Bornstein P, Mercado M, Phair J, Murphy R; International Conference on AIDS.

Int Conf AIDS. 1993 Jun 6-11; 9: 293 (abstract no. PO-B02-0950).

Division of Infectious Diseases, Northwestern Univ. Med. School, Chicago.

Recent studies have indicated HGH and IGF-1 may have a lymphoproliferative function in adults. In order to assess the relationship of these hormones in HIV infection, we examined baseline HGH and IGF-1 levels, and HGH response to provocation with dopamine and propranolol, in 26 age and nutritionally matched HIV-infected individuals of varying levels of CD4-lymphocyte count, and in six matched controls. Average baseline HGH levels were 1.7 ng/L (S.D. = 0.36) for controls, and 3.3 ng/L (S.D. = 3.4) for HIV-infected participants. Average post-provocation HGH levels were 4.5 ng/L (S.D. = 4.7) for controls and 10.7 ng/L (S.D. = 12.3) for HIV-infected participants. Average baseline IGF-levels were 218 ng/L (S.D. = 70.2) for controls and 189 ng/L (S.D. = 72.4) for HIV-infected participants. RESULTS: HIV-infected individuals had higher baseline HGH levels (p < 0.05) and a higher response to provocation (p < 0.001) and a trend toward higher post-provocation HGH levels and lower IGF-1 levels, compared to controls. There was no correlation between CD4-lymphocyte counts and either HGH or IGF-1 levels. This study suggests HIV-infected individuals have abnormal regulation of somatotropic factors, suggesting resistance to HGH. TABULAR DATA, SEE ABSTRACT VOLUME.

Publication Types:

• Meeting Abstracts

Keywords:

• AIDS Vaccines
• Acquired Immunodeficiency Syndrome
• Adult
• Case-Control Studies
• HIV Infections
• HIV Seropositivity
• Human Growth Hormone
• Humans
• Insulin-Like Growth Factor I
• Somatomedins

Other ID:

• 93334453

UI: 102203827

From Meeting Abstracts