Lange M, Inada Y, Buimovici-Klein E, Cooper LZ, Grieco MH; International Conference on AIDS.

Int Conf AIDS. 1992 Jul 19-24; 8: Mo22 (abstract no. MoC 0088).

St. Luke's-Roosevelt Hospital Center/Columbia University, NY, NY 10025.

OBJECTIVE: To report the 10 year status of a prospectively followed cohort of initially healthy gay male volunteers recruited between 11/81 & 12/82 in New York city. METHOD: Cohort members were followed twice a year from 1981 to 1987 and subsequently at annual intervals to 1992. Clinical and laboratory parameters were monitored as follows: total lymphocytes, CD4 & CD8 positive lymphocytes, acid-labile alpha interferon (AL IFN) serum p24 ag, tumor necrosis factor (TNF), Erythrocyte CR1 (complement 3b receptor) binding activity (E-CR1), erythrocyte direct Coombs tests for IgG, IgM and C3, as well as routine virus cultures from blood, semen, urine, throat, and rectum. RESULTS: Retrospective analysis indicated that of the initial 125 volunteers, 60 were HIV seropositive (HIV +ve) & 65 were HIV seronegative (HIV -ve) of whom 6 seroconverted during follow-up. Of 125 enrolled, 25 were lost to follow up. Of the remaining 100 62 were HIV +ve, & 38 HIV -ve. Of the 62 HIV +ve, 35 have developed AIDS; 30 have died and 27 remain alive & asymptomatic. Persistence of an asymptomatic stage had a high correlation with normal E-CR1 binding activity. Declining or absent E-CR1 binding, presence of triple positive direct Coombs test and appearance of a +ve serum AL-IFN bore a high relationship to clinical deterioration, rapid CD4 decline and development of clinical AIDS. Serum TNF and p24 ag levels did not correlate with clinical disease progression. CMV was persistently found in more than 50% of the cohort members, both HIV +ve and HIV -ve. The presence of +ve CMV cultures did not demonstrate a correlation with progression to AIDS. CONCLUSION: Among the 58.3% of HIV +ves who progressed to AIDS or death over the 10 years only E-CR1 binding, triple +ve Coombs & persistence of AL IFN were predictive for progression of CD4 decline and clinical disease.

Publication Types:

• Meeting Abstracts

Keywords:

• AIDS Vaccines
• Acquired Immunodeficiency Syndrome
• Antigens, CD4
• CD4-Positive T-Lymphocytes
• Disease Progression
• HIV
• HIV Antibodies
• HIV Antigens
• HIV Core Protein p24
• HIV Infections
• HIV Seropositivity
• Homosexuality
• Homosexuality, Male
• Humans
• Male
• New York
• New York City
• Receptors, Complement 3b
• immunology

Other ID:

• 92400041

UI: 102197754

From Meeting Abstracts