United States National Library of Medicine National Institutes of Health

2008AB UMLS Metathesaurus: New and Updated Sources - Expanded Representation Information

General Information:

For 2008AB, there are 2 new sources (FMA, MEDCIN), 1 new translation source (MDRCZE), 27 updated English sources, and 10 updated translation sources.

      FMA (Foundation Model of Anatomy) is a reference ontology for the domain of anatomy and makes available anatomical information in symbolic form.

      MEDCIN, developed by Medicomp Systems, is a medical terminology that encompasses symptoms, history, tests, diagnoses, physical   examinations, and therapy.

      MDRCZE (Medical Dictionary for Regulatory Activities Terminology (MedDRA), Czech Edition)

As translation sources are updated, we continue to attempt to represent them as closely as possible to the English version. This includes using the same term types and creating the same relationships in the translation source. If there are concepts missing from the translation source that would cause gaps in the hierarchy, those gaps are filled in with the English language version of the missing concept. For 2008AB, affected sources are MSHJPN and MSHSWE.

For more detailed information about each source:

A. General notes/comments

We only inverted English and Latin-language terms, both with LAT=ENG; we create a LANGUAGE attribute (sg_type=SRC_ATOM_ID) with value "Latin" for the Latin terms. We did not process other non-English terms, since they occur in relatively small numbers:

Count	Language Value
4650	French
491	Spanish
361	German
70	Filipino
52	Italian

For the most part, we only inverted the data in the "instances.fma.pins" file, because most of the data in the "classes.fma.pons" file is actually meta-data, such as the data types of the various slots each instance may have.

However, to get the hierarchy, we used the Class -> Parent-class ("is-a") relationships from the "classes" file rather than the Instance -> Class "is-a" relationships from the "instances" file because, although about 90% of the time these two relationships duplicate each other, the other 10% are meaningful only in the "classes" data.

Also, while there are some other relationships (represented as instance slots) besides these is-a rels that could also be considered hierarchical (e.g. "regional_part_of"), these were so incomplete and complex that we decided to invert them only as relationships, not as additional hierarchies.

There are 2005 classes that have a "comment" field, and a few (203)concept-instances that are referenced by the ":ANNOTATED-INSTANCE" slot of a separate ":INSTANCE-ANNOTATION" instance, which is also like a comment, and which sometimes duplicates the "comment" field of the referenced instance's class; currently, neither of these is being inverted. Here is one example of this: the concept-instance for Clavicle is referenced by an :INSTANCE-ANNOTATION with the following value in the ":ANNOTATION-TEXT" slot:

"Surg Radiol Anat. 1989;11(3):211-4. The arterial supply of the clavicle - Knudsen FW, Andersen M, Krag C.- Department of Plastic Surgery, Gentofte Hospital, University of Copenhagen, Denmark.\n\nThis report based on delineation of the arterial system with 3 component plastic material on 10 human cadavers describes the arterial supply to the clavicle. The study was performed in 2 parts. One part, which showed the total arterial supply to the clavicle and one part with selective injections of the relevant arteries, with the intention of finding a central nutrient arterial supply to the clavicle. Three arteries were found to supply the clavicle: the suprascapular a.; the thoracoacromial a.; and the internal thoracic (mammary) a. The main supply was primarily periosteal. No nutrient artery was found."

B. Mapping of source data:

For each field/piece of data in the source files, explain where it will end up in the inversion. Note any data that is being ignored.

Slot names are mapped to UMLS TTY, ATN (sg_type=ROOT_SOURCE_CUI or SRC_REL_ID for relationship attributes), and RELA (sg_type=ROOT_SOURCE_CUI) values as follows, as specified in the etc/fma.cfg file:

Slot                    TTY

----------------------  ---

Preferred+name          PT

Synonym                 SY

Non-English+equivalent  SY [names with Language=Latin only]

Slot                    ATN

----------------------  ----------------------------

adjacent                ADJACENT

anatomical%2Farbitrary  ANATOMICAL_OR_ARBITRARY

cell+appendage+type     CELL_APPENDAGE_TYPE

cell+layer              CELL_LAYER

chromosome+pair+number  CHROMOSOME_PAIRS_PER_NUCLEUS

connected+to            CONNECTED_TO

connection+type         CONNECTION_TYPE

contact+type            CONTACT_TYPE

coordinate              COORDINATE

definition              DEFINITON

dimension               DIMENSION

has+boundary            HAS_BOUNDARY

has+mass                HAS_MASS

has+shape+type          SHAPE_TYPE

laterality              LATERALITY

muscle+insertion        MUSCLE_INSERTION

muscle+origin           MUSCLE_ORIGIN

partition               PARTITION

polarity                POLARITY

shared%2Funshared       SHARED_OR_UNSHARED

state+of+determination  STATE_OF_DETERMINATION

view                    VIEW

Slot                             RELA

-------------------------------  ---------------------

adjacent+to                      adjacent_to

afferent+to                      afferent_to

arterial+supply+of               arterial_supply_of

arterial+supply                  has_arterial_supply

attaches+to                      attaches_to

attributed+constitutional+part   has_attributed_constitutional_part

attributed+continuous+with       attributed_continuous_with

attributed+part                  has_attributed_part

attributed+regional+part         has_attributed_regional_part

bounded+by                       bounded_by

bounds                           bounds

branch+%28continuity%29          has_continuation_branch

branch+of                        branch_of

branch                           has_branch

cell+connectivity                has_cell_connecting_part

cell+shape                       has_cell_shape

cell+surface+specialization      has_cell_surface_specialization

constitutional+part+of           constitutional_part_of

constitutional+part              has_constitutional_part

contained+in                     contained_in

contains                         contains

continuous+with+distally         continuous_with_distally

continuous+with+proximally       continuous_with_proximally

continuous+with                  continuous_with

develops+from                    develops_from

efferent+to                      efferent_to

epithelial+morphology            has_eipthelial_cell_shape

fascicular+architecture          has_fascicular_architecture

germ+origin                      has_germ_origin

gives+rise+to                    gives_rise_to

has+shape                        has_shape

homonym+for                      homonym_for

inherent+3-D+shape               has_inherent_3d_shape

location                         has_location

lymphatic+drainage+of            lymphatic_drainage_of

lymphatic+drainage               has_lymphatic_drainage

member+of                        member_of_cluster

member                           has_member

muscle+attachment                has_muscle_attachment

muscle+insertion                 has_muscle_insertion

muscle+origin                    has_muscle_origin

nerve+supply+of                  nerve_supply_of

nerve+supply                     has_nerve_supply

orientation                      has_orientation

origin+of                        origin_of

physical+state                   has_physical_state

primary+segmental+supply+of      primary_segmental_supply_of

primary+segmental+supply         has_primary_segmental_supply

receives+attachment              receives_attachment

receives+input+from              receives_input_from

input+from  [used only once]     receives_input_from

regional+part+of                 regional_part_of

regional+part                    has_regional_part

secondary+segmental+supply+of    secondary_segmental_supply_of

secondary+segmental+supply       has_secondary_segmental_supply

segmental+composition+of         segmental_composition_of

segmental+composition            has_segmental_composition

segmental+supply+of              segmental_supply_of

segmental+supply                 has_segmental_supply

sends+output+to                  sends_output_to

surrounded+by                    surrounded_by

surrounds                        surrounds

systemic+part+of                 systemic_part_of

systemic+part                    has_systemic_part

tributary+of                     tributary_of

tributary                        has_tributary

venous+drainage+of               venous_drainage_of

venous+drainage                  has_venous_drainage

C. META UI fields:

Indicate what source data (if any) is being used to populate the following fields:

CODE: FMAID
SAUI: (blank)
SCUI: FMAID
SDUI: (blank)

There were 27 concepts that didn't have an explicit name in the instances file, so we created a "cleansed" form (with "+" characters translated to blanks) of their instance name as their PT atom. This was necessary because without these concepts, there would be "holes" in their hierarchy. It also represents what the Protege browser does automatically when a nameless concept is viewed.

There were 27 concepts that lack an explicit name in the instances File. NLM generated names for these based on their instance names.

General notes/comments:

1. There is one RELATIONSHIPTYPE value, "Grade" (103421006), that is not used as a RELATIONSHIPTYPE in SNOMEDCT. The 3 relationships that use this value are not represented.

2. There are 15 complete MEDCIN concepts (including concept IDs, descriptions,and hierarchical positions) that seem to be end-of-file markers, copyright info, etc. These all have the form "**<concept>**":

    1|**-copyright-1984-05-by-Medicomp-Systems,-Inc.-** (symptom)
    2|**-msi-** (symptom)
    1098|**-mvi-** (symptom)
    1267|**-end-of-symptom-file-** (symptom)
    3411|**Medicomp-Systems-14500 Avion Parkway-Chantilly,VA-20151 (history)
    3468|**copyright 1984-2005, Medicomp Systems inc, all rights reserved (history)
    9199|**-end-of-physical-findings-file-** (physical finding)
    12000|**-msi-** (procedure)
    13255|**-msi-** (procedure)
    17892|**-end-of-test-file-** (procedure)
    30000|**-copyright_1984-2005_Medicomp_Systems,_inc._all_rights_reserved-* (diagnosis)
    33716|**14500 Avion Parkway-Suite 175, Chantilly, VA 20151-** (diagnosis)
    33717|**-end-of-disease-file-** (diagnosis)
    41813|**copyright 1984-2005, Medicomp Systems inc-all rights reserved (treatment)
    41814|**-end-of-therapy-file-** (treatment)

There is also a concept, complete with ID and hierarchical position, whose full concept name is "[see also: specific organ system] (treatment)". This is treed under "transfusions, transplantation (treatment)".

These metadata concepts are included as part of MEDCIN.

3. There are various other concepts ending with "[bracketed]" notes of various sorts (preceeding the parenthesized "domain" which occurs at the end of every fully-specified concept name). We represented these terms as they were supplied.

4. Mapping of source data:

UMLS_MEDCIN_CONCEPTS.txt:
MEDCINID: represented as Source CUI (SCUI) and CODE
CONCEPT_DESCRIPTION: represented as atom name (TTY=FN)

UMLS_MEDCIN_DESCRIPTIONS.txt:
MEDCINID: represented as Source CUI (SCUI) and CODE
DESCRIPTION: represented as atom name
PREF_FLAG_ID: represented as an attribute; determines TTY (0=SY, 1=PT)

UMLS_MEDCIN_HIERARCHY.txt:
MEDCINID: represented as ID for context attributes
NODEKEY: used to generate concept tree position for contexts

UMLS_MEDCIN_SNOMED.txt (SNOMED mapping relationships):
MEDCINID: represented as id_1
RELATIONSHIPTYPE: mapped to values used as relationship_name and relationship_attribute
SCT_CONCEPTID: represented as id_2
PREF_FLAG_ID: represented as a relationship attribute (RELA)

-----------------------------------------------

Source: Gene Ontology
VSAB: GO2008_04_01
status: update
prev. ver.: GO2007_02_01

1) New term type (TTY):
      ET
      OET (obsolete)
      MTH_ET

Discussion: Previously, the TTYs were assigned based on the information
in the “synonym” tag, which indicated whether the “synonym”; was BROAD, NARROW,
RELATED, or EXACT. However, for consistency, these were changed to ET or
OET. The relationship between the entry term and its preferred term (PT or OP)
is represented in MRREL.RRF.

2) Dropped term type (TTY):
      BSY
      MTH_BSY
      MTH_NSY
      MTH_RLS
      NSY
      OBS
      ONS
      ORS
      RLS

3) New attribute name (ATN):
      DISJOINT_FROM
      SYN_QUALIFIER

4) Dropped attribute name (ATN):
      none

5) New relationship|relationship attribute (RELA)| RELA inverse:
      RO|negatively_regulates|negative_regulated_by
      RO|regulates|regulated_by
      RO|positively_regulates|positively_regulated_by
      RQ|replaced_by|replaces
      RQ|consider|consider_from

6) Dropped relationship|relationship attribute (RELA):
      none

--------------------------------------------

Source: Gold Standard Alchemy
VSAB: GS_2008_08_11
status: update
prev. ver.: GS_2008_01_08

See RXNORM_08AA_080902F

--------------------------------------------

Source: HUGO Gene Nomenclature
VSAB: HUGO2008_03
status: update
prev. ver.: HUGO2007_01

1) New term type (TTY):
      SYN

Discussion: In the previous version of the data, the value in the 'Alias'
field was assigned the term type of SYM. For this version, SYM was changed
to SYN.

2) Dropped term type (TTY):
      SYM

3) New attribute name (ATN):
      none

4) Dropped attribute name (ATN):
      none

5) New relationship/relationship attribute (RELA):

Discussion: It was determined that the “SY|expanded_form_of” relationship between the PT and ACR was backwards. To resolve, the relationships were flipped in the database to indicate that the PT is the expanded version of the ACR.

6) Dropped relationship|relationship attribute (RELA):
      none

--------------------------------------------

Source: ICD-9-CM
VSAB: ICD9CM_2009
status: update
prev. ver.: ICD9CM_2008

no changes

----------------------------------------------

Source: Logical Observation Identifier Names and Codes (LOINC)
VSAB: LNC224
status: update
prev. ver.: LNC222

1) New term type (TTY):
      none

2) Dropped term type (TTY):
      none

3) New attribute name (ATN):
      LSU

4) New attribute value (ATV):

   New class names:
      ATTACH.GENERAL
      ATTACH.REHAB.PULM
      MOLPATH.GENERAL
      PANEL.MISC
      PANEL.SURVEY.BIMS
      PANEL.SURVEY.CAM
      PANEL.SURVEY.NMMDS
      SURVEY.NMMDS

Discussion: New class names were added in this version. The class names are
represented as the value (ATV) for the LCL attribute name and are also used
to build the hierarchy.

5) Dropped attribute name (ATN):
      none

6) New relationship/relationship attribute (RELA):
      none

7) Dropped relationship|relationship attribute (RELA):
      none

8) Wrong year on BRADEN subsource
      VSAB was corrected to LNC*_BRADEN_1988 from LNC*_BRADEN_1998.

9) Updated subsources:
      LNC224_MDS20
      LNC224_OASIS_2002
      LNC224_PHQ_9_1999
      LNC224_BRADEN_1988
      LNC224_FLACC_1997
      LNC224_WHO_2006

-----------------------------------------------

Source: The Braden Scale for Predicting Pressure Sore Risk
VSAB: LNC224_BRADEN_1988
status: update
prev. ver.: LNC222_BRADEN_1998

See LNC224.

-----------------------------------------------

Source: The Faces, Legs, Activity, Cry, and Consolability (FLACC) Scale
VSAB: LNC224_FLACC_1997
status: update
prev. ver.: LNC222_FLACC_1997

See LNC224

-----------------------------------------------

Source: Minimum Data Set
VSAB: LNC224_MDS20
status: update
prev. ver.: LNC222_MDS20

See LNC224

-----------------------------------------------

Source: Outcome and Assessment Information Set
VSAB: LNC224_OASIS_2002
status: update
prev. ver.: LNC222_OASIS_2002

See LNC224

-----------------------------------------------

Source: Patient Health Questionnaire
VSAB: LNC224_PHQ_9_1999
status: update
prev. ver.: LNC222_PHQ_9_1999

See LNC224

-----------------------------------------------

Source: Patient Monitoring Guidelines for HIV care and antiretroviral therapy       (ART)
VSAB: LNC224_WHO_2006
status: update
prev. ver.: LNC222_WHO_2006

See LNC224

-----------------------------------------------

Source: Master Drug Data Base
VSAB: MDDB_2008_08_06
status: update
prev. ver.: MDDB_2008_01_03

See RXNORM_08AA_080902F

-----------------------------------------------

Source: Medical Dictionary for Regulatory Activities Terminology (MedDRA)
VSAB: MDR11_0
status: update
prev. ver.: MDR10_1

1) New term type (TTY):
      AB

Discussion: Organ System abbreviations were previously represented as
ATN=MSA. They are now atoms assigned to the TTY=AB.

2) Dropped term type (TTY):
      none

3) New attribute name (ATN):
      none

4) Dropped attribute name (ATN):
      MSA

5) New relationship|relationship attribute (RELA)|RELA inverse:
      SY|expanded_form_of|expanded_form_of

Discussion: This is the relationship between the OS and AB terms.

6) Dropped relationship|relationship attribute (RELA):
      none

7) Translation updates:
      MDRCZE11_0
      MDRDUT11_0
      MDRFRE11_0
      MDRGER11_0
      MDRITA11_0
      MDRJPN11_0
      MDRPOR11_0
      MDRSPA11_0

-----------------------------------------------

Source: Medical Dictionary for Regulatory Activities Terminology (MedDRA),
      Czech Edition
VSAB: MDRCZE11_0
status: new source

See MDR11_0

-----------------------------------------------

Source: Medical Dictionary for Regulatory Activities Terminology (MedDRA),
      Dutch Edition
VSAB: MDRDUT11_0
status: update
prev. ver.: MDRDUT10_1

See MDR11_0

-----------------------------------------------

Source: Medical Dictionary for Regulatory Activities Terminology (MedDRA),
      French Edition
VSAB: MDRFRE11_0
status: update
prev. ver.: MDRFRE10_1

See MDR11_0

-----------------------------------------------

Source: Medical Dictionary for Regulatory Activities Terminology (MedDRA),
      German Edition
VSAB: MDRGER11_0
status: update
prev. ver.: MDRGER10_1

See MDR11_0
-----------------------------------------------

Source: Medical Dictionary for Regulatory Activities Terminology (MedDRA),
      Italian Edition
VSAB: MDRITA11_0
status: update
prev. ver.: MDRITA10_1

See MDR11_0

-----------------------------------------------

Source: Medical Dictionary for Regulatory Activities Terminology (MedDRA),
      Japanese Edition
VSAB: MDRJPN11_0
status: update
prev. ver.: MDRJPN10_1

See MDR11_0

-----------------------------------------------

Source: Medical Dictionary for Regulatory Activities Terminology (MedDRA),
      Portuguese Edition
VSAB: MDRPOR11_0
status: update
prev. ver.: MDRPOR10_1

See MDR11_0

-----------------------------------------------

Source: Medical Dictionary for Regulatory Activities Terminology (MedDRA),
      Spanish Edition
VSAB: MDRSPA11_0
status: update
prev. ver.: MDRSPA10_1

See MDR11_0

-----------------------------------------------

Source: MedlinePlus Health Topics
VSAB: MEDLINEPLUS_20080614
status: update
prev. ver.: MEDLINEPLUS_20040814

1) New term type (TTY):
      HT
      SY

2) Dropped term type (TTY):
      none

3) New attribute name (ATN):
      none

4) Dropped attribute name (ATN):
        none

5) New relationship|relationship attribute (RELA)|RELA inverse:
        RQ|
        RO|
        RO|associated_with|associated_with
        RO|related_to|related_to
        SY|

The relationship between the Medical Topic Entry terms (from SeeRefs)
and the Preferred Term was changed to 'RQ|' from 'RQ|mapped_to'.

6) Dropped relationship|relationship attribute (RELA):
      RB|

-----------------------------------------------

Source: Multum MediSource Lexicon
VSAB: MMSL_2008_08_01
status: update
prev. ver.: MMSL_2008_01_01

See RXNORM_08AA_080902F

-----------------------------------------------

Source: Micromedex DRUGDEX
VSAB: MMX_2008_08_04
status: update
prev. ver.: MMX_2008_01_02

See RXNORM_08AA_080902F

-----------------------------------------------

Source: Medical Subject Headings (MeSH)
VSAB: MSH2009_2008_08_06
status: update
prev. ver.: MSH2008_2008_02_04

1) New term type (TTY):
      none

2) Dropped term type (TTY):
        none

3) New attribute name (ATN):
      none

4) Dropped attribute name (ATN):
      none

5) New relationship/relationship attribute (RELA):
      none

6) Dropped relationship|relationship attribute (RELA):
      none

7) Translation updates:
      MSHJPN2008
      MSHSWE2008

-----------------------------------------------

Source: Japanese translations of the Medical Subject Headings (MeSH)
VSAB: MSHJPN2008
status: update
prev. ver.: MSHJPN2005

1) New term type (TTY):
      PT

Discussion: For each English term and its MUI, multiple Japanese terms are provided. The first Japanese string is considered the preferred term (PT) and all remaining strings are assigned the TTY=SY. These strings have the same DUI as the English MUI.

2) Dropped term type (TTY):
      MH

3) New attribute name (ATN):
      none

4) Dropped attribute name (ATN):
        none

5) New relationship|relationship attribute (RELA)|RELA inverse:
      RB|
RB|inverse_isa|isa
RB|mapped_from|mapped_to
RN|
RO|
RO|entry_combination_of|has_entry_combination

6) Dropped relationship|relationship attribute (RELA):
        none

7) Hierarchy new for this version.

-----------------------------------------------

Source: Swedish Translation of MeSH
VSAB: MSHSWE2008
status: update
prev. ver.: MSHSWE2007

1) New term type (TTY):
      SY

2) Dropped term type (TTY):
      ET

3) New attribute name (ATN):
      none

4) Dropped attribute name (ATN):
      none

5) New relationship|relationship attribute (RELA)|RELA inverse:
      RB|inverse_isa|isa
      RB|mapped_from|mapped_to
      RN|
      RO|
      RO|entry_combination_of|has_entry_combination

Discussion: As translation sources are updated, we continue to attempt to represent them as closely as possible to the English version. This includes using the same term types and creating the same relationships in the translation source.

6) Dropped relationship|relationship attribute (RELA):
      none

-----------------------------------------------

Source: Metathesaurus FDA National Drug Code Directory
VSAB: MTHFDA_2008_08_04
status: update
prev. ver.: MTHFDA_2008_01_04

See RXNORM_08AA_080902F

-----------------------------------------------

Source: Metathesaurus additional entry terms for ICD-9-CM
VSAB: MTHICD9_2009
status: update
prev. ver.: MTHICD9_2008

no changes

----------------------------------------------

Source: Metathesaurus FDA Structured Product Labels
VSAB: MTHSPL_2008_08_26
status: update
prev. ver.: MTHSPL_2008_01_23

See RXNORM_08AA_080902F

----------------------------------------------

Source: NCBI Taxonomy
VSAB: NCBI2008_05_07
status: update
prev. ver.: NCBI2007_07_02

no changes

-----------------------------------------------

Source: NCI Thesaurus
VSAB: NCI2008_05D
status: update
prev. ver.: NCI2007_05E

1) New term type (TTY):
      CRCHPT
      CRCHSY
      DICOMPT
      ICHAB
      ICHPT
      ICHSY
      NCI-HL7AB (Health Level 7)
      NCI-HL7PT
      NCI-HL7SY
      UCUMAB (Unified Code for Units of Measure)
      UCUMPT
      UCUMSY

Discussion: New subsources have been added for this version.

2) Dropped term type (TTY):
      none

3) New attribute name (ATN):
      CHEMICAL_FORMULA
      ESSENTIAL_AMINO_ACID
      ESSENTIAL_FATTY_ACID
      INFOODS
      MACRONUTRIENT
      MICRONUTRIENT
      NUTRIENT
      TOLERABLE_LEVEL
      UNIT
      USDA_ID
      US_RECOMMENDED_INTAKE

4) Dropped attribute name (ATN):
      none

5) New relationship/relationship attribute (RELA):
      none

6) Dropped relationship|relationship attribute (RELA):
        none

-----------------------------------------------

Source: First DataBank NDDF Plus Source Vocabulary
VSAB: NDDF_2008_08_08
status: update
prev. ver.: NDDF_2008_01_04

See RXNORM_08AA_080902F

-----------------------------------------------

Source: National Drug File - Reference Terminology Public Inferred Edition
VSAB: NDFRT_2008_03_11
status: update
prev. ver.: NDFRT_2004_01

1) New term type (TTY):
      AB
      FN
      PT

2) Dropped term type (TTY):
      CD
      CDC
      DF
      DI
      IN
      INP
      MOA
      PE
      PK

3) New attribute name (ATN):
      DRUG_CLASS_TYPE
      MESH_NAME
      NCI_PT
      NDFRT_KIND
      NUI
      RXNORM_CUI
      RXNORM_NAME
      RXNORM_PTT
      SNOMED_MAPID
      SPL_PL_MAPID
      UMLS_CUI
      UMLS_PTT
      UPN
      VA_NDF_TYPE
      VUID

4) Dropped attribute name (ATN):
      CRIT_INTERACT_WITH
      DDF
      DRT
      EXCLUDE_DI_CHECK
      LAST_REVIEWED
      NDF_GCN_SEQ_NUMBER
      NDF_TRANSMIT_TO_CMOP
      NFI
      PRN
      RXNORM_SCD
      RXNORM_SCDC
      SIGNIF_INTERACT_WITH
      SNGL_OR_MULT_SRC_PRD
      VA_CLASS_NAME
      VA_DISPENSE_UNIT
      VA_GENERIC_NAME
      VMO

5) New relationship|relationship attribute (RELA)|RELA inverse:
      RO|active_metabolites_of|has_active_metabolites
      RO|chemical_structure_of|has_chemical_structure
      RO|contraindicated_drug|contraindicated_drug
      RO|contraindicating_class_of|has_contraindicating_class
      RO|contraindicating_mechanism_of_action_of|has_contraindicating_mechanism_of_action
      RO|contraindicating_physiologic_effect_of|has_contraindicating_physiologic_effect
      RO|dose_form_of|has_dose_form
      RO|encoded_by|encodes_for
      RO|induced_by|induces
      RO|ingredient_of|has_ingredient
      RO|mapped_from|mapped_to
      RO|may_be_diagnosed_by|may_diagnose
      RO|may_be_prevented_by|may_prevent
      RO|may_be_treated_by|may_treat
      RO|may_inhibit_effect_of|effect_may_be_inhibited_by
      RO|mechanism_of_action_of|has_mechanism_of_action
      RO|metabolic_site_of|site_of_metabolism
      RO|metabolizes|metabolized_by
      RO|pharmacokinetics_of|has_pharmacokinetics
      RO|physiologic_effect_of|has_physiologic_effect
      RO|va_product_component_2_of|has_va_product_component_2
      RO|va_product_component_of|has_va_product_component
      RO|va_secondary_drug_class_of|has_va_secondary_drug_class
      RO|variant_of|has_variant
      SY|has_print_name|print_name_of

6) Dropped relationship|relationship attribute (RELA):
      RN|isa
      RO|
      RO|contraindicated_with
      RO|drug_contraindicated_for

7) Definitions
      Definitions are included in MRDEF.RRF.

-----------------------------------------------

Source: RXNORM Vocabulary
VSAB: RXNORM_08AA_080902F
status: update
prev. ver.: RXNORM_07AC_080131F

1) New term type (TTY):
      AB

2) Dropped term type (TTY):
      none

3) New attribute name (ATN):
        LABEL_TYPE
        UNII_CODE

4) Dropped attribute (ATN):
      PRN

5) New relationship|relationship attribute (RELA)|RELA inverse:
      RB|contained_in|contains
      RO|print_name_of|has_print_name

6) Dropped relationship|relationship attribute (RELA):
      none

7) This release contains updates to the following subsources:

      GS_2008_08_11 (Gold Standard Alchemy)
      MDDB_2008_08_06 (Master Drug Data Base. Medi-Span, a division of Wolters Kluwer Health)
      MMSL_2008_08_01 (Multum MediSource Lexicon)
      MMX_2008_08_04 (Micromedex DRUGDEX)
      MTHFDA_2008_08_04 (FDA National Drug Code Directory)
      MTHSPL_2008_08_26 (FDA Structured Product Labels)
      NDDF_2008_08_08 (First DataBank NDDF Plus Source Vocabulary)
      VANDF_2008_08_11 (Veterans Health Administration National Drug File)
      SNOMEDCT_2008_07_31 (SNOMED Clinical Terms (drug information). SNOMED International)

---------------------------------------------

Source: SNOMED Clinical Terms, Spanish Edition
VSAB: SCTSPA_2008_04_30
status: update
prev. ver.: SCTSPA_2007_10_31

1) New term type (TTY):
      none

2) Dropped term type (TTY):
        none

3) New attribute name (ATN):
      none

4) Dropped attribute name (ATN):
        none

5) New relationship|relationship attribute (RELA)|RELA inverse:
      RO|has_surgical_approach|surgical_approach_of

6) Dropped relationship|relationship attribute (RELA):
      RO|has_approach

Discussion: The concept “approach” has been replaced by the new
relationship concept “Surgical approach” from the SNOMEDCT_2008_01_31
release onwards.

7) SAUIs are no longer assigned to MTH_* term types.

---------------------------------------------------------------------

Source: SNOMED Clinical Terms
VSAB: SNOMEDCT_2008_07_31
status: update
prev. ver.: SNOMEDCT_2008_01_31

1) New term type (TTY):
      none

2) Dropped term type (TTY):
        none

3) New attribute name (ATN):
      none

4) Dropped attribute name (ATN):
        none

5) New relationship|relationship attribute (RELA)|RELA inverse:
      RO|refers_to|referred_to_by

Discussion: There is a new file in the SNOMEDCT release called
"References Table" which contains references from inactive components
to other equivalent or related components. These have been represented
using a ‘refers_to/referred_to_by ’ relationship.

6) Dropped relationship|relationship attribute (RELA):
      RN|was_a

-------------------------------------------------

Source: Veterans Health Administration National Drug File
VSAB: VANDF_2008_08_11
status: update
prev. ver.: VANDF_2007_12_18

See RXNORM_08AA_080902F

-------------------------------------------------

Last reviewed: 21 November 2008
Last updated: 21 November 2008
First published: 18 November 2008
Metadata| Permanence level: Permanent: Dynamic Content