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• 7. HIV Biology: Bridging the Gap Between In Vitro and In Vivo
  Chaired by Edward Berger, NIAID, and Leonid Margolis, NICHD
  Thursday, October 8
  10:30 a.m.-12:30 p.m.
  Natcher Conference Center
  Conference Room E1/E2

  Edward A. Berger, NIAID
  HIV Env Interaction with Receptors and Coreceptors

  Phillip M. Murphy, NIAID
  CCR5 and the Regulation of HIV Pathogenesis

  Leonid B. Margolis, NICHD
  HIV Tropism and Pathogenesis in Human Lymphoid Tissue ex vivo

  Tae-Wook Chun, NIAID
  Studies of HIV Latency: Implications for Treatment and Eradication of Infection

• 8. Molecular, Cellular, and Tissue Imaging
  Chaired by Peter Basser, NICHD, and Carolyn L. Smith, NINDS
  Thursday, October 8
  10:30 a.m.-12:30 p.m.
  Natcher Conference Center
  Balcony B

  Michael Edidin, The Johns Hopkins University
  Near-Field Microscopy of Cell Membranes

  Kuan Wang, NIAMS
  Molecular Imaging and Manipulation by Fluorescence and Atomic Force Microscopy

  Carolyn L. Smith, NINDS
  Insights into Intracellular Protein Dynamics Using GFP and Photobleaching

  Paul S. Blank, NICHD
  Two-Photon Laser Microscopy: A Primer

  G. Alan Johnson, Duke University Center for In Vivo Microscopy
  Tissue and Organ Structure Using MR Microscopy

  Carlo Pierpaoli, NINDS
  In Vivo Investigation of the Structural Anatomy of the Brain Using Diffusion Tensor MRI

  Robert F. Bonner, NICHD
  Mapping Cellular Genomic and Protenomic Changes within Complex Tissues Using Laser Capture Microdissection (LCM)

• 9. Molecular Epidemiology: Incorporating State-of-the-Art Technologies into Population Studies
  Chaired by Nathaniel Rothman, NCI, Douglas Bell, NIEHS, and Neil Caporaso, NCI
  Thursday, October 8
  10:30 a.m.-12:30 p.m.
  Natcher Conference Center
  Balcony C

  A. Introduction

  Nathaniel Rothman, NCI
  Overview

  Richard Hayes, NCI
  Biospecimen Collections in Cohort Studies

  B. Analysis of Macromolecular Damage

  Miriam Poirier, NCI
  DNA Adducts

  Gerald Wogan, MIT
  Protein Adducts

  Martyn Smith, U. Cal Berkeley
  Chromosomal Aberrations and Somatic Cell Mutations

  Discussion

  C. Analysis of Common Genetic Polymorphisms

  Neil Caporaso, NCI
  Overview

  Doug Bell, NIEHS
  Currently Available High Through-Put Technologies

  Peter Shields, NCI
  Analysis of Non-Blood Sources of DNA

  Michael Dean, NCI
  The Human Genome Map and Complex Diseases
  
  Ken Beutow, NCI
  Emerging Technologies

  Round-Table Discussion

• 10. Protein Engineering
  Chaired by Ira Pastan, NCI, and Christine A. Hrycyna, NCI
  Thursday, October 8
  10:30 a.m.-12:30 p.m.
  Natcher Conference Center
  Balcony A

  Kenneth Yamada, NIDR
  Chimeric Membrane and Cytoskeletal Molecules for Studying Cell Interactions and Signal Transduction

  Chris Hrycyna, NCI
  Structural Flexibility of the Linker Region of Human P-glycoprotein permits ATP Hydrolysis and Drug Transport

  Charles Vinson, NCI
  Inhibition of AP1 DNA Binding Helps Cisplatinum Kill Cancer Cells

  Partha Chowdhury, NCI
  Improved Stability and Yield of a Fv-toxin Fusion Protein by Computer Design and Protein Engineering of the Fv

  David Davies, NIDDK
  Protein Engineering Applied to Crystallography

• 11. Receptors of the Immune System
  Chaired by Eric Long , NIAID, and Warren Leonard, NHLBI
  Thursday, October 8
  10:30 a.m.-12:30 p.m.
  Natcher Conference Center
  Main Auditorium

  Bill Paul, NIAID
  The IL-4 Receptor: A Prototypic Cytokine Signaling System

  Warren Leonard, NHLBI
  Signaling through the IL-2 Receptor

  Irena Stefanova, NIAID
  Modulation of T Cell Receptor Signaling

  Sumati Rajagopalan, NIAID
  A Repertoire of Inhibitory Receptors on NK Cells

• 12. The Molecular and Cellular Biology of Diabetes Mellitus
  Chaired by Abner Notkins, NIDR, and Phillip Gorden, NIDDK
  Thursday, October 8
  10:30 a.m.-12:30 p.m.
  Natcher Conference Center
  Conference Room F1/F2

  Phillip Gorden, NIDDK
  Overview

  Sam Cushman, NIDDK
  Regulation of Glucose Transport

  Simeon Taylor, NIDDK
  Molecular Mechanisms in Insulin Action and Resistance

  Domenico Accilli, NICHD
  Transgenic and Knockout Models of Type II Diabetes

  Soumitra Ghosh, NHGRI
  Genetics of Type II Diabetes

  Abner Notkins, NIDR
  IA-2 and IA-2 Beta are Major Autoantigens in Type I Diabetes: Prediction of Disease