Gene ID:TDE1112
DNA Molecule Name:
1
GenBank ID:
42526622
Gene Name:
adk
Definition:
adenylate kinase
Cellular Location:
Cytoplasm [Evidence]
Gene Start:
1147058
Gene Stop:
1147684
Gene Length:
651
Molecular Weight*:
24215
pI*:
Net Charge*:
EC:
2.7.4.3
Functional Class:
Purines, pyrimidines, nucleosides, and nucleotides; Purine ribonucleotide biosynthesis
Gene Ontology:
Pathway: pathway table
Purine metabolism
Secondary Evidence:
Munier-Lehmann H, Chenal-Francisque V, Ionescu M, Christova P, Foulon J, Carniel E, Barzu O.
Relationship between bacterial virulence and nucleotide metabolism: a mutation in the adenylate kinase gene renders Yersinia pestis avirulent.
Biochem J. 2003 Apr;Pt.
PMID: 12693989
Ferber DM, Haney PJ, Berk H, Lynn D, Konisky J.
The adenylate kinase genes of M. voltae, M. thermolithotrophicus, M. jannaschii, and M. igneus define a new family of adenylate kinases.
Gene. 1997 Feb;185(2):239-44.
PMID: 9055821
Feil E, Carpenter G, Spratt BG.
Electrophoretic variation in adenylate kinase of Neisseria meningitidis is due to inter- and intraspecies recombination.
Proc Natl Acad Sci U S A. 1995 Nov;92(23):10535-9.
PMID: 7479835
Comment:
View in HOMD Genome Viewer
Blast Summary: PSI-Blast Search
Top Blast Hits: Updated monthly
Click here to view the entire PsiBlast results.
COGS Summary: COGS Search
BeTs to clades of COG0563
COG name: Adenylate kinase and related kinases
Functional Class: F
The phylogenetic pattern of COG0563 is ao--k-yqvdrlbcefghsnujxitw
Number of proteins in this genome belonging to this COG is
Blocks Summary: Blocks Search
Significant hit ( 6.5e-58) to 4/4 blocks of the IPB000850 family, which is described as "Adenylate kinase". Interpro entry for IPR000850.
IPB000850A 4-36 2e-15
IPB000850B 76-90 7.1e-09
IPB000850C 110-140 3.2e-15
IPB000850D 155-181 3.9e-14
Significant hit ( 1.4e-05) to 1/4 blocks of the IPB003136 family, which is described as "Cytidylate kinase". Interpro entry for IPR003136.
IPB003136A 3-36 1.4e-05
ProDom Summary: Protein Domain Search
Residues 120 to 192 match (1e-14) PD:PD506373 which is described as KINASE PROTEOME ADENYLATE COMPLETE ATP-BINDING ATP-AMP TRANSPHOSPHORYLASE TRANSFERASE
Residues 4 to 63 match (2e-14) PD:PD000657 which is described as KINASE TRANSFERASE ADENYLATE ATP-BINDING ATP-AMP TRANSPHOSPHORYLASE PROTEOME COMPLETE ISOENZYME MITOCHONDRIAL
Residues 65 to 120 match (2e-10) PD:PD581534 which is described as KINASE ADENYLATE TRANSFERASE TRANSPHOSPHORYLASE ATP-BINDING ATP-AMP PROTEOME COMPLETE 3D-STRUCTURE CHLOROPLAST
Residues 68 to 158 match (9e-10) PD:PD516878 which is described as KINASE ADENYLATE ATP-BINDING ATP-AMP TRANSPHOSPHORYLASE TRANSFERASE
Residues 121 to 158 match (2e-09) PD:PD550362 which is described as KINASE TRANSFERASE ADENYLATE TRANSPHOSPHORYLASE ATP-AMP ATP-BINDING COMPLETE PROTEOME MITOCHONDRIAL MITOCHONDRION
Residues 1 to 63 match (6e-09) PD:PD501887 which is described as KINASE TRANSFERASE ATP-BINDING ATP-AMP ADENYLATE TRANSPHOSPHORYLASE PYRIMIDINE BIOSYNTHESIS DEOXYCYTIDYLATE PROTEOME
Residues 122 to 204 match (7e-09) PD:PD016477 which is described as KINASE PROTEOME ADENYLATE COMPLETE ATP-BINDING ATP-AMP TRANSPHOSPHORYLASE TRANSFERASE
Residues 6 to 62 match (1e-07) PD:PD540763 which is described as KINASE TRANSFERASE ADENYLATE ANON-DAK2 ISOENZYME POSSIBLE PROBABLE CG17146 ISOZYME F38B2.4
Residues 67 to 119 match (2e-07) PD:PD507519 which is described as KINASE ADENYLATE TRANSFERASE COMPLETE PROTEOME ATP-BINDING ATP-AMP TRANSPHOSPHORYLASE CDNA SIMILAR
Residues 67 to 120 match (2e-07) PD:PD574675 which is described as KINASE TRANSFERASE ADENYLATE ATP-AMP TRANSPHOSPHORYLASE ATP-BINDING COMPLETE PROTEOME ISOENZYME MYOKINASE
Residues 4 to 129 match (3e-07) PD:PD492888 which is described as FIS SIMILAR KINASE ADENYLATE WEAKLY KINASE CHLOROPLAST CDNA TRANSFERASE FLJ30976
Paralogs: Local Blast Search
Pfam Summary: Pfam Search
Residues 5 to 186 (E-value = 2.9e-78) place TDE1112 in the ADK family which is described as Adenylate kinase (PF00406)
Residues 122 to 157 (E-value = 7.1e-17) place TDE1112 in the ADK_lid family which is described as Adenylate kinase, active site lid (PF05191)
Top PDB Hits:
PDB hits to TDE1112 from Psi-BLAST round 5 vs. nr database
47.2% similar to PDB:1ZIN Adenylate Kinase With Bound Ap5a (1e-54)
47.2% similar to PDB:1ZIO Phosphotransferase (1e-54)
47.2% similar to PDB:1ZIP Bacillus Stearothermophilus Adenylate Kinase (1e-54)
42.3% similar to PDB:2AK2 Adenylate Kinase Isoenzyme-2 (3e-53)
42.3% similar to PDB:1AK2 Adenylate Kinase Isoenzyme-2 (3e-53)
44.6% similar to PDB:1AKE Adenylate Kinase (E.C.2.7.4.3) Complex With The Inhibitor Ap5a (Chain A,B; 1e-52)
44.6% similar to PDB:1ANK Adenylate Kinase (Adk) (E.C.2.7.4.3) (Chain A,B; 1e-52)
44.6% similar to PDB:4AKE Adenylate Kinase (Chain A,B; 1e-52)
44.1% similar to PDB:1E4V Mutant G10v Of Adenylate Kinase From E. Coli, Modified In The Gly-Loop (Chain A,B; 5e-51)
35.4% similar to PDB:2AK3 Adenylate Kinase Isoenzyme-3 (Gtp: Amp Phosphotransferase) (E.C.2.7.4.10) (Chain A,B; 4e-50)
Gene Protein Sequence:
MNCIFLGPPGAGKGTLAFEVSKSYKIPHISTGDLFRAAIKEQTDLGKKVK
AVIDSGALVSDDLTIALVKERLERDDTKKGFILDGFPRTIAQADALEDIV
KIDSVINFDISDDEVIKRLSGRRVCSSCGQSFHIEFVKPKKEGICDSCSG
DLMIRPDDKIEAIQKRLETYRNQTAPLIDYYTKKDLIVNIDARPASEKVL
ASFKVKFPH
Gene Nucleotide Sequence: Sequence Viewer
ATGAACTGTATTTTTTTGGGCCCGCCGGGCGCAGGAAAGGGAACCCTTGC
TTTTGAGGTTTCAAAATCGTATAAGATTCCGCATATTTCGACCGGAGATC
TTTTTAGAGCTGCAATCAAGGAGCAAACCGACTTGGGGAAAAAAGTTAAG
GCTGTCATTGATTCCGGGGCATTGGTAAGCGACGACCTTACAATCGCCCT
TGTAAAGGAAAGGTTGGAAAGGGATGACACCAAAAAAGGTTTTATCCTCG
ACGGCTTTCCCCGTACAATCGCTCAGGCCGATGCCCTAGAGGACATCGTA
AAAATAGATTCCGTTATCAACTTCGATATAAGCGATGATGAGGTTATCAA
ACGCCTTTCAGGAAGAAGGGTTTGTTCCTCATGCGGTCAAAGTTTTCATA
TCGAATTCGTAAAACCGAAAAAAGAAGGCATTTGCGATTCATGTTCCGGA
GATCTGATGATCCGTCCGGATGATAAAATTGAAGCAATCCAAAAACGCCT
TGAAACTTACAGAAACCAAACAGCTCCGTTAATCGACTATTATACAAAAA
AAGATCTGATAGTAAATATAGATGCCCGCCCGGCATCGGAGAAGGTATTG
GCTTCTTTTAAAGTAAAATTTCCGCAT