PAPPAS PG, MORGAN J, HAJJEH RA; The Transplant Associated Infection Surveillance Network (TRANSNET); Interscience Conference on Antimicrobial Agents and Chemotherapy (43rd: 2003: Chicago, Ill.).
Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 2003 Sep 14-17; 43: abstract no. M-1010.
University of Alabama at Birmingham, Birmingham, AL.
BACKGROUND: IFIs are a significant cause of morbidity and mortality in transplant recipients (TRs), but there are only limited data available in the U.S. on the burden and epidemiology of these infections. METHODS: We are conducting a prospective surveillance study to better describe the epidemiology of IFIs among TRs through a network of 25 participating transplant centers in the U.S. Only proven and probable IFIs, defined using the EORTC/MSG criteria, are included. RESULTS: Preliminary data reveal that between March 2001 and December 2002, 487 IFIs were identified, including 217 (46%) cases of invasive aspergillosis (IA), zygomycosis, and other molds; 209 (43%) invasive candidiasis (IC); 20 (4%) cryptococcosis (CC); 17 (3%) endemic mycoses (EM); 13 (2.7%) other yeasts; and 11 (2.3%) pneumocystosis (PCP). Median age was 48 years (range: <1 to 73yrs), 59% were male and 84% were white. Median time from transplant to IFI diagnosis was 84d, 149d, 200d, 279d, and 386d for IC, IA, PCP, CC, and EM, respectively. Of 212 IFIs in HSCTs, 149 (70%) cases were due to IA (median time to IFI diagnosis =128 d), zygomycosis and other molds. Of 274 IFIs in SOTs, 153 (56%) cases were due to IC. CC and EM occurred only in SOTs. Overall mortality at 3 mo following IFI diagnosis was 46% (36% for IC; 60% for IA and other molds), and was significantly higher in HSCTs than among SOTs (68% vs. 29%; p <0.001). CONCLUSIONS: These initial results highlight the significant epidemiologic and clinical features of IFIs among TRs, and will help to prioritize research efforts in developing new methods for earlier diagnosis, more effective prevention measures, and innovative therapeutic approaches. Ongoing surveillance and analysis of IFI in TRs will also provide critically important information on rates of individual IFIs and trends in their occurrence.
Publication Types:
Keywords:
- Aspergillosis
- Candidiasis
- Fungi
- Longitudinal Studies
- Male
- Mycoses
- Prospective Studies
- United States
- Zygomycosis
- epidemiology
- mortality
- transplantation
Other ID:
UI: 102264913
From Meeting Abstracts