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J Med Genet. 1974 September; 11(3): 283–287.
PMCID: PMC1013144
Another human chimaera
Diana A. Battey, G. W. G. Bird, A. McDermott, C. W. Mortimer, O. M. Mutchinick, and June Wingham
Regional Blood Transfusion Service, Birmingham, the Good Hope General Hospital, Sutton Coldfield, and the Department of Human Genetics, University of Birmingham
Abstract
Another human chimaera is described, which we are unable to classify because of limited family data. Evidence of chimaerism was confined to haemopoietic tissues. There were two red cell populations with differences in four blood group systems and, although the patient was female, chromosome analysis of cultured lymphocytes showed that 96% of cells had the male karyotype 46,XY. Possible mechanisms for the production of chimaeras are discussed.
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  • BOOTH, PB; PLAUT, G; JAMES, JD; IKIN, EW; MOORES, P; SANGER, R; RACE, RR. Blood chimerism in a pair of twins. Br Med J. 1957 Jun 22;1(5033):1456–1458. [PubMed]
  • BRENDEMOEN, OJ. Some factors influencing Rh immunization during pregnancy. 1. ABO compatibility between mates. 2. Secretor-non secretor properties. 3. Husbands' Rh genotypes. Acta Pathol Microbiol Scand. 1952;31(4):579–583. [PubMed]
  • Crookston, MC; Tilley, CA; Crookston, JH. Human blood chimaera with seeming breakdown of immune tolerance. Lancet. 1970 Nov 28;2(7683):1110–1111. [PubMed]
  • Ford, CE. Mosaics and chimaeras. Br Med Bull. 1969 Jan;25(1):104–109. [PubMed]
  • GARTLER, SM; WAXMAN, SH; GIBLETT, E. An XX/XY human hermaphrodite resulting from double fertilization. Proc Natl Acad Sci U S A. 1962 Mar 15;48:332–335. [PubMed]
  • Kaeser, A; Nennstiel, HJ. Chimärismus vom Typ O-B in zwei neuentdeckten Fällen mit Differenz der Lewis-Gruppen und der Antigenstärken von H und P1. Blut. 1971 May;22(5):229–236. [PubMed]
  • Race, RR; Sanger, R. Blood group mosaics. Haematologia (Budap). 1972;6(1):63–71. [PubMed]
  • ROSENFIELD, RE; HABER, GV; KISSMEYER-NIELSEN, F; JACK, JA; SANGER, R; RACE, RR. Ge, a very common red-cell antigen. Br J Haematol. 1960 Oct;6:344–349. [PubMed]
  • UCHIDA, IA; WANG, HC; RAY, M. DIZYGOTIC TWINS WITH XX-XY CHIMERISM. Nature. 1964 Oct 10;204:191. [PubMed]