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Title Satellite DNA and cytogenetic evolution: molecular aspects and implications for man
Creator/Author Hatch, F.T. ; Mazrimas, J.
Publication Date1977 Feb 28
OSTI IdentifierOSTI ID: 7324032
Report Number(s)UCRL-79120;CONF-770308-3
DOE Contract NumberW-7405-ENG-48
Resource TypeConference
Specific TypeTechnical Report
Resource RelationICN-UCLA symposium on molecular and cellular biology; 7 Mar 1977; Keystone, CO, USA
Research OrgCalifornia Univ., Livermore (USA). Lawrence Livermore Lab.
Subject550400 -- Genetics ;550300 -- Cytology; ;DNA REPLICATION-- GENETIC VARIABILITY;RODENTS-- BIOLOGICAL EVOLUTION;RODENTS-- GENOME MUTATIONS; CHROMOSOMES;CYTOLOGY;GENETICS;MOLECULAR BIOLOGY;WILD ANIMALS
Related SubjectANIMALS;BIOLOGICAL VARIABILITY;BIOLOGY;MAMMALS;MUTATIONS;NUCLEIC ACID REPLICATION;VERTEBRATES
Description/Abstract Simple, highly reiterated DNA sequences, often observed in density gradients as satellite DNAs, exist in condensed heterochromatin.^This material is predominantly located at chromosomal centromeres, occasionally at telomeres, or intercalated within arms; in a few species it occupies entire chromosome arms.^Satellite DNAs are a highly variable component of the genome of most higher eukaryotes, but their functions have remained speculative.^The genus of kangaroo rats (Dipodomys) exhibits remarkable interspecies variations in content of three satellite DNAs, consisting of simple sequences 3 to 10 base pairs long, and in species karyotypes.^A broad range of diploid-DNA content is correlated with satellite-DNA content.^The latter is correlated positively with predominance of biarmed over uniarmed chromosomes (high fundamental number FN) and inversely with two anatomical indices (leg-bone-length ratios) of specialization for the jumping gait.^Karyotypic variation is achieved via chromosomal rearrangements, e.g., Robertsonian fusion, C-band heteromorphism, and pericentric inversion.^Environmental adaptation is achieved, in part, by reassortment of gene-linkage groups and regulatory controls as a result of the chromosomal rearrangements.^The foregoing relationships led to the postulation that highly reiterated DNA sequences play a supragenic, global role in environmental adaptation and the evolution of new species.
Country of PublicationUnited States
LanguageEnglish
FormatPages: 21
AvailabilityDep. NTIS, PC A02/MF A01.
System Entry Date2001 May 13

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