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Title Effect of MSH/ACTH peptides on fast axonal transport in intact and regenerating sciatic nerves
Creator/Author Crescitelli, L.A.
Publication Date1985 Jan 01
OSTI IdentifierOSTI ID: 5071491
Resource TypeThesis/Dissertation
Resource RelationThesis (Ph. D.)
Research OrgNew York Univ., NY (USA)
Subject560172 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987); ACTH-- BIOLOGICAL EFFECTS;SCIATIC NERVE-- RADIONUCLIDE KINETICS; ADRENALECTOMY;BIOELECTRICITY;BIOLOGICAL REGENERATION;HYPOPHYSECTOMY;LEUCINE;RATS;TRITIUM COMPOUNDS
Related SubjectAMINO ACIDS;ANIMALS;BIOLOGICAL RECOVERY;CARBOXYLIC ACIDS;ELECTRICITY;HORMONES;LABELLED COMPOUNDS;MAMMALS;MEDICINE;NERVES;NERVOUS SYSTEM;ORGANIC ACIDS;ORGANIC COMPOUNDS;PEPTIDE HORMONES;PITUITARY HORMONES;RECOVERY;RODENTS;SURGERY;VERTEBRATES
Description/Abstract Fast axonal transport was examined in intact rats treated with ACTH 4-10 or ACTH 4-9 (ORG 2766), hypophysectomized rats, adrenalectomized rats, and in ACTH 4-10 treated rats with crushed regenerating sciatic nerves by injecting /sup 3/H-leucine into the ventral horn region of the spinal cord.^The distance traveled by the transported activity along the sciatic nerve and the rate of fast axonal transport were not significantly altered as a result of treatment with ACTH 4-10, ACTH 4-9 (ORG 2766), hypophysectomy, or adrenalectomy.^Treatment with ACTH 4-9 (ORG 2766) at concentrations of 1 ..mu..g/Kg /day and 10 ..mu..g/Kg/day caused significant reductions (62% and 64% respectively) in the crest height of the fast axonal transport curve as compared to 0.9% saline treated control animals.^No significant differences were found in comparing the distance, rate, slope, or crest height of ACTH 4-10 treated animals with crushed regenerating (7 or 14d) sciatic nerves to control animals.^In the group of animals in days, the amount of radiolabeled activity was significantly increased in the ACTH 4-10 treated animals as compared to control animals.^The results indicate that during regeneration the peptide acts to prolong the initially high levels of synthetic activity which occur in regenerating axons.
PublisherNew York Univ.,New York, NY
Country of PublicationUnited States
LanguageEnglish
FormatPages: 206
AvailabilityUniversity Microfilms Order No. 85-22,024.
System Entry Date2001 May 13

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