US 7,338,666 B2
	Methods for modulating the axonal outgrowth of central nervous system neurons
Larry I. Benowitz, Newton, Mass. (US)
Assigned to Children's Medical Center Corporation,
Filed on May 19, 2005, as Appl. No. 11/132,701.
Application 11/132701 is a continuation of application No. 10/385031, filed on Mar. 10, 2003, abandoned.
Application 10/385031 is a continuation of application No. 09/997687, filed on Nov. 29, 2001, abandoned.
Application 09/997687 is a continuation of application No. 08/921902, filed on Sep. 02, 1997, granted, now 6,440,455.
Prior Publication US 2005/0277614 A1, Dec. 15, 2005
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/127 (2006.01); A61K 9/16 (2006.01); A61K 31/52 (2006.01)

U.S. Cl. 424—450  [514/45]

18 Claims

1. A method for stimulating the axonal outgrowth of central nervous system neurons following traumatic brain injury in a mammal, comprising intrathecal administration into the central nervous system of the mammal a pharmaceutical composition consisting essentially of an effective amount of inosine such that axonal outgrowth is stimulated in vivo.