§1 report of VACTERL association (vertebral, anal, cardiac, tracheo-esophageal, renal, limb defects)
§dose: 10 mg/d,
gestational weeks 6-11
§birth prevalence:
1/500,000 (5 VACTERL features)
§VACTERL was also reported as 1 of 10
simvastatin malformation
cases
§dose: 10 mg/d simvastatin, gestational weeks 0 - 13
§birth prevalence: 1/50,000 (4 VACTERL features)
§4
additional malformations reported: microtia with absent auditory canal (40 mg/d); unspecified
cardiovascular malformation; unspecified “severe deformity” (doses unknown)