US 7,351,527 B2
Immunizing fish against viral infection
Moshe Kotler, Mevasseret Zion (Israel); Arnon Dishon, Jerusalem (Israel); Janette Bishara Shieban, Haifa (Israel); Maya Ilouze, Jerusalem (Israel); Izhak Bejerano, Kibbutz Nir-David (Israel); Ayana Benet, Kibbutz Ein-Carmel (Israel); Nissim Chen, Givataiim (Israel); Marina Hutoran, Jerusalem (Israel); and Ariel Ronen, Jerusalem (Israel)
Assigned to Yissum Research Development Company of the Hebrew University of Jerusalem, Jerusalem (Israel); and Ministry of Agriculture and Rural Development Dept. of Fisheries and Aquaculture, Beit Dagan (Israel)
Filed on Jun. 30, 2005, as Appl. No. 11/170,793.
Application 11/170793 is a continuation in part of application No. PCT/IL03/001097, filed on Dec. 22, 2003.
Claims priority of application No. 153775 (IL), filed on Jan. 01, 2003.
Prior Publication US 2006/0013828 A1, Jan. 19, 2006
Int. Cl. C12Q 1/70 (2006.01); C12N 7/04 (2006.01); A61K 39/12 (2006.01)
U.S. Cl. 435—5  [435/236; 424/204.1] 20 Claims
 
1. An isolated avirulent form of a CV DNA virus that causes viral disease in fish, the CV DNA virus being a double stranded DNA virus having a capsid with a icosahedron morphology, the capsid being of about 90-110 nm in size as determined by electron microscopy, the DNA of the CV DNA virus having between about 250,000 and 300,000 base pairs.