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Pathology Tables for Peer Review
Pathology Tables for Peer Review
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INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) BENZYL ACETATE NTP Experiment-Test: 05120-04 Report: PEIRPT03 Study Type: CHRONIC Date: 09/16/94 Route: DOSED FEED Time: 03:33:00 Facility: Southern Research Institute Chemical CAS #: 140-11-4 Lock Date: None Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 05120-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC BENZYL ACETATE Date: 09/16/94 Route: DOSED FEED Time: 03:33:00 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0% .033% .1% .3% ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 60 60 60 60 Scheduled Sacrifice 10 10 10 10 Early Deaths Moribund Sacrifice 12 16 7 3 Natural Death 9 6 6 3 Survivors Terminal Sacrifice 29 28 37 44 Animals Examined Microscopically 60 60 60 60 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Gallbladder (60) (58) (58) (60) Dilatation 2 (3%) 1 (2%) Inflammation, Subacute 1 (2%) Intestine Large, Cecum (59) (60) (60) (58) Edema 1 (2%) Intestine Small, Duodenum (59) (58) (59) (59) Dilatation 1 (2%) Intestine Small, Ileum (58) (58) (59) (59) Hyperplasia, Lymphoid 1 (2%) Intestine Small, Jejunum (58) (60) (59) (59) Dilatation 1 (2%) Hyperplasia, Lymphoid 1 (2%) 2 (3%) Liver (60) (60) (60) (60) Angiectasis 2 (3%) 2 (3%) Basophilic Focus 4 (7%) 2 (3%) 5 (8%) Clear Cell Focus 2 (3%) 2 (3%) 2 (3%) Cyst 1 (2%) 1 (2%) Fibrosis 1 (2%) Hematopoietic Cell Proliferation 13 (22%) 7 (12%) 10 (17%) 1 (2%) Hemorrhage 1 (2%) Hyperplasia, Focal 2 (3%) 2 (3%) 2 (3%) Hyperplasia, Lymphoid 3 (5%) 5 (8%) 5 (8%) 2 (3%) Inflammation, Subacute 12 (20%) 4 (7%) 7 (12%) 13 (22%) Metaplasia, Osseous 1 (2%) Mineralization 1 (2%) 1 (2%) Mixed Cell Focus 2 (3%) 2 (3%) 1 (2%) Nuclear Alteration 3 (5%) Bile Duct, Hyperplasia 2 (3%) Centrilobular, Necrosis 1 (2%) Hepatocyte, Cytomegaly 1 (2%) Hepatocyte, Karyomegaly 1 (2%) Hepatocyte, Vacuolization Cytoplasmic 3 (5%) 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 05120-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC BENZYL ACETATE Date: 09/16/94 Route: DOSED FEED Time: 03:33:00 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0% .033% .1% .3% ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Kupffer Cell, Hyperplasia 7 (12%) 6 (10%) 11 (18%) 5 (8%) Kupffer Cell, Pigmentation 2 (3%) 5 (8%) 2 (3%) Lobules, Necrosis 7 (12%) 8 (13%) 4 (7%) 6 (10%) Mesentery (9) (7) (7) (3) Inflammation, Suppurative 3 (33%) 3 (43%) 4 (57%) 1 (33%) Capillary, Fat, Congestion 1 (33%) Fat, Necrosis 2 (22%) 2 (29%) 1 (14%) Pancreas (60) (60) (60) (59) Atrophy 4 (7%) 5 (8%) 2 (3%) Cyst 1 (2%) 4 (7%) 1 (2%) Focal Cellular Change 2 (3%) Hyperplasia, Lymphoid 4 (7%) 2 (3%) 8 (13%) 4 (7%) Necrosis 2 (3%) Acinar Cell, Cytoplasmic Alteration 8 (13%) 2 (3%) 3 (5%) Salivary Glands (60) (60) (60) (60) Atrophy 1 (2%) Hyperplasia, Lymphoid 11 (18%) 13 (22%) 13 (22%) 15 (25%) Stomach, Forestomach (59) (60) (60) (60) Diverticulum 2 (3%) 2 (3%) 2 (3%) Edema 1 (2%) 1 (2%) Inflammation, Subacute 4 (7%) 7 (12%) 2 (3%) Ulcer 2 (3%) Mucosa, Hyperplasia 8 (14%) 6 (10%) 9 (15%) 3 (5%) Stomach, Glandular (60) (60) (60) (60) Cyst 6 (10%) 3 (5%) 3 (5%) 2 (3%) Edema 1 (2%) 1 (2%) Erosion 4 (7%) 1 (2%) 1 (2%) Inflammation, Chronic 2 (3%) Inflammation, Subacute 1 (2%) 1 (2%) 1 (2%) Ulcer 1 (2%) Mucosa, Dysplasia 1 (2%) Tongue (60) (60) (60) (60) Inflammation, Chronic 1 (2%) 3 (5%) 2 (3%) Mineralization 1 (2%) Tooth (1) Dysplasia 1 (100%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Blood Vessel (2) (2) (5) Inflammation, Chronic Active 2 (100%) 2 (100%) 5 (100%) Heart (60) (60) (60) (60) Cardiomyopathy 1 (2%) 1 (2%) Thrombosis 1 (2%) Myocardium, Inflammation, Chronic 2 (3%) 2 (3%) Myocardium, Mineralization 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 3 NTP Experiment-Test: 05120-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC BENZYL ACETATE Date: 09/16/94 Route: DOSED FEED Time: 03:33:00 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0% .033% .1% .3% ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Gland, Cortex (60) (60) (60) (60) Accessory Adrenal Cortical Nodule 17 (28%) 6 (10%) 14 (23%) 14 (23%) Angiectasis 1 (2%) 1 (2%) Cyst 2 (3%) 2 (3%) Developmental Malformation 1 (2%) Hematopoietic Cell Proliferation 3 (5%) 2 (3%) 4 (7%) Hyperplasia, Diffuse 1 (2%) 1 (2%) Hyperplasia, Focal 1 (2%) 1 (2%) 1 (2%) Hypertrophy, Focal 1 (2%) 2 (3%) Inflammation, Subacute 1 (2%) Vacuolization Cytoplasmic, Focal 1 (2%) Capsule, Hyperplasia 1 (2%) 1 (2%) 5 (8%) 5 (8%) X-Zone, Degeneration, Fatty 1 (2%) 1 (2%) Adrenal Gland, Medulla (60) (60) (60) (60) Hyperplasia 2 (3%) 4 (7%) 5 (8%) 3 (5%) Islets, Pancreatic (60) (60) (60) (59) Hyperplasia 5 (8%) 1 (2%) Parathyroid Gland (56) (60) (57) (55) Cyst 2 (4%) 1 (2%) 1 (2%) Ectopic Thymus 1 (2%) 2 (4%) Hyperplasia 1 (2%) 1 (2%) Pituitary Gland (57) (56) (60) (59) Pars Distalis, Angiectasis 5 (9%) 4 (7%) 6 (10%) Pars Distalis, Cyst 1 (2%) 1 (2%) 1 (2%) Pars Distalis, Hyperplasia 18 (32%) 14 (25%) 15 (25%) 14 (24%) Pars Intermedia, Hyperplasia 1 (2%) Thyroid Gland (60) (60) (60) (60) Degeneration, Cystic 10 (17%) 9 (15%) 14 (23%) 13 (22%) Ectopic Thymus 2 (3%) 1 (2%) Inflammation, Subacute 1 (2%) Follicle, Cyst 5 (8%) 3 (5%) 2 (3%) 5 (8%) Follicular Cell, Hyperplasia 11 (18%) 10 (17%) 12 (20%) 17 (28%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM Tissue NOS (1) (1) (1) Infiltration Cellular, Lymphocyte 1 (100%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 4 NTP Experiment-Test: 05120-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC BENZYL ACETATE Date: 09/16/94 Route: DOSED FEED Time: 03:33:00 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0% .033% .1% .3% ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Clitoral Gland (1) (1) (1) Ectasia 1 (100%) Pigmentation 1 (100%) 1 (100%) Ovary (59) (58) (59) (59) Angiectasis 8 (14%) 8 (14%) 9 (15%) 5 (8%) Cyst 11 (19%) 14 (24%) 16 (27%) 17 (29%) Hemorrhage 1 (2%) 2 (3%) 1 (2%) 1 (2%) Inflammation, Suppurative 13 (22%) 7 (12%) 10 (17%) 4 (7%) Pigmentation 1 (2%) 2 (3%) Thrombosis 1 (2%) Interstitial Cell, Hyperplasia 4 (7%) 1 (2%) 1 (2%) Uterus (60) (59) (60) (60) Angiectasis 2 (3%) 2 (3%) 3 (5%) 3 (5%) Granuloma 1 (2%) 1 (2%) Hemorrhage 1 (2%) Hydrometra 1 (2%) 3 (5%) 4 (7%) 2 (3%) Hyperplasia, Cystic 56 (93%) 55 (93%) 58 (97%) 58 (97%) Inflammation, Suppurative 14 (23%) 6 (10%) 10 (17%) 6 (10%) Necrosis 1 (2%) 2 (3%) Endometrium, Pigmentation 1 (2%) 1 (2%) Epithelium, Metaplasia, Squamous 7 (12%) 8 (14%) 15 (25%) 7 (12%) Myometrium, Hyperplasia 1 (2%) 1 (2%) 1 (2%) Vagina (1) Granuloma 1 (100%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (60) (60) (60) (60) Hypercellularity 19 (32%) 11 (18%) 20 (33%) 8 (13%) Myelofibrosis 16 (27%) 12 (20%) 14 (23%) 15 (25%) Necrosis 1 (2%) Pigmentation, Hemosiderin 3 (5%) 2 (3%) 7 (12%) 4 (7%) Lymph Node (60) (60) (60) (59) Iliac, Angiectasis 1 (2%) Iliac, Hematopoietic Cell Proliferation 2 (3%) Iliac, Hyperplasia, Lymphoid 2 (3%) Iliac, Hyperplasia, Plasma Cell 2 (3%) 3 (5%) 1 (2%) Lumbar, Hyperplasia, Lymphoid 1 (2%) Lumbar, Hyperplasia, Plasma Cell 2 (3%) Mediastinal, Hyperplasia, Plasma Cell 5 (8%) 4 (7%) 2 (3%) Mediastinal, Inflammation, Suppurative 1 (2%) 2 (3%) Renal, Ectasia 1 (2%) Renal, Hematopoietic Cell Proliferation 2 (3%) 1 (2%) Renal, Hemorrhage 1 (2%) Renal, Hyperplasia, Lymphoid 3 (5%) 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 5 NTP Experiment-Test: 05120-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC BENZYL ACETATE Date: 09/16/94 Route: DOSED FEED Time: 03:33:00 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0% .033% .1% .3% ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - CONT Renal, Hyperplasia, Plasma Cell 5 (8%) 5 (8%) 3 (5%) 1 (2%) Lymph Node, Mandibular (60) (58) (60) (59) Hematopoietic Cell Proliferation 2 (3%) 1 (2%) 2 (3%) Hyperplasia, Lymphoid 5 (8%) 5 (9%) 5 (8%) Hyperplasia, Plasma Cell 6 (10%) 4 (7%) 1 (2%) 1 (2%) Pigmentation 1 (2%) 2 (3%) 1 (2%) Lymph Node, Mesenteric (60) (56) (59) (58) Angiectasis 2 (3%) 1 (2%) Ectasia 2 (3%) Hematopoietic Cell Proliferation 11 (18%) 5 (9%) 4 (7%) 2 (3%) Hemorrhage 7 (12%) 3 (5%) 5 (8%) 6 (10%) Hyperplasia, Lymphoid 3 (5%) 3 (5%) 3 (5%) 3 (5%) Hyperplasia, Plasma Cell 2 (3%) 1 (2%) Necrosis 1 (2%) Spleen (60) (60) (60) (59) Hematopoietic Cell Proliferation 27 (45%) 24 (40%) 27 (45%) 15 (25%) Hyperplasia, Reticulum Cell 2 (3%) Pigmentation, Hemosiderin 8 (13%) 7 (12%) 6 (10%) 2 (3%) Lymphoid Follicle, Atrophy 1 (2%) 1 (2%) 1 (2%) Lymphoid Follicle, Hyperplasia 4 (7%) 6 (10%) 6 (10%) 6 (10%) Red Pulp, Hyperplasia 3 (5%) 1 (2%) 1 (2%) 1 (2%) Thymus (55) (56) (56) (57) Angiectasis 4 (7%) 2 (4%) 1 (2%) Cyst 9 (16%) 3 (5%) 11 (20%) 13 (23%) Depletion Cellular 8 (15%) 9 (16%) 6 (11%) 2 (4%) Ectopic Parathyroid Gland 2 (4%) Hyperplasia, Lymphoid 3 (5%) 2 (4%) 2 (4%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (60) (59) (60) (60) Hyperplasia, Cystic 5 (8%) 4 (7%) 2 (3%) Hyperplasia, Lobular 1 (2%) 1 (2%) Skin (60) (60) (59) (60) Acanthosis 2 (3%) 1 (2%) 4 (7%) 3 (5%) Cyst Epithelial Inclusion 1 (2%) Inflammation, Chronic 3 (5%) 1 (2%) 3 (5%) 2 (3%) Ulcer 1 (2%) 1 (2%) Subcutaneous Tissue, Edema 2 (3%) 2 (3%) 2 (3%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 6 NTP Experiment-Test: 05120-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC BENZYL ACETATE Date: 09/16/94 Route: DOSED FEED Time: 03:33:00 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0% .033% .1% .3% ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Skeletal Muscle (60) (60) (60) (60) Foreign Body 1 (2%) Inflammation, Chronic 7 (12%) 2 (3%) 7 (12%) 1 (2%) Sarcolemmal Nuclei, Hyperplasia 1 (2%) 1 (2%) 4 (7%) Sarcoplasm, Atrophy 1 (2%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (60) (60) (60) (60) Compression 3 (5%) 3 (5%) 1 (2%) Cyst 1 (2%) Hydrocephalus 1 (2%) Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%) Vacuolization Cytoplasmic 1 (2%) 1 (2%) Glial Cell, Proliferation 1 (2%) Thalamus, Mineralization 38 (63%) 53 (88%) 47 (78%) 42 (70%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (60) (60) (60) (60) Adenomatosis 1 (2%) Bacterium 1 (2%) 1 (2%) 1 (2%) Congestion 1 (2%) Edema 1 (2%) 1 (2%) Hemorrhage 1 (2%) 6 (10%) 4 (7%) 4 (7%) Hyperplasia, Lymphoid 9 (15%) 7 (12%) 10 (17%) 14 (23%) Infiltration Cellular, Histiocyte 7 (12%) 4 (7%) 3 (5%) 1 (2%) Inflammation, Subacute 1 (2%) 3 (5%) Inflammation, Suppurative 2 (3%) Thrombosis 2 (3%) Alveolar Epithelium, Hyperplasia 1 (2%) 1 (2%) 1 (2%) Artery, Hypertrophy 1 (2%) 1 (2%) Bronchiole, Foreign Body 1 (2%) 3 (5%) 1 (2%) Nose (60) (60) (60) (60) Exudate 15 (25%) 26 (43%) 36 (60%) 45 (75%) Glands, Cyst 1 (2%) Glands, Hyperplasia, Cystic 47 (78%) 54 (90%) 59 (98%) 60 (100%) Mucosa, Atrophy 46 (77%) 57 (95%) 59 (98%) 60 (100%) Mucosa, Degeneration 58 (97%) 57 (95%) 60 (100%) 60 (100%) Mucosa, Pigmentation 53 (88%) 58 (97%) 58 (97%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 7 NTP Experiment-Test: 05120-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC BENZYL ACETATE Date: 09/16/94 Route: DOSED FEED Time: 03:33:00 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0% .033% .1% .3% ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (60) (60) (60) (60) Bacterium 1 (2%) 1 (2%) 1 (2%) Casts Protein 39 (65%) 39 (65%) 38 (63%) 31 (52%) Cyst 2 (3%) 2 (3%) 2 (3%) Glomerulosclerosis 7 (12%) 5 (8%) 1 (2%) Hydronephrosis 1 (2%) Hyperplasia, Lymphoid 28 (47%) 27 (45%) 22 (37%) 23 (38%) Inflammation, Suppurative 5 (8%) Metaplasia, Osseous 2 (3%) 2 (3%) Mineralization 2 (3%) 1 (2%) 3 (5%) Interstitial Tissue, Pigmentation 2 (3%) Renal Tubule, Atrophy 2 (3%) 1 (2%) 1 (2%) Renal Tubule, Cytoplasmic Alteration 1 (2%) Renal Tubule, Dilatation 6 (10%) 1 (2%) 2 (3%) Renal Tubule, Necrosis 1 (2%) 1 (2%) Renal Tubule, Pigmentation 1 (2%) 2 (3%) Renal Tubule, Regeneration 22 (37%) 9 (15%) 15 (25%) 14 (23%) Transitional Epithelium, Hyperplasia 1 (2%) Urinary Bladder (60) (59) (60) (60) Edema 1 (2%) 1 (2%) Hyperplasia, Lymphoid 24 (40%) 15 (25%) 22 (37%) 17 (28%) Inflammation, Chronic 1 (2%) Mucosa, Hyperplasia 2 (3%) a Number of animals examined microscopically at site and number of animals with lesion Page 8 NTP Experiment-Test: 05120-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC BENZYL ACETATE Date: 09/16/94 Route: DOSED FEED Time: 03:33:00 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0% .033% .1% .3% ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 60 60 60 60 Scheduled Sacrifice 10 10 10 10 Early Deaths Moribund Sacrifice 7 3 6 7 Natural Death 4 4 3 4 Survivors Terminal Sacrifice 39 43 41 39 Animals Examined Microscopically 60 60 60 60 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Gallbladder (57) (60) (58) (60) Cyst 1 (2%) Inflammation, Subacute 1 (2%) 1 (2%) Mucosa, Hyperplasia 1 (2%) 1 (2%) Intestine Large, Cecum (59) (58) (60) (58) Edema 1 (2%) Intestine Small, Ileum (58) (59) (60) (58) Hyperplasia, Lymphoid 1 (2%) 1 (2%) Inflammation, Chronic 1 (2%) Intestine Small, Jejunum (60) (59) (60) (59) Hyperplasia, Lymphoid 2 (3%) 1 (2%) 1 (2%) Liver (60) (60) (60) (60) Basophilic Focus 2 (3%) 2 (3%) 2 (3%) Clear Cell Focus 7 (12%) 4 (7%) 5 (8%) 2 (3%) Hematopoietic Cell Proliferation 2 (3%) 1 (2%) 1 (2%) Hyperplasia, Focal 2 (3%) 3 (5%) 1 (2%) Hyperplasia, Lymphoid 1 (2%) 1 (2%) Inflammation, Subacute 1 (2%) 3 (5%) 2 (3%) 3 (5%) Mixed Cell Focus 3 (5%) 2 (3%) 2 (3%) 2 (3%) Nuclear Alteration 1 (2%) 1 (2%) Thrombosis 1 (2%) Bile Duct, Hyperplasia 1 (2%) Centrilobular, Necrosis 1 (2%) 2 (3%) 1 (2%) 1 (2%) Hepatocyte, Cytomegaly 2 (3%) 1 (2%) Hepatocyte, Vacuolization Cytoplasmic 4 (7%) 1 (2%) 2 (3%) 2 (3%) Kupffer Cell, Hyperplasia 3 (5%) 2 (3%) 2 (3%) 4 (7%) Kupffer Cell, Pigmentation 1 (2%) 2 (3%) Lobules, Necrosis 4 (7%) 1 (2%) 2 (3%) 4 (7%) Mesentery (3) (3) (2) (1) Inflammation, Suppurative 1 (33%) Fat, Hemorrhage 1 (33%) Fat, Necrosis 2 (67%) 1 (33%) 2 (100%) a Number of animals examined microscopically at site and number of animals with lesion Page 9 NTP Experiment-Test: 05120-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC BENZYL ACETATE Date: 09/16/94 Route: DOSED FEED Time: 03:33:00 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0% .033% .1% .3% ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Pancreas (60) (60) (60) (60) Atrophy 2 (3%) 2 (3%) 2 (3%) Cyst 1 (2%) Focal Cellular Change 3 (5%) 2 (3%) 1 (2%) 1 (2%) Hyperplasia, Lymphoid 1 (2%) 1 (2%) Acinar Cell, Cytoplasmic Alteration 3 (5%) 2 (3%) 5 (8%) Acinar Cell, Hyperplasia, Focal 1 (2%) Pharynx (1) Ulcer 1 (100%) Salivary Glands (60) (60) (60) (60) Hyperplasia, Lymphoid 8 (13%) 4 (7%) 5 (8%) 7 (12%) Stomach, Forestomach (60) (60) (60) (60) Diverticulum 3 (5%) 3 (5%) Erosion 1 (2%) Inflammation, Subacute 3 (5%) 3 (5%) 3 (5%) 1 (2%) Mucosa, Hyperplasia 5 (8%) 4 (7%) 5 (8%) 3 (5%) Stomach, Glandular (60) (60) (60) (60) Cyst 5 (8%) 6 (10%) 2 (3%) 6 (10%) Erosion 3 (5%) Ulcer 1 (2%) Tongue (60) (60) (60) (60) Inflammation, Chronic 1 (2%) Epithelium, Degeneration, Ballooning 1 (2%) Tooth (3) (4) (1) (2) Dysplasia 3 (100%) 3 (75%) 1 (100%) 2 (100%) Inflammation, Chronic 1 (25%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Blood Vessel (1) (1) (2) (1) Inflammation, Chronic Active 1 (100%) 1 (100%) 2 (100%) 1 (100%) Heart (60) (60) (60) (60) Cardiomyopathy 2 (3%) Myocardium, Hemorrhage 1 (2%) Myocardium, Inflammation, Chronic 2 (3%) Myocardium, Mineralization 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Gland, Cortex (60) (60) (60) (60) Accessory Adrenal Cortical Nodule 9 (15%) 10 (17%) 8 (13%) 8 (13%) Angiectasis 1 (2%) 1 (2%) Cyst 1 (2%) Hyperplasia, Diffuse 1 (2%) Hyperplasia, Focal 7 (12%) 13 (22%) 8 (13%) 7 (12%) a Number of animals examined microscopically at site and number of animals with lesion Page 10 NTP Experiment-Test: 05120-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC BENZYL ACETATE Date: 09/16/94 Route: DOSED FEED Time: 03:33:00 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0% .033% .1% .3% ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - CONT Hypertrophy, Focal 29 (48%) 22 (37%) 23 (38%) 26 (43%) Vacuolization Cytoplasmic, Focal 5 (8%) 4 (7%) 2 (3%) 5 (8%) Capsule, Hyperplasia 11 (18%) 8 (13%) 9 (15%) 7 (12%) Adrenal Gland, Medulla (60) (60) (60) (60) Hyperplasia 2 (3%) 1 (2%) 1 (2%) Islets, Pancreatic (60) (60) (59) (60) Cyst 1 (2%) Hyperplasia 11 (18%) 13 (22%) 11 (19%) 4 (7%) Parathyroid Gland (52) (58) (55) (59) Cyst 1 (2%) 2 (3%) 2 (4%) Ectopic Thymus 1 (2%) Pituitary Gland (58) (59) (58) (57) Pars Distalis, Cyst 4 (7%) 1 (2%) 3 (5%) Pars Distalis, Hyperplasia 2 (3%) 1 (2%) 2 (3%) Pars Intermedia, Hyperplasia 1 (2%) Thyroid Gland (60) (60) (60) (60) Degeneration, Cystic 5 (8%) 4 (7%) 8 (13%) 8 (13%) Follicle, Cyst 6 (10%) 2 (3%) 3 (5%) 5 (8%) Follicular Cell, Hyperplasia 6 (10%) 8 (13%) 7 (12%) 2 (3%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Coagulating Gland (1) Dilatation 1 (100%) Epididymis (60) (60) (60) (60) Atypia Cellular 1 (2%) 1 (2%) 2 (3%) 2 (3%) Hypospermia 1 (2%) Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%) Spermatocele 1 (2%) Preputial Gland (38) (42) (35) (25) Atrophy 1 (3%) Ectasia 33 (87%) 40 (95%) 32 (91%) 24 (96%) Inflammation, Chronic 18 (47%) 25 (60%) 18 (51%) 11 (44%) Inflammation, Suppurative 3 (8%) 4 (10%) 1 (3%) Prostate (60) (60) (60) (60) Fibrosis 1 (2%) Hemorrhage 1 (2%) 1 (2%) 1 (2%) Inflammation, Chronic 1 (2%) 4 (7%) 1 (2%) Inflammation, Suppurative 1 (2%) Epithelium, Hyperplasia 1 (2%) Seminal Vesicle (60) (60) (60) (60) a Number of animals examined microscopically at site and number of animals with lesion Page 11 NTP Experiment-Test: 05120-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC BENZYL ACETATE Date: 09/16/94 Route: DOSED FEED Time: 03:33:00 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0% .033% .1% .3% ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM - CONT Depletion Cellular 1 (2%) Dilatation 1 (2%) 1 (2%) Fibrosis 1 (2%) Hemorrhage 1 (2%) Inflammation, Chronic 1 (2%) Testes (60) (60) (60) (60) Angiectasis 1 (2%) Granuloma Sperm 2 (3%) Mineralization 1 (2%) Seminiferous Tubule, Atrophy 1 (2%) 3 (5%) 6 (10%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (60) (60) (60) (60) Hypercellularity 8 (13%) 6 (10%) 3 (5%) 4 (7%) Necrosis 1 (2%) Pigmentation, Hemosiderin 2 (3%) 1 (2%) 2 (3%) Lymph Node (60) (60) (60) (60) Inguinal, Hyperplasia, Lymphoid 2 (3%) 1 (2%) Mediastinal, Hyperplasia, Lymphoid 1 (2%) Mediastinal, Hyperplasia, Plasma Cell 2 (3%) Lymph Node, Mandibular (58) (56) (60) (59) Depletion Cellular 1 (2%) Hyperplasia, Lymphoid 1 (2%) 3 (5%) 4 (7%) Hyperplasia, Plasma Cell 3 (5%) 1 (2%) 1 (2%) Pigmentation 2 (3%) Lymph Node, Mesenteric (58) (59) (60) (60) Angiectasis 1 (2%) Depletion Cellular 1 (2%) Ectasia 1 (2%) 1 (2%) Hematopoietic Cell Proliferation 3 (5%) 5 (8%) 8 (13%) 1 (2%) Hemorrhage 18 (31%) 24 (41%) 19 (32%) 23 (38%) Hyperplasia, Lymphoid 4 (7%) 5 (8%) 1 (2%) 4 (7%) Hyperplasia, Plasma Cell 1 (2%) 1 (2%) 1 (2%) Necrosis 1 (2%) Pigmentation 1 (2%) 1 (2%) Spleen (60) (60) (60) (60) Hematopoietic Cell Proliferation 13 (22%) 14 (23%) 9 (15%) 8 (13%) Hyperplasia, Reticulum Cell 1 (2%) Necrosis 1 (2%) Lymphoid Follicle, Atrophy 1 (2%) 1 (2%) 1 (2%) 3 (5%) Lymphoid Follicle, Hyperplasia 1 (2%) 1 (2%) 1 (2%) 3 (5%) Red Pulp, Atrophy 1 (2%) 1 (2%) 1 (2%) Red Pulp, Hyperplasia 1 (2%) Thymus (52) (55) (57) (54) Cyst 12 (23%) 12 (22%) 15 (26%) 10 (19%) a Number of animals examined microscopically at site and number of animals with lesion Page 12 NTP Experiment-Test: 05120-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC BENZYL ACETATE Date: 09/16/94 Route: DOSED FEED Time: 03:33:00 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0% .033% .1% .3% ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - CONT Depletion Cellular 4 (8%) 4 (7%) 4 (7%) 5 (9%) Ectopic Parathyroid Gland 1 (2%) Hyperplasia, Lymphoid 2 (4%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (60) (60) (60) (60) Acanthosis 2 (3%) 1 (2%) 2 (3%) Granuloma 1 (2%) Hemorrhage 1 (2%) Inflammation, Chronic 2 (3%) 1 (2%) Subcutaneous Tissue, Edema 1 (2%) 1 (2%) 1 (2%) 2 (3%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (60) (60) (60) (60) Dysplasia 1 (2%) Hyperostosis 2 (3%) Skeletal Muscle (60) (60) (60) (60) Inflammation, Chronic 1 (2%) 3 (5%) 2 (3%) Sarcolemmal Nuclei, Hyperplasia 1 (2%) 2 (3%) 1 (2%) 2 (3%) Sarcoplasm, Atrophy 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (60) (60) (60) (60) Compression 1 (2%) Ectopic Tissue 1 (2%) Hydrocephalus 1 (2%) Vacuolization Cytoplasmic 1 (2%) 1 (2%) Glial Cell, Proliferation 1 (2%) Thalamus, Mineralization 46 (77%) 48 (80%) 54 (90%) 47 (78%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (60) (60) (60) (60) Angiectasis 1 (2%) Congestion 1 (2%) Hemorrhage 2 (3%) 2 (3%) 5 (8%) Hyperplasia, Lymphoid 5 (8%) 2 (3%) 2 (3%) Infiltration Cellular, Histiocyte 7 (12%) 8 (13%) 8 (13%) 4 (7%) Inflammation, Suppurative 1 (2%) Thrombosis 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 13 NTP Experiment-Test: 05120-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC BENZYL ACETATE Date: 09/16/94 Route: DOSED FEED Time: 03:33:00 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0% .033% .1% .3% ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - CONT Alveolar Epithelium, Hyperplasia 1 (2%) 3 (5%) 6 (10%) 1 (2%) Nose (60) (60) (60) (60) Cyst 1 (2%) Developmental Malformation 1 (2%) Exudate 8 (13%) 18 (30%) 39 (65%) 31 (52%) Glands, Hyperplasia, Cystic 24 (40%) 46 (77%) 48 (80%) 60 (100%) Mucosa, Atrophy 30 (50%) 57 (95%) 60 (100%) 60 (100%) Mucosa, Degeneration 36 (60%) 55 (92%) 60 (100%) 60 (100%) Mucosa, Metaplasia, Squamous 1 (2%) Mucosa, Pigmentation 52 (87%) 60 (100%) 60 (100%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (3) (1) Inflammation, Chronic 3 (100%) 1 (100%) Cornea, Hyperplasia 3 (100%) 1 (100%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (60) (60) (60) (60) Casts Protein 10 (17%) 16 (27%) 13 (22%) 7 (12%) Cyst 21 (35%) 16 (27%) 16 (27%) 17 (28%) Glomerulosclerosis 1 (2%) 4 (7%) 1 (2%) 2 (3%) Hyperplasia, Lymphoid 18 (30%) 17 (28%) 15 (25%) 12 (20%) Inflammation, Suppurative 2 (3%) Mineralization 29 (48%) 48 (80%) 42 (70%) 38 (63%) Renal Tubule, Atrophy 6 (10%) 3 (5%) 5 (8%) 2 (3%) Renal Tubule, Dilatation 2 (3%) 1 (2%) 1 (2%) 2 (3%) Renal Tubule, Hyperplasia 2 (3%) 1 (2%) 1 (2%) Renal Tubule, Pigmentation 1 (2%) Renal Tubule, Regeneration 57 (95%) 51 (85%) 47 (78%) 51 (85%) Transitional Epithelium, Hyperplasia 1 (2%) 1 (2%) Urinary Bladder (60) (60) (60) (60) Dilatation 1 (2%) 1 (2%) Hyperplasia, Lymphoid 2 (3%) 2 (3%) 2 (3%) Inflammation, Chronic 1 (2%) Inflammation, Suppurative 2 (3%) Mucosa, Hyperplasia 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 14 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------
Web page last updated on November 11, 2004
The National Institute of Environmental Health Sciences is one of the National Institutes of Health within the U.S. Department of Health and Human Services. The National Toxicology Program is headquartered on the NIEHS campus in Research Triangle Park, NC.