Diffusion Tensor and q-Space MRI Specimen Characterization
Description of Invention:
This new in vivo magnetic resonance imaging (MRI) method, especially suited for the characterization of brain white matter, combines q-space and diffusion tensor imaging concepts: Diffusion within axons is modeled as hindered diffusion parallel to an axis of the axon and restricted diffusion perpendicular to the axis. Diffusion exterior to axons is modeled as hindered diffusion with differing diffusivities parallel and perpendicular to the nerve axis. Diffusion weighted magnetic resonance images are obtained from specimens at different q values (magnitude and direction). Parameters associated with tissue microstructure are then extracted, such as the intra and extra-axonal principal diffusivities and their corresponding principal directions, and the volume fractions of intra and extra-axonal space. Improved angular resolution of fiber tracts orientation can be obtained for tractography studies, and more microstructural information can be gleaned both diagnostic and therapeutic purposes than from conventional diffusion tensor MRI.
For Additional Information Please Contact: Michael Shmilovich J.D.
NIH Office of Technology Transfer
6011 Executive Blvd, Suite 325
Rockville, MD 20852-3804
Phone: (301) 435-5019
Email: shmilovm@mail.nih.gov
Fax: (301) 402-0220
