ANTTILA TI; Interscience Conference on Antimicrobial Agents and Chemotherapy (42nd : 2002 : San Diego, Calif.).
Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 2002 Sep 27-30; 42: abstract no. L-778.
NPHI, Oulu, Finland.
Backround: The prostate cancer is one of the most significant causes of cancer morbidity in men all over the world, but relatively little is known of its aetiology. Our earlier seroepidemiological studies have suggested that chronic C. trachomatis infections are associated to cervical cancer. The aim of the present study was to evaluate the serological association of past C. trachomatis infection and the risk for prostate cancer risk in a longitudinal nested case-control study design. METHODS: Serum banks of Finland, Norway and Sweden were used to study the association between C. trachomatis infection and prostate carcinoma. From the time of the serum sampling until end of 1996, the total number of cases was 738 for which 2271 (matched) controls were selected. C. trachomatis and C. pneumoniae-specific IgG antibodies were measured by the immunofluorescence (MIF) method. EBs of pooled serovars BED, CJHI, and GFK of C. trachomatis, and Kajaani 6 strain of C. pneumoniae were used as antigens. Relative risks were estimated by odds ratios (OR) and their 95% confidence intervals (CI) using conditional logistic regression analysis. RESULTS: The risk for prostate cancer was significantly decreased among those with seropositivity for C. trachomatis (OR 0.69, 95% CI 0.51-0.94). In addition, the higher the titer level of antibodies for C. trachomatis were, the higher protective effect (OR 0.57, 95% CI 0.34-0.96) was found. Conclusion: In the present prospective case-control study, we showed that the presence of C. trachomatis antibodies seems to protect from the prostate cancer. Furthermore, the higher antibody prevalence in controls compared to cases was consistently found in different countries, and there was also a dose response gradient strengthening the hypothesis of real protective effect.
Publication Types:
Keywords:
- Adenocarcinoma
- Antibodies
- Carcinoma
- Carcinoma, Squamous Cell
- Case-Control Studies
- Chlamydia
- Chlamydia Infections
- Chlamydia trachomatis
- Female
- Finland
- Humans
- Longitudinal Studies
- Male
- Norway
- Prostatic Neoplasms
- Seroepidemiologic Studies
- Sweden
- Uterine Cervical Neoplasms
Other ID:
UI: 102268221
From Meeting Abstracts