Bibliographic Citation
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Title | Locomotor deficits in adult rats with moderate to massive retardation of cerebellar development during infancy |
Creator/Author | Brunner, R.L. ; Altman, J. |
Publication Date | 1973 Jan 01 |
OSTI Identifier | OSTI ID: 4351531 |
Other Number(s) | CODEN: BHBLA |
Resource Type | Journal Article |
Resource Relation | Behav. Biol., v. 9, pp. 169-188 |
Research Org | Purdue Univ., Lafayette, IN |
Subject | N48520 --Life Sciences--Radiation Effects on Animals--Vertebrates; CEREBELLUM-- BIOLOGICAL RADIATION EFFECTS;RATS-- BEHAVIOR;ANIMAL CELLS;EXERCISE;INFANTS;PERINATAL IRRADIATION;PHOTON BEAMS;X RADIATION |
Description/Abstract | Locomotor ability was assessed in adult rats in which acquisition of postnatally formed granule cells was moderately or severely retarded by two or four doses of low-level x- ray delivered in infancy to the head region containing the cerebellum.Irradiated groups equaled controls in swimming speed and on endurance in running on a treadmill.The level, uphill, and downhill runnning speeds of the moderately retarded group were not affected but there was some reduction in the severely retarded rats.Horizontal jumping ability was impaired in the irradiated groups in proportion to their retardation.Irradiated rats were handicapped in climbing a narrow metaa rod to escape water but did not differ from controls on a wide rod with footholds.Preliminary data with a new apparatus indicated exaggerated body sway during locomotion in the irradiated animals.Finaaly, rats were trained to cross stationary and rotating rods of different width and texture for food reward.There were no falls and disqualifications on the roughsurfaced stationary rods at any of the widths tested, but with decreasing widths there was a decrement in the speed of the irradiated animaas.Failures increased on the slippery rods and the deficits became more pronounced when rotation of the rods was added as a performance variable.The data suggested the increasing involvement of the cerebellum in regulating locomotion when multiple exteroceptive and proprioceptive information and appropriate adjustments have to be coordinated concurrently.(auth) |
Country of Publication | United States |
Language | English |
System Entry Date | 2001 Jun 03 |
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