US 7,357,928 B2
Method for the diagnosis and prognosis of malignant diseases
Paula J. Bates, Louisville, Ky. (US); Donald M. Miller, Louisville, Ky. (US); John O. Trent, Louisville, Ky. (US); and Xiaohua Xu, Louisville, Ky. (US)
Assigned to University of Louisville Research Foundation, Inc., Louisville, Ky. (US)
Filed on Oct. 09, 2003, as Appl. No. 10/683,480.
Application 10/683480 is a continuation in part of application No. 10/118854, filed on Apr. 08, 2002.
Prior Publication US 2005/0053607 A1, Mar. 10, 2005
Int. Cl. A61K 39/395 (2006.01); A61K 51/00 (2006.01); A01N 61/00 (2006.01)
U.S. Cl. 424—130.1  [424/1.11; 514/1] 21 Claims
 
1. A method of treating cancer in a mammal comprising administering to said mammal a therapeutically effective amount of an anti-nucleolin agent and a pharmaceutically acceptable carrier;
wherein the anti-nucleolin agent comprises a nucleolin monoclonal antibody.