Relationship between susceptibility to protein oxidation, aging, and maximum life span potential of different species.

Department of Biological Sciences, Southern Methodist University, Dallas, Texas 75205, USA.

The main objective of this study was to determine whether antioxidative potential of the tissues plays a role in the aging process. Antioxidative potential was ascertained as the susceptibility of tissues to undergo protein oxidation, manifested as protein carbonyls, in response to acute oxidative stress, induced by exposure to x-rays. Brain homogenates from 22-month-old rats were more susceptible to oxidative stress than those from three-month-old rats. Brain was more susceptible to oxidative damage than the heart. A comparison of the susceptibility of brain and heart homogenates in five different species (mouse, rat, rabbit, pig, and pigeon) indicated that maximum life span potential of the species was inversely related to their susceptibility to acute oxidative stress.

PMID: 9415119 [PubMed - indexed for MEDLINE]