Metazoan | X X | 2 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Hepatodiaphragmatic Nodule | X | 1 | Inflammation, Chronic | 1 1 1 1 1 1 1 | 7 1.0| |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | Artery, Mineralization | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 26 NTP Experiment-Test: 56348-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY CITRAL Date: 07/05/01 Route: DOSED FEED Time: 08:02:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | VEHICLE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| CARDIOVASCULAR SYSTEM - cont | | | Cardiomyopathy | 1 1 1 1 1 1 1 1 | 8 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Parathyroid Gland | M + M + + + + + M + | 7 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + M + + | 9 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 10 | Inflammation | 1 | 1 1.0| |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + | 10 | Inflammation | 1 1 1 1 | 4 1.0| |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 10 | Inflammation | 1 2 | 2 1.5| |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 27 NTP Experiment-Test: 56348-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY CITRAL Date: 07/05/01 Route: DOSED FEED Time: 08:02:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | VEHICLE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + M + M + + + | 8 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | Inflammation, Chronic | 1 1 | 2 1.0| Alveolus, Infiltration Cellular, | | | Histiocyte | 1 1 1 | 3 1.0| |__________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | Inflammation | 1 1 1 1 1 1 1 | 7 1.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 28 NTP Experiment-Test: 56348-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY CITRAL Date: 07/05/01 Route: DOSED FEED Time: 08:02:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | VEHICLE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | Inflammation | 1 1 | 2 1.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Developmental Malformation | X | 1 | Mineralization | 1 1 1 1 1 | 5 1.0| Renal Tubule, Regeneration | 1 1 1 1 1 1 1 1 1 1 | 10 1.0| |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | Inflammation | 1 | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 29 NTP Experiment-Test: 56348-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY CITRAL Date: 07/05/01 Route: DOSED FEED Time: 08:02:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 3900 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Liver | + | 1 | Hepatodiaphragmatic Nodule | X | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 30 NTP Experiment-Test: 56348-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY CITRAL Date: 07/05/01 Route: DOSED FEED Time: 08:02:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 3900 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Nephropathy | 1 1 1 | 3 1.0| Renal Tubule, Casts Granular | 1 1 1 | 3 1.0| Renal Tubule, Regeneration | 1 1 1 1 1 1 1 | 7 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 31 NTP Experiment-Test: 56348-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY CITRAL Date: 07/05/01 Route: DOSED FEED Time: 08:02:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 7800 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 32 NTP Experiment-Test: 56348-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY CITRAL Date: 07/05/01 Route: DOSED FEED Time: 08:02:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 7800 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM - cont | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Nephropathy | 1 1 1 1 1 1 1 1 1 1 | 10 1.0| Renal Tubule, Casts Granular | 1 1 1 1 1 1 1 1 2 2 | 10 1.2| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 33 NTP Experiment-Test: 56348-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY CITRAL Date: 07/05/01 Route: DOSED FEED Time: 08:02:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 15600 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L | PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | Parasite Metazoan | X | 1 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Inflammation, Chronic | 1 1 1 1 1 | 5 1.0| |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | Atrophy | 1 | 1 1.0| |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | Cardiomyopathy | 1 1 1 1 1 1 1 1 | 8 1.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 34 NTP Experiment-Test: 56348-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY CITRAL Date: 07/05/01 Route: DOSED FEED Time: 08:02:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 15600 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L | PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + M + + + + | 9 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + | 10 | Hyperplasia | 3 | 1 3.0| Inflammation | 1 1 | 2 1.0| |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 10 | Inflammation | 1 1 | 2 1.0| |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 35 NTP Experiment-Test: 56348-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY CITRAL Date: 07/05/01 Route: DOSED FEED Time: 08:02:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 15600 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L | PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | Atrophy | 1 1 1 1 1 1 1 | 7 1.0| |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | Inflammation, Chronic | 1 | 1 1.0| |__________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | Inflammation | 1 1 | 2 1.0| |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 36 NTP Experiment-Test: 56348-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY CITRAL Date: 07/05/01 Route: DOSED FEED Time: 08:02:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 15600 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L | PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Mineralization | 1 1 1 1 1 1 | 6 1.0| Nephropathy | 1 1 1 1 1 1 1 1 | 8 1.0| Renal Tubule, Casts Granular | 1 2 2 1 1 2 2 1 2 1 | 10 1.5| Renal Tubule, Regeneration | 1 1 1 1 1 | 5 1.0| |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 37 NTP Experiment-Test: 56348-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY CITRAL Date: 07/05/01 Route: DOSED FEED Time: 08:02:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 31300 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Inflammation, Chronic | 1 1 | 2 1.0| |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | Hyperkeratosis | 1 1 | 2 1.0| Inflammation, Chronic Active | 1 | 1 1.0| Epithelium, Hyperplasia | 1 3 | 2 2.0| |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 38 NTP Experiment-Test: 56348-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY CITRAL Date: 07/05/01 Route: DOSED FEED Time: 08:02:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 31300 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| CARDIOVASCULAR SYSTEM - cont | | | Cardiomyopathy | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 10 | Inflammation | 2 | 1 2.0| |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | Aspermia | 4 4 4 4 4 4 4 4 4 4 | 10 4.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 39 NTP Experiment-Test: 56348-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY CITRAL Date: 07/05/01 Route: DOSED FEED Time: 08:02:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 31300 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | Atrophy | 1 1 1 3 2 3 3 2 1 2 | 10 1.9| Hemorrhage | 2 2 1 2 2 2 3 2 2 1 | 10 1.9| |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | Atrophy | 3 4 4 1 2 | 5 2.8| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + M M + + + + | 8 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 40 NTP Experiment-Test: 56348-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY CITRAL Date: 07/05/01 Route: DOSED FEED Time: 08:02:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 31300 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | Trachea | + + + + + + + + + + | 10 | Inflammation | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 41 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------