Bibliographic Citation
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Title | Satellite DNA and cytogenetic evolution: molecular aspects and implications for man |
Creator/Author | Hatch, F.T. ; Mazrimas, J. |
Publication Date | 1977 Feb 28 |
OSTI Identifier | OSTI ID: 7324032 |
Report Number(s) | UCRL-79120;CONF-770308-3 |
DOE Contract Number | W-7405-ENG-48 |
Resource Type | Conference |
Specific Type | Technical Report |
Resource Relation | ICN-UCLA symposium on molecular and cellular biology; 7 Mar 1977; Keystone, CO, USA |
Research Org | California Univ., Livermore (USA). Lawrence Livermore Lab. |
Subject | 550400 -- Genetics ;550300 -- Cytology; ;DNA REPLICATION-- GENETIC VARIABILITY;RODENTS-- BIOLOGICAL EVOLUTION;RODENTS-- GENOME MUTATIONS; CHROMOSOMES;CYTOLOGY;GENETICS;MOLECULAR BIOLOGY;WILD ANIMALS |
Related Subject | ANIMALS;BIOLOGICAL VARIABILITY;BIOLOGY;MAMMALS;MUTATIONS;NUCLEIC ACID REPLICATION;VERTEBRATES |
Description/Abstract | Simple, highly reiterated DNA sequences, often observed in density gradients as satellite DNAs, exist in condensed heterochromatin.^This material is predominantly located at chromosomal centromeres, occasionally at telomeres, or intercalated within arms; in a few species it occupies entire chromosome arms.^Satellite DNAs are a highly variable component of the genome of most higher eukaryotes, but their functions have remained speculative.^The genus of kangaroo rats (Dipodomys) exhibits remarkable interspecies variations in content of three satellite DNAs, consisting of simple sequences 3 to 10 base pairs long, and in species karyotypes.^A broad range of diploid-DNA content is correlated with satellite-DNA content.^The latter is correlated positively with predominance of biarmed over uniarmed chromosomes (high fundamental number FN) and inversely with two anatomical indices (leg-bone-length ratios) of specialization for the jumping gait.^Karyotypic variation is achieved via chromosomal rearrangements, e.g., Robertsonian fusion, C-band heteromorphism, and pericentric inversion.^Environmental adaptation is achieved, in part, by reassortment of gene-linkage groups and regulatory controls as a result of the chromosomal rearrangements.^The foregoing relationships led to the postulation that highly reiterated DNA sequences play a supragenic, global role in environmental adaptation and the evolution of new species. |
Country of Publication | United States |
Language | English |
Format | Pages: 21 |
Availability | Dep. NTIS, PC A02/MF A01. |
System Entry Date | 2001 May 13 |
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